Browse Items · NEOMED Bibliography Database

Effect of estrogen upon methamphetamine-induced neurotoxicity within the impaired nigrostriatal dopaminergic system.

In the present study, we investigated whether estrogen remains effective as a neuroprotectant within an impaired nigrostriatal dopaminergic (NSDA) system of gonadectomized female and male mice. In Experiment 1, mice were treated with four different…

Nomifensine alters sex differences in striatal dopaminergic function.

A series of three experiments are presented in which the acute effects of the catecholamine reuptake inhibitor, nomifensine, upon striatal dopaminergic function are compared in female and male mice. In Experiment 1, treatment with nomifensine (5 mg…

The effect of GDNF on nigrostriatal dopaminergic function in response to a two-pulse K(+) stimulation.

We examined the effect of glial cell line-derived neurotrophic factor (GDNF) upon nigrostriatal dopaminergic function in response to two-pulse potassium (K(+)) stimulation in rats under in vivo microdialysis conditions. The two-pulse infusion…

L-DOPA modulation of corpus striatal dopamine and dihydroxyphenylacetic acid output from intact and 6-OHDA lesioned rats.

In the present report we examined the differences in in vitro dopamine (DA) and dihydroxyphenylacetic acid (DOPAC) efflux from the corpus striatum (CS) of intact versus 6-hydroxydopamine (6-OHDA) lesioned (in substantia nigra) male rats in response…

Tags: *Sympathectomy, 1996, 3, 4-Dihydroxyphenylacetic Acid/*metabolism, Animals, Antiparkinson Agents/*pharmacology, Chemical, Corpus Striatum/drug effects/*metabolism, Dluzen D E, Dopamine/*metabolism, Journal of neural transmission (Vienna, Austria : 1996), Levodopa/*pharmacology, Male, Oxidopamine, Rats, Sprague-Dawley, Substantia Nigra/drug effects/metabolism, Xu K

The effect of reserpine treatment in vivo upon L-dopa and amphetamine evoked dopamine and DOPAC efflux in vitro from the corpus striatum of male rats.

In the present experiment we tested the effects of L-DOPA and amphetamine upon dopamine and DOPAC efflux in vitro from superfused corpus striatal tissue fragments of male rats who had been pretreated with reserpine. Male rats were treated with…

Tags: 1994, 3, 4-Dihydroxyphenylacetic Acid/*metabolism, Amphetamine/*pharmacology, Animals, Cell Compartmentation, Corpus Striatum/*drug effects/metabolism, Dluzen D E, Dopamine/*metabolism, Drug Interactions, Journal of neural transmission. General section, Levodopa/*pharmacology, Liu B, Male, Rats, Research Design, Reserpine/*pharmacology, Secretory Rate/drug effects, Sprague-Dawley

Rotenone produces opposite effects upon mouse striatal dopamine function as a result of environmental temperature.

Rotenone is a commonly used pesticide that can function as an environmental neurotoxin. Rotenone is a known mitochondrial complex I inhibitor which can lead to oxidative stress and results in dopaminergic cell death. Another environmental factor…

Tags: *temperature, 2006, 3, 4-Dihydroxyphenylacetic Acid/metabolism, Analysis of Variance, Animals, Brain Chemistry/drug effects/physiology/radiation effects, Corpus Striatum/*drug effects/metabolism, Crutchfield Karla C, Dluzen Dean E, Dopamine/*metabolism, Dose-Response Relationship, Drug, Insecticides/*pharmacology, Methamphetamine/pharmacology, Mice, Neurotoxicity research, Rotenone/*pharmacology

Acute effects of estrogen upon methamphetamine induced neurotoxicity of the nigrostriatal dopaminergic system.

Estrogen acts as a neuroprotectant of the nigrostriatal dopaminergic system when given chronically to female mice prior to Methamphetamine (MA) insult. In this report, we tested the acute effects of Estradiol Benzoate (EB-10 microg in Oil) in…

Alteration in L-DOPA evoked dopamine and DOPAC output under conditions of impaired vesicular dopamine storage.

We examined the effect of L-dihydroxyphenylalanine (L-DOPA) infusion in vitro upon dopamine (DA) and dihydroxyphenylacetic acid (DOPAC) output from superfused corpus striatum of vehicle and reserpine or tetrabenazine (TBZ) treated male rats.…

Tags: 1998, 3, 4-Dihydroxyphenylacetic Acid/*metabolism, Animals, Dluzen D E, Dopamine Agents/*pharmacology, Dopamine/*metabolism, Journal of neural transmission (Vienna, Austria : 1996), Levodopa/*pharmacology, Male, Pharmaceutical Vehicles, Rats, Reserpine/pharmacology, Sprague-Dawley, Synaptic Vesicles/*drug effects/metabolism, Tetrabenazine/pharmacology, Xu K

Sex differences in striatal dopaminergic function within heterozygous mutant dopamine transporter knock-out mice.

The issue of whether a deletion of the dopamine transporter (DAT) allele (+/- DAT) would differentially alter striatal dopamine (DA) and dihydroxyphenylacetic acid (DOPAC) concentrations and DA release upon potassium and methamphetamine (MA)…

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) reduces norepinephrine concentrations in the olfactory bulbs of male mice.

Male retired breeder C57/Bl and CD-1 mice were treated with either MPTP or its vehicle. At 7-10 days post-treatment, catecholamine concentrations within the olfactory bulbs (OB) and hypothalamus were determined. Norepinephrine concentrations within…

Tags: *Sex Characteristics, 1-Methyl-4-phenyl-1, 1992, 2, 3, 6-tetrahydropyridine/*pharmacology, Animals, Brain research, Dluzen D E, Dopamine/metabolism, Drug Resistance/genetics, Inbred C57BL, Inbred Strains, Male, Mice, Norepinephrine/*metabolism, Olfactory Bulb/*metabolism, Osmolar Concentration

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) disrupts social memory/recognition processes in the male mouse.

Male mice treated with MPTP or vehicle were tested for their ability to demonstrate a memory-recognition response as evaluated in a habituation-dishabituation task. Treatment with MPTP severely disrupted the male's habituation-dishabituation response…

Effects of testosterone upon MPTP-induced neurotoxicity of the nigrostriatal dopaminergic system of C57/B1 mice.

We have recently reported that treatment of gonadectomized female and male C57/B1 mice with the gonadal steroid hormone, estrogen, reduced nigrostriatal dopaminergic neurotoxicity resulting from the Parkinson's-like inducing agent

The aromatic amino acid decarboxylase inhibitor, NSD-1015, increases release of dopamine: response characteristics.

Addition of the aromatic amino acid decarboxylase inhibitor, NSD-1015 (10 microM), to Krebs'-Ringer phosphate (KRP) superfusion medium, significantly increased the release of dopamine in vitro from superfused corpus striatum tissue fragments of male…

Tags: *Aromatic Amino Acid Decarboxylase Inhibitors, 1992, 3, 4-Dihydroxyphenylacetic Acid/metabolism, Animals, Brain/*drug effects/metabolism, Dluzen D, Dopamine/*metabolism, Hydrazines/*pharmacology, Male, McDermott J, Neuropharmacology, Rats, Reddy A, Sprague-Dawley

Age-related changes in monoamines within the olfactory bulbs of the Fischer 344 male rat.

In this report the olfactory bulbs (OB) were removed from 5-6 month, 15-16 month and 25-26 month male Fischer 344 rats and assayed for concentrations of monoamines and their metabolites using HPLC-EC. Concentrations of norepinephrine were…

Tags: 1996, 3, 4-Dihydroxyphenylacetic Acid/metabolism, Aging/*metabolism, Animals, Biogenic Monoamines/*metabolism, Dluzen D E, Dopamine/metabolism, Inbred F344, Male, Mechanisms of ageing and development, Olfactory Bulb/*metabolism, Rats, Serotonin/metabolism

L-dopa reverses castration-induced disruption of dishabituation responses to female chemical cues in male rats.

In the present experiment, habituation/dishabituation behavioral tests were conducted to measure discriminatory olfactory recognition responses to chemical cues among control, castrated, and castrated+L-3,4-dihydroxyphenylalanine (L-DOPA)-treated…

A system for measuring electrophysiological multiple unit activity and extracellular dopamine concentration at single electrodes.

A technique is described for measuring electrophysiological multiple-unit activity and extracellular dopamine concentration with in vivo voltammetry at an array of 8 electrodes. In addition, new procedures in the construction of the voltammetric…

Striatal dopamine release in vitro from immature male rats shows enhanced responsiveness to pulsatile, but not continuous, infusions of L-dopa.

In the present experiment we compared the effects of continuous versus pulsed infusions of L-beta-3,4,dihydroxyphenylalanine (L-DOPA) upon dopamine and 3,4-dihydroxyphenylacetic acid (DOPAC) release in vitro from superfused corpus striatal tissue…

Tags: 1991, 3, 4-Dihydroxyphenylacetic Acid/metabolism, Aging/*metabolism, Animals, Brain research. Developmental brain research, Corpus Striatum/*metabolism, Dluzen D, Dopamine/*metabolism, Inbred Strains, Levodopa/*administration & dosage/pharmacology, Male, McDermott J, Pulsatile Flow, Rats

Dopamine transporter function differences between male and female CD-1 mice.

It has been reported that male mice are more susceptible to the neurotoxic effects of methamphetamine (MA) upon the nigrostriatal dopaminergic (NSDA) system. Since MA utilizes the dopamine transporter (DAT) to exert its effects, in the present study,…

Tags: *Sex Characteristics, 2005, 3, 4-Dihydroxyphenylacetic Acid/metabolism, Animals, Bhatt Sandeep D, Brain research, Corpus Striatum/physiology, Dluzen Dean E, Dopamine Plasma Membrane Transport Proteins, Dopamine/physiology, Female, Male, Membrane Glycoproteins/*physiology, Membrane Transport Proteins/*physiology, Mice, Nerve Tissue Proteins/*physiology

A quantitative LC-MS/MS method for determination of thiazolidinedione mitoNEET ligand NL-1 in mouse serum suitable for pharmacokinetic studies.

Thiazolidinedione (TZD) compounds have shown promise as antidiabetic, antibiotics, antifungal and neuroprotective agents. The mitochondrial effect of a novel mitoNEET ligand, NL-1…

Tags: %CV, %RE, 1-Methyl-4-phenyl-1, 2, 2014, 3, 3-thiazolidine-2, 4-dione, 5-[3, 5-[4-hydroxy-3, 5-di-tert-butyl-4-hydroxyphenyl)methyl]-1, 5-dimethyl-phenyl)methyl]thiazolidine-2, 6-tetrahydropyridine, Anderson David J, Animals, Carroll Richard T, Carry-over, Chromatography, Department of Internal Medicine, Geldenhuys Werner J, High Pressure Liquid/*methods, internal standard, IS, Jogiraju Harini, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, LC-MS/MS, Limit of Detection, Lin Li, LLOQ, lower limit of quantification, Methanol, Mice, mitoNEET, Mouse serum, MPTP, MRM, multiple reaction monitoring, NEOMED College of Medicine, NL-1, NL-2, Pedada Kiran K, percent coefficient of variation, peroxisome proliferator activated receptor-gamma, pharmacokinetic, PK, PPAR-gamma, QC, Quality Control, relative error, relative matrix effect, RME, SD, standard deviation, Tandem Mass Spectrometry/*methods, thiazolidinedione, Thiazolidinedione (TZD), Thiazolidinediones/*blood, TZD, Zhou Xiang

The effect of freezing and extraction upon striatal dopaminergic function.

Determinations of striatal dopamine (DA) and 3,4-dihydroxyphenylacetic acid (DOPAC) concentrations were compared under conditions where tissue was either frozen followed by extraction (FE) or extracted followed by freezing (EF). In Experiment 1,…

Tags: *Freezing, 2011, 3, 4-Dihydroxyphenylacetic Acid/metabolism, Analysis of Variance, Animals, Chemical Fractionation/methods, Corpus Striatum/*metabolism, Cryopreservation/methods, Dluzen Dean E, Dopamine/*metabolism, Journal of neuroscience methods, Male, Mice, Time Factors

Age-related changes in nigrostriatal dopaminergic function in heterozygous mutant dopamine transporter knock-out mice.

In this report we compared three different parameters of nigrostriatal dopaminergic (NSDA) function - locomotor activity, striatal dopamine (DA) levels and 3,4-dihydroxyphenylacetic acid (DOPAC)/DA ratios between heterozygous mutant dopamine…

MPTP neurotoxicity is highly concordant between the sexes among BXD recombinant inbred mouse strains.

Continuing our previous work in which we showed wide-ranging strain differences in MPTP neurotoxicity in male mice among ten BXD recombinant inbred strains, we replicated our work in females from nine of the same strains. Mice received a single s.c.…

Single low doses of MPTP decrease tyrosine hydroxylase expression in the absence of overt neuron loss.

Parkinson's disease (PD) is the second most common age-related neurodegenerative disease. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is a prototypical neurotoxicant used in mice to mimic primary features of PD pathology including striatal…

Aging and sex differences in striatal dopaminergic function.

In this report the potassium- (30 mM) and amphetamine- (10 microM) stimulated responses of dopamine (DA) and 3,4-dihydroxy phenylacetic acid (DOPAC) from superfused striatal tissue of female and male mice as sampled at 2, 6, 18 and 24 months of age…

Relationships among gender, age, time, and temperature in methamphetamine-induced striatal dopaminergic neurotoxicity.

A neurotoxic regimen of methamphetamine (MA-40 mg/kg ip) administered at 0 (control-MA vehicle), 0.5 and 72 h prior to determinations of striatal dopamine (DA) and DOPAC (3,4-dihydroxyphenylacetic acid)/DA ratios were compared among juvenile and…

Estrogen reduces acute striatal dopamine responses in vivo to the neurotoxin MPP+ in female, but not male rats.

The effects of in vivo estrogen treatment upon MPP(+)-induced dopamine (DA) release were determined using in vivo microdialysis in female and male rats. Ovariectomized female rats were implanted or not with an estrogen pellet (0.1 mg, 17beta…

The effects of nicotine on dopamine and DOPAC output from rat striatal tissue.

The effects of varying doses of nicotine infusion upon spontaneous (basal) and subsequent potassium chloride-stimulated dopamine and 3,4-dihydroxyphenylacetic acid (DOPAC) output from superfused corpus striatal tissue fragments of male rats were…

Tags: 1998, 3, 4-Dihydroxyphenylacetic Acid/*metabolism, Amphetamine/pharmacology, Anderson L I, Animals, Central Nervous System Stimulants/pharmacology, Corpus Striatum/*drug effects/*metabolism, Dluzen D E, Dopamine/*metabolism, Dose-Response Relationship, Drug, European journal of pharmacology, Ganglionic Stimulants/administration & dosage/*pharmacology, Male, Nicotine/administration & dosage/*pharmacology, Potassium Chloride/pharmacology, Rats, Sprague-Dawley

Estrogen alters MPTP-induced neurotoxicity in female mice: effects on striatal dopamine concentrations and release.

The effects of estrogen on MPTP-induced neurotoxicity of the nigrostriatal dopaminergic system were examined in C57Bl and CD-1 mice. Ovariectomized mice with and without estrogen were treated with MPTP or its vehicle. The effects of these treatments…

Tags: *MPTP Poisoning, 1996, 3, 4-Dihydroxyphenylacetic Acid/metabolism, Animals, Corpus Striatum/*drug effects/*metabolism, Dluzen D E, Dopamine/*metabolism, Estradiol/*pharmacology, Female, Inbred C57BL, Inbred Strains, Journal of neurochemistry, Levodopa/pharmacology, Liu B, McDermott J L, Mice, Osmolar Concentration, Ovariectomy

Dose-response effects of estrogen and tamoxifen upon methamphetamine-induced behavioral responses and neurotoxicity of the nigrostriatal dopaminergic system in female mice.

In the present experiment we evaluated the dose-response effects of estrogen (estradiol benzoate; EB) and tamoxifen (TMX) in modulating the acute behavioral and chronic effects of methamphetamine (MA) upon the nigrostriatal dopaminergic (NSDA) system…

Effects of estrogen and related agents upon methamphetamine-induced neurotoxicity within an impaired nigrostriatal dopaminergic system of ovariectomized mice.

Estrogen increases methamphetamine (MA)-induced neurotoxicity within the impaired nigrostriatal dopaminergic (NSDA) system of ovariectomized female mice, as defined by enhanced striatal dopamine (DA) depletion. In this study we compared the effects…

Sex differences in dopamine- and vesicular monoamine-transporter functions.

Men and women differ with regard to their use of, and responses to, methamphetamine (MA). Analogous sex differences with regard to MA are observed in animal models. In this report, data from a series of experiments that focus upon dopamine…

Behavioral effects of N-ethyl-3,4-methylenedioxyamphetamine (MDE; "EVE").

Eight male rats were trained to discriminate 2.0 mg/kg

Tags: 1987, 3, 4-methylenedioxyamphetamine, 4-Methylenedioxyamphetamine/analogs & derivatives/*pharmacology, Amphetamines/*pharmacology, Animals, Boja J W, Discrimination (Psychology), Dose-Response Relationship, Drug, Inbred Strains, Legislation, Male, N-Methyl-3, Pharmacology, biochemistry, and behavior, Rats, Schechter M D, Time Factors, United States

Possible serotonergic and dopaminergic mediation of the

Eight male rats previously trained to discriminate 2.0 mg/kg

The antinociceptive effects of 3,4-methylenedioxymethamphetamine (MDMA) in the rat.

The antinociceptive effects of MDMA and morphine were examined in rats using the tail-flick and hot-plate analgesiometric tests. MDMA, in the dose range of 1.5-6.0 mg/kg IP, produced a dose-dependent elevation in hot-plate latency, but did not…

The effect of long-term treatment with deprenyl on basal and L-dopa evoked dopamine release in vitro from the corpus striatum of aged rats.

In the present experiment, male rats (15-17 months) were injected with deprenyl (0.25 mg/kg) three times per week for six months. At 21-23 months of age the male rats were sacrificed, the corpus striatum removed and superfused in vitro. Basal and…

Tags: 1991, 3, 4-Dihydroxyphenylacetic Acid/*metabolism, Aging/metabolism, Amphetamine/pharmacology, Animals, Corpus Striatum/*drug effects/metabolism, Dluzen D E, Dopamine/*metabolism, In Vitro Techniques, Journal of neural transmission. General section, Levodopa/pharmacology, Male, McDermott J L, Rats, Selegiline/*pharmacology

The effects of intranasal infusion of

Male C57/B1 mice received bilateral intranasal infusions of saline, MPTP or an intraperitoneal injection of MPTP. Infusions were performed using a peristaltic pump at a setting of 100 microliters/min. The MPTP, diluted in saline at concentrations of…

Estrogen decreases corpus striatal neurotoxicity in response to

Ovariectomized rats treated or not with an estradiol pellet were subjected to an unilateral intrastriatal infusion of 6-hydroxydopamine (6-OHDA). Various parameters of nigrostriatal dopaminergic function as derived from measurements of dopamine and…

Tags: 1997, 3, 4-Dihydroxyphenylacetic Acid/metabolism, Animal, Animals, Brain research, Corpus Striatum/*drug effects, Disease Models, Dluzen D, Dopamine/metabolism, Estradiol/*pharmacology, Female, Neurotoxins/*toxicity, Oxidopamine/*toxicity, Parkinson Disease/*physiopathology, Rats, Sprague-Dawley

Modulatory effects of testosterone on

In this experiment, we examined the modulatory effects of testosterone on the parkinsonism-inducing drug 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in two strains of mice. Orchidectomized male CD-1 and C57/B1 mice were implanted with either…

In vivo neurochemical and anatomical heterogeneity of the dopamine uptake system in the rat caudate putamen.

The neurochemical and anatomical heterogeneity of dopamine uptake blockade was studied at a medial and lateral position in each of 3 rostrocaudal areas of the rat caudate-putamen. In vivo voltammetric measures of extracellular dopamine indicated a…

Tags: 1989, 3, 4-Dihydroxyphenylacetic Acid/metabolism, Animals, Brain research, Caudate Nucleus/drug effects/*metabolism, Dopamine/*metabolism, Electrochemistry, Glynn G E, Homovanillic Acid/metabolism, Inbred Strains, Indoles/*pharmacology, Male, Mazindol/*pharmacology, Neurotransmitter Uptake Inhibitors/*pharmacology, Nomifensine/*pharmacology, Putamen/drug effects/*metabolism, Rats, Yamamoto B K

Effects of cathinone and amphetamine on the neurochemistry of dopamine in vivo.

The effects of (-)cathinone, the primary psychoactive alkaloid of the Khat plant, were compared to those of (+)amphetamine in the anterior caudate-putamen and the nucleus accumbens. In vivo microdialysis was used to measure extracellular levels of…

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