Browse Items · NEOMED Bibliography Database

Assessing noncognitive attributes: the primary care orientation scale.

Tags: *Career Choice, *Primary Health Care, *School Admission Criteria, *Schools, 2012, Achievement, Clinical Competence, Fabbro Stephanie K, Health Services Needs and Demand, Humans, Medical, Medicine, Motivation, Porfeli Erik, Surveys and Questionnaires, The virtual mentor : VM, United States, Vocational Guidance, Workforce

Gait selection and the ontogeny of quadrupedal walking in squirrel monkeys (Saimiri boliviensis).

Locomotor researchers have long known that adult primates employ a unique footfall sequence during walking. Most mammals use lateral sequence (LS) gaits, in which hind foot touchdowns are followed by ipsilateral forefoot touchdowns. In contrast, most…

Tags: 2012, American journal of physical anthropology, Animals, Biomechanical Phenomena/physiology, Body Size, Cross-Sectional Studies, Department of Anatomy & Neurobiology, Female, Gait/*physiology, Logistic Models, NEOMED College of Medicine, Saimiri/*physiology, Walking/*physiology, Young Jesse W

Primary cilia regulates the directional migration and barrier integrity of endothelial cells through the modulation of hsp27 dependent actin cytoskeletal organization.

Cilia are mechanosensing organelles that communicate extracellular signals into intracellular responses. Altered functions of primary cilia play a key role in the development of various diseases including polycystic kidney disease. Here, we show that…

Hibernation does not reduce cortical bone density, area or second moments of inertia in woodchucks (Marmota monax).

Long periods of inactivity in most mammals result in bone loss that may not be completely recoverable during an individual's lifetime regardless of future activity. Prolonged inactivity is normal during hibernation, but it remains uncertain whether…

Tags: 2012, Animals, Bone and Bones/metabolism, Bone Density/*physiology, Doherty Alison H, Female, Femur/metabolism, Frampton Jason D, Hibernation/*physiology, Humerus/metabolism, Journal of morphology, Male, Marmota/growth & development/*metabolism, Tibia/metabolism, Vinyard Christopher J

Modulation of angiogenesis by dietary phytoconstituents in the prevention and intervention of breast cancer.

Breast cancer is the leading cause of cancer-related deaths for women in the United States and the rest of the world. About 8% of women develop breast cancer during the course of their lives. Dietary habits are closely associated with both the risk…

Tags: *Diet, 2012, Anticarcinogenic Agents/*chemistry/*pharmacology, Bishayee Anupam, Breast Neoplasms/*blood supply/*prevention & control, Female, Gopalan Ashwin, Humans, Malus/chemistry, Molecular nutrition & food research, Neovascularization, Pathologic/metabolism/prevention & control, Petit Danielle M, Reuben Sharon C

Nomifensine alters sex differences in striatal dopaminergic function.

A series of three experiments are presented in which the acute effects of the catecholamine reuptake inhibitor, nomifensine, upon striatal dopaminergic function are compared in female and male mice. In Experiment 1, treatment with nomifensine (5 mg…

Career development during childhood and adolescence.

Identity development is central to the career development of children and adolescents. This article reviews the literature pertaining to identity development as being composed of career exploration, commitment, and reconsideration and offers some…

Tags: *Adolescent Development, *Career Choice, *Child Development, *Employment, *Social Identification, 2012, Adolescent, Child, Humans, Lee Bora, New directions for youth development, Personnel Loyalty, Porfeli Erik J, Vocational Guidance/methods

A new dimension: robotic reconstruction in plastic surgery.

BACKGROUND: Robot-assisted surgery was first approved by the Federal Drug Administration in 1994. The robotic system has the advantages of three-dimensional visualization of the operating field, 7 degrees range of motion, tremor elimination, 360…

Tags: 2012, Journal of robotic surgery, Latissimus dorsi flap, Patel Nima P, Pedersen John, Robotic surgery, Van Meeteren Justin

Migraine and allergy: a review and clinical update.

Migraine and allergy are both common diseases. Many patients suffer from both, and the vast majority of patients with "sinus headache" complaints are found to have migraine, making migraine identification important to allergists. This review…

Tags: 2012, Causality, Comorbidity, Current allergy and asthma reports, Humans, Hypersensitivity/*epidemiology/metabolism/therapy, Mehle Mark E, Migraine Disorders/*epidemiology/metabolism/therapy

On small, good things in medicine.

Tags: *Attitude to Death, *Medicine in Literature, *Social Support, 2012, Department of Family & Community Medicine, Department of Internal Medicine, Grief, Humans, NEOMED College of Medicine, Parents/*psychology, The American journal of medicine, Wear Delese, Zarconi Joseph

The role of transcervical thymectomy in patients with hyperparathyroidism.

BACKGROUND: The most common location for supernumerary or ectopic parathyroid glands is the thymus. METHODS: A review of patients who underwent parathyroidectomy for hyperparathyroidism from 1990 to 2010 was completed to determine indications for…

Tags: *Thymectomy/methods, 2012, Adult, Aged, American journal of surgery, Female, Humans, Hyperparathyroidism/etiology/pathology/*surgery, Hypocalcemia/etiology, Male, McHenry Christopher R, Middle Aged, Parathyroidectomy, Postoperative Complications, Retrospective Studies, Thymus Gland/pathology/surgery, Treatment Outcome, Welch Kellen

A scaffold hopping approach to identify novel monoamine oxidase B inhibitors.

Monoamine oxidase B (MAO-B) inhibitors are used to treat Parkinson's disease. In this study, we searched for novel MAO-B inhibitors using a scaffold hopping approach based on our experience with the thiazolidinedione (TZD) class of compounds as MAO-B…

Tags: *Monoamine Oxidase/chemistry/metabolism, 2012, Benzofurans/chemistry/pharmacology, Bioorganic & medicinal chemistry letters, Carroll Richard T, Enzyme Activation/drug effects, Flavonoids/chemistry/pharmacology, Funk Max O, Geldenhuys Werner J, Humans, Inhibitory Concentration 50, Models, Molecular, Molecular Structure, Monoamine Oxidase Inhibitors/*chemistry/*pharmacology, Protein Binding/drug effects, Small Molecule Libraries, Structure-Activity Relationship, Van der Schyf Cornelis J

Identification of a novel serum and glucocorticoid regulated kinase-1 (SGK1) ligand from virtual screening.

The serum and glucocorticoid regulated kinase-1 (SGK1) is part of the serine/threonine kinase family and has therapeutic potential in several neurodegenerative diseases such as ischemic stroke and Parkinson's disease. Here we use structure-based…

Tags: 2012, Binding Sites, Bioorganic & medicinal chemistry letters, Department of Pharmaceutical Sciences, Department of Pharmacy Practice, Drug Discovery, Geldenhuys Werner J, Humans, Immediate-Early Proteins/*antagonists & inhibitors/chemistry/metabolism, Ligands, Molecular Docking Simulation, NEOMED College of Graduate Studies, NEOMED College of Pharmacy, Protein Kinase Inhibitors/*chemistry/*pharmacology, Protein-Serine-Threonine Kinases/*antagonists & inhibitors/chemistry/metabolism, Sadana Prabodh, Talasila Phani K

Inhibition of monoamine oxidase by derivatives of piperine, an alkaloid from the pepper plant Piper nigrum, for possible use in Parkinson's disease.

A series of compounds related to piperine and antiepilepsirine was screened in a monoamine oxidase A and B assay. Piperine is an alkaloid from the source plant of both black and white pepper grains, Piper nigrum. Piperine has been shown to have a…

Methodological optimization of tinnitus assessment using prepulse inhibition of the acoustic startle reflex.

Recently prepulse inhibition of the acoustic startle reflex (ASR) became a popular technique for tinnitus assessment in laboratory animals. This method confers a significant advantage over the previously used time-consuming behavioral approaches…

Tags: 2012, Acoustic Stimulation/instrumentation/*methods, Animal/physiology, Animals, Behavior, Brain research, Department of Anatomy & Neurobiology, Galazyuk A V, Habituation, Longenecker R J, Mice, NEOMED College of Medicine, Psychophysiologic/physiology, Reflex, Startle/*physiology, Tinnitus/*diagnosis/physiopathology

Effects of gelucire content on stability, macrophage interaction and blood circulation of nanoparticles engineered from nanoemulsions.

The main objective of the study is to investigate the efficacy of Gelucire 44/14 (gelucire) in facilitating formation of cetyl alcohol (CA)-based nanoparticle (NP) and to assess the effects on key NP properties and functions. NPs from oil-in-water…

Protein thiyl radical mediates S-glutathionylation of complex I.

Complex I is a critical site of O(2)(*-) production and the major host of reactive protein thiols in mitochondria. In response to oxidative stress, complex I protein thiols at the 51- and 75-kDa subunits are reversibly

Tags: *Oxidative Stress, 2012, Amino Acid Motifs, Amino Acid Sequence, Animals, Binding Sites, Cattle, Cell Line, Chen Chwen-Lih, Chen Jingfeng, Chen Yeong-Renn, Cyclic N-Oxides/chemistry/pharmacology, Cysteine/chemistry/*metabolism, Department of Integrative Medical Sciences, Electron Transport Complex I/chemistry/*metabolism, Free radical biology & medicine, Free Radical Scavengers/chemistry/pharmacology, Free Radicals/chemistry/*metabolism, Glutathione/chemistry/*metabolism, Green Kari B, Heart/enzymology/metabolism, Kang Patrick T, Mice, Mitochondria, Models, Molecular, Molecular Sequence Data, Muscle Cells/drug effects/metabolism, NEOMED College of Medicine, Onium Compounds/pharmacology, Peptide Fragments/chemistry, Peptide Mapping, Protein, Rats, Rotenone/pharmacology, Structural Homology, Superoxides/metabolism, Zhang Liwen

Combined laser treatment of actinic sun damage and acne scarring.

Since its approval for use in 2007, many surgeons have been using the laser for subcutaneous use, primarily for lipolysis, facial neck and body contouring, and skin tightening. Techniques have recently evolved to enable use of the subcutaneous laser…

Tags: *Laser Therapy/instrumentation, *Skin Aging, 2012, Acne Vulgaris, Cicatrix/*surgery, Facial plastic surgery clinics of North America, Gentile Richard D, Humans, Sunlight/*adverse effects

Pathologies in the extinct Pleistocene Eurasian steppe lion Panthera leo spelaea ()-Results of fights with hyenas, bears and lions and other ecological stresses.

Late Pleistocene Eurasian steppe lions Panthera leo spelaea (Goldfuss, 1810) frequently (3 of 13) have skull damage attributable to bites. Such evidence is found only in lions from hyena or cave bear dens. Wounds on frontal and parietal bones appear…

Tags: 2012, Diedrich Cajus G, International journal of paleopathology, Rothschild Bruce M

The natural history of halo nevi: a retrospective case series.

BACKGROUND: The time period between onset of depigmentation around the halo nevus (HN) to complete resolution of the nevus and halo has not been well studied. OBJECTIVE: We sought to better understand the natural history of the HN. METHODS: A…

Ontogeny of limb force distribution in squirrel monkeys (Saimiri boliviensis): insights into the mechanical bases of primate hind limb dominance.

The distribution of peak vertical forces between the forelimbs and the hind limbs is one of the key traits distinguishing primate quadrupedal locomotion from that of other mammals. Whereas most mammals generate greater peak vertical forelimb forces,…

Tags: *locomotion, 2012, Age Factors, Animals, Biological, Biomechanical Phenomena, Department of Anatomy & Neurobiology, Female, Journal of human evolution, Leg/anatomy & histology/*growth & development/*physiology, Models, NEOMED College of Medicine, Saimiri/anatomy & histology/*growth & development/*physiology, Videotape Recording, Weight-Bearing, Young Jesse W

Professional judgments about advance care planning with community-dwelling consumers.

CONTEXT: There is limited research on how community-based long-term care (CBLTC) providers' personal characteristics and attitudes affect their decisions to initiate advance care planning (ACP) conversations with consumers. OBJECTIVES: To examine…

Tags: *Attitude of Health Personnel, *Decision Making, *Health Care Surveys, 2012, advance care planning, Advance Care Planning/organization & administration/*statistics & numerical data, Attitude of Health Personnel, Baughman Kristin R, Consumer Behavior/*statistics & numerical data, Consumer Satisfaction – Statistics and Numerical Data, Decision Making, Department of Family & Community Medicine, Hazelett Susan, Hewit Michael, Human, Humans, Journal of pain and symptom management, Ludwick Ruth E, Management, Merolla David M, Midwestern United States, Models, NEOMED College of Medicine, Organizational, Palmisano Barbara, Patient Satisfaction – Statistics and Numerical Data, Patient Satisfaction/*statistics & numerical data, Population Surveillance, Questionnaires, RANDOMIZED controlled trials, Surveys, Surveys and Questionnaires, Winchell Janice

Pilomatricoma of the upper arm in an orthopaedic clinic.

Dimebon attenuates methamphetamine, but not MPTP, striatal dopamine depletion.

Dimebon is an anti-histamine with central nervous system activity. In this report the effects of dimebon as a neuroprotectant in animal models of Parkinson's disease were tested as assessed in methamphetamine- and MPTP-induced striatal dopaminergic…

Tags: 2012, Animals, Corpus Striatum/*drug effects/metabolism, Darvesh Altaf S, Department of Pharmaceutical Sciences, Dluzen Dean E, Dopamine/*metabolism, Drug Synergism, Geldenhuys Werner J, Inbred C57BL, Indoles/*pharmacology, Methamphetamine/*pharmacology, Mice, NEOMED College of Pharmacy, Neurochemistry international

Synaptic activity-induced Ca(2+) signaling in avian cochlear nucleus magnocellularis neurons.

Neurons of the avian cochlear nucleus magnocellularis (NM) receive glutamatergic inputs from the spiral ganglion cells via the auditory nerve and feedback GABAergic inputs primarily from the superior olivary nucleus. We investigated regulation of…

Selectivity and persistent firing responses to social vocalizations in the basolateral amygdala.

This study examined responsiveness to acoustic stimuli among neurons of the basolateral amygdala. While recording from single neurons in awake mustached bats (Pteronotus parnellii), we presented a wide range of acoustic stimuli including tonal,…

Tags: 2012, Acoustic Stimulation, Action Potentials/*physiology, Amygdala/*physiology, Animal/*physiology, Animals, Auditory/physiology, Chiroptera/*physiology, College of Anatomy & Neurobiology, Department of Anatomy & Neurobiology, Echolocation/physiology, Evoked Potentials, NEOMED College of Medicine, Neurons/*physiology, Neuroscience, Peterson D C, Vocalization, Wenstrup J J

Markers associated with testosterone enhancement of methamphetamine-induced striatal dopaminergic neurotoxicity.

Intact male CD-1 mice received an injection of testosterone propionate (TP–5 ug), progesterone (P–5 mg), the oil vehicle or remained untreated (control). At 24 hours after hormonal treatments the mice received an injection of methamphetamine (MA–40…

Characterization of combat-related spinal injuries sustained by a US Army Brigade Combat Team during Operation Iraqi Freedom.

BACKGROUND CONTEXT: The United States is presently engaged in the largest scale armed conflict since Vietnam. Despite recent investigations into the scope of injuries sustained by soldiers in Iraq and Afghanistan, little information is available…

Tags: *Iraq War, 2003-2011, 2012, Adolescent, Adult, Belmont Philip J Jr, Female, Goodman Gens P, Humans, Incidence, Male, Middle Aged, Military Personnel/statistics & numerical data, Schoenfeld Andrew J, Spinal Injuries/*epidemiology, The spine journal : official journal of the North American Spine Society, United States/epidemiology, Young Adult

Epidemiology of cervical spine fractures in the US military.

BACKGROUND CONTEXT: The epidemiology of cervical spine fractures and associated spinal cord injury (SCI) has not previously been estimated within the American population. PURPOSE: To determine the incidence of cervical spine fractures and associated…

Evaluation and management of combat-related spinal injuries: a review based on recent experiences.

BACKGROUND CONTEXT: The current approach to the evaluation and treatment of military casualties in the Global War on Terror is informed by medical experience from prior conflicts and combat encounters from the last 10 years. In an effort to…

Tags: *Practice Guidelines as Topic, 2003-2011, 2012, Afghan Campaign 2001-, Hsu Joseph R, Humans, Iraq War, Lehman Ronald A Jr, Military Medicine/*methods, Schoenfeld Andrew J, Spinal Injuries/*diagnosis/*therapy, The spine journal : official journal of the North American Spine Society

Coronary collateral growth–back to the future.

The coronary collateral circulation is critically important as an adaptation of the heart to prevent the damage from ischemic insults. In their native state, collaterals in the heart would be classified as part of the microcirculation, existing as…

Tags: 2012, Chilian William M, Collateral Circulation/*physiology, Coronary Artery Disease/physiopathology/therapy, Coronary Circulation/physiology, Department of Integrative Medical Sciences, Dong Feng, Humans, Journal of molecular and cellular cardiology, Logan Suzanna, Mayorga Maritza, Myocardial Ischemia/physiopathology/therapy, NEOMED College of Medicine, Neovascularization, Ohanyan Vahagn, Penn Marc S, Physiologic/physiology, Pung Yuh Fen, Yin Liya

Cognitive behavioral therapy for psychosis in clinical practice.

Across two continents, Cognitive-Behavioral Therapy for Psychosis (CBT-P) has been endorsed as an adjunctive treatment for individuals who experience persistent positive symptoms of schizophrenia. The moderate effect sizes reported in early studies…

The health benefits of blackcurrants.

The blackcurrant (Ribes nigrum L., Grossulariceae), a small, perennial shrub native to central Europe and northern Asia, is cultivated throughout the world, including the United States. In addition to its anecdotal use in traditional herbal medicine,…

Robotic harvest of the rectus abdominis muscle: a preclinical investigation and case report.

In an attempt to decrease donor-site morbidity for rectus abdominis muscle harvest during free tissue transfer, we developed a technique of minimally invasive harvest. The da Vinci Surgical System (Intuitive Surgical, Sunnyvale, CA) was used in two…

Tags: *Robotics, 2012, Adult, Cadaver, Dissection, Female, Free Tissue Flaps, Humans, Journal of reconstructive microsurgery, Limb Salvage, Lower Extremity, Minimally Invasive Surgical Procedures, Muscle Neoplasms/*therapy, Patel Niyant V, Pedersen John C, Rectus Abdominis/*surgery, Sarcoma/*therapy, Tissue and Organ Harvesting/*methods, Wounds and Injuries/*surgery

Glucose and insulin induction of bile acid synthesis: mechanisms and implication in diabetes and obesity.

Bile acids facilitate postprandial absorption of nutrients. Bile acids also activate the farnesoid X receptor (FXR) and the G protein-coupled receptor TGR5 and play a major role in regulating lipid, glucose, and energy metabolism. Transgenic…

Managing in the trenches of consumer care: the challenges of understanding and initiating the advance care planning process.

To better understand how community-based long-term care providers define advance care planning and their role in the process, we conducted 8 focus groups with 62 care managers (social workers and registered nurses) providing care for Ohio's Medicaid…

Tags: *Health Personnel/psychology/standards, *Health Services for the Aged, *Long-Term Care/methods/organization & administration/psychology, *Patient Care Management/methods/organization & administration, 2012, advance care planning, Advance Care Planning/*organization & administration, Attitude of Health Personnel, Aultman Julie, Baughman Kristin R, Case Management, College of Graduate Studies, Convenience Sample, Decision Making, Department of Family & Community Medicine, Family Relations, Focus Groups, Funding Source, Hazelett Susan, Human, Humans, Interpersonal Relations, Journal of gerontological social work, Long Term Care, Ludwick Ruth, Needs Assessment, NEOMED College of Graduate Studies, NEOMED College of Medicine, Nurse Attitudes, O'Neill Anne, Ohio, Palmisano Barbara, Patient Education as Topic, Professional Role, Professional-Patient Relations, Qualitative Research, Qualitative Studies, Sanders Margaret, Social Work/*standards, Social Worker Attitudes, Terminal Care/organization & administration/psychology, Thematic Analysis

Mindfulness as a predictor of positive reappraisal and burnout in standardized patients.

BACKGROUND: Standardized patients (SPs) portray emotionally intense roles that can have unintended deleterious effects including burnout. PURPOSE: This study explored SP characteristics that could serve as protective factors against these adverse…

Development and validation of a novel RP-HPLC method for the analysis of reduced glutathione.

The objective of this study was the development, optimization, and validation of a novel reverse-phase high-pressure liquid chromatography (RP-HPLC) method for the quantification of reduced glutathione in pharmaceutical formulations utilizing simple…

Tags: 2012, Chromatography, Geldenhuys Werner J, Glutathione/*analysis, High Pressure Liquid/*methods, Journal of chromatographic science, Limit of Detection, Linear Models, Nanoparticles/chemistry, Pharmaceutical Preparations/chemistry, Reproducibility of Results, Reverse-Phase/*methods, Spectrophotometry, Sutariya Vijaykumar, Ultraviolet, Wehrung Daniel

Life-threatening respiratory pasteurellosis associated with palliative pet care.

Pasteurella multocida is a zoonotic Gram-negative cocco-bacillus often associated with soft tissue infections due to dog and cat bites. Here we report 3 patients who developed life-threatening P. multocida respiratory tract infections after providing…

Summary of ceftaroline fosamil clinical trial studies and clinical safety.

In October 2010, the new cephalosporin, ceftaroline fosamil, was approved by the US Food and Drug Administration for therapy of community-acquired bacterial pneumonia (CABP) and acute bacterial skin and skin structure infections (ABSSSIs). The active…

Tags: 2012, Anti-Bacterial Agents/adverse effects/*therapeutic use, Bacterial/drug therapy, Cephalosporins/adverse effects/*therapeutic use, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, Clinical Trials as Topic, Department of Internal Medicine, File Thomas M Jr, Humans, NEOMED College of Medicine, Pneumonia, Staphylococcal Skin Infections/drug therapy, Stein Gary E, Wilcox Mark H

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