1
40
55
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1002/ajmg.a.35739" target="_blank" rel="noreferrer noopener">http://doi.org/10.1002/ajmg.a.35739</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
835-840
Issue
4
Volume
161A
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The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Partial Deletion Of Ankrd11 Results In The Kbg Phenotype Distinct From The 16q24.3 Microdeletion Syndrome
Publisher
An entity responsible for making the resource available
American Journal of Medical Genetics Part A
Date
A point or period of time associated with an event in the lifecycle of the resource
2013
2013-04
Subject
The topic of the resource
16q24; 3; ANKRD11; ASD; autism; delineation; diagnostic-criteria; Genetics & Heredity; KBG; macrodontia; MCA; microdeletion; mosaicism; MR
Creator
An entity primarily responsible for making the resource
Khalifa M; Stein J; Grau L; Nelson V; Meck J; Aradhya S; Duby J
Description
An account of the resource
KBG syndrome (OMIM 148050) is a very rare genetic disorder characterized by macrodontia, distinctive craniofacial abnormalities, short stature, intellectual disability, skeletal, and neurologic involvement. Approximately 60 patients have been reported since it was first described in 1975. Recently mutations in ANKRD11 have been documented in patients with KBG syndrome, and it has been proposed that haploinsufficiency of ANKRD11 is the cause of this syndrome. In addition, copy number variation in the 16q24.3 region that includes ANKRD11 results in a variable phenotype that overlaps with KBG syndrome and also includes autism spectrum disorders and other dysmorphic facial features. In this report we present a 21/2-year-old African American male with features highly suggestive of KBG syndrome. Genomic microarray identified an intragenic 154kb deletion at 16q24.3 within ANKRD11. This child's mother was mosaic for the same deletion (present in approximately 38% of cells) and exhibited a milder phenotype including macrodontia, short stature and brachydactyly. This family provides additional evidence that ANKRD11 causes KBG syndrome, and the mild phenotype in the mosaic form suggests that KBG phenotypes might be dose dependent, differentiating it from the more variable 16q24.3 microdeletion syndrome. This family has additional features that might expand the phenotype of KBG syndrome. (c) 2013 Wiley Periodicals, Inc.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1002/ajmg.a.35739" target="_blank" rel="noreferrer noopener">10.1002/ajmg.a.35739</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
16q24
2013
3
American Journal of Medical Genetics Part A
ANKRD11
Aradhya S
ASD
autism
delineation
diagnostic-criteria
Duby J
Genetics & Heredity
Grau L
Journal Article or Conference Abstract Publication
KBG
Khalifa M
macrodontia
MCA
Meck J
microdeletion
mosaicism
mr
Nelson V
Stein J
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1002/syn.10309" target="_blank" rel="noreferrer noopener">http://doi.org/10.1002/syn.10309</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
11-19
Issue
1
Volume
52
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Methamphetamine-induced Loss Of Striatal Dopamine Innervation In Bdnf Heterozygote Mice Does Not Further Reduce D-3 Receptor Concentrations
Publisher
An entity responsible for making the resource available
Synapse
Date
A point or period of time associated with an event in the lifecycle of the resource
2004
2004-04
Subject
The topic of the resource
1-methyl-4-phenyl-1; 2; 3; 6-tetrahydropyridine mptp; behavioral; caudate putamen; differential regulation; dopamine; haloperidol treatment; monkey; motor neurons; mutant mice; Neurosciences & Neurology; neurotrophic factor; nucleus accumbens; parkinsons-disease; parkinsons-disease; sensitization; Striatum; substantia-nigra; transporter; tyrosine hydroxylase
Creator
An entity primarily responsible for making the resource
Joyce J N; Renish L; Osredkar T; Walro J M; Kucera J; Dluzen D E
Description
An account of the resource
Depletion of dopamine (DA) reduces D, receptor number, but D-3 receptor expression is also regulated by brain-derived neurotrophic factor (BDNF). We took advantage of transgenic heterozygous BDNF mutant mice (+/-) to determine if reduced BDNF and loss of DA fibers produced by methamphetamine were additive in their impact on D-3 receptor number. We assessed selective markers of the dopaminergic system including caudate-putamen DA concentrations and quantitative autoradiographic measurement of tyrosine hydroxylase (TH) levels, DA transporter (DAT), and DA D-3 receptor binding between vehicle and methamphetamine-treated BDNF +/- and their wildtype (WT) littermate control mice. Caudate-putamen DA concentrations, TH and DAT levels were significantly reduced following methamphetamine treatment in both WT and BDNF +/- mice. The extent of methamphetamine-induced reduction in TH and DAT was greater for the WT than BDNF +/- mice and DAT levels were also decreased to a greater extent in nucleus accumbens of WT as compared to BDNF +/- mice. Lower D-3 receptor existed in caudate-putamen and nucleus accumbens in BDNF +/- mice and these differences were not affected by methamphetamine treatment. Taken together, these results not only substantiate the importance of BDNF in controlling D-3 receptor expression, but also indicate that a methamphetamine-induced depletion of DA fibers fails to produce an additive effect with lowered BDNF for control of D-3 receptor expression. In addition, the reduction of D-3 receptor expression is associated with a decreased neurotoxic response to methamphetamine in BDNF +/- mice. (C) 2004 Wiley-Liss, Inc.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1002/syn.10309" target="_blank" rel="noreferrer noopener">10.1002/syn.10309</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
1-Methyl-4-phenyl-1
2
2004
3
6-tetrahydropyridine mptp
Behavioral
caudate putamen
differential regulation
Dluzen D E
Dopamine
haloperidol treatment
Journal Article or Conference Abstract Publication
Joyce J N
Kucera J
monkey
motor neurons
mutant mice
Neurosciences & Neurology
neurotrophic factor
nucleus accumbens
Osredkar T
parkinsons-disease
Renish L
Sensitization
striatum
substantia-nigra
synapse
transporter
Tyrosine hydroxylase
Walro J M
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
n/a
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
112-126
Volume
914
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Neuroprotective Role Of Estrogen Upon Methamphetamine And Related Neurotoxins Within The Nigrostriatal Dopaminergic System
Publisher
An entity responsible for making the resource available
Neurobiological Mechanisms of Drugs of Abuse: Cocaine, Ibogaine, and Substituted Amphetamines
Date
A point or period of time associated with an event in the lifecycle of the resource
2000
2000
Subject
The topic of the resource
1-methyl-4-phenyl-1; 1-methyl-4-phenylpyridinium ion; 2; 3; 6-tetrahydropyridine; c57/b1 mice; estradiol; lipid-peroxidation; mptp-induced neurotoxicity; parkinsons-disease; release; sexual differences; striatum
Creator
An entity primarily responsible for making the resource
Dluzen D E; McDermott J L
Identifier
An unambiguous reference to the resource within a given context
n/a
Format
The file format, physical medium, or dimensions of the resource
Book Chapter
1-Methyl-4-phenyl-1
1-methyl-4-phenylpyridinium ion
2
2000
3
6-tetrahydropyridine
c57/b1 mice
Dluzen D E
estradiol
lipid-peroxidation
McDermott J L
mptp-induced neurotoxicity
Neurobiological Mechanisms of Drugs of Abuse: Cocaine, Ibogaine, and Substituted Amphetamines
parkinsons-disease
release
sexual differences
striatum
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1046/j.1471-4159.1994.62010094.x" target="_blank" rel="noreferrer noopener">http://doi.org/10.1046/j.1471-4159.1994.62010094.x</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
94-101
Issue
1
Volume
62
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Title
A name given to the resource
Modulatory Effects Of Testosterone On 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Neurotoxicity
Publisher
An entity responsible for making the resource available
Journal of Neurochemistry
Date
A point or period of time associated with an event in the lifecycle of the resource
1994
1994-01
Subject
The topic of the resource
1-methyl-4-phenyl-1; 2; 3; 6-tetrahydropyridine; aged rats; amphetamine; Biochemistry & Molecular Biology; castrated male-rats; corpus striatum; dopamine; dopamine release invitro; estrogen-treatment; l-dopa; mice; Neurosciences & Neurology; parkinsons-disease; rotational behavior; sex-differences; steroid-hormones; testosterone
Creator
An entity primarily responsible for making the resource
Dluzen D; Jain R; Liu B J
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1046/j.1471-4159.1994.62010094.x" target="_blank" rel="noreferrer noopener">10.1046/j.1471-4159.1994.62010094.x</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
1-Methyl-4-phenyl-1
1994
2
3
6-tetrahydropyridine
aged rats
amphetamine
Biochemistry & Molecular Biology
castrated male-rats
corpus striatum
Dluzen D
Dopamine
dopamine release invitro
estrogen-treatment
Jain R
Journal of neurochemistry
l-dopa
Liu B J
Mice
Neurosciences & Neurology
parkinsons-disease
rotational behavior
sex-differences
steroid-hormones
Testosterone
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.psyneuen.2010.12.007" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.psyneuen.2010.12.007</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
955-969
Issue
7
Volume
36
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Dublin Core
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Title
A name given to the resource
Sex differences in methamphetamine toxicity in mice: Effect on brain dopamine signaling pathways
Publisher
An entity responsible for making the resource available
Psychoneuroendocrinology
Date
A point or period of time associated with an event in the lifecycle of the resource
2011
2011-08
Subject
The topic of the resource
dopamine; mice; Psychiatry; Akt; 3; 2; 1-methyl-4-phenyl-1; Neurosciences & Neurology; Endocrinology & Metabolism; cell-death; activation; neurotoxicity; induced; rat striatum; kinase; striatum; Methamphetamine; evoked striatal dopamine; neurotoxicity; cd-1; element-binding protein; Sex difference; transporter function; 6-tetrahydropyridine mice
Creator
An entity primarily responsible for making the resource
Bourque M; Liu B; Dluzen D E; Di Paolo T
Description
An account of the resource
Mate mice were reported to display greater methamphetamine-induced neurotoxicity than females. The present study evaluated the involvement of phosphatidylinositol-3 kinase (PI3K)/Akt and extracellular signal-regulated kinase (ERK1/2) pathways in this sex-dependent methamphetamine toxicity. Intact female and male mice were administered methamphetamine (20 or 40 mg/kg) and euthanized a week later. Dopamine transporter (DAT) and vesicular monoamine transporter 2 (VMAT2) autoradiography in the lateral striatum showed a greater sensitivity in male mice treated with 20 mg/kg methamphetamine compared to female mice. Striatal dopamine concentration and DAT autoradiography showed a more extensive depletion in male mice given 40 mg/kg methamphetamine compared to female mice. Mice administered 40 mg/kg methamphetamine showed no sex difference in striatal VMAT2 autoradiography. In the substantia nigra, DAT specific binding was decreased only in male mice treated with 40 mg/kg methamphetamine and DAT mRNA levels decreased in methamphetamine-treated female and male mice. Methamphetamine-treated male mice presented a dose-dependent decrease of VMAT2 mRNA levels. Methamphetamine reduced insulin-like growth factor 1 receptor levels in females at both methamphetamine doses tested whereas it elevated G protein-coupled estrogen receptor 1 (GPER1) only in male mice. Phosphorylated Akt levels decreased only in male mice treated with 40 mg/kg methamphetamine. Glycogen synthase kinase 30 levels were reduced in male mice at both methamphetamine doses tested and in females receiving 40 mg/kg. Bcl-2 Levels were increased in male mice treated with methamphetamine, whereas ERK1/2 and BAD levels were unchanged. These results implicate some of the signaling pathways associated with the sex differences in methamphetamine-induced toxicity. (C) 2011 Elsevier Ltd. All rights reserved.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/j.psyneuen.2010.12.007" target="_blank" rel="noreferrer noopener">10.1016/j.psyneuen.2010.12.007</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
1-Methyl-4-phenyl-1
2
2011
3
6-tetrahydropyridine mice
activation
Akt
Bourque M
cd-1
cell-death
Di Paolo T
Dluzen D E
Dopamine
element-binding protein
Endocrinology & Metabolism
evoked striatal dopamine
Induced
Journal Article or Conference Abstract Publication
Kinase
Liu B
Methamphetamine
Mice
Neurosciences & Neurology
Neurotoxicity
Psychiatry
Psychoneuroendocrinology
rat striatum
Sex difference
striatum
transporter function
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.yfrne.2012.02.003" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.yfrne.2012.02.003</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
169-178
Issue
2
Volume
33
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Title
A name given to the resource
Signaling pathways mediating the neuroprotective effects of sex steroids and SERMs in Parkinson's disease
Publisher
An entity responsible for making the resource available
Frontiers in Neuroendocrinology
Date
A point or period of time associated with an event in the lifecycle of the resource
2012
2012-04
Subject
The topic of the resource
Signaling; Neuroprotection; MPTP; mice; Akt; 3; 2; 1-methyl-4-phenyl-1; 6-tetrahydropyridine; receptor; Neurosciences & Neurology; Endocrinology & Metabolism; nervous-system; plasma-membrane; estrogen-receptor-alpha; er-alpha; gender-differences; rat-brain; striatum; estrogen; ERK; estradiol; growth-factor-i; protein-coupled receptor-30; selective estrogen; SERMs; Substantia nigra
Creator
An entity primarily responsible for making the resource
Bourque M; Dluzen D E; Di Paolo T
Description
An account of the resource
Studies with the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) animal model of Parkinson's disease have shown the ability of 17 beta-estradiol to protect the nigrostriatal dopaminergic system. This paper reviews the signaling pathways mediating the neuroprotective effect of 17 beta-estradiol against MPTP-induced toxicity. The mechanisms of 17 beta-estradiol action implicate activation of signaling pathways such as the phosphatidylinositol-3 kinase/Akt and the mitogen-activated protein kinase pathways. 17 beta-estradiol signaling is complex and integrates multiple interactions with signaling molecules that act to potentiate a protective effect. 17 beta-estradiol signaling is mediated via estrogen receptors, including GPER1, but others receptors, such as the IGF-1 receptor, are implicated in the neuroprotective effect. Glial and neuronal crosstalk is a critical factor in the maintenance of dopamine neuronal survival and in the neuroprotective action of 17 beta-estradiol. Compounds that stimulate GPER1 such as selective estrogen receptor modulators and phytoestrogens show neuroprotective activity and are alternatives to 17 beta-estradiol. (C) 2012 Published by Elsevier Inc.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/j.yfrne.2012.02.003" target="_blank" rel="noreferrer noopener">10.1016/j.yfrne.2012.02.003</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
1-Methyl-4-phenyl-1
2
2012
3
6-tetrahydropyridine
Akt
Bourque M
Di Paolo T
Dluzen D E
Endocrinology & Metabolism
er-alpha
ERK
estradiol
estrogen
estrogen-receptor-alpha
Frontiers in Neuroendocrinology
gender-differences
growth-factor-i
Journal Article or Conference Abstract Publication
Mice
MPTP
nervous-system
Neuroprotection
Neurosciences & Neurology
plasma-membrane
protein-coupled receptor-30
rat-brain
Receptor
selective estrogen
SERMs
Signaling
striatum
SUBSTANTIA nigra
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0014-2999(91)90277-w" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0014-2999(91)90277-w</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
347-353
Issue
3
Volume
202
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Title
A name given to the resource
POSSIBLE SEROTONERGIC AND DOPAMINERGIC MEDIATION OF THE N-ETHYL-3,4-METHYLENEDIOXYAMPHETAMINE DISCRIMINATIVE STIMULUS
Publisher
An entity responsible for making the resource available
European Journal of Pharmacology
Date
A point or period of time associated with an event in the lifecycle of the resource
1991
1991-09
Subject
The topic of the resource
rat; 3; 2; Pharmacology & Pharmacy; dopamine; drug discrimination; fenfluramine; serotonin; quipazine; amphetamine; mde; mdma; p-chlorophenylalanine; pigeons; saline; tfmpp; (3; 4-methylenedioxyamphetamine); 4-methylenedioxymethamphetamine); 4-tetrahydro-beta-carboline; 5-ht (5-hydroxytryptamine; 6-methoxy-1; mde (n-ethyl-3
Creator
An entity primarily responsible for making the resource
Boja J W; Schechter M D
Description
An account of the resource
Eight male rats previously trained to discriminate 2.0 mg/kg N-ethyl-3,4-methylenedioxyamphetamine (MDE) from its vehicle in a two-lever, food motivated task were utilized to characterize the stimulus properties of MDE. The 5-HT receptor agonists 1-(m-trifluoromethylphenyl)piperazine (TFMPP), quipazine and 6-methoxy-1,2,3,4 tetrahydro-beta-carboline were able to generalize to the stimulus produced by MDE. However, the 5-HT receptor agonists m-chlorophenylpiperazine (mCPP), buspirone and norfenfluramine, the dopamine receptor agonist amphetamine, as well as the acetylcholine receptor agonist arecoline did not completely generalize. In addition, the simultaneous administration of norfenfluramine and amphetamine generalized to MDE. Pretreatment with the serotonin receptor antagonists cinanserin and metergoline or the dopamine receptor antagonist haloperidol failed to completely inhibit the discriminative stimulus produced by MDE. Multiple p-chlorophenylalanine (PCPA) pretreatments significantly reduced MDE discrimination, whereas vehicle discrimination was unaffected. Five days following cessation of PCPA pretreatment, MDE discrimination returned to criterion levels and remained at that level. These results suggest that the stimulus produced by MDE involve a complex interaction of various neurotransmitters, with both serotonergic and dopaminergic components.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0014-2999(91)90277-w" target="_blank" rel="noreferrer noopener">10.1016/0014-2999(91)90277-w</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
(3
1991
2
3
4-methylenedioxyamphetamine)
4-methylenedioxymethamphetamine)
4-tetrahydro-beta-carboline
5-ht (5-hydroxytryptamine
6-methoxy-1
amphetamine
Boja J W
Dopamine
drug discrimination
European journal of pharmacology
fenfluramine
Journal Article or Conference Abstract Publication
mde
mde (n-ethyl-3
mdma
p-chlorophenylalanine
Pharmacology & Pharmacy
pigeons
quipazine
rat
saline
Schechter M D
serotonin
tfmpp
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1038/nbt750" target="_blank" rel="noreferrer noopener">http://doi.org/10.1038/nbt750</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
1103-1110
Issue
11
Volume
20
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Title
A name given to the resource
Neural stem cells display an inherent mechanism for rescuing dysfunctional neurons
Publisher
An entity responsible for making the resource available
Nature Biotechnology
Date
A point or period of time associated with an event in the lifecycle of the resource
2002
2002-11
Subject
The topic of the resource
1-methyl-4-phenyl-1; 2; 3; 6-tetrahydropyridine mptp; adult brain; Biotechnology & Applied Microbiology; central-nervous-system; dopaminergic; gene-transfer; growth factor; juvenile neocortex; mouse-brain; neurotoxicity; parkinsons-disease; replacement
Creator
An entity primarily responsible for making the resource
Ourednik J; Ourednik V; Lynch W P; Schachner M; Snyder E Y
Description
An account of the resource
We investigated the hypothesis that neural stem cells (NSCs) possess an intrinsic capacity to "rescue" dysfunctional neurons in the brains of aged mice. The study focused on a neuronal cell type with stereotypical projections that is commonly compromised in the aged brain-the dopaminergic (DA) neuron. Unilateral implantation of murine NSCs into the midbrains of aged mice, in which the presence of stably impaired but nonapoptotic DA neurons was increased by treatment with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), was associated with bilateral reconstitution of the mesostriatal system. Functional assays paralleled the spatiotemporal recovery of tyrosine hydroxylase (TH) and dopamine transporter (DAT) activity, which, in turn, mirrored the spatiotemporal distribution of donor-derived cells. Although spontaneous conversion of donor NSCs to TH+ cells contributed to nigral reconstitution in DA-depleted areas, the majority of DA neurons in the mesostriatal system were "rescued" host cells. Undifferentiated donor progenitors spontaneously expressing neuroprotective substances provided a plausible molecular basis for this finding. These observations suggest that host structures may benefit not only from NSC-derived replacement of lost neurons but also from the "chaperone" effect of some NSC-derived progeny.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1038/nbt750" target="_blank" rel="noreferrer noopener">10.1038/nbt750</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article
1-Methyl-4-phenyl-1
2
2002
3
6-tetrahydropyridine mptp
adult brain
Biotechnology & Applied Microbiology
central-nervous-system
dopaminergic
gene-transfer
growth factor
Journal Article
juvenile neocortex
Lynch W P
mouse-brain
Nature Biotechnology
Neurotoxicity
Ourednik J
Ourednik V
parkinsons-disease
Replacement
Schachner M
Snyder E Y
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1186/s12974-018-1100-1" target="_blank" rel="noreferrer noopener">http://doi.org/10.1186/s12974-018-1100-1</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
73-73
Issue
1
Volume
15
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
The glycoprotein GPNMB attenuates astrocyte inflammatory responses through the CD44 receptor.
Publisher
An entity responsible for making the resource available
Journal of neuroinflammation
Date
A point or period of time associated with an event in the lifecycle of the resource
2018
2018-03
Subject
The topic of the resource
Female; Humans; Male; Animals; Mice; Reactive Oxygen Species/metabolism; Astrocyte; CD44; GPNMB; *Neuroinflammation; *Parkinson's disease; Case-Control Studies; Analysis of Variance; Signal Transduction/drug effects; Hyaluronan Receptors/*metabolism; Glial Fibrillary Acidic Protein/metabolism; Nitric Oxide/metabolism; Cells; Cultured; RNA; Messenger/metabolism; Chemical; 3; Databases; 1-Methyl-4-phenyl-1; 2; 6-tetrahydropyridine/pharmacology; Anti-Inflammatory Agents/*therapeutic use; Astrocytes/*drug effects; Cytokines/genetics/metabolism; Inflammation/*drug therapy/etiology; Membrane Glycoproteins/*therapeutic use; Neurotoxins/toxicity; Parkinson Disease/complications/*pathology
Creator
An entity primarily responsible for making the resource
Neal Matthew L; Boyle Alexa M; Budge Kevin M; Safadi Fayez F; Richardson Jason R
Description
An account of the resource
BACKGROUND: Neuroinflammation is one of the hallmarks of neurodegenerative diseases, such as Parkinson's disease (PD). Activation of glial cells, including microglia and astrocytes, is a characteristic of the inflammatory response. Glycoprotein non-metastatic melanoma protein B (GPNMB) is a transmembrane glycoprotein that releases a soluble signaling peptide when cleaved by ADAM10 or other extracellular proteases. GPNMB has demonstrated a neuroprotective role in animal models of ALS and ischemia. However, the mechanism of this protection has not been well established. CD44 is a receptor expressed on astrocytes that can bind GPNMB, and CD44 activation has been demonstrated to reduce NFkappaB activation and subsequent inflammatory responses in macrophages. GPNMB signaling has not been investigated in models of PD or specifically in astrocytes. More recently, genetic studies have linked polymorphisms in GPNMB with risk for PD. Therefore, it is important to understand the role this signaling protein plays in PD. METHODS: We used data mining techniques to evaluate mRNA expression of GPNMB and its receptor CD44 in the substantia nigra of PD and control brains. Immunofluorescence and qPCR techniques were used to assess GPNMB and CD44 levels in mice treated with MPTP. In vitro experiments utilized the immortalized mouse astrocyte cell line IMA2.1 and purified primary mouse astrocytes. The effects of recombinant GPNMB on cytokine-induced astrocyte activation was determined by qPCR, immunofluorescence, and measurement of nitric oxide and reactive oxygen production. RESULTS: Increased GPNMB and CD44 expression was observed in the substantia nigra of human PD brains and in GFAP-positive astrocytes in an animal model of PD. GPNMB treatment attenuated cytokine-induced levels of inducible nitric oxide synthase, nitric oxide, reactive oxygen species, and the inflammatory cytokine IL-6 in an astrocyte cell line and primary mouse astrocytes. Using primary mouse astrocytes from CD44 knockout mice, we found that the anti-inflammatory effects of GPNMB are CD44-mediated. CONCLUSIONS: These results demonstrate that GPNMB may exert its neuroprotective effect through reducing astrocyte-mediated neuroinflammation in a CD44-dependent manner, providing novel mechanistic insight into the neuroprotective properties of GPNMB.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1186/s12974-018-1100-1" target="_blank" rel="noreferrer noopener">10.1186/s12974-018-1100-1</a>
*Neuroinflammation
*Parkinson's disease
1-Methyl-4-phenyl-1
2
2018
3
6-tetrahydropyridine/pharmacology
Analysis of Variance
Animals
Anti-Inflammatory Agents/*therapeutic use
Astrocyte
Astrocytes/*drug effects
Boyle Alexa M
Budge Kevin M
Case-Control Studies
CD44
Cells
Chemical
Cultured
Cytokines/genetics/metabolism
Databases
Female
Glial Fibrillary Acidic Protein/metabolism
GPNMB
Humans
Hyaluronan Receptors/*metabolism
Inflammation/*drug therapy/etiology
Journal of neuroinflammation
Male
Membrane Glycoproteins/*therapeutic use
Messenger/metabolism
Mice
Neal Matthew L
Neurotoxins/toxicity
Nitric Oxide/metabolism
Parkinson Disease/complications/*pathology
Reactive Oxygen Species/metabolism
Richardson Jason R
RNA
Safadi Fayez F
Signal Transduction/drug effects
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0006-8993(90)91256-g" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0006-8993(90)91256-g</a>
Pages
236–242
Issue
2
Volume
506
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
A neurochemical heterogeneity of the rat striatum as measured by in vivo electrochemistry and microdialysis.
Publisher
An entity responsible for making the resource available
Brain research
Date
A point or period of time associated with an event in the lifecycle of the resource
1990
1990-01
Subject
The topic of the resource
Male; Animals; Rats; Dopamine/*metabolism; Corpus Striatum/*metabolism; Amphetamines/*pharmacology; Electrochemistry; Sulpiride/*pharmacology; Inbred Strains; Receptors; 3; 4-Dihydroxyphenylacetic Acid/metabolism; Dopamine/drug effects; Dopamine D2
Creator
An entity primarily responsible for making the resource
Yamamoto B K; Pehek E A
Description
An account of the resource
The neurochemical heterogeneity of the rat striatum was assessed in vivo by measuring subregional changes in extracellular dopamine and DOPAC by in vivo electrochemistry and microdialysis in response to amphetamine and the D2 antagonist, (-)-sulpiride. Both in vivo electrochemical and microdialysis experiments indicated a significant rostrocaudal gradient in dopamine release following amphetamine. The increase in dopamine release was highest in the rostral areas (over 800% of baseline values) and lowest in the most caudal subregion (425% of baseline). No lateromedial differences in dopamine release were observed. DOPAC levels decreased in dialysates but were similar for all 6 subregions examined. In contrast, D2 blockade with (-)-sulpiride revealed a lateromedial gradient in the increases seen for dopamine and DOPAC such that greater increases were observed in the lateral subregions. (-)-Sulpiride did not produce any differential effects along the rostrocaudal axis. The regional gradients detected in extracellular fluid changes of dopamine and DOPAC indicate that dopamine release is locally regulated by an interaction between the density of dopaminergic innervation to a particular subregion and the D2 receptor density.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0006-8993(90)91256-g" target="_blank" rel="noreferrer noopener">10.1016/0006-8993(90)91256-g</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1990
3
4-Dihydroxyphenylacetic Acid/metabolism
Amphetamines/*pharmacology
Animals
Brain research
Corpus Striatum/*metabolism
Dopamine D2
Dopamine/*metabolism
Dopamine/drug effects
Electrochemistry
Inbred Strains
Male
Pehek E A
Rats
Receptors
Sulpiride/*pharmacology
Yamamoto B K
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0014-2999(88)90564-x" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0014-2999(88)90564-x</a>
Pages
195–203
Issue
2
Volume
148
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
The acute effects of methylenedioxymethamphetamine on dopamine release in the awake-behaving rat.
Publisher
An entity responsible for making the resource available
European journal of pharmacology
Date
A point or period of time associated with an event in the lifecycle of the resource
1988
1988-03
Subject
The topic of the resource
Male; Animals; Rats; Dopamine/*metabolism; Consciousness; Amphetamines/*pharmacology; Brain/drug effects/metabolism; Caudate Nucleus/drug effects/metabolism; Nucleus Accumbens/drug effects/metabolism; Inbred Strains; 3; 4-Dihydroxyphenylacetic Acid/metabolism; N-Methyl-3; 4-methylenedioxyamphetamine; 4-Methylenedioxyamphetamine/analogs & derivatives/*pharmacology
Creator
An entity primarily responsible for making the resource
Yamamoto B K; Spanos L J
Description
An account of the resource
The effects of the recently classified Schedule I amphetamine analog, 3,4-methylenedioxymethamphetamine [+/-)-MDMA) on caudate and nucleus accumbens dopamine release and metabolism were studied by in vivo voltammetry and HPLC with electrochemical detection. Monitored over a 3 h period, the magnitude of increase in dopamine release and the onset of effect were dose-dependent and similar for both brain areas following the 2.5 and 5 mg/kg dose of the drug. However, responses were different for these brain regions using 10 mg/kg of MDMA; the magnitude of increase was greater and the onset of effect more immediate in caudate. Analysis of dopamine and DOPAC tissue content in both caudate and nucleus accumbens verified the voltammetry results. This study provides the first evidence that MDMA induces dopamine release in vivo and that this effect is region, time- and dose-dependent.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0014-2999(88)90564-x" target="_blank" rel="noreferrer noopener">10.1016/0014-2999(88)90564-x</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1988
3
4-Dihydroxyphenylacetic Acid/metabolism
4-methylenedioxyamphetamine
4-Methylenedioxyamphetamine/analogs & derivatives/*pharmacology
Amphetamines/*pharmacology
Animals
Brain/drug effects/metabolism
Caudate Nucleus/drug effects/metabolism
Consciousness
Dopamine/*metabolism
European journal of pharmacology
Inbred Strains
Male
N-Methyl-3
Nucleus Accumbens/drug effects/metabolism
Rats
Spanos L J
Yamamoto B K
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0091-3057(89)90044-0" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0091-3057(89)90044-0</a>
Pages
835–840
Issue
4
Volume
32
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Acute and subchronic effects of methylenedioxymethamphetamine [(+/-)MDMA] on locomotion and serotonin syndrome behavior in the rat.
Publisher
An entity responsible for making the resource available
Pharmacology, biochemistry, and behavior
Date
A point or period of time associated with an event in the lifecycle of the resource
1989
1989-04
Subject
The topic of the resource
Male; Time Factors; Animals; Rats; Behavior; Motor Activity/*drug effects; Amphetamines/*pharmacology; Designer Drugs/*pharmacology; Dose-Response Relationship; Drug; Inbred Strains; Receptors; 3; Animal/*drug effects; N-Methyl-3; 4-methylenedioxyamphetamine; 4-Methylenedioxyamphetamine/analogs & derivatives/*pharmacology; Serotonin/*drug effects
Creator
An entity primarily responsible for making the resource
Spanos L J; Yamamoto B K
Description
An account of the resource
Specific behaviors comprising the serotonin syndrome (low body posture, forepaw treading, headweaving) and the autonomic signs of piloerection and salivation were determined and analyzed with locomotor activity in response to MDMA at three doses (2.5, 5.0, and 7.5 mg/kg). All behaviors were dose-responsive. Serotonin syndrome behaviors increased in both intensity and duration of response with increasing doses. In contrast, locomotion varied only in intensity. Subchronic injections, in the same group of animals, permitted an analysis of acute vs. subchronic effects on these same behaviors. Both the serotonin syndrome and locomotor behaviors were augmented on subsequent testing, indicating that, (+/-)MDMA, like amphetamine, is capable of producing behavioral sensitization.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0091-3057(89)90044-0" target="_blank" rel="noreferrer noopener">10.1016/0091-3057(89)90044-0</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1989
3
4-methylenedioxyamphetamine
4-Methylenedioxyamphetamine/analogs & derivatives/*pharmacology
Amphetamines/*pharmacology
Animal/*drug effects
Animals
Behavior
Designer Drugs/*pharmacology
Dose-Response Relationship
Drug
Inbred Strains
Male
Motor Activity/*drug effects
N-Methyl-3
Pharmacology, biochemistry, and behavior
Rats
Receptors
Serotonin/*drug effects
Spanos L J
Time Factors
Yamamoto B K
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0091-3057(88)90390-5" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0091-3057(88)90390-5</a>
Pages
817–824
Issue
4
Volume
31
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Serotonergic-dopaminergic mediation of 3,4-methylenedioxymethamphetamine (MDMA, "ecstasy").
Publisher
An entity responsible for making the resource available
Pharmacology, biochemistry, and behavior
Date
A point or period of time associated with an event in the lifecycle of the resource
1988
1988-12
Subject
The topic of the resource
Male; Time Factors; Animals; Rats; Dopamine Agents/*pharmacology; Discrimination (Psychology)/*drug effects; Serotonin/*physiology; *Dopamine Antagonists; Serotonin Antagonists/*pharmacology; Amphetamines/*pharmacology; Dose-Response Relationship; Drug; Inbred Strains; 3; N-Methyl-3; Stimulus; 4-methylenedioxyamphetamine; 4-Methylenedioxyamphetamine/analogs & derivatives/*pharmacology; *Generalization
Creator
An entity primarily responsible for making the resource
Schechter M D
Description
An account of the resource
A series of three experiments were conducted to investigate the possible serotonergic and dopaminergic mediation of the discriminative stimulus properties of the "designer" drug MDMA. In Experiment 1, rats trained to discriminate 1.5 mg/kg (+/-)-MDMA from its vehicle at 20 min postadministration were shown to generalize to another drug of abuse, N-ethyl-3,4-methylenedioxyamphetamine (MDE) and to the serotonergically-active agents norfenfluramine and TFMPP. In contrast, testing of various dopaminergically-active agonists did not result in MDMA-like responding. In Experiment 2, dopaminergic and serotonergic antagonist were employed to observe their effect upon MDMA discrimination at 20 min postinjection. The serotonin antagonist pirenperone significantly decreased MDMA discrimination, whereas the dopamine decreasing drugs CGS 10746B and haloperidol had no effect. In Experiment 3, another group of rats were trained to discriminate MDMA at 105 min postadministration to investigate if, at this (later) time, the dopaminergic properties of MDMA may be more salient. Indeed, the dopaminergically-active drugs had a heightened effect upon MDMA at this later time, although the serotonergic component of the MDMA discriminative stimulus was predominant. The results suggest that the effects of MDMA at 20 min postadministration are solely serotonergic in nature. At 105 min postinjection there appears to be the presence of a weak dopaminergic component. This biphasic serotonergic-then-dopaminergic action of MDMA may explain the reported human experience with the drug, as well as the often controversial results in the literature.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0091-3057(88)90390-5" target="_blank" rel="noreferrer noopener">10.1016/0091-3057(88)90390-5</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Dopamine Antagonists
*Generalization
1988
3
4-methylenedioxyamphetamine
4-Methylenedioxyamphetamine/analogs & derivatives/*pharmacology
Amphetamines/*pharmacology
Animals
Discrimination (Psychology)/*drug effects
Dopamine Agents/*pharmacology
Dose-Response Relationship
Drug
Inbred Strains
Male
N-Methyl-3
Pharmacology, biochemistry, and behavior
Rats
Schechter M D
Serotonin Antagonists/*pharmacology
Serotonin/*physiology
Stimulus
Time Factors
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0091-3057(91)90010-y" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0091-3057(91)90010-y</a>
Pages
539–544
Issue
3
Volume
38
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Effect of MDMA neurotoxicity upon its conditioned place preference and discrimination.
Publisher
An entity responsible for making the resource available
Pharmacology, biochemistry, and behavior
Date
A point or period of time associated with an event in the lifecycle of the resource
1991
1991-03
Subject
The topic of the resource
Male; Animals; Rats; Discrimination Learning/*drug effects; Choice Behavior/*drug effects; Designer Drugs/*toxicity; Nervous System/*drug effects; Sodium Chloride/pharmacology; Dose-Response Relationship; Drug; Inbred Strains; 3; Conditioning; Classical/*drug effects; N-Methyl-3; 4-methylenedioxyamphetamine; 4-Methylenedioxyamphetamine/*analogs & derivatives/toxicity
Creator
An entity primarily responsible for making the resource
Schechter M D
Description
An account of the resource
Experiments were conducted to investigate the functional consequences of a neurotoxic regimen of MDMA administration upon two behaviors, conditioned place preference and drug discrimination. Rats were trained to discriminate 1.5 mg/kg MDMA from its vehicle and their discriminative performance was shown to be dose-responsive. Subsequently, MDMA was observed to produce a conditioned place preference as three conditioning sessions with 1.5 mg/kg MDMA paired with the nonpreferred chamber increased the time the rats spent in the chamber paired with MDMA. Administration of a proportedly neurotoxic dose (20 mg/kg subcutaneous) of MDMA, twice-a-day for four days, did not affect this conditioned place preference when it was redetermined at a time of maximal neurochemical compromise. In contrast, sensitivity to 1.0 mg/kg MDMA in the drug discrimination task was shown to be significantly decreased after the neurotoxic regimen. Results are discussed in light of MDMA effects upon both central serotonergic and dopaminergic neurons.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0091-3057(91)90010-y" target="_blank" rel="noreferrer noopener">10.1016/0091-3057(91)90010-y</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1991
3
4-methylenedioxyamphetamine
4-Methylenedioxyamphetamine/*analogs & derivatives/toxicity
Animals
Choice Behavior/*drug effects
Classical/*drug effects
Conditioning
Designer Drugs/*toxicity
Discrimination Learning/*drug effects
Dose-Response Relationship
Drug
Inbred Strains
Male
N-Methyl-3
Nervous System/*drug effects
Pharmacology, biochemistry, and behavior
Rats
Schechter M D
Sodium Chloride/pharmacology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0091-3057(88)90340-1" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0091-3057(88)90340-1</a>
Pages
239–242
Issue
1
Volume
31
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Advantages and disadvantages of a rapid method to train drug discrimination.
Publisher
An entity responsible for making the resource available
Pharmacology, biochemistry, and behavior
Date
A point or period of time associated with an event in the lifecycle of the resource
1988
1988-09
Subject
The topic of the resource
Male; Animals; Rats; Drug Tolerance; Methods; Discrimination Learning/*drug effects; Amphetamines/*pharmacology; Dose-Response Relationship; Drug; 3; N-Methyl-3; 4-methylenedioxyamphetamine; 4-Methylenedioxyamphetamine/analogs & derivatives/*pharmacology
Creator
An entity primarily responsible for making the resource
Schechter M D
Description
An account of the resource
In an effort to reduce the often extensive period of time needed to train rats to discriminate between a drugged and nondrugged state, a fast training regimen was employed with 1.5 mg/kg 3,4-methylenedioxymethamphetamine (MDMA) used as the training drug in ten rats. This protocol consisted of one to three training sessions per day and it was compared to the more conventional method of once-per-day training in an equal number of rats. Results indicate that the fast-trained rats learned the discrimination in significantly fewer sessions than the slowly-trained rats. However, the subsequent dose-response experiments indicate that when the fast-trained rats are tested with various doses of MDMA, without prior vehicle treatment, their sensitivity to the drug is less than that of the slowly-trained rats. When a vehicle session is presented prior to drug dose-response testing, both groups perform similarly. It appears that the preceding vehicle sessions function as a reference point for the fast-trained rats and, although the more rapid training regimen allows for faster learning, these treatment regimens should be employed with caution when subsequent dose-response tests and generalization tests with other drugs are conducted.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0091-3057(88)90340-1" target="_blank" rel="noreferrer noopener">10.1016/0091-3057(88)90340-1</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1988
3
4-methylenedioxyamphetamine
4-Methylenedioxyamphetamine/analogs & derivatives/*pharmacology
Amphetamines/*pharmacology
Animals
Discrimination Learning/*drug effects
Dose-Response Relationship
Drug
Drug Tolerance
Male
Methods
N-Methyl-3
Pharmacology, biochemistry, and behavior
Rats
Schechter M D
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0028-3908(90)90041-o" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0028-3908(90)90041-o</a>
Pages
1171–1176
Issue
12
Volume
29
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Effects of cathinone and amphetamine on the neurochemistry of dopamine in vivo.
Publisher
An entity responsible for making the resource available
Neuropharmacology
Date
A point or period of time associated with an event in the lifecycle of the resource
1990
1990-12
Subject
The topic of the resource
Male; Animals; Rats; Molecular Structure; Structure-Activity Relationship; Reference Values; Kinetics; Dopamine/*metabolism; Brain/drug effects/*metabolism; Psychotropic Drugs/*pharmacology; Alkaloids/*pharmacology; Amphetamine/*pharmacology; Caudate Nucleus/metabolism; Homovanillic Acid/metabolism; Nucleus Accumbens/metabolism; Putamen/metabolism; Inbred Strains; 3; 4-Dihydroxyphenylacetic Acid/metabolism
Creator
An entity primarily responsible for making the resource
Pehek E A; Schechter M D; Yamamoto B K
Description
An account of the resource
The effects of (-)cathinone, the primary psychoactive alkaloid of the Khat plant, were compared to those of (+)amphetamine in the anterior caudate-putamen and the nucleus accumbens. In vivo microdialysis was used to measure extracellular levels of dopamine and metabolites in both regions of the brain simultaneously, after intraperitoneal administration of 0.8, 1.6 or 3.2 mg/kg of either drug (doses expressed as the salts). Both drugs increased levels of dopamine but decreased levels of metabolites in a dose-dependent manner. However, the relative magnitude of these effects depended upon the specific drug, the dose and area of the brain examined. At the largest dose used, amphetamine had a relatively greater effect than cathinone on dopamine in both caudate and accumbens. However, among smaller doses, this difference was only observed in the nucleus accumbens after administration of 1.6 mg/kg. The results also demonstrated a differential regional effect of both drugs at 3.2 mg/kg, in that both had a greater effect on dopamine in the caudate, as opposed to the accumbens. These findings demonstrate a functional heterogeneity of the striatum of the rat, that may be relevant to the understanding of both normal brain function and the neural responses to psychoactive drugs.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0028-3908(90)90041-o" target="_blank" rel="noreferrer noopener">10.1016/0028-3908(90)90041-o</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1990
3
4-Dihydroxyphenylacetic Acid/metabolism
Alkaloids/*pharmacology
Amphetamine/*pharmacology
Animals
Brain/drug effects/*metabolism
Caudate Nucleus/metabolism
Dopamine/*metabolism
Homovanillic Acid/metabolism
Inbred Strains
Kinetics
Male
Molecular Structure
Neuropharmacology
Nucleus Accumbens/metabolism
Pehek E A
Psychotropic Drugs/*pharmacology
Putamen/metabolism
Rats
Reference Values
Schechter M D
Structure-Activity Relationship
Yamamoto B K
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0006-8993(89)90799-3" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0006-8993(89)90799-3</a>
Pages
235–241
Issue
2
Volume
481
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
In vivo neurochemical and anatomical heterogeneity of the dopamine uptake system in the rat caudate putamen.
Publisher
An entity responsible for making the resource available
Brain research
Date
A point or period of time associated with an event in the lifecycle of the resource
1989
1989-03
Subject
The topic of the resource
Male; Animals; Rats; Dopamine/*metabolism; Indoles/*pharmacology; Nomifensine/*pharmacology; Homovanillic Acid/metabolism; Electrochemistry; Caudate Nucleus/drug effects/*metabolism; Mazindol/*pharmacology; Neurotransmitter Uptake Inhibitors/*pharmacology; Putamen/drug effects/*metabolism; Inbred Strains; 3; 4-Dihydroxyphenylacetic Acid/metabolism
Creator
An entity primarily responsible for making the resource
Glynn G E; Yamamoto B K
Description
An account of the resource
The neurochemical and anatomical heterogeneity of dopamine uptake blockade was studied at a medial and lateral position in each of 3 rostrocaudal areas of the rat caudate-putamen. In vivo voltammetric measures of extracellular dopamine indicated a lateral-to-medial and rostral-to-caudal gradient in the effect of uptake blockade. The percentage increase in dopamine was greatest in the rostrolateral area (300%) and least in the caudomedial area (10%). The existence of these lateromedial and rostrocaudal gradients was confirmed by tissue content measures of DOPAC and dopamine to DOPAC ratios in each area. The rostrocaudal gradient in the effect of uptake blockade was independent of the rostrocaudal gradient in dopamine tissue content. The regional gradients detected in dopamine uptake blockade may indicate a heterogeneous distribution in the number of uptake sites, a regional variation in the affinity of the uptake site for the blocker and/or altered neuronal activity mediated by an action of the blocker on dopaminergic cell bodies.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0006-8993(89)90799-3" target="_blank" rel="noreferrer noopener">10.1016/0006-8993(89)90799-3</a>
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Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1989
3
4-Dihydroxyphenylacetic Acid/metabolism
Animals
Brain research
Caudate Nucleus/drug effects/*metabolism
Dopamine/*metabolism
Electrochemistry
Glynn G E
Homovanillic Acid/metabolism
Inbred Strains
Indoles/*pharmacology
Male
Mazindol/*pharmacology
Neurotransmitter Uptake Inhibitors/*pharmacology
Nomifensine/*pharmacology
Putamen/drug effects/*metabolism
Rats
Yamamoto B K
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Pages
94–101
Issue
1
Volume
62
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Modulatory effects of testosterone on
Publisher
An entity responsible for making the resource available
Journal of neurochemistry
Date
A point or period of time associated with an event in the lifecycle of the resource
1994
1994-01
Subject
The topic of the resource
Male; Animals; Mice; Species Specificity; Reference Values; Dopamine/*metabolism; Corpus Striatum/drug effects/*metabolism; Orchiectomy; Drug Implants; Testosterone/administration & dosage/*pharmacology; Neurotoxins/antagonists & inhibitors/*toxicity; *MPTP Poisoning; Levodopa/pharmacology; Inbred Strains; Inbred C57BL; 3; 1-Methyl-4-phenyl-1; 2; Parkinson Disease; 6-tetrahydropyridine/antagonists & inhibitors; Secondary/chemically induced/*physiopathology
Creator
An entity primarily responsible for making the resource
Dluzen D; Jain R; Liu B
Description
An account of the resource
In this experiment, we examined the modulatory effects of testosterone on the parkinsonism-inducing drug 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in two strains of mice. Orchidectomized male CD-1 and C57/B1 mice were implanted with either empty Silastic capsules or capsules containing testosterone and subsequently treated with MPTP. A small area of the corpus striatum was removed for determination of dopamine (DA) content, whereas the remainder was superfused and used to measure L-DOPA (5 microM)-evoked DA release. In animals treated with MPTP, L-DOPA-evoked DA release was reduced significantly in CD-1 mice, but not in C57/B1 mice, treated with testosterone. No differences in L-DOPA-stimulated DA release between MPTP-versus vehicle-treated mice was observed in either the CD-1 or C57/B1 mice receiving empty Silastic capsules. Corpus striatum DA contents were more severely depleted in the MPTP-sensitive C57/B1 versus the CD-1 mouse strain irrespective of hormone treatment. These results confirm previous results demonstrating differences in these two mouse strains in response to the neurotoxic effects of MPTP upon corpus striatum DA content. More interestingly, they show an important differential modulatory effect of testosterone upon
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*MPTP Poisoning
1-Methyl-4-phenyl-1
1994
2
3
6-tetrahydropyridine/antagonists & inhibitors
Animals
Corpus Striatum/drug effects/*metabolism
Dluzen D
Dopamine/*metabolism
Drug Implants
Inbred C57BL
Inbred Strains
Jain R
Journal of neurochemistry
Levodopa/pharmacology
Liu B
Male
Mice
Neurotoxins/antagonists & inhibitors/*toxicity
Orchiectomy
Parkinson Disease
Reference Values
Secondary/chemically induced/*physiopathology
Species Specificity
Testosterone/administration & dosage/*pharmacology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Pages
340–344
Issue
2
Volume
767
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Estrogen decreases corpus striatal neurotoxicity in response to
Publisher
An entity responsible for making the resource available
Brain research
Date
A point or period of time associated with an event in the lifecycle of the resource
1997
1997-09
Subject
The topic of the resource
Female; Animals; Rats; Corpus Striatum/*drug effects; Dopamine/metabolism; Neurotoxins/*toxicity; Estradiol/*pharmacology; Oxidopamine/*toxicity; Parkinson Disease/*physiopathology; Sprague-Dawley; Animal; Disease Models; 3; 4-Dihydroxyphenylacetic Acid/metabolism
Creator
An entity primarily responsible for making the resource
Dluzen D
Description
An account of the resource
Ovariectomized rats treated or not with an estradiol pellet were subjected to an unilateral intrastriatal infusion of 6-hydroxydopamine (6-OHDA). Various parameters of nigrostriatal dopaminergic function as derived from measurements of dopamine and dihydroxyphenylacetic acid (DOPAC) concentrations were determined from the 6-OHDA lesioned and non-lesioned sides of the corpus striatum in these animals. Dopamine concentrations within the 6-OHDA lesioned striatum of estrogen-treated rats were significantly greater than non-estrogen-treated rats. There were no differences in striatal dopamine concentrations between estrogen- versus non-estrogen-treated rats on their non-lesioned side. In contrast to that of dopamine, no differences in DOPAC concentrations between estrogen and non-estrogen-treated rats were obtained within the 6-OHDA-lesioned side. The DOPAC concentrations on the non-lesioned side of the striatum were significantly greater in the non-estrogen-treated rats. These results demonstrate that estrogen significantly diminishes the depletion of striatal dopamine resulting from the neurotoxin 6-OHDA. The data obtained from the DOPAC determinations imply that this capacity of estrogen may be exerted through actions upon uptake processes of striatal dopaminergic neurons. Such findings suggest that estrogen may function as an important modulatory factor capable of attenuating degeneration within the corpus striatum, and in this way serve as a neuroprotectant of the nigrostriatal dopaminergic system.
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1997
3
4-Dihydroxyphenylacetic Acid/metabolism
Animal
Animals
Brain research
Corpus Striatum/*drug effects
Disease Models
Dluzen D
Dopamine/metabolism
Estradiol/*pharmacology
Female
Neurotoxins/*toxicity
Oxidopamine/*toxicity
Parkinson Disease/*physiopathology
Rats
Sprague-Dawley
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Pages
215–219
Issue
1
Volume
741
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
The effects of intranasal infusion of
Publisher
An entity responsible for making the resource available
Brain research
Date
A point or period of time associated with an event in the lifecycle of the resource
1996
1996-11
Subject
The topic of the resource
Male; Animals; Mice; Corpus Striatum/drug effects/*metabolism; Dopamine/metabolism; Olfactory Bulb/drug effects/*metabolism; Norepinephrine/metabolism; Injections; Catecholamines/*metabolism; Dopamine Agents/administration & dosage/*pharmacology; Inbred C57BL; 3; Intraperitoneal; 1-Methyl-4-phenyl-1; 2; Administration; Intranasal; 6-tetrahydropyridine/administration & dosage/*pharmacology
Creator
An entity primarily responsible for making the resource
Dluzen D E; Kefalas G
Description
An account of the resource
Male C57/B1 mice received bilateral intranasal infusions of saline, MPTP or an intraperitoneal injection of MPTP. Infusions were performed using a peristaltic pump at a setting of 100 microliters/min. The MPTP, diluted in saline at concentrations of 2 mg/ml, was infused over 15 (0.1 mg) or 30 (0.2 mg) s, while the saline (control) infusions were of 30 s duration. In a separate group of mice, MPTP was injected via the intraperitoneal route at a dose equivalent to that of the 30-s intranasal concentration (0.2 mg). At 7 days post-treatment, catecholamine concentrations were determined from the olfactory bulbs and corpus striatum. Concentrations of norepinephrine within both the olfactory bulbs and corpus striatum of mice receiving the intranasal infusion of MPTP were significantly lower than those of the intranasal saline and intraperitoneal
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1-Methyl-4-phenyl-1
1996
2
3
6-tetrahydropyridine/administration & dosage/*pharmacology
Administration
Animals
Brain research
Catecholamines/*metabolism
Corpus Striatum/drug effects/*metabolism
Department of Internal Medicine
Dluzen D E
Dopamine Agents/administration & dosage/*pharmacology
Dopamine/metabolism
Inbred C57BL
Injections
Intranasal
Intraperitoneal
Kefalas G
Male
Mice
NEOMED College of Medicine
Norepinephrine/metabolism
Olfactory Bulb/drug effects/*metabolism
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1007/bf01244706" target="_blank" rel="noreferrer noopener">http://doi.org/10.1007/bf01244706</a>
Pages
145–156
Issue
2
Volume
85
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
The effect of long-term treatment with deprenyl on basal and L-dopa evoked dopamine release in vitro from the corpus striatum of aged rats.
Publisher
An entity responsible for making the resource available
Journal of neural transmission. General section
Date
A point or period of time associated with an event in the lifecycle of the resource
1991
1991
Subject
The topic of the resource
Male; Animals; Rats; Corpus Striatum/*drug effects/metabolism; Aging/metabolism; In Vitro Techniques; Dopamine/*metabolism; Amphetamine/pharmacology; Levodopa/pharmacology; Selegiline/*pharmacology; 3; 4-Dihydroxyphenylacetic Acid/*metabolism
Creator
An entity primarily responsible for making the resource
Dluzen D E; McDermott J L
Description
An account of the resource
In the present experiment, male rats (15-17 months) were injected with deprenyl (0.25 mg/kg) three times per week for six months. At 21-23 months of age the male rats were sacrificed, the corpus striatum removed and superfused in vitro. Basal and evoked dopamine and DOPAC levels, as obtained with either two infusions of
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1007/bf01244706" target="_blank" rel="noreferrer noopener">10.1007/bf01244706</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1991
3
4-Dihydroxyphenylacetic Acid/*metabolism
Aging/metabolism
Amphetamine/pharmacology
Animals
Corpus Striatum/*drug effects/metabolism
Dluzen D E
Dopamine/*metabolism
In Vitro Techniques
Journal of neural transmission. General section
Levodopa/pharmacology
Male
McDermott J L
Rats
Selegiline/*pharmacology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0091-3057(89)90547-9" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0091-3057(89)90547-9</a>
Pages
497–501
Issue
3
Volume
34
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
The antinociceptive effects of 3,4-methylenedioxymethamphetamine (MDMA) in the rat.
Publisher
An entity responsible for making the resource available
Pharmacology, biochemistry, and behavior
Date
A point or period of time associated with an event in the lifecycle of the resource
1989
1989-11
Subject
The topic of the resource
Male; Animals; Rats; Analgesics/*pharmacology; Methysergide/pharmacology; Naltrexone/pharmacology; Amphetamines/*pharmacology; Pain/*metabolism; Morphine/pharmacology; Dose-Response Relationship; Drug; Inbred Strains; Receptors; 3; N-Methyl-3; 4-methylenedioxyamphetamine; 4-Methylenedioxyamphetamine/analogs & derivatives/*pharmacology; Serotonin/drug effects/*physiology
Creator
An entity primarily responsible for making the resource
Crisp T; Stafinsky J L; Boja J W; Schechter M D
Description
An account of the resource
The antinociceptive effects of MDMA and morphine were examined in rats using the tail-flick and hot-plate analgesiometric tests. MDMA, in the dose range of 1.5-6.0 mg/kg IP, produced a dose-dependent elevation in hot-plate latency, but did not elevate tail-flick latency. In contrast, morphine (2-8 mg/kg, IP) produced analgesia on both the tail-flick and hot-plate tests in a dose-dependent manner. Neither the opiate antagonist naltrexone nor the adrenoceptor antagonist phentolamine effectively attenuated MDMA-induced analgesia. Conversely, the serotonin antagonist methysergide significantly reversed the analgesic effects of MDMA on the hot-plate test. These findings suggest that the antinociceptive effects of MDMA are serotonergically mediated. Furthermore, the results verify earlier findings describing the test-specific effects of serotonin-induced pain modulation.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0091-3057(89)90547-9" target="_blank" rel="noreferrer noopener">10.1016/0091-3057(89)90547-9</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1989
3
4-methylenedioxyamphetamine
4-Methylenedioxyamphetamine/analogs & derivatives/*pharmacology
Amphetamines/*pharmacology
Analgesics/*pharmacology
Animals
Boja J W
Crisp T
Dose-Response Relationship
Drug
Inbred Strains
Male
Methysergide/pharmacology
Morphine/pharmacology
N-Methyl-3
Naltrexone/pharmacology
Pain/*metabolism
Pharmacology, biochemistry, and behavior
Rats
Receptors
Schechter M D
Serotonin/drug effects/*physiology
Stafinsky J L
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Pages
347–353
Issue
3
Volume
202
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Possible serotonergic and dopaminergic mediation of the
Publisher
An entity responsible for making the resource available
European journal of pharmacology
Date
A point or period of time associated with an event in the lifecycle of the resource
1991
1991-09
Subject
The topic of the resource
Male; Animals; Rats; Serotonin/pharmacology; Discrimination Learning/drug effects; Serotonin Antagonists/pharmacology; Motor Activity/drug effects; Designer Drugs/pharmacology; Fenclonine/pharmacology; Inbred Strains; Receptors; 3; N-Methyl-3; 4-methylenedioxyamphetamine; 4-Methylenedioxyamphetamine/*analogs & derivatives/pharmacology; Dopamine/*drug effects; Serotonin/*drug effects
Creator
An entity primarily responsible for making the resource
Boja J W; Schechter M D
Description
An account of the resource
Eight male rats previously trained to discriminate 2.0 mg/kg
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1991
3
4-methylenedioxyamphetamine
4-Methylenedioxyamphetamine/*analogs & derivatives/pharmacology
Animals
Boja J W
Designer Drugs/pharmacology
Discrimination Learning/drug effects
Dopamine/*drug effects
European journal of pharmacology
Fenclonine/pharmacology
Inbred Strains
Male
Motor Activity/drug effects
N-Methyl-3
Rats
Receptors
Schechter M D
Serotonin Antagonists/pharmacology
Serotonin/*drug effects
Serotonin/pharmacology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0091-3057(87)90206-1" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0091-3057(87)90206-1</a>
Pages
153–156
Issue
2
Volume
28
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Behavioral effects of N-ethyl-3,4-methylenedioxyamphetamine (MDE; "EVE").
Publisher
An entity responsible for making the resource available
Pharmacology, biochemistry, and behavior
Date
A point or period of time associated with an event in the lifecycle of the resource
1987
1987-10
Subject
The topic of the resource
Male; Time Factors; Animals; United States; Rats; Discrimination (Psychology); Amphetamines/*pharmacology; Dose-Response Relationship; Drug; Inbred Strains; 3; N-Methyl-3; 4-methylenedioxyamphetamine; 4-Methylenedioxyamphetamine/analogs & derivatives/*pharmacology; Legislation
Creator
An entity primarily responsible for making the resource
Boja J W; Schechter M D
Description
An account of the resource
Eight male rats were trained to discriminate 2.0 mg/kg
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0091-3057(87)90206-1" target="_blank" rel="noreferrer noopener">10.1016/0091-3057(87)90206-1</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1987
3
4-methylenedioxyamphetamine
4-Methylenedioxyamphetamine/analogs & derivatives/*pharmacology
Amphetamines/*pharmacology
Animals
Boja J W
Discrimination (Psychology)
Dose-Response Relationship
Drug
Inbred Strains
Legislation
Male
N-Methyl-3
Pharmacology, biochemistry, and behavior
Rats
Schechter M D
Time Factors
United States
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1196/annals.1432.010" target="_blank" rel="noreferrer noopener">http://doi.org/10.1196/annals.1432.010</a>
Pages
140–150
Volume
1139
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Sex differences in dopamine- and vesicular monoamine-transporter functions.
Publisher
An entity responsible for making the resource available
Annals of the New York Academy of Sciences
Date
A point or period of time associated with an event in the lifecycle of the resource
2008
2008-10
Subject
The topic of the resource
3; 4-Dihydroxyphenylacetic Acid/metabolism; Adrenergic Uptake Inhibitors/metabolism; Animal/drug effects; Animals; Behavior; Behavior/drug effects; Corpus Striatum/metabolism; Dopamine Agents/pharmacology; Dopamine Plasma Membrane Transport Proteins/*metabolism; Dopamine Uptake Inhibitors/metabolism; Female; Humans; Male; Methamphetamine/pharmacology; Mice; Nomifensine/metabolism; Reserpine/metabolism; Sex Factors; Vesicular Monoamine Transport Proteins/*metabolism
Creator
An entity primarily responsible for making the resource
Dluzen D E; McDermott J L
Description
An account of the resource
Men and women differ with regard to their use of, and responses to, methamphetamine (MA). Analogous sex differences with regard to MA are observed in animal models. In this report, data from a series of experiments that focus upon dopamine transporter (DAT) and vesicular monoamine transporter2 (VMAT2) function are reviewed by way of providing some understanding for these sex differences to MA. The amount of dopamine (DA) recovered after infusion of DA into superfused striatal tissue was greater in females and an accentuated amount of extracellular DA was obtained from females after infusion of the DAT-blocking drug, nomifensine. These data suggest a higher level of DAT activity in females. To evaluate the implications of this sex difference in DAT function as related to MA, the amount of DA evoked by an infusion of MA into superfused striatal tissue was tested and found to be significantly greater in males. In contrast, potassium chloride-stimulated DA release was greater in females. The results of these
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1196/annals.1432.010" target="_blank" rel="noreferrer noopener">10.1196/annals.1432.010</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2008
3
4-Dihydroxyphenylacetic Acid/metabolism
Adrenergic Uptake Inhibitors/metabolism
Animal/drug effects
Animals
Annals of the New York Academy of Sciences
Behavior
Behavior/drug effects
Corpus Striatum/metabolism
Dluzen D E
Dopamine Agents/pharmacology
Dopamine Plasma Membrane Transport Proteins/*metabolism
Dopamine Uptake Inhibitors/metabolism
Female
Humans
Male
McDermott J L
Methamphetamine/pharmacology
Mice
Nomifensine/metabolism
Reserpine/metabolism
Sex Factors
Vesicular Monoamine Transport Proteins/*metabolism
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1159/000095338" target="_blank" rel="noreferrer noopener">http://doi.org/10.1159/000095338</a>
Pages
295–302
Issue
5
Volume
83
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Effects of estrogen and related agents upon methamphetamine-induced neurotoxicity within an impaired nigrostriatal dopaminergic system of ovariectomized mice.
Publisher
An entity responsible for making the resource available
Neuroendocrinology
Date
A point or period of time associated with an event in the lifecycle of the resource
2006
2006
Subject
The topic of the resource
3; 4-Dihydroxyphenylacetic Acid/metabolism; Androgens/administration & dosage; Animals; Dopamine Agents/*administration & dosage/toxicity; Dopamine/metabolism; Dose-Response Relationship; Drug; Drug Administration Schedule; Estradiol/administration & dosage/*analogs & derivatives/physiology; Estrogen Antagonists/administration & dosage; Female; Methamphetamine/*administration & dosage/toxicity; Mice; Neostriatum/*drug effects/metabolism; Nerve Degeneration/chemically induced/prevention & control; Neuroprotective Agents/administration & dosage; Neurotoxins/*administration & dosage; Ovariectomy; Parkinson Disease/physiopathology; Substantia Nigra/*drug effects/metabolism; Tamoxifen/administration & dosage
Creator
An entity primarily responsible for making the resource
Liu Bin; Dluzen Dean E
Description
An account of the resource
Estrogen increases methamphetamine (MA)-induced neurotoxicity within the impaired nigrostriatal dopaminergic (NSDA) system of ovariectomized female mice, as defined by enhanced striatal dopamine (DA) depletion. In this study we compared the effects of a lower dose of estradiol benzoate (EB, 1 microg) with related agents–tamoxifen (TMX, 12.5 microg), testosterone (5 microg) and dehydroepiandrosterone (DHEA, 3 mg) in this paradigm. In experiment 1, ovariectomized mice received an initial treatment with MA. At 1 week after MA, mice were treated with EB, TMX, testosterone, DHEA or oil vehicle and 24 h later a second MA treatment. Striatal DA and 3,4-dihydroxyphenylacetic acid (DOPAC) concentrations in the MA-treated groups were decreased compared to the non-MA-treated control. Neither EB nor any of the other agents tested showed enhanced neurodegenerative or neuroprotective effects against a second MA invasion. To verify that estrogen was capable of showing a neuroprotective effect under a condition of two administrations of MA, in experiment 2, EB was administered either once or twice prior to each of the two MA treatments. EB treatment prior to the first MA invasion or first and second MA protected the NSDA system against DA and DOPAC depletion. These results imply that a lower dose of EB, TMX, testosterone and DHEA cannot exert neurodegenerative or neuroprotective effects in the impaired NSDA model. However, EB administered prior to the introduction of neurotoxicity can protect the NSDA system. This study may provide an understanding of the variations in results on the effects of estrogen upon the NSDA neurodegenerative disorder, Parkinson's disease.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1159/000095338" target="_blank" rel="noreferrer noopener">10.1159/000095338</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2006
3
4-Dihydroxyphenylacetic Acid/metabolism
Androgens/administration & dosage
Animals
Dluzen Dean E
Dopamine Agents/*administration & dosage/toxicity
Dopamine/metabolism
Dose-Response Relationship
Drug
Drug Administration Schedule
Estradiol/administration & dosage/*analogs & derivatives/physiology
Estrogen Antagonists/administration & dosage
Female
Liu Bin
Methamphetamine/*administration & dosage/toxicity
Mice
Neostriatum/*drug effects/metabolism
Nerve Degeneration/chemically induced/prevention & control
Neuroendocrinology
Neuroprotective Agents/administration & dosage
Neurotoxins/*administration & dosage
Ovariectomy
Parkinson Disease/physiopathology
Substantia Nigra/*drug effects/metabolism
Tamoxifen/administration & dosage
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1159/000079710" target="_blank" rel="noreferrer noopener">http://doi.org/10.1159/000079710</a>
Pages
305–316
Issue
6
Volume
79
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Dose-response effects of estrogen and tamoxifen upon methamphetamine-induced behavioral responses and neurotoxicity of the nigrostriatal dopaminergic system in female mice.
Publisher
An entity responsible for making the resource available
Neuroendocrinology
Date
A point or period of time associated with an event in the lifecycle of the resource
2004
2004
Subject
The topic of the resource
3; 4-Dihydroxyphenylacetic Acid/metabolism; Animal/*drug effects; Animals; Behavior; Brain Chemistry/drug effects; Dopamine/*metabolism; Dose-Response Relationship; Drug; Drug Interactions; Estrogen Antagonists/pharmacology; Estrogens/*pharmacology; Female; Methamphetamine/*toxicity; Mice; Movement/drug effects; Neostriatum/*drug effects/physiology; Neurotoxins/*toxicity; Organ Size/drug effects; Ovariectomy/methods; Stereotyped Behavior/drug effects; Substantia Nigra/drug effects/physiology; Tamoxifen/*pharmacology; Uterus
Creator
An entity primarily responsible for making the resource
Mickley Katherine R; Dluzen Dean E
Description
An account of the resource
In the present experiment we evaluated the dose-response effects of estrogen (estradiol benzoate; EB) and tamoxifen (TMX) in modulating the acute behavioral and chronic effects of methamphetamine (MA) upon the nigrostriatal dopaminergic (NSDA) system in ovariectomized (OVX) mice. EB over a range of doses from 1-40 microg resulted in a neuroprotective effect upon the NSDA system as defined by both a preservation of striatal dopamine (DA) concentrations and a decrease in DOPAC/DA ratios. Interestingly, the neuroprotective effect of the 1-microg EB dose occurred in the absence of any statistically significant effect upon the bioassay parameter of uterine weight. With the exception of an increase in stereotypy time as a response to the 40-microg dose, EB at any of the doses tested failed to alter any acute behavioral responses evoked by MA. In response to TMX, a statistically significant NSDA neuroprotectant response was obtained for DOPAC/DA ratios, but not DA concentrations, to doses ranging from 12.5 to 500 microg. No statistically significant effects upon uterine weights were obtained for any of the doses of TMX tested. Behaviorally, TMX at 500 microg had the effect of increasing the amount of time spent in the center of the cage. Taken together these results demonstrate: (1) EB and TMX at relatively low doses can exert a neuroprotective effect against MA; (2) these neuroprotective effects of EB and TMX can occur in the absence of an effect upon the bioassay parameter–uterine weights; (3) the parameter of DOPAC/DA ratio may indicate a more sensitive index of NSDA neuroprotection, and (4) modulatory effects of EB and TMX upon acute behavioral responses of the NSDA system to MA can be distinguished from their neuroprotective actions.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1159/000079710" target="_blank" rel="noreferrer noopener">10.1159/000079710</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2004
3
4-Dihydroxyphenylacetic Acid/metabolism
Animal/*drug effects
Animals
Behavior
Brain Chemistry/drug effects
Dluzen Dean E
Dopamine/*metabolism
Dose-Response Relationship
Drug
Drug Interactions
Estrogen Antagonists/pharmacology
Estrogens/*pharmacology
Female
Methamphetamine/*toxicity
Mice
Mickley Katherine R
Movement/drug effects
Neostriatum/*drug effects/physiology
Neuroendocrinology
Neurotoxins/*toxicity
Organ Size/drug effects
Ovariectomy/methods
Stereotyped Behavior/drug effects
Substantia Nigra/drug effects/physiology
Tamoxifen/*pharmacology
Uterus
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1046/j.1471-4159.1996.66020658.x" target="_blank" rel="noreferrer noopener">http://doi.org/10.1046/j.1471-4159.1996.66020658.x</a>
Pages
658–666
Issue
2
Volume
66
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Estrogen alters MPTP-induced neurotoxicity in female mice: effects on striatal dopamine concentrations and release.
Publisher
An entity responsible for making the resource available
Journal of neurochemistry
Date
A point or period of time associated with an event in the lifecycle of the resource
1996
1996-02
Subject
The topic of the resource
*MPTP Poisoning; 3; 4-Dihydroxyphenylacetic Acid/metabolism; Animals; Corpus Striatum/*drug effects/*metabolism; Dopamine/*metabolism; Estradiol/*pharmacology; Female; Inbred C57BL; Inbred Strains; Levodopa/pharmacology; Mice; Osmolar Concentration; Ovariectomy
Creator
An entity primarily responsible for making the resource
Dluzen D E; McDermott J L; Liu B
Description
An account of the resource
The effects of estrogen on MPTP-induced neurotoxicity of the nigrostriatal dopaminergic system were examined in C57Bl and CD-1 mice. Ovariectomized mice with and without estrogen were treated with MPTP or its vehicle. The effects of these treatments on striatal dopamine concentrations and L-DOPA-stimulated dopamine and L-3,4-dihydroxyphenylacetic acid (DOPAC) release in vitro were determined. Dopamine concentrations of C57Bl mice receiving estrogen before MPTP were significantly greater than those of non-estrogen-treated MPTP mice as well as estrogen-treated mice receiving the MPTP vehicle. Dopamine concentrations of the CD-1 mice did not differ with these treatments. L-DOPA-evoked dopamine release values of estrogen-treated C57Bl mice were significantly increased compared with non-estrogen-treated mice. No such differences were observed in the
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1046/j.1471-4159.1996.66020658.x" target="_blank" rel="noreferrer noopener">10.1046/j.1471-4159.1996.66020658.x</a>
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Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*MPTP Poisoning
1996
3
4-Dihydroxyphenylacetic Acid/metabolism
Animals
Corpus Striatum/*drug effects/*metabolism
Dluzen D E
Dopamine/*metabolism
Estradiol/*pharmacology
Female
Inbred C57BL
Inbred Strains
Journal of neurochemistry
Levodopa/pharmacology
Liu B
McDermott J L
Mice
Osmolar Concentration
Ovariectomy
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/s0014-2999(97)01438-6" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/s0014-2999(97)01438-6</a>
Pages
23–32
Issue
1
Volume
341
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
The effects of nicotine on dopamine and DOPAC output from rat striatal tissue.
Publisher
An entity responsible for making the resource available
European journal of pharmacology
Date
A point or period of time associated with an event in the lifecycle of the resource
1998
1998-01
Subject
The topic of the resource
3; 4-Dihydroxyphenylacetic Acid/*metabolism; Amphetamine/pharmacology; Animals; Central Nervous System Stimulants/pharmacology; Corpus Striatum/*drug effects/*metabolism; Dopamine/*metabolism; Dose-Response Relationship; Drug; Ganglionic Stimulants/administration & dosage/*pharmacology; Male; Nicotine/administration & dosage/*pharmacology; Potassium Chloride/pharmacology; Rats; Sprague-Dawley
Creator
An entity primarily responsible for making the resource
Dluzen D E; Anderson L I
Description
An account of the resource
The effects of varying doses of nicotine infusion upon spontaneous (basal) and subsequent potassium chloride-stimulated dopamine and 3,4-dihydroxyphenylacetic acid (DOPAC) output from superfused corpus striatal tissue fragments of male rats were tested. Spontaneous dopamine and DOPAC outputs were increased in response to 1, 5 and 10, but not to 0.1 and 0 (control) microM concentrations of nicotine. Interestingly, the subsequent K+-stimulated (30 mM) dopamine output was completely abolished in preparations infused with the 5 and 10 microM nicotine, but not with the 1 or 0.1 microM nicotine. No overall significant differences in K+-stimulated DOPAC were obtained among the five doses. In experiment 2, the effects of an initial infusion of amphetamine (10 microM), potassium chloride (30 mM), nicotine (10 microM) or normal superfusion medium (control) were compared upon subsequent K+-evoked dopamine release. The amount of dopamine released in response to the second (subsequent) infusion of K+ was significantly greater in the potassium chloride and control conditions versus the nicotine and amphetamine stimulated groups. No overall differences in DOPAC output were observed among the four conditions of experiment 2. These results demonstrate that nicotine can exert differential modulatory effects upon striatal dopaminergic activity as a function of the dose. The augmented levels of DOPAC output along with the abolition of the K+-stimulated dopamine release in response to the 5 and 10 microM nicotine doses suggest that these doses may simultaneously produce an activation of intraneuronal metabolism of dopamine to DOPAC along with an activation of release and inhibition of uptake to diminish stores available for subsequent responses to K+ stimulation.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/s0014-2999(97)01438-6" target="_blank" rel="noreferrer noopener">10.1016/s0014-2999(97)01438-6</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1998
3
4-Dihydroxyphenylacetic Acid/*metabolism
Amphetamine/pharmacology
Anderson L I
Animals
Central Nervous System Stimulants/pharmacology
Corpus Striatum/*drug effects/*metabolism
Dluzen D E
Dopamine/*metabolism
Dose-Response Relationship
Drug
European journal of pharmacology
Ganglionic Stimulants/administration & dosage/*pharmacology
Male
Nicotine/administration & dosage/*pharmacology
Potassium Chloride/pharmacology
Rats
Sprague-Dawley
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/s0006-8993(00)02329-5" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/s0006-8993(00)02329-5</a>
Pages
95–104
Issue
1
Volume
868
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Estrogen reduces acute striatal dopamine responses in vivo to the neurotoxin MPP+ in female, but not male rats.
Publisher
An entity responsible for making the resource available
Brain research
Date
A point or period of time associated with an event in the lifecycle of the resource
2000
2000-06
Subject
The topic of the resource
*Sex Characteristics; 1-Methyl-4-phenylpyridinium/*toxicity; 3; 4-Dihydroxyphenylacetic Acid/metabolism; Animals; Corpus Striatum/*metabolism; Dopamine/*metabolism; Estrogens/*pharmacology; Extracellular Space/metabolism; Female; Herbicides/*toxicity; Male; Microdialysis; Nerve Degeneration/chemically induced/metabolism; Parkinson Disease; Rats; Secondary/chemically induced/metabolism; Sprague-Dawley
Creator
An entity primarily responsible for making the resource
Disshon K A; Dluzen D E
Description
An account of the resource
The effects of in vivo estrogen treatment upon MPP(+)-induced dopamine (DA) release were determined using in vivo microdialysis in female and male rats. Ovariectomized female rats were implanted or not with an estrogen pellet (0.1 mg, 17beta estradiol) and subjected to microdialysis 6 days later. After baseline DA release was determined, 5 mM MPP(+) was infused through the microdialysis probe for one 20-min interval. Perfusion resumed with normal medium for the duration of the experiment. A significant attenuation of MPP(+)-induced DA release was obtained in estrogen-treated females. One week later, striatal DA and dihydroxyphenylacetic acid (DOPAC) concentrations were determined for the lesioned and non-lesioned striata of each animal. MPP(+) infusion significantly decreased striatal DA concentrations, however, there was no effect of estrogen treatment on striatal DA depletion. This experiment was repeated using orchidectomized male rats treated with 0, 0.1, or 5 mg estradiol. In contrast to the females, no differences in MPP(+)-induced DA release were seen among these males, and there was no significant effect of the varying estrogen treatments on striatal DA or DOPAC concentrations. These results demonstrate that in vivo estrogen treatment attenuates MPP(+)-induced striatal DA release in gonadectomized female, but not male, rats.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/s0006-8993(00)02329-5" target="_blank" rel="noreferrer noopener">10.1016/s0006-8993(00)02329-5</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Sex Characteristics
1-Methyl-4-phenylpyridinium/*toxicity
2000
3
4-Dihydroxyphenylacetic Acid/metabolism
Animals
Brain research
Corpus Striatum/*metabolism
Disshon K A
Dluzen D E
Dopamine/*metabolism
Estrogens/*pharmacology
Extracellular Space/metabolism
Female
Herbicides/*toxicity
Male
Microdialysis
Nerve Degeneration/chemically induced/metabolism
Parkinson Disease
Rats
Secondary/chemically induced/metabolism
Sprague-Dawley
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.neuroscience.2010.02.076" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.neuroscience.2010.02.076</a>
Pages
985–993
Issue
4
Volume
167
Dublin Core
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Title
A name given to the resource
Relationships among gender, age, time, and temperature in methamphetamine-induced striatal dopaminergic neurotoxicity.
Publisher
An entity responsible for making the resource available
Neuroscience
Date
A point or period of time associated with an event in the lifecycle of the resource
2010
2010-06
Subject
The topic of the resource
3; 4-Dihydroxyphenylacetic Acid/metabolism; Age Factors; Animals; Body Temperature/drug effects; Central Nervous System Stimulants/*toxicity; Corpus Striatum/*drug effects/metabolism; Dopamine/*metabolism; Female; In Vitro Techniques; Male; Methamphetamine/*toxicity; Mice; Neurotoxicity Syndromes/etiology/*metabolism/physiopathology; Sex Factors; Time Factors
Creator
An entity primarily responsible for making the resource
Dluzen D E; McDermott J L; Darvesh A S
Description
An account of the resource
A neurotoxic regimen of methamphetamine (MA-40 mg/kg ip) administered at 0 (control-MA vehicle), 0.5 and 72 h prior to determinations of striatal dopamine (DA) and DOPAC (3,4-dihydroxyphenylacetic acid)/DA ratios were compared among juvenile and adult female and male mice. Adult females and males showed similar depletions in striatal DA at 0.5 h post-MA, but males showed greater DA depletions and DOPAC/DA ratios at 72 h post-MA. Juvenile mice showed neither sex differences, nor any MA neurotoxicity upon striatal DA or DOPAC/DA ratios. Following MA, body temperatures increased in all mice, but increases in adult males were greater than adult females; juveniles showed no sex differences and body temperature increases were similar to that of adult males. MA-evoked DA output was greater in adult compared to juvenile males and a biologically effective regimen of testosterone to juvenile males neither increased MA-evoked DA output nor decreased MA-induced striatal DA like that observed in adult males. These results demonstrate: (1) Unlike adults, juvenile mice show neither a sex difference for MA-induced neurotoxicity or body temperature increases, nor MA neurotoxicity, (2) Initial effects of MA (0.5 h) in adult females and males are similar, but at 72 h post-MA females show no further striatal DA depletion, (3) Increased striatal DA depletion within adult versus juvenile males may be related to initially higher MA-evoked DA responses, and (4) Testosterone fails to convert juvenile males into adults with regard to MA effects.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/j.neuroscience.2010.02.076" target="_blank" rel="noreferrer noopener">10.1016/j.neuroscience.2010.02.076</a>
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Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2010
3
4-Dihydroxyphenylacetic Acid/metabolism
Age Factors
Animals
Body Temperature/drug effects
Central Nervous System Stimulants/*toxicity
Corpus Striatum/*drug effects/metabolism
Darvesh A S
Department of Pharmaceutical Sciences
Dluzen D E
Dopamine/*metabolism
Female
In Vitro Techniques
Male
McDermott J L
Methamphetamine/*toxicity
Mice
NEOMED College of Pharmacy
Neuroscience
Neurotoxicity Syndromes/etiology/*metabolism/physiopathology
Sex Factors
Time Factors
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.neuroscience.2007.06.058" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.neuroscience.2007.06.058</a>
Pages
401–408
Issue
2
Volume
149
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Aging and sex differences in striatal dopaminergic function.
Publisher
An entity responsible for making the resource available
Neuroscience
Date
A point or period of time associated with an event in the lifecycle of the resource
2007
2007-10
Subject
The topic of the resource
3; 4-Dihydroxyphenylacetic Acid/metabolism; Aging/*physiology; Amphetamine/pharmacology; Animals; Chemical; Dopamine Uptake Inhibitors/pharmacology; Dopamine/metabolism/*physiology; Female; In Vitro Techniques; Male; Mice; Neostriatum/metabolism/*physiology; Organ Size/physiology; Potassium/pharmacology; Sex Characteristics; Stimulation; Uterus/physiology
Creator
An entity primarily responsible for making the resource
McDermott J L; Dluzen D E
Description
An account of the resource
In this report the potassium- (30 mM) and amphetamine- (10 microM) stimulated responses of dopamine (DA) and 3,4-dihydroxy phenylacetic acid (DOPAC) from superfused striatal tissue of female and male mice as sampled at 2, 6, 18 and 24 months of age were compared. When assessed relative to responses obtained from
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/j.neuroscience.2007.06.058" target="_blank" rel="noreferrer noopener">10.1016/j.neuroscience.2007.06.058</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2007
3
4-Dihydroxyphenylacetic Acid/metabolism
Aging/*physiology
Amphetamine/pharmacology
Animals
Chemical
Dluzen D E
Dopamine Uptake Inhibitors/pharmacology
Dopamine/metabolism/*physiology
Female
In Vitro Techniques
Male
McDermott J L
Mice
Neostriatum/metabolism/*physiology
Neuroscience
Organ Size/physiology
Potassium/pharmacology
Sex Characteristics
Stimulation
Uterus/physiology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.neuro.2017.03.008" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.neuro.2017.03.008</a>
Pages
99–106
Volume
60
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Single low doses of MPTP decrease tyrosine hydroxylase expression in the absence of overt neuron loss.
Publisher
An entity responsible for making the resource available
Neurotoxicology
Date
A point or period of time associated with an event in the lifecycle of the resource
2017
2017-05
Subject
The topic of the resource
1-Methyl-4-phenyl-1; 2; 3; 6-tetrahydropyridine/*administration & dosage; Animals; Catecholamines/metabolism; Cell Count; Corpus Striatum/*drug effects/metabolism; Dopamine; Dopamine transporter; Dopaminergic Neurons/*drug effects/metabolism; Inbred C57BL; Male; Mice; MPTP; MPTP Poisoning; Parkinsonian Disorders/*metabolism/*pathology; Stereology; Substantia Nigra/*drug effects/metabolism; Tyrosine 3-Monooxygenase/*metabolism; Tyrosine hydroxylase; Vesicular monoamine transporter
Creator
An entity primarily responsible for making the resource
Alam Gelareh; Edler Melissa; Burchfield Shelbie L; Richardson Jason R
Description
An account of the resource
Parkinson's disease (PD) is the second most common age-related neurodegenerative disease. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is a prototypical neurotoxicant used in mice to mimic primary features of PD pathology including striatal dopamine depletion and dopamine neuron loss in the substantia nigra pars compacta (SNc). In the literature, there are several experimental paradigms involving multiple doses of MPTP that are used to elicit dopamine neuron loss. However, a recent study reported that a single low dose caused significant loss of dopamine neurons. Here, we determined the effect of a single intraperitoneal injection of one of three doses of MPTP (0.1, 2 and 20mg/kg) on dopamine neurons, labeled by tyrosine hydroxylase (TH(+)), and total neuron number (Nissl(+)) in the SNc using unbiased stereological counting. Data reveal a significant loss of neurons in the SNc (TH(+) and Nissl(+)) only in the group treated with 20mg/kg MPTP. Groups treated with lower dose of MPTP (0.1 and 2mg/kg) only showed significant loss of TH(+) neurons rather than TH(+) and Nissl(+) neurons. Striatal dopamine levels were decreased in the groups treated with 2 and 20mg/kg MPTP and striatal terminal markers including, TH and the dopamine transporter (DAT), were only decreased in the groups treated with 20mg/kg MPTP. These data demonstrate that lower doses of MPTP likely result in loss of TH expression rather than actual dopamine neuron loss in the SN. This finding reinforces the need to measure both total neuron number along with TH(+) cells in determining dopamine neuron loss.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/j.neuro.2017.03.008" target="_blank" rel="noreferrer noopener">10.1016/j.neuro.2017.03.008</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1-Methyl-4-phenyl-1
2
2017
3
6-tetrahydropyridine/*administration & dosage
Alam Gelareh
Animals
Burchfield Shelbie L
Catecholamines/metabolism
Cell Count
Corpus Striatum/*drug effects/metabolism
Department of Pharmaceutical Sciences
Dopamine
Dopamine transporter
Dopaminergic Neurons/*drug effects/metabolism
Edler Melissa
Inbred C57BL
Male
Mice
MPTP
MPTP Poisoning
NEOMED College of Pharmacy
Neurotoxicology
Parkinsonian Disorders/*metabolism/*pathology
Richardson Jason R
Stereology
Substantia Nigra/*drug effects/metabolism
Tyrosine 3-Monooxygenase/*metabolism
Tyrosine hydroxylase
Vesicular monoamine transporter
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.neuro.2016.04.008" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.neuro.2016.04.008</a>
Pages
40–47
Volume
55
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
MPTP neurotoxicity is highly concordant between the sexes among BXD recombinant inbred mouse strains.
Publisher
An entity responsible for making the resource available
Neurotoxicology
Date
A point or period of time associated with an event in the lifecycle of the resource
2016
2016-07
Subject
The topic of the resource
*QTL; *Recombinant inbred mice; *Sex Characteristics; *Sex differences; 1-Methyl-4-phenyl-1; 2; 3; 4-Dihydroxyphenylacetic Acid/metabolism; 6-tetrahydropyridine/pharmacology; Animal; Animals; Corpus Striatum/drug effects/*metabolism; Disease Models; Dopamine/metabolism; Female; Gene Expression Regulation/drug effects/*genetics; Glial Fibrillary Acidic Protein/*metabolism; Homovanillic Acid/metabolism; Inbred Strains; Male; Mice; MPTP Poisoning/chemically induced/*pathology; Serotonin/metabolism; Species Specificity; Tyrosine 3-Monooxygenase/metabolism
Creator
An entity primarily responsible for making the resource
Alam Gelareh; Miller Diane B; O'Callaghan James P; Lu Lu; Williams Robert W; Jones Byron C
Description
An account of the resource
Continuing our previous work in which we showed wide-ranging strain differences in MPTP neurotoxicity in male mice among ten BXD recombinant inbred strains, we replicated our work in females from nine of the same strains. Mice received a single s.c. injection of 12.5mg/kg MPTP or saline. Forty-eight hours later the striatum was dissected for neurochemical analysis. Striatal dopamine (DA) and its metabolites, DOPAC and HVA, striatal serotonin (5-HT) and its metabolite, 5-HIAA, were analyzed using HPLC. Tyrosine hydroxylase (TH) and glial fibrillary acidic protein (GFAP), an astrocytic protein that increases during the astroglial response to neural injury, were measured using ELISA. There were wide genetic variations in the DA, DOPAC, HVA, TH and GFAP responses to MPTP. We also performed principal component analysis (PCA) on the difference values, saline minus MPTP, for DA, DOPAC, HVA and TH and mapped the dominant principal component to a suggestive QTL on chromosome 1 at the same location that we observed previously for males. Moreover, there were significant correlations between the sexes for the effect of MPTP on DA, HVA, and TH. Our findings suggest that the systems genetic approach as utilized here can help researchers understand the role of sex in individual differences. The same approach can pave the way to understand and pinpoint the genetic bases for individual differences in pathology attributable to toxicants. Such systems genetics approach has broad implications for elucidating gene-environment contributions to neurodegenerative diseases.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/j.neuro.2016.04.008" target="_blank" rel="noreferrer noopener">10.1016/j.neuro.2016.04.008</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*QTL
*Recombinant inbred mice
*Sex Characteristics
*Sex differences
1-Methyl-4-phenyl-1
2
2016
3
4-Dihydroxyphenylacetic Acid/metabolism
6-tetrahydropyridine/pharmacology
Alam Gelareh
Animal
Animals
Corpus Striatum/drug effects/*metabolism
Department of Family & Community Medicine
Disease Models
Dopamine/metabolism
Female
Gene Expression Regulation/drug effects/*genetics
Glial Fibrillary Acidic Protein/*metabolism
Homovanillic Acid/metabolism
Inbred Strains
Jones Byron C
Lu Lu
Male
Mice
Miller Diane B
MPTP Poisoning/chemically induced/*pathology
NEOMED College of Medicine
Neurotoxicology
O'Callaghan James P
Serotonin/metabolism
Species Specificity
Tyrosine 3-Monooxygenase/metabolism
Williams Robert W
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.neulet.2010.04.004" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.neulet.2010.04.004</a>
Pages
66–69
Issue
2
Volume
476
Dublin Core
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Title
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Age-related changes in nigrostriatal dopaminergic function in heterozygous mutant dopamine transporter knock-out mice.
Publisher
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Neuroscience letters
Date
A point or period of time associated with an event in the lifecycle of the resource
2010
2010-05
Subject
The topic of the resource
3; 4-Dihydroxyphenylacetic Acid/*metabolism; Aging/*physiology; Animals; Corpus Striatum/*metabolism; Dopamine Plasma Membrane Transport Proteins/*genetics; Dopamine/*metabolism; Heterozygote; Inbred C57BL; Knockout; Male; Mice; Motor Activity; Mutation; Substantia Nigra/*metabolism
Creator
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Dluzen Dean E; Ji Jing; McDermott Janet L
Description
An account of the resource
In this report we compared three different parameters of nigrostriatal dopaminergic (NSDA) function - locomotor activity, striatal dopamine (DA) levels and 3,4-dihydroxyphenylacetic acid (DOPAC)/DA ratios between heterozygous mutant dopamine transporter mice (+/- DAT) and their wild type controls (+/+ DAT) at three different age range periods: 4-10, 11-17 and 18-24 months of age. Locomotor activity of the +/- DAT mice failed to differ over the three age periods sampled. In +/+ DAT mice a significant decrease in locomotor activity was obtained at the
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/j.neulet.2010.04.004" target="_blank" rel="noreferrer noopener">10.1016/j.neulet.2010.04.004</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2010
3
4-Dihydroxyphenylacetic Acid/*metabolism
Aging/*physiology
Animals
Corpus Striatum/*metabolism
Dluzen Dean E
Dopamine Plasma Membrane Transport Proteins/*genetics
Dopamine/*metabolism
Heterozygote
Inbred C57BL
Ji Jing
Knockout
Male
McDermott Janet L
Mice
Motor Activity
Mutation
Neuroscience letters
Substantia Nigra/*metabolism
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.jneumeth.2011.02.031" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.jneumeth.2011.02.031</a>
Pages
23–28
Issue
1
Volume
198
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
The effect of freezing and extraction upon striatal dopaminergic function.
Publisher
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Journal of neuroscience methods
Date
A point or period of time associated with an event in the lifecycle of the resource
2011
2011-05
Subject
The topic of the resource
*Freezing; 3; 4-Dihydroxyphenylacetic Acid/metabolism; Analysis of Variance; Animals; Chemical Fractionation/methods; Corpus Striatum/*metabolism; Cryopreservation/methods; Dopamine/*metabolism; Male; Mice; Time Factors
Creator
An entity primarily responsible for making the resource
Dluzen Dean E
Description
An account of the resource
Determinations of striatal dopamine (DA) and 3,4-dihydroxyphenylacetic acid (DOPAC) concentrations were compared under conditions where tissue was either frozen followed by extraction (FE) or extracted followed by freezing (EF). In Experiment 1, these determinations were performed at 0 (control), 0.5, 1 or 2h postmortem. In Experiment 2, these two protocols were compared at 0 (control), 0.5 or 72 h after a neurotoxic regimen of methamphetamine. In Experiment 3, potassium-stimulated DA release from superfused striatal tissue was compared between frozen and fresh tissue. The results from the 0 h (control) groups of Experiments 1 and 2 revealed that FE results in significant reductions in DA concentrations as compared with the EF procedure. However, FE diminishes the time-dependent reductions in striatal DA and increases in DOPAC present in the EF group, as obtained under conditions of natural (Experiment 1) or neurotoxin-induced (Experiment 2) degradation. Potassium-stimulated DA release from superfused striatal tissue is significantly decreased when measured from frozen versus fresh tissue. While freezing seems to produce an initial detrimental effect upon measuring striatal DA concentrations and potassium-stimulated release, there appears to be a capacity for preservation of striatal DA and diminution in DOPAC production by freezing when tissue is undergoing degradation. Such results demonstrate the significance of the protocol used for determination of neurotransmitters in postmortem tissue and suggest a potential means for diminishing the adverse effects of insult to striatal tissue that may result from conditions like stroke and exposure to neurotoxins.
Identifier
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<a href="http://doi.org/10.1016/j.jneumeth.2011.02.031" target="_blank" rel="noreferrer noopener">10.1016/j.jneumeth.2011.02.031</a>
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Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Freezing
2011
3
4-Dihydroxyphenylacetic Acid/metabolism
Analysis of Variance
Animals
Chemical Fractionation/methods
Corpus Striatum/*metabolism
Cryopreservation/methods
Dluzen Dean E
Dopamine/*metabolism
Journal of neuroscience methods
Male
Mice
Time Factors
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.jchromb.2013.11.048" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.jchromb.2013.11.048</a>
Pages
141–146
Volume
945-946
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
A quantitative LC-MS/MS method for determination of thiazolidinedione mitoNEET ligand NL-1 in mouse serum suitable for pharmacokinetic studies.
Publisher
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Journal of chromatography. B, Analytical technologies in the biomedical and life sciences
Date
A point or period of time associated with an event in the lifecycle of the resource
2014
2014-01
Subject
The topic of the resource
%CV; %RE; 1-methyl-4-phenyl-1; 2; 3; 3-thiazolidine-2; 4-dione; 5-[3; 5-[4-hydroxy-3; 5-di-tert-butyl-4-hydroxyphenyl)methyl]-1; 5-dimethyl-phenyl)methyl]thiazolidine-2; 6-tetrahydropyridine; Animals; Carry-over; Chromatography; High Pressure Liquid/*methods; internal standard; IS; LC-MS/MS; Limit of Detection; LLOQ; lower limit of quantification; Methanol; Mice; mitoNEET; Mouse serum; MPTP; MRM; multiple reaction monitoring; NL-1; NL-2; percent coefficient of variation; peroxisome proliferator activated receptor-gamma; pharmacokinetic; PK; PPAR-gamma; QC; quality control; relative error; relative matrix effect; RME; SD; standard deviation; Tandem Mass Spectrometry/*methods; thiazolidinedione; Thiazolidinedione (TZD); Thiazolidinediones/*blood; TZD
Creator
An entity primarily responsible for making the resource
Pedada Kiran K; Zhou Xiang; Jogiraju Harini; Carroll Richard T; Geldenhuys Werner J; Lin Li; Anderson David J
Description
An account of the resource
Thiazolidinedione (TZD) compounds have shown promise as antidiabetic, antibiotics, antifungal and neuroprotective agents. The mitochondrial effect of a novel mitoNEET ligand, NL-1 {5-[(3,5-di-tert-butyl-4-hydroxyphenyl)methyl]-1,3-thiazolidine-2,4-dione}, and other TZD compounds, is a newly proposed mechanism for the neuroprotective action of these TZD compounds. In this work, a sensitive LC-MS/MS assay has been developed and validated for quantification of NL-1 in mouse serum. Sample preparation involved an acetonitrile protein precipitation procedure with addition of an internal standard NL-2 {5-[(4-hydroxy-3,5-dimethyl-phenyl)methyl]thiazolidine-2,4-dione}. LC-MS/MS analysis utilized a Columbus C-18 HPLC column (2mmx50mm, 5mum). Chromatography employed a multiple step gradient program that featured a steep linear gradient (25-95% in 0.5min) of 15muM ammonium acetate (additive for eliminating carry-over) in 2% methanol mixing with increasing proportions of 100% methanol. The HPLC was interfaced to a QTrap 5500 mass spectrometer (AB Sciex) equipped with an electrospray ionization source used in a negative ionization mode. Multiple reaction monitoring (MRM) of m/z 334–\textgreater263 for NL-1 and m/z 250–\textgreater179 for NL-2 was done. The method had a linear range of at least 1-100ng/mL in serum. The intra-assay and inter-assay percent coefficient of variation (%CV) were less than 4% and accuracies (%RE) ranged from -2.7% to 2.0%. The analytical procedure gave 96-115% absolute extraction recovery of NL-1. The relative matrix effect was measured and found to be insignificant. The analyte in serum was confirmed to be stable during storage and treatment. The method is suitable for pharmacokinetic (PK) studies of the parent drug NL-1 based on the preliminary serum results from dosed NL-1 mouse studies.
Identifier
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<a href="http://doi.org/10.1016/j.jchromb.2013.11.048" target="_blank" rel="noreferrer noopener">10.1016/j.jchromb.2013.11.048</a>
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Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
%CV
%RE
1-Methyl-4-phenyl-1
2
2014
3
3-thiazolidine-2
4-dione
5-[3
5-[4-hydroxy-3
5-di-tert-butyl-4-hydroxyphenyl)methyl]-1
5-dimethyl-phenyl)methyl]thiazolidine-2
6-tetrahydropyridine
Anderson David J
Animals
Carroll Richard T
Carry-over
Chromatography
Department of Internal Medicine
Geldenhuys Werner J
High Pressure Liquid/*methods
internal standard
IS
Jogiraju Harini
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences
LC-MS/MS
Limit of Detection
Lin Li
LLOQ
lower limit of quantification
Methanol
Mice
mitoNEET
Mouse serum
MPTP
MRM
multiple reaction monitoring
NEOMED College of Medicine
NL-1
NL-2
Pedada Kiran K
percent coefficient of variation
peroxisome proliferator activated receptor-gamma
pharmacokinetic
PK
PPAR-gamma
QC
Quality Control
relative error
relative matrix effect
RME
SD
standard deviation
Tandem Mass Spectrometry/*methods
thiazolidinedione
Thiazolidinedione (TZD)
Thiazolidinediones/*blood
TZD
Zhou Xiang
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.brainres.2004.12.013" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.brainres.2004.12.013</a>
Pages
188–195
Issue
2
Volume
1035
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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Dopamine transporter function differences between male and female CD-1 mice.
Publisher
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Brain research
Date
A point or period of time associated with an event in the lifecycle of the resource
2005
2005-02
Subject
The topic of the resource
*Sex Characteristics; 3; 4-Dihydroxyphenylacetic Acid/metabolism; Animals; Corpus Striatum/physiology; Dopamine Plasma Membrane Transport Proteins; Dopamine/physiology; Female; Male; Membrane Glycoproteins/*physiology; Membrane Transport Proteins/*physiology; Mice; Nerve Tissue Proteins/*physiology
Creator
An entity primarily responsible for making the resource
Bhatt Sandeep D; Dluzen Dean E
Description
An account of the resource
It has been reported that male mice are more susceptible to the neurotoxic effects of methamphetamine (MA) upon the nigrostriatal dopaminergic (NSDA) system. Since MA utilizes the dopamine transporter (DAT) to exert its effects, in the present study, we tested for differences in the dynamics of DAT function between male and female mice as an approach to understand some of the bases for this sex difference in MA-induced NSDA neurotoxicity. To accomplish this goal, in Experiment 1, the amount of dopamine (DA) obtained following DA infusion into the superfused striatal tissue fragments of male and female mice was measured while in Experiment 2 responses to the DA uptake blocker, nomifensine (NMF), were assessed in these preparations. The differences obtained to these treatments demonstrate that marked differences in DA transporter activity exist between male and female mice. When combining the DA and DOPAC measures from these two experiments, the data suggest that the female mice show a more active and efficient recovery and vesicular packaging of extracellular DA. These findings have important implications for sex differences in NSDA functions and responses to neurotoxins which enter the neurons via the DAT.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/j.brainres.2004.12.013" target="_blank" rel="noreferrer noopener">10.1016/j.brainres.2004.12.013</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Sex Characteristics
2005
3
4-Dihydroxyphenylacetic Acid/metabolism
Animals
Bhatt Sandeep D
Brain research
Corpus Striatum/physiology
Dluzen Dean E
Dopamine Plasma Membrane Transport Proteins
Dopamine/physiology
Female
Male
Membrane Glycoproteins/*physiology
Membrane Transport Proteins/*physiology
Mice
Nerve Tissue Proteins/*physiology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0165-3806(91)90175-i" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0165-3806(91)90175-i</a>
Pages
273–276
Issue
2
Volume
62
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Striatal dopamine release in vitro from immature male rats shows enhanced responsiveness to pulsatile, but not continuous, infusions of L-dopa.
Publisher
An entity responsible for making the resource available
Brain research. Developmental brain research
Date
A point or period of time associated with an event in the lifecycle of the resource
1991
1991-10
Subject
The topic of the resource
3; 4-Dihydroxyphenylacetic Acid/metabolism; Aging/*metabolism; Animals; Corpus Striatum/*metabolism; Dopamine/*metabolism; Inbred Strains; Levodopa/*administration & dosage/pharmacology; Male; Pulsatile Flow; Rats
Creator
An entity primarily responsible for making the resource
Dluzen D; McDermott J
Description
An account of the resource
In the present experiment we compared the effects of continuous versus pulsed infusions of L-beta-3,4,dihydroxyphenylalanine (L-DOPA) upon dopamine and 3,4-dihydroxyphenylacetic acid (DOPAC) release in vitro from superfused corpus striatal tissue fragments of immature (25-32 day) and adult (90-120 day) male rats. In response to two pulse infusions of L-DOPA (5 microM) a significantly greater amount of dopamine and DOPAC was released from the striatal fragments of immature vs adult males. In contrast, when L-DOPA was infused continuously throughout the superfusion virtually identical amounts of dopamine and DOPAC were obtained for immature and adult male rats. No differences in postsuperfusion dopamine tissue content were obtained between adult and immature rats following the two pulses or continuous infusion of L-DOPA. These results suggest that the corpus striatum of the immature rat has an enhanced capacity to convert and release dopamine in response to a submaximal pulsatile infusion of L-DOPA.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0165-3806(91)90175-i" target="_blank" rel="noreferrer noopener">10.1016/0165-3806(91)90175-i</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1991
3
4-Dihydroxyphenylacetic Acid/metabolism
Aging/*metabolism
Animals
Brain research. Developmental brain research
Corpus Striatum/*metabolism
Dluzen D
Dopamine/*metabolism
Inbred Strains
Levodopa/*administration & dosage/pharmacology
Male
McDermott J
Pulsatile Flow
Rats
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0165-0270(93)90086-7" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0165-0270(93)90086-7</a>
Pages
235–246
Issue
3
Volume
47
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
A system for measuring electrophysiological multiple unit activity and extracellular dopamine concentration at single electrodes.
Publisher
An entity responsible for making the resource available
Journal of neuroscience methods
Date
A point or period of time associated with an event in the lifecycle of the resource
1993
1993-05
Subject
The topic of the resource
3; 4-Dihydroxyphenylacetic Acid/analysis; Amphetamine/pharmacology; Animals; Ascorbic Acid/analysis; Cerebral Cortex/drug effects/metabolism/*physiology; Dopamine/*analysis/metabolism; Electric Stimulation/instrumentation/methods; Electrochemistry/instrumentation/methods; Electrophysiology/instrumentation/*methods; Extracellular Space/chemistry; Hydroxyindoleacetic Acid/analysis; Male; Rats; Serotonin/analysis; Sprague-Dawley
Creator
An entity primarily responsible for making the resource
Glynn G E; Yamamoto B K
Description
An account of the resource
A technique is described for measuring electrophysiological multiple-unit activity and extracellular dopamine concentration with in vivo voltammetry at an array of 8 electrodes. In addition, new procedures in the construction of the voltammetric electrode that reduce the effects of capacitance and improve sensitivity are outlined. A system of relays controlling the connections of the electrode and associated systems is also detailed. Both in vitro and in vivo voltammetric selectivity tests indicate an almost exclusive response to dopamine. A large increase in extracellular dopamine concentration was detected in response to 2.5 mg/kg D-amphetamine. Both prestimulus and cortical stimulation evoked increases in striatal multiple-unit activity were measured.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0165-0270(93)90086-7" target="_blank" rel="noreferrer noopener">10.1016/0165-0270(93)90086-7</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1993
3
4-Dihydroxyphenylacetic Acid/analysis
Amphetamine/pharmacology
Animals
Ascorbic Acid/analysis
Cerebral Cortex/drug effects/metabolism/*physiology
Dopamine/*analysis/metabolism
Electric Stimulation/instrumentation/methods
Electrochemistry/instrumentation/methods
Electrophysiology/instrumentation/*methods
Extracellular Space/chemistry
Glynn G E
Hydroxyindoleacetic Acid/analysis
Journal of neuroscience methods
Male
Rats
Serotonin/analysis
Sprague-Dawley
Yamamoto B K