Browse Items · NEOMED Bibliography Database

Prevalence of Inappropriate Antibiotic Prescriptions Among US Ambulatory Care Visits, 2010-2011.

IMPORTANCE: The National Action Plan for Combating Antibiotic-Resistant Bacteria set a goal of reducing inappropriate outpatient antibiotic use by 50% by 2020, but the extent of inappropriate outpatient antibiotic use is unknown. OBJECTIVE: To…

Tags: 2016, Adolescence, Adolescent, Adult, Aged, Ambulatory Care – Statistics and Numerical Data, Ambulatory Care/*statistics & numerical data, Anti-Bacterial Agents/*therapeutic use, Antibiotics – Therapeutic Use, Bartoces Monina, Child, Department of Internal Medicine, Enns Eva A, Female, File Thomas M Jr, Finkelstein Jonathan A, Fleming-Dutra Katherine E, Gerber Jeffrey S, Health Care Surveys, Hersh Adam L, Hicks Lauri A, Human, Humans, Hyun David Y, Inappropriate Prescribing – Statistics and Numerical Data, Inappropriate Prescribing/*statistics & numerical data, Infant, JAMA, Linder Jeffrey A, Lynfield Ruth, Male, Margolis David J, May Larissa S, Merenstein Daniel, Metlay Joshua P, Middle Age, Middle Aged, NEOMED College of Medicine, Newborn, Newland Jason G, Otitis Media, Otitis Media – Drug Therapy, Pharyngitis – Drug Therapy, Pharyngitis/drug therapy, Physicians'/*statistics & numerical data, Piccirillo Jay F, Practice Patterns, Preschool, Prevalence, Respiratory Tract Infections – Drug Therapy, Respiratory Tract Infections/drug therapy, Roberts Rebecca M, Sanchez Guillermo V, Shapiro Daniel J, Suda Katie J, Suppurative/*drug therapy, Surveys, Thomas Ann, United States, Woo Teri Moser, Zetts Rachel M

Painful Cutaneous Nodule of the Jawline.

Tags: 2016, Adult, Biopsy, Cernik Christina, Department of Internal Medicine, Diagnosis, Differential, Facial Dermatoses – Diagnosis, Facial Dermatoses – Pathology, Facial Dermatoses/diagnosis/pathology, Female, Hereditary – Diagnosis, Hereditary – Pathology, Hereditary/diagnosis/*pathology, Humans, Immunohistochemistry, JAMA dermatology, Kunzler Elaine, Leiomyoma – Diagnosis, Leiomyoma – Pathology, Leiomyomatosis/diagnosis/*pathology, Neck – Pathology, Neck/pathology, Needle, NEOMED College of Medicine, Neoplastic Syndromes, Skin Abnormalities – Diagnosis, Skin Abnormalities – Pathology, Skin Abnormalities/diagnosis/*pathology, Skin Neoplasms – Diagnosis, Skin Neoplasms – Pathology, Skin Neoplasms/diagnosis/*pathology, Uterine Neoplasms – Diagnosis, Uterine Neoplasms – Pathology, Uterine Neoplasms/diagnosis/*pathology, Weaver Joshua

Patterns of Needlestick and Sharps Injuries Among Training Residents.

Tags: 2016, Gemmel David, Hand Injuries – Epidemiology, Hand Injuries/*epidemiology, Humans, Internship and Residency – Statistics and Numerical Data, Internship and Residency/statistics & numerical data, JAMA internal medicine, Marnejon Thomas, Medical – Statistics and Numerical Data, Medical/*statistics & numerical data, Mulhern Kelli, Needlestick Injuries – Epidemiology, Needlestick Injuries/*epidemiology, Ohio, Ohio/epidemiology, Students

Psychiatric Diagnostic Uncertainty: Challenges to Patient-Centered Care.

In this case and commentary, a patient's request to be treated for depression without a stigmatizing diagnostic label of bipolar II disorder challenges a clinician's obligation to provide a clinically and ethically appropriate diagnosis and safe…

Grasping primate development: Ontogeny of intrinsic hand and foot proportions in capuchin monkeys (Cebus albifrons and Sapajus apella).

Young primates have relatively large hands and feet for their body size, perhaps enhancing grasping ability. We test the hypothesis that selection for improved grasping ability is responsible for these scaling trends by examining the ontogeny of…

Synthesis and Biological Evaluation of Pentacycloundecylamines and Triquinylamines as Voltage-Gated Calcium Channel Blockers.

Preclinical studies for neurodegenerative diseases have shown a multi-targeted approach to be successful in the treatment of these complex disorders with several pathoetiological pathways. Polycyclic compounds, such as NGP1-01 (7a), have demonstrated…

Primary or Secondary Effect of Quadriceps Exercises on Subsequent Need for Knee Replacement? Comment on the Article by Culvenor et al.

Tags: *Arthroplasty, *Quadriceps Muscle, 2016, Arthritis & rheumatology (Hoboken, N.J.), Arthroplasty, Exercise Therapy, Humans, Joint Instability, Knee, Knee – Utilization, Knee Pain – Etiology, Muscle Strengthening – Methods, Quadriceps Muscles – Physiology, Replacement, Rothschild Bruce

Persistence of intact retinal ganglion cell terminals after axonal transport loss in the DBA/2J mouse model of glaucoma.

Axonal transport defects are an early pathology occurring within the retinofugal projection of the DBA/2J mouse model of glaucoma. Retinal ganglion cell (RGC) axons and terminals are detectable after transport is affected, yet little is known about…

Tags: *Axonal Transport/physiology, *bouton, *Mitochondria, *neurodegeneration, *retinal, *RRID:IMSRJAX:000671, *RRID:IMSRJAX:007048, *RRID:SCR002716, *RRID:SCR002865, *superior colliculus, *synapse, 2016, Animal, Animals, Crish Samuel D, Dengler-Crish Christine M, Department of Anatomy & Neurobiology, Department of Pharmaceutical Sciences, Disease Models, Electron, Fening Kelly M, Glaucoma/metabolism/*pathology, Imaging, Inbred DBA, Inman Denise M, Mice, Microscopy, Mitochondria/pathology, NEOMED College of Medicine, NEOMED College of Pharmacy, Neuroanatomical Tract-Tracing Techniques, Regression Analysis, Retinal Ganglion Cells/metabolism/*pathology, Scanning, Schofield Brett R, Smith Matthew A, Superior Colliculi/metabolism/*pathology, Synapses/metabolism/*pathology, The Journal of comparative neurology, Three-Dimensional, Visual Pathways/metabolism/pathology, Xia Christina Z

Carboxylesterase 2 prevents liver steatosis by modulating lipolysis, endoplasmic reticulum stress, and lipogenesis and is regulated by hepatocyte nuclear factor 4 alpha in mice.

UNLABELLED: Nonalcoholic fatty liver disease (NAFLD) is a common liver disease that ranges from simple steatosis to nonalcoholic steatohepatitis (NASH). So far, the underlying mechanism remains poorly understood. Here, we show that hepatic…

Tags: *Lipid Metabolism, 2016, Adiposity, Animals, Carboxylesterase/*metabolism, Carboxylic Ester Hydrolases/genetics/*metabolism, Department of Integrative Medical Sciences, Department of Pharmaceutical Sciences, Diabetes Mellitus, Diet, Endoplasmic Reticulum Stress, Energy Metabolism, Experimental/enzymology, Gene Knockdown Techniques, Glucose Tolerance Test, Glucose/metabolism, Hepatocyte Nuclear Factor 4/*metabolism, Hepatology (Baltimore, Md.), High-Fat/adverse effects, Homeostasis, Humans, Inbred C57BL, Jadhav Kavita, Kasumov Takhar, Li Yuanyuan, Lipogenesis, Lipolysis, Liver/enzymology, Male, Mice, NEOMED College of Medicine, NEOMED College of Pharmacy, Non-alcoholic Fatty Liver Disease/*etiology/metabolism, Obesity/enzymology/etiology, Sterol Regulatory Element Binding Protein 1/metabolism, Xu Yang, Yin Liya, Zalzala Munaf, Zhang Yanqiao

Farnesoid X receptor activation increases reverse cholesterol transport by modulating bile acid composition and cholesterol absorption in mice.

UNLABELLED: Activation of farnesoid X receptor (FXR) markedly attenuates development of atherosclerosis in animal models. However, the underlying mechanism is not well elucidated. Here, we show that the FXR agonist, obeticholic acid (OCA), increases…

Macrophage-Associated Osteoactivin/GPNMB Mediates Mesenchymal Stem Cell Survival, Proliferation, and Migration Via a CD44-Dependent Mechanism.

Although MSCs have been widely recognized to have therapeutic potential in the repair of injured or diseased tissues, it remains unclear how functional activities of mesenchymal stem cells (MSCs) are influenced by the surrounding inflammatory milieu…

Transgenic Expression of Osteoactivin/gpnmb Enhances Bone Formation In Vivo and Osteoprogenitor Differentiation Ex Vivo.

Initial identification of osteoactivin (OA)/glycoprotein non-melanoma clone B (gpnmb) was demonstrated in an osteopetrotic rat model, where OA expression was increased threefold in mutant bones, compared to normal. OA mRNA and protein expression…

Osteoactivin Promotes Migration of Oral Squamous Cell Carcinomas.

Nearly 50% of patients with oral squamous cell carcinoma (OSCC) die of metastases or locoregional recurrence. Metastasis is mediated by cancer cell adhesion, migration, and invasion. Osteoactivin (OA) overexpression plays a role in metastases in…

Effects of Substrate Size and Orientation on Quadrupedal Gait Kinematics in Mouse Lemurs (Microcebus murinus).

As the smallest living primate, the mouse lemur is a suitable model for reconstructing the locomotor mechanisms by which primate ancestors might have responded to the challenges of an arboreal environment. In this study, we tested the effects of…

Tags: 2016, Animals, Biomechanical Phenomena, Cheirogaleidae/*physiology, Department of Anatomy & Neurobiology, Female, Gait/*physiology, Journal of experimental zoology. Part A, Ecological genetics and physiology, Kemp Addison D, Male, NEOMED College of Medicine, Shapiro Liza J, Young Jesse W

Prevalence and Predictors of Metformin Prescribing in Adults with Type 2 Diabetes Mellitus: A National Cross-Sectional Study.

OBJECTIVE: Metformin is the first-line oral type 2 diabetes treatment. Despite an abundance of evidence, metformin is routinely underused. This study evaluated the rates of metformin use in an appropriate outpatient type 2 diabetes population and…

Lichen striatus.

Tags: 2016, Adolescent, Age Factors, Child, Cutis, Diagnosis, Differential, Female, Graham Jacqueline N, Hossler Eric W, Humans, Inflammation/*diagnosis/pathology, Lichenoid Eruptions/*diagnosis/epidemiology/pathology, Male, Preschool, Sex Factors

No rheumatoid arthritis in ancient Egypt: a reappraisal.

Antiquity of rheumatoid arthritis (RA) remains controversial, and its origins in Americas or in the Old World are disputed. Proponents of the latter frequently refer to RA in ancient Egypt, but validity of those claims has never been examined. Review…

Thrombosed external hemorrhoids in pregnancy: a retrospective review of outcomes.

Tags: 2016, Adult, Female, Hemorrhoids/*complications, Humans, International journal of colorectal disease, Mirhaidari Shayda J, Porter Joel A, Pregnancy, Retrospective Studies, Slezak Frederick A, Thrombosis/*complications, Treatment Outcome

Differential regulation of TRPV1 channels by H2O2: implications for diabetic microvascular dysfunction.

We demonstrated previously that TRPV1-dependent coupling of coronary blood flow (CBF) to metabolism is disrupted in diabetes. A critical amount of H2O2 contributes to CBF regulation; however, excessive H2O2 impairs responses. We sought to determine…

Impaired coronary metabolic dilation in the metabolic syndrome is linked to mitochondrial dysfunction and mitochondrial DNA damage.

Mitochondrial dysfunction in obesity and diabetes can be caused by excessive production of free radicals, which can damage mitochondrial DNA. Because mitochondrial DNA plays a key role in the production of ATP necessary for cardiac work, we…

Revisiting classification of pain from bone metastases as mild, moderate, or severe based on correlation with function and quality of life.

PURPOSE: The objective of our study was to determine the optimal cut points for classification of pain scores as mild, moderate, and severe based on interference with function and quality of life (QOL). METHODS: We evaluated 822 patients who…

Tags: *Quality of Life, *Severity of Illness Index, 2016, 80 and over, Adolescence, Adolescent, Adult, Aged, Babington Scott, Bone metastases, Bone Neoplasms, Bone Neoplasms – Complications, Bone Neoplasms/*complications/secondary, Brief pain inventory, Brundage Michael, Chow Edward, Demas William F, Ding Keyue, Female, Functional interference, Funding Source, Hartsell William F, Hoskin Peter, Human, Humans, Male, Meyer Ralph M, Middle Age, Middle Aged, Nabid Abdenour, Ong Francisca, Pain – Classification, Pain – Etiology, Pain Measurement – Methods, Pain Measurement/*methods, Pain severity, Pain/*classification/etiology, Parulekar Wendy R, Quality of Life, Questionnaires, Re-irradiation, Roos Daniel, Severity of Illness Indices, Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, Survival, van der Linden Yvette M, van Tienhoven Geertjan, Wilson Carolyn F, Wong Rebecca K S, Wu Jackson S Y, Young Adult, Zhu Liting

Identification of plasma microRNA expression profile in radiographic axial spondyloarthritis-a pilot study.

At present, there are no studies that have established a microRNA (miRNA)-based signature profile in patients with radiographic axial spondyloarthritis (rad-axial SpA), and we hypothesized that these patients may have aberrantly expressed circulating…

Disease Burden Among Individuals with Severe Mental Illness in a Community Setting.

This study examines the prevalence of comorbid physical health conditions within a community sample of individuals with severe mental illness (SMI), compares them to a matched national sample without SMI, and identifies which comorbidities create the…

The Lilacs.

Tags: 2016, HORATTAS, Horattas Ileana, Ileana, LILACS, The (Poem), The Journal of medical humanities

An Engagement Intervention for Young Adults with Serious Mental Health Conditions.

Young adults with serious mental health conditions (SMHCs) often do not engage continuously with mental health services, and there are few engagement interventions designed for them. This qualitative study presents a blueprint for conceptualizing and…

Partial or non-union after triple arthrodesis in children: does it really matter?

PURPOSE: Triple arthrodesis is a commonly performed salvage procedure to correct hindfoot deformity. Non-union is considered an undesirable radiographic outcome; however, the clinical ramifications of this are not as well defined. The purpose of this…

Tags: 2016, Calcaneocuboid joint, Hindfoot deformity, Hindfoot fusion, Journal of children's orthopaedics, Morscher Melanie A, Newton Meadow, Pseudoarthrosis, Radiographic non-union, Steiner Richard P, Subtalar joint, Talonavicular joint, Triple arthrodesis, Weiner Dennis S, Wicks Eric D

The Role of MicroRNAs and Their Targets in Osteoarthritis.

Micro ribonucleic acid (microRNA) regulation and expression has become an emerging field in determining the mechanisms regulating a variety of inflammation-mediated diseases. Several studies have focused on specific microRNAs that are differentially…

Tags: *Cartilage, *Inflammation, *MicroRNA, *OSTEOARTHRITIS, *Targets, 2016, Articular/*metabolism, Cartilage, Current rheumatology reports, Department of Anatomy & Neurobiology, Haqqi Tariq M, Inflammation/genetics/*metabolism, Intracellular Signaling Peptides and Proteins, MicroRNAs/genetics/*metabolism, NEOMED College of Medicine, Osteoarthritis/genetics/*metabolism, Sondag Gregory R

Signet Ring Cell Carcinoma of the Ampulla of Vater with Early Development of Bone Metastasis: Case Report and Review of the Rare Malignancy.

Tags: 2016, Ampulla of Vater/*pathology/surgery, Bone Neoplasms/*secondary/surgery, Carcinoma, Cocieru Andrei, Common Bile Duct Neoplasms/*pathology/surgery, Damania Rahul, Humans, Journal of gastrointestinal cancer, Male, Middle Aged, Prognosis, Signet Ring Cell/*pathology/surgery, Weaver Joshua

The Asian Grocery Store-Based Cancer Education Program: Creating New Education Modules.

Operating since 1994, the UCSD Moores Cancer Center's Asian Grocery Store-Based Cancer Education Program (the Program) is a proven and sustainable strategy for disseminating cancer and poison control information to Asian and Pacific Islander (API)…

Behavioral Health and Primary Care Integration in Ohio's Psychiatry Residency Training.

Tags: *Internship and Residency, 2016, Academic psychiatry : the journal of the American Association of Directors of Psychiatric Residency Training and the Association for Academic Psychiatry, Crane Dushka, Delivery of Health Care, Education, Evans Brian, Graduate, Health Care Delivery, Herman Lon, Humans, Integrated, Internship and Residency, Medical, Mental Health Services – Administration, Mental Health Services/*organization & administration, Niedermier Julie, Ohio, Physician's Role, Primary Health Care – Administration, Primary Health Care/*organization & administration, Psychiatry, Psychiatry – Education, Psychiatry/*education/organization & administration, Qualitative Research, Qualitative Studies, Reed Eric, Referral and Consultation, Resch William, Ronis Robert, Svendsen Dale, Varley Joseph, Welton Randy

Orthosilicic acid, Si(OH)4, stimulates osteoblast differentiation in vitro by upregulating miR-146a to antagonize NF-kappaB activation.

UNLABELLED: Accumulating evidence over the last 40years suggests that silicate from dietary as well as silicate-containing biomaterials is beneficial to bone formation. However, the exact biological role(s) of silicate on bone cells are still unclear…

Outcomes of non-STEMI patients transported by emergency medical services vs private vehicle.

BACKGROUND: Non-ST-segment elevation myocardial infarctions (NSTEMIs) are more common but less studied than ST-segment elevation myocardial infarctions (STEMIs) treated by emergency medical services (EMS). OBJECTIVE: The purpose of this study was to…

Tags: *Electrocardiography, 2016, 80 and over, Adult, Age Distribution, Aged, Baughman Kristin, Bhalla Mary Colleen, Comparative Studies, Demography, Department of Family & Community Medicine, Dials Sarah, Electrocardiography, Emergency Medical Services – Methods, Emergency Medical Services – Statistics and Numerical Data, Emergency Medical Services/methods/*statistics & numerical data, Evaluation Research, Female, Frey Jennifer, Hospital Mortality, Human, Humans, Length of Stay – Statistics and Numerical Data, Length of Stay/statistics & numerical data, Male, Medical Records – Statistics and Numerical Data, Medical Records/statistics & numerical data, Middle Age, Middle Aged, Multicenter Studies, Myocardial Infarction – Diagnosis, Myocardial Infarction – Mortality, Myocardial Infarction – Therapy, Myocardial Infarction/diagnosis/*mortality/therapy, NEOMED College of Medicine, Ohio, Ohio/epidemiology, Outcome Assessment – Statistics and Numerical Data, Outcome Assessment (Health Care)/*statistics & numerical data, Retrospective Design, Retrospective Studies, Severity of Illness Index, Severity of Illness Indices, The American journal of emergency medicine, Time Factors, Transportation of Patients – Methods, Transportation of Patients – Statistics and Numerical Data, Transportation of Patients/*methods/*statistics & numerical data, Trauma Centers – Statistics and Numerical Data, Trauma Centers/statistics & numerical data, Validation Studies

Prevalence of strangulation in survivors of sexual assault and domestic violence.

OBJECTIVES: Both sexual assault (SA) survivors and domestic violence (DV) survivors are populations at risk of strangulation injury. Our goal was to identify the prevalence of strangulation in patients who are survivors of SA and DV, identify…

Characterizing Children Presenting to Three Freestanding EDs.

Noncontrast abdomen/pelvis computed tomographic scan in the evaluation of older adults.

Frailty defined by the SHARE Frailty Instrument and adverse outcomes after an ED visit.

The Detrimental Role Played by Lipocalin-2 in Alcoholic Fatty Liver in Mice.

We have previously shown that the ethanol-mediated elevation of lipocaline-2 (LCN2) is closely associated with the development of alcoholic fatty liver disease (AFLD) in mice. Herein, we aimed to understand the functional significance of LCN2…

Histone Deacetylase Inhibitor Vorinostat (SAHA) Suppresses IL-1beta-Induced Matrix Metallopeptidase-13 Expression by Inhibiting IL-6 in Osteoarthritis Chondrocyte.

Osteoarthritis (OA) is the most common whole-joint disease and is characterized by progressive loss of the cartilage matrix. Matrix metallopeptidase-13 (MMP-13) is a highly active and an abundantly expressed protease in OA cartilage and chondrocytes…

Implementation of Milestones-Based Assessment for a Safe and Effective Discharge.

Identification of small molecules that bind to the mitochondrial protein mitoNEET.

MitoNEET (CISD1) is a 2Fe-2S iron-sulfur cluster protein belonging to the zinc-finger protein family. Recently mitoNEET has been shown to be a major role player in the mitochondrial function associated with metabolic type diseases such as obesity and…

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