Browse Items · NEOMED Bibliography Database

Increased mitochondrial prooxidant activity mediates up-regulation of Complex I

In response to oxidative stress, mitochondrial Complex I is reversibly

Hepatoid carcinoma of the ovary: A case report and review of the literature.

Primary hepatoid carcinoma of the ovary (HCO) is a rare aggressive tumor that typically presents at an advanced stage in postmenopausal women with unilateral or bilateral ovarian masses and elevated AFP and CA125. We report a case of HCO in a 73…

Tags: 2015, Alpha-fetoprotein, Gynecologic oncology reports, Hepatoid ovarian carcinoma, Hopkins Maeve K, Hopkins Michael P, Randolph Laura K, Wasdahl Daniel A

Canertinib induces ototoxicity in three preclinical models.

Neuregulin-1 (NRG1) ligand and its epidermal growth factor receptor (EGFR)/ERBB family regulate normal cellular proliferation and differentiation in many tissues including the cochlea. Aberrant NRG1 and ERBB signaling cause significant hearing…

Plication augmentation of the modified Hummelsheim procedure for treatment of large-angle esotropia due to abducens nerve palsy and type 1 Duane syndrome.

BACKGROUND: Multiple procedures have been described to treat a large-angle esodeviation with an associated abduction deficit. We report a plication augmentation of the Hummelsheim procedure for the management of esotropia and severe abduction deficit…

Tags: *Ophthalmologic Surgical Procedures, 2015, 80 and over, Abducens Nerve Diseases/complications/physiopathology/*surgery, Adolescent, Adult, Aged, Binocular/physiology, Botulinum Toxins, Child, Cochran Megan, Duane Retraction Syndrome/complications/physiopathology/*surgery, El Sahn Mahmoud, Esotropia/etiology/physiopathology/*surgery, Eye Movements/physiology, Female, Granet David B, Hertle Richard W, Humans, Injections, Intramuscular, Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus, Khayali Salma, Kinori Michael, Male, Middle Aged, Miller Kyle E, Neuromuscular Agents/administration & dosage, Oculomotor Muscles/drug effects/physiopathology/*surgery, Patil Preeti A, Preschool, Retrospective Studies, Robbins Shira L, Suture Techniques, Tendon Transfer, Type A/administration & dosage, Vision, Young Adult

Cardiovascular Effects of Exposure to Cigarette Smoke and Electronic Cigarettes: Clinical Perspectives From the Prevention of Cardiovascular Disease Section Leadership Council and Early Career Councils of the American College of Cardiology.

Cardiovascular morbidity and mortality as a result of inhaled tobacco products continues to be a global healthcare crisis, particularly in low- and middle-income nations lacking the infrastructure to develop and implement effective public health…

Tags: 2015, Al-Mallah Mouaz H, atherogenesis, Bahrami Hossein, Benowitz Neal L, Bhakta Shyam, Cardiovascular Diseases – Etiology, Cardiovascular Diseases/*etiology, Deedwania Prakash, Department of Internal Medicine, El-Chami Mikhael F, Electronic Cigarettes – Adverse Effects, Electronic Nicotine Delivery Systems/*adverse effects, Epigenesis, Feldman Dmitriy N, Ference Brian A, Genes, Genetic, genetic and epigenetic effects, Humans, Impact of Events Scale, Jahangir Eiman, Journal of the American College of Cardiology, Mehta Laxmi S, Morris Pamela B, NEOMED College of Medicine, Phan Binh An P, Ryan John J, Sanchez Shields Monica, Scales, smoke-free legislation, Smoking – Complications, Smoking – Legislation and Jurisprudence – United States, Smoking Cessation, Smoking/*adverse effects/legislation & jurisprudence, Thrombosis, tobacco cessation, United States, Winchester David E

Protein Kinase Cbeta: Linking Intestine Fibroblast Growth Factor 15 to Hepatic Extracellular Signal Regulated Kinase 1/2 Signaling in Bile Acid and Cholesterol Homeostasis.

Tags: 2015, Cellular and molecular gastroenterology and hepatology, Chiang John Y L, Department of Integrative Medical Sciences, NEOMED College of Medicine

Short-term circadian disruption impairs bile acid and lipid homeostasis in mice.

BACKGROUND & AIMS: Bile acids are physiological detergents that also activate nuclear receptors to regulate glucose and lipid homeostasis. Cholesterol 7alpha-hydroxylase (Cyp7a1), the rate-limiting enzyme that converts cholesterol to bile acids, is…

Tags: 2015, Bile acid synthesis, Cellular and molecular gastroenterology and hepatology, Chiang John Y L, Circadian Rhythm, Department of Integrative Medical Sciences, Ferrell Jessica M, Lipid Metabolism, NEOMED College of Medicine

Freestanding emergency departments and the trauma patient.

BACKGROUND: Freestanding emergency departments (FEDs) continue to grow in number and more research is needed on these facilities. OBJECTIVE: We sought to characterize the types of injuries and patients who initially presented to two FEDs and were…

Type 1 Brugada Pattern Associated with Nicotine Toxicity.

BACKGROUND: Brugada pattern (BrP) findings on electrocardiogram (ECG) are mandatory for the diagnosis of Brugada syndrome (BrS). BrS is an incompletely understood cause of sudden cardiac death. CASE REPORT: Our patient was a young woman who was using…

Jaw-muscle architecture and mandibular morphology influence relative maximum jaw gapes in the sexually dimorphic Macaca fascicularis.

Maximum jaw gape is a performance variable related to feeding and non-feeding oral behaviors, such as canine gape displays, and is influenced by several factors including jaw-muscle fiber architecture, muscle position on the skull, and jaw…

An improved approach to separating startle data from noise.

BACKGROUND: The acoustic startle reflex (ASR) is a rapid, involuntary movement to sound, found in many species. The ASR can be modulated by external stimuli and internal state, making it a useful tool in many disciplines. ASR data collection and…

Anti-edema action of thyroid hormone in MCAO model of ischemic brain stroke: Possible association with AQP4 modulation.

The use of neuroprotective strategies to mitigate the fatal consequences of ischemic brain stroke is a focus of robust research activity. We have previously demonstrated that thyroid hormone (T3; 3,3',5-triiodo-l-thyronine) possesses neuroprotective…

Coccidioides parenchymal cerebral abscess in the setting of lymphoma.

Coccidioides immitis is a dimorphic fungus endemic to southwestern United States of America. When symptomatic, infection usually results in a subacute respiratory infection. Disseminated coccidioidomycosis occurs in less than 1% of all cases. We…

Tags: 2015, Aged, Brain Abscess/*etiology/pathology, Coccidioides, Coccidioides/*pathogenicity, Coccidioidomycosis/*complications, Follicular lymphoma, Follicular/*drug therapy, Fungus, Grabowski Matthew, Humans, Immunologic Factors/*therapeutic use, Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia, Lymphoma, Male, Motley Benjamin D, Prayson Richard A, Rituximab/*therapeutic use, United States

Another Reason to Avoid Second-Hand Smoke.

Role of inflammation in the aging bones.

Chronic inflammation in aging is characterized by increased inflammatory cytokines, bone loss, decreased adaptation, and defective tissue repair in response to injury. Aging leads to inherent changes in mesenchymal stem cell (MSC) differentiation,…

Dewetting based fabrication of fibrous micro-scaffolds as potential injectable cell carriers.

Although regenerative medicine utilizing tissue scaffolds has made enormous strides in recent years, many constraints still hamper their effectiveness. A limitation of many scaffolds is that they form surface patches, which are not particularly…

Pilot Study of Intensive Chemotherapy With Peripheral Hematopoietic Cell Support for Children Less Than 3 Years of Age With Malignant Brain Tumors, the CCG-99703 Phase I/II Study. A Report From the Children's Oncology Group.

BACKGROUND: The primary goals of the Children's Cancer Group 99703 study were to assess the feasibility and tolerability of-as well as the response rate to-a novel dose-intensive chemotherapy regimen. METHODS: Between March 1998 and October 2004, 92…

Tags: *Hematopoietic Stem Cell Transplantation/adverse effects, 2015, Antineoplastic Agents/administration & dosage/adverse effects, Brain Neoplasms/*therapy, Carboplatin/administration & dosage/adverse effects, Child, Children's Oncology Group, Cisplatin/administration & dosage/adverse effects, Cohen Bruce H, Combined Modality Therapy/adverse effects/methods, Consolidation Chemotherapy, Curran John G, Cyclophosphamide/administration & dosage/adverse effects/therapeutic use, Department of Family & Community Medicine, Dunkel Ira J, Etoposide/administration & dosage/adverse effects, Feasibility Studies, Female, Finlay Jonathan L, Gajjar Amar, Geyer J Russell, high-dose chemotherapy, Hilden Joanne, Holmes Emi, Humans, Induction Chemotherapy, Infant, infant brain tumor, Ingles Sue Ann, Male, Miller Douglas C, NEOMED College of Medicine, Packer Roger J, Pediatric neurology, Pilot Projects, Pollack Ian F, Preschool, stem-cell support, Thiotepa/administration & dosage/adverse effects, Treatment Outcome, Vincristine/adverse effects/therapeutic use, Zhou Tianni

Liver disease in the morbidly obese: a review of 1000 consecutive patients undergoing weight loss surgery.

BACKGROUND: Liver disease among the morbidly obese is increasingly prevalent, contributing to significant morbidity. Obesity-related liver pathologies including nonalcoholic steatohepatitis (NASH) have become a leading cause for liver transplant.…

WFUMB guidelines and recommendations for clinical use of ultrasound elastography: Part 3: liver.

The World Federation for Ultrasound in Medicine and Biology (WFUMB) has produced these guidelines for the use of elastography techniques in liver disease. For each available technique, the reproducibility, results, and limitations are analyzed, and…

Tags: *Practice Guidelines as Topic, 2015, Amy Dominique, Bamber Jeffrey C, Barr Richard, Castera Laurent, Choi Byung Ihn, Chou Yi-Hong, Cosgrove David, Dietrich Christoph F, Ding Hong, Elastic Modulus, Elasticity Imaging Techniques/*standards, elastography, Farrokh Andre, Ferraioli Giovanna, Filice Carlo, focal liver lesions, Friedrich-Rust Mireen, guidelines, Hall Timothy J, Internationality, Kudo Masatoshi, Liver, Liver Cirrhosis/*diagnostic imaging/*physiopathology, Liver Diseases, Liver fibrosis, Liver stiffness, Liver/*diagnostic imaging/*physiopathology, Mechanical, Nakashima Kazutaka, Nightingale Kathryn R, Palmeri Mark L, Schafer Fritz, Shear Strength, Shear wave elastography, Shiina Tsuyoshi, Sporea Ioan, Strain elastography, Stress, Suzuki Shinichi, transient elastography, Ultrasound, Ultrasound in medicine & biology, WFUMB, Wilson Stephanie R

WFUMB guidelines and recommendations for clinical use of ultrasound elastography: Part 2: breast.

The breast section of these Guidelines and Recommendations for Elastography produced under the auspices of the World Federation of Ultrasound in Medicine and Biology (WFUMB) assesses the clinically used applications of all forms of elastography used…

WFUMB guidelines and recommendations for clinical use of ultrasound elastography: Part 1: basic principles and terminology.

Conventional diagnostic ultrasound images of the anatomy (as opposed to blood flow) reveal differences in the acoustic properties of soft tissues (mainly echogenicity but also, to some extent, attenuation), whereas ultrasound-based elasticity images…

Feasibility of a lifestyle intervention for overweight/obese endometrial and breast cancer survivors using an interactive mobile application.

OBJECTIVE: The study aimed to assess a one-month lifestyle intervention delivered via a web- and mobile-based weight-loss application (app) (LoseIt!) using a healthcare-provider interface. METHODS: Early-stage overweight/obese (body mass index…

Overexpressing superoxide dismutase 2 induces a supernormal cardiac function by enhancing redox-dependent mitochondrial function and metabolic dilation.

During heightened cardiac work, O2 consumption by the heart benefits energy production via mitochondria. However, some electrons leak from the respiratory chain and yield superoxide, which is rapidly metabolized into H2O2 by SOD2. To understand the…

Tags: 2015, Adenosine Triphosphate/biosynthesis, Animals, Arterial Pressure/drug effects, Bioenergetics, Blood Flow Velocity/drug effects, Cardiac function, Cardiac/drug effects/*enzymology, Catalase/pharmacology, Chen Chwen-Lih, Chen Yeong-Renn, Chilian William M, Department of Integrative Medical Sciences, Echocardiography, Female, Gene Expression, Heart/drug effects/*enzymology, Hydrogen Peroxide/*metabolism/pharmacology, Injections, Intravenous, Journal of molecular and cellular cardiology, Kang Patrick T, Luther Daniel J, Male, Meszaros J Gary, Metabolic dilation, Mice, Mitochondria, Myocardium/*enzymology, Myocytes, NEOMED College of Medicine, NG-Nitroarginine Methyl Ester/pharmacology, Ohanyan Vahagn, Oxidation-Reduction, Oxygen Consumption/drug effects, Redox regulation, Signal Transduction, Stroke Volume/drug effects, Superoxide dismutase 2 (SOD2), Superoxide Dismutase/*genetics/metabolism, Transgenic, Transgenic mice, Vasodilation/*drug effects

Cytochrome P450 Function and Pharmacological Roles in Inflammation and Cancer. Preface.

Tags: 2015, Advances in pharmacology (San Diego, Calif.), Animals, Cytochrome P-450 Enzyme System/*metabolism, Department of Integrative Medical Sciences, Hardwick James P, Humans, Inflammation/*metabolism, NEOMED College of Medicine, Neoplasms/*metabolism

Radical changes in medical education needed globally.

Tags: *Health Care Reform, 2015, Bourne Peter G, Chalkidou Kalipso, Department of Family & Community Medicine, di Fabio Jose Luis, Ebrahim Shah, Education, Health Personnel/*education, Humans, Keck William, NEOMED College of Medicine, Neusy Andre-Jaques, Professional/*standards, Reed Gail, Squires Neil, The Lancet. Global health

International Federation for emergency medicine model curriculum for continuing professional development.

Geriatric Disaster Preparedness.

INTRODUCTION: The elderly population has proven to be vulnerable in times of a disaster. Many have chronic medical problems for which they depend on medications or medical equipment. Some older adults are dependent on caregivers for managing their…

The assessment and treatment of back and neck pain: an initial investigation in a primary care practice-based research network.

AIM: The purpose of this study was to conduct an exploratory examination of the current state of non-malignant acute and chronic back and neck pain assessment and management among primary care providers in a multi-site, practice-based research…

miR-139 modulates MCPIP1/IL-6 expression and induces apoptosis in human OA chondrocytes.

IL-6 is an inflammatory cytokine and its overexpression plays an important role in osteoarthritis (OA) pathogenesis. Expression of IL-6 is regulated post-transcriptionally by MCPIP1. The 3' untranslated region (UTR) of MCPIP1 mRNA harbors a miR-139…

A metabolic stress-inducible miR-34a-HNF4alpha pathway regulates lipid and lipoprotein metabolism.

Non-alcoholic fatty liver disease (NAFLD) is one of the most common liver diseases, but its underlying mechanism is poorly understood. Here we show that hepatocyte nuclear factor 4alpha (HNF4alpha), a liver-enriched nuclear hormone receptor, is…

TRPV4 channel activation selectively inhibits tumor endothelial cell proliferation.

Endothelial cell proliferation is a critical event during angiogenesis, regulated by both soluble factors and mechanical forces. Although the proliferation of tumor cells is studied extensively, little is known about the proliferation of tumor…

Integrated zwitterionic conjugated poly(carboxybetaine thiophene) as a new biomaterial platform.

An integrated zwitterionic conjugated polymer-based biomaterial platform was designed and studied to address some of the key challenges of conjugated polymers in biomedical applications. This biomaterial platform consists of conjugated polymer…

Tags: 2015, Cao Bin, Castaneda Homero, Chemical science, Cheng Gang, Lee Chen-Jung, Li Linlin, Tang Qiong, Wang Hua, Zhang Yanqiao

Orphan nuclear receptor oestrogen-related receptor gamma (ERRgamma) plays a key role in hepatic cannabinoid receptor type 1-mediated induction of CYP7A1 gene expression.

Bile acids are primarily synthesized from cholesterol in the liver and have important roles in dietary lipid absorption and cholesterol homoeostasis. Detailed roles of the orphan nuclear receptors regulating cholesterol 7alpha-hydroxylase (CYP7A1),…

Tags: 2015, Animals, bile acid, Bile Acids and Salts/metabolism, Cannabinoid, cannabinoid receptors, CB1/agonists/genetics/*metabolism, Cells, Chiang John Y L, Choi Hueng-Sik, Cholesterol 7-alpha-Hydroxylase/*biosynthesis/genetics, cholesterol 7alpha-hydroxylase (CYP7A1), Cultured, Cytoplasmic and Nuclear/metabolism, Department of Integrative Medical Sciences, Drug Inverse Agonism, Estrogen/genetics/*metabolism, Ethanol/pharmacology, Gene Expression, Genetic, Glycerides/pharmacology, GSK5182, HEK293 Cells, Hepatocytes/metabolism, Humans, Inbred C57BL, Jeong Won-Il, Kim Don-Kyu, Kim Seong Heon, Knockout, Lee Chul-Ho, Lee In-Kyu, Lee Ji-Min, Liver/*metabolism, Mice, NEOMED College of Medicine, oestrogen-related receptor gamma (ERRgamma), orphan nuclear receptor, Park Seung Bum, Promoter Regions, Rats, Receptor, Receptors, small heterodimer partner (SHP), Sprague-Dawley, The Biochemical journal, Transcription, Zhang Yaochen

Modern, multi-media, advances in surgical information.

The need for education does not end with residency. Practicing surgeons must find ways to stay current. The boom in new technologic developments may significantly enhance our methods of teaching through the use of new mutli-media. Here we will…

Tags: 2015, General Surgery/*education, Humans, Multi-media, Multimedia/*standards, Online education, Ponsky Todd A, Rothenberg Steven S, Seminars in pediatric surgery, Surgical education, Teleconferencing, Telementoring, Videoconferencing/*standards, Virtual education

Moth tails divert bat attack: evolution of acoustic deflection.

Adaptations to divert the attacks of visually guided predators have evolved repeatedly in animals. Using high-speed infrared videography, we show that luna moths (Actias luna) generate an acoustic diversion with spinning hindwing tails to deflect…

Generation and characterization of ATP analog-specific protein kinase Cdelta.

To better study the role of PKCdelta in normal function and disease, we developed an ATP analog-specific (AS) PKCdelta that is sensitive to specific kinase inhibitors and can be used to identify PKCdelta substrates. AS PKCdelta showed nearly 200…

Mutation in Osteoactivin Promotes Receptor Activator of NFkappaB Ligand (RANKL)-mediated Osteoclast Differentiation and Survival but Inhibits Osteoclast Function.

We previously reported on the importance of osteoactivin (OA/Gpnmb) in osteogenesis. In this study, we examined the role of OA in osteoclastogenesis, using mice with a nonsense mutation in the Gpnmb gene (D2J) and wild-type controls (D2J/Gpnmb(+)).…

Tags: *Communication, *Physician-Patient Relations, 2015, Academic medicine : journal of the Association of American Medical Colleges, Cole-Kelly Kathy, Department of Family & Community Medicine, Department of Internal Medicine, Education, Humans, Kumagai Arno, Medical/*organization & administration, NEOMED College of Medicine, Time Factors, Wear Delese, Zarconi Joseph

Browse Items (310 total)