1
40
26
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0006-8993(90)91256-g" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0006-8993(90)91256-g</a>
Pages
236–242
Issue
2
Volume
506
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
A neurochemical heterogeneity of the rat striatum as measured by in vivo electrochemistry and microdialysis.
Publisher
An entity responsible for making the resource available
Brain research
Date
A point or period of time associated with an event in the lifecycle of the resource
1990
1990-01
Subject
The topic of the resource
Male; Animals; Rats; Dopamine/*metabolism; Corpus Striatum/*metabolism; Amphetamines/*pharmacology; Electrochemistry; Sulpiride/*pharmacology; Inbred Strains; Receptors; 3; 4-Dihydroxyphenylacetic Acid/metabolism; Dopamine/drug effects; Dopamine D2
Creator
An entity primarily responsible for making the resource
Yamamoto B K; Pehek E A
Description
An account of the resource
The neurochemical heterogeneity of the rat striatum was assessed in vivo by measuring subregional changes in extracellular dopamine and DOPAC by in vivo electrochemistry and microdialysis in response to amphetamine and the D2 antagonist, (-)-sulpiride. Both in vivo electrochemical and microdialysis experiments indicated a significant rostrocaudal gradient in dopamine release following amphetamine. The increase in dopamine release was highest in the rostral areas (over 800% of baseline values) and lowest in the most caudal subregion (425% of baseline). No lateromedial differences in dopamine release were observed. DOPAC levels decreased in dialysates but were similar for all 6 subregions examined. In contrast, D2 blockade with (-)-sulpiride revealed a lateromedial gradient in the increases seen for dopamine and DOPAC such that greater increases were observed in the lateral subregions. (-)-Sulpiride did not produce any differential effects along the rostrocaudal axis. The regional gradients detected in extracellular fluid changes of dopamine and DOPAC indicate that dopamine release is locally regulated by an interaction between the density of dopaminergic innervation to a particular subregion and the D2 receptor density.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0006-8993(90)91256-g" target="_blank" rel="noreferrer noopener">10.1016/0006-8993(90)91256-g</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1990
3
4-Dihydroxyphenylacetic Acid/metabolism
Amphetamines/*pharmacology
Animals
Brain research
Corpus Striatum/*metabolism
Dopamine D2
Dopamine/*metabolism
Dopamine/drug effects
Electrochemistry
Inbred Strains
Male
Pehek E A
Rats
Receptors
Sulpiride/*pharmacology
Yamamoto B K
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0014-2999(88)90564-x" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0014-2999(88)90564-x</a>
Pages
195–203
Issue
2
Volume
148
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
The acute effects of methylenedioxymethamphetamine on dopamine release in the awake-behaving rat.
Publisher
An entity responsible for making the resource available
European journal of pharmacology
Date
A point or period of time associated with an event in the lifecycle of the resource
1988
1988-03
Subject
The topic of the resource
Male; Animals; Rats; Dopamine/*metabolism; Consciousness; Amphetamines/*pharmacology; Brain/drug effects/metabolism; Caudate Nucleus/drug effects/metabolism; Nucleus Accumbens/drug effects/metabolism; Inbred Strains; 3; 4-Dihydroxyphenylacetic Acid/metabolism; N-Methyl-3; 4-methylenedioxyamphetamine; 4-Methylenedioxyamphetamine/analogs & derivatives/*pharmacology
Creator
An entity primarily responsible for making the resource
Yamamoto B K; Spanos L J
Description
An account of the resource
The effects of the recently classified Schedule I amphetamine analog, 3,4-methylenedioxymethamphetamine [+/-)-MDMA) on caudate and nucleus accumbens dopamine release and metabolism were studied by in vivo voltammetry and HPLC with electrochemical detection. Monitored over a 3 h period, the magnitude of increase in dopamine release and the onset of effect were dose-dependent and similar for both brain areas following the 2.5 and 5 mg/kg dose of the drug. However, responses were different for these brain regions using 10 mg/kg of MDMA; the magnitude of increase was greater and the onset of effect more immediate in caudate. Analysis of dopamine and DOPAC tissue content in both caudate and nucleus accumbens verified the voltammetry results. This study provides the first evidence that MDMA induces dopamine release in vivo and that this effect is region, time- and dose-dependent.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0014-2999(88)90564-x" target="_blank" rel="noreferrer noopener">10.1016/0014-2999(88)90564-x</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1988
3
4-Dihydroxyphenylacetic Acid/metabolism
4-methylenedioxyamphetamine
4-Methylenedioxyamphetamine/analogs & derivatives/*pharmacology
Amphetamines/*pharmacology
Animals
Brain/drug effects/metabolism
Caudate Nucleus/drug effects/metabolism
Consciousness
Dopamine/*metabolism
European journal of pharmacology
Inbred Strains
Male
N-Methyl-3
Nucleus Accumbens/drug effects/metabolism
Rats
Spanos L J
Yamamoto B K
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0028-3908(90)90041-o" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0028-3908(90)90041-o</a>
Pages
1171–1176
Issue
12
Volume
29
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Effects of cathinone and amphetamine on the neurochemistry of dopamine in vivo.
Publisher
An entity responsible for making the resource available
Neuropharmacology
Date
A point or period of time associated with an event in the lifecycle of the resource
1990
1990-12
Subject
The topic of the resource
Male; Animals; Rats; Molecular Structure; Structure-Activity Relationship; Reference Values; Kinetics; Dopamine/*metabolism; Brain/drug effects/*metabolism; Psychotropic Drugs/*pharmacology; Alkaloids/*pharmacology; Amphetamine/*pharmacology; Caudate Nucleus/metabolism; Homovanillic Acid/metabolism; Nucleus Accumbens/metabolism; Putamen/metabolism; Inbred Strains; 3; 4-Dihydroxyphenylacetic Acid/metabolism
Creator
An entity primarily responsible for making the resource
Pehek E A; Schechter M D; Yamamoto B K
Description
An account of the resource
The effects of (-)cathinone, the primary psychoactive alkaloid of the Khat plant, were compared to those of (+)amphetamine in the anterior caudate-putamen and the nucleus accumbens. In vivo microdialysis was used to measure extracellular levels of dopamine and metabolites in both regions of the brain simultaneously, after intraperitoneal administration of 0.8, 1.6 or 3.2 mg/kg of either drug (doses expressed as the salts). Both drugs increased levels of dopamine but decreased levels of metabolites in a dose-dependent manner. However, the relative magnitude of these effects depended upon the specific drug, the dose and area of the brain examined. At the largest dose used, amphetamine had a relatively greater effect than cathinone on dopamine in both caudate and accumbens. However, among smaller doses, this difference was only observed in the nucleus accumbens after administration of 1.6 mg/kg. The results also demonstrated a differential regional effect of both drugs at 3.2 mg/kg, in that both had a greater effect on dopamine in the caudate, as opposed to the accumbens. These findings demonstrate a functional heterogeneity of the striatum of the rat, that may be relevant to the understanding of both normal brain function and the neural responses to psychoactive drugs.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0028-3908(90)90041-o" target="_blank" rel="noreferrer noopener">10.1016/0028-3908(90)90041-o</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1990
3
4-Dihydroxyphenylacetic Acid/metabolism
Alkaloids/*pharmacology
Amphetamine/*pharmacology
Animals
Brain/drug effects/*metabolism
Caudate Nucleus/metabolism
Dopamine/*metabolism
Homovanillic Acid/metabolism
Inbred Strains
Kinetics
Male
Molecular Structure
Neuropharmacology
Nucleus Accumbens/metabolism
Pehek E A
Psychotropic Drugs/*pharmacology
Putamen/metabolism
Rats
Reference Values
Schechter M D
Structure-Activity Relationship
Yamamoto B K
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0006-8993(89)90799-3" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0006-8993(89)90799-3</a>
Pages
235–241
Issue
2
Volume
481
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
In vivo neurochemical and anatomical heterogeneity of the dopamine uptake system in the rat caudate putamen.
Publisher
An entity responsible for making the resource available
Brain research
Date
A point or period of time associated with an event in the lifecycle of the resource
1989
1989-03
Subject
The topic of the resource
Male; Animals; Rats; Dopamine/*metabolism; Indoles/*pharmacology; Nomifensine/*pharmacology; Homovanillic Acid/metabolism; Electrochemistry; Caudate Nucleus/drug effects/*metabolism; Mazindol/*pharmacology; Neurotransmitter Uptake Inhibitors/*pharmacology; Putamen/drug effects/*metabolism; Inbred Strains; 3; 4-Dihydroxyphenylacetic Acid/metabolism
Creator
An entity primarily responsible for making the resource
Glynn G E; Yamamoto B K
Description
An account of the resource
The neurochemical and anatomical heterogeneity of dopamine uptake blockade was studied at a medial and lateral position in each of 3 rostrocaudal areas of the rat caudate-putamen. In vivo voltammetric measures of extracellular dopamine indicated a lateral-to-medial and rostral-to-caudal gradient in the effect of uptake blockade. The percentage increase in dopamine was greatest in the rostrolateral area (300%) and least in the caudomedial area (10%). The existence of these lateromedial and rostrocaudal gradients was confirmed by tissue content measures of DOPAC and dopamine to DOPAC ratios in each area. The rostrocaudal gradient in the effect of uptake blockade was independent of the rostrocaudal gradient in dopamine tissue content. The regional gradients detected in dopamine uptake blockade may indicate a heterogeneous distribution in the number of uptake sites, a regional variation in the affinity of the uptake site for the blocker and/or altered neuronal activity mediated by an action of the blocker on dopaminergic cell bodies.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0006-8993(89)90799-3" target="_blank" rel="noreferrer noopener">10.1016/0006-8993(89)90799-3</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1989
3
4-Dihydroxyphenylacetic Acid/metabolism
Animals
Brain research
Caudate Nucleus/drug effects/*metabolism
Dopamine/*metabolism
Electrochemistry
Glynn G E
Homovanillic Acid/metabolism
Inbred Strains
Indoles/*pharmacology
Male
Mazindol/*pharmacology
Neurotransmitter Uptake Inhibitors/*pharmacology
Nomifensine/*pharmacology
Putamen/drug effects/*metabolism
Rats
Yamamoto B K
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Pages
340–344
Issue
2
Volume
767
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Estrogen decreases corpus striatal neurotoxicity in response to
Publisher
An entity responsible for making the resource available
Brain research
Date
A point or period of time associated with an event in the lifecycle of the resource
1997
1997-09
Subject
The topic of the resource
Female; Animals; Rats; Corpus Striatum/*drug effects; Dopamine/metabolism; Neurotoxins/*toxicity; Estradiol/*pharmacology; Oxidopamine/*toxicity; Parkinson Disease/*physiopathology; Sprague-Dawley; Animal; Disease Models; 3; 4-Dihydroxyphenylacetic Acid/metabolism
Creator
An entity primarily responsible for making the resource
Dluzen D
Description
An account of the resource
Ovariectomized rats treated or not with an estradiol pellet were subjected to an unilateral intrastriatal infusion of 6-hydroxydopamine (6-OHDA). Various parameters of nigrostriatal dopaminergic function as derived from measurements of dopamine and dihydroxyphenylacetic acid (DOPAC) concentrations were determined from the 6-OHDA lesioned and non-lesioned sides of the corpus striatum in these animals. Dopamine concentrations within the 6-OHDA lesioned striatum of estrogen-treated rats were significantly greater than non-estrogen-treated rats. There were no differences in striatal dopamine concentrations between estrogen- versus non-estrogen-treated rats on their non-lesioned side. In contrast to that of dopamine, no differences in DOPAC concentrations between estrogen and non-estrogen-treated rats were obtained within the 6-OHDA-lesioned side. The DOPAC concentrations on the non-lesioned side of the striatum were significantly greater in the non-estrogen-treated rats. These results demonstrate that estrogen significantly diminishes the depletion of striatal dopamine resulting from the neurotoxin 6-OHDA. The data obtained from the DOPAC determinations imply that this capacity of estrogen may be exerted through actions upon uptake processes of striatal dopaminergic neurons. Such findings suggest that estrogen may function as an important modulatory factor capable of attenuating degeneration within the corpus striatum, and in this way serve as a neuroprotectant of the nigrostriatal dopaminergic system.
Rights
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1997
3
4-Dihydroxyphenylacetic Acid/metabolism
Animal
Animals
Brain research
Corpus Striatum/*drug effects
Disease Models
Dluzen D
Dopamine/metabolism
Estradiol/*pharmacology
Female
Neurotoxins/*toxicity
Oxidopamine/*toxicity
Parkinson Disease/*physiopathology
Rats
Sprague-Dawley
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1196/annals.1432.010" target="_blank" rel="noreferrer noopener">http://doi.org/10.1196/annals.1432.010</a>
Pages
140–150
Volume
1139
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Sex differences in dopamine- and vesicular monoamine-transporter functions.
Publisher
An entity responsible for making the resource available
Annals of the New York Academy of Sciences
Date
A point or period of time associated with an event in the lifecycle of the resource
2008
2008-10
Subject
The topic of the resource
3; 4-Dihydroxyphenylacetic Acid/metabolism; Adrenergic Uptake Inhibitors/metabolism; Animal/drug effects; Animals; Behavior; Behavior/drug effects; Corpus Striatum/metabolism; Dopamine Agents/pharmacology; Dopamine Plasma Membrane Transport Proteins/*metabolism; Dopamine Uptake Inhibitors/metabolism; Female; Humans; Male; Methamphetamine/pharmacology; Mice; Nomifensine/metabolism; Reserpine/metabolism; Sex Factors; Vesicular Monoamine Transport Proteins/*metabolism
Creator
An entity primarily responsible for making the resource
Dluzen D E; McDermott J L
Description
An account of the resource
Men and women differ with regard to their use of, and responses to, methamphetamine (MA). Analogous sex differences with regard to MA are observed in animal models. In this report, data from a series of experiments that focus upon dopamine transporter (DAT) and vesicular monoamine transporter2 (VMAT2) function are reviewed by way of providing some understanding for these sex differences to MA. The amount of dopamine (DA) recovered after infusion of DA into superfused striatal tissue was greater in females and an accentuated amount of extracellular DA was obtained from females after infusion of the DAT-blocking drug, nomifensine. These data suggest a higher level of DAT activity in females. To evaluate the implications of this sex difference in DAT function as related to MA, the amount of DA evoked by an infusion of MA into superfused striatal tissue was tested and found to be significantly greater in males. In contrast, potassium chloride-stimulated DA release was greater in females. The results of these
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1196/annals.1432.010" target="_blank" rel="noreferrer noopener">10.1196/annals.1432.010</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2008
3
4-Dihydroxyphenylacetic Acid/metabolism
Adrenergic Uptake Inhibitors/metabolism
Animal/drug effects
Animals
Annals of the New York Academy of Sciences
Behavior
Behavior/drug effects
Corpus Striatum/metabolism
Dluzen D E
Dopamine Agents/pharmacology
Dopamine Plasma Membrane Transport Proteins/*metabolism
Dopamine Uptake Inhibitors/metabolism
Female
Humans
Male
McDermott J L
Methamphetamine/pharmacology
Mice
Nomifensine/metabolism
Reserpine/metabolism
Sex Factors
Vesicular Monoamine Transport Proteins/*metabolism
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1159/000095338" target="_blank" rel="noreferrer noopener">http://doi.org/10.1159/000095338</a>
Pages
295–302
Issue
5
Volume
83
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Effects of estrogen and related agents upon methamphetamine-induced neurotoxicity within an impaired nigrostriatal dopaminergic system of ovariectomized mice.
Publisher
An entity responsible for making the resource available
Neuroendocrinology
Date
A point or period of time associated with an event in the lifecycle of the resource
2006
2006
Subject
The topic of the resource
3; 4-Dihydroxyphenylacetic Acid/metabolism; Androgens/administration & dosage; Animals; Dopamine Agents/*administration & dosage/toxicity; Dopamine/metabolism; Dose-Response Relationship; Drug; Drug Administration Schedule; Estradiol/administration & dosage/*analogs & derivatives/physiology; Estrogen Antagonists/administration & dosage; Female; Methamphetamine/*administration & dosage/toxicity; Mice; Neostriatum/*drug effects/metabolism; Nerve Degeneration/chemically induced/prevention & control; Neuroprotective Agents/administration & dosage; Neurotoxins/*administration & dosage; Ovariectomy; Parkinson Disease/physiopathology; Substantia Nigra/*drug effects/metabolism; Tamoxifen/administration & dosage
Creator
An entity primarily responsible for making the resource
Liu Bin; Dluzen Dean E
Description
An account of the resource
Estrogen increases methamphetamine (MA)-induced neurotoxicity within the impaired nigrostriatal dopaminergic (NSDA) system of ovariectomized female mice, as defined by enhanced striatal dopamine (DA) depletion. In this study we compared the effects of a lower dose of estradiol benzoate (EB, 1 microg) with related agents–tamoxifen (TMX, 12.5 microg), testosterone (5 microg) and dehydroepiandrosterone (DHEA, 3 mg) in this paradigm. In experiment 1, ovariectomized mice received an initial treatment with MA. At 1 week after MA, mice were treated with EB, TMX, testosterone, DHEA or oil vehicle and 24 h later a second MA treatment. Striatal DA and 3,4-dihydroxyphenylacetic acid (DOPAC) concentrations in the MA-treated groups were decreased compared to the non-MA-treated control. Neither EB nor any of the other agents tested showed enhanced neurodegenerative or neuroprotective effects against a second MA invasion. To verify that estrogen was capable of showing a neuroprotective effect under a condition of two administrations of MA, in experiment 2, EB was administered either once or twice prior to each of the two MA treatments. EB treatment prior to the first MA invasion or first and second MA protected the NSDA system against DA and DOPAC depletion. These results imply that a lower dose of EB, TMX, testosterone and DHEA cannot exert neurodegenerative or neuroprotective effects in the impaired NSDA model. However, EB administered prior to the introduction of neurotoxicity can protect the NSDA system. This study may provide an understanding of the variations in results on the effects of estrogen upon the NSDA neurodegenerative disorder, Parkinson's disease.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1159/000095338" target="_blank" rel="noreferrer noopener">10.1159/000095338</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2006
3
4-Dihydroxyphenylacetic Acid/metabolism
Androgens/administration & dosage
Animals
Dluzen Dean E
Dopamine Agents/*administration & dosage/toxicity
Dopamine/metabolism
Dose-Response Relationship
Drug
Drug Administration Schedule
Estradiol/administration & dosage/*analogs & derivatives/physiology
Estrogen Antagonists/administration & dosage
Female
Liu Bin
Methamphetamine/*administration & dosage/toxicity
Mice
Neostriatum/*drug effects/metabolism
Nerve Degeneration/chemically induced/prevention & control
Neuroendocrinology
Neuroprotective Agents/administration & dosage
Neurotoxins/*administration & dosage
Ovariectomy
Parkinson Disease/physiopathology
Substantia Nigra/*drug effects/metabolism
Tamoxifen/administration & dosage
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1159/000079710" target="_blank" rel="noreferrer noopener">http://doi.org/10.1159/000079710</a>
Pages
305–316
Issue
6
Volume
79
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Dose-response effects of estrogen and tamoxifen upon methamphetamine-induced behavioral responses and neurotoxicity of the nigrostriatal dopaminergic system in female mice.
Publisher
An entity responsible for making the resource available
Neuroendocrinology
Date
A point or period of time associated with an event in the lifecycle of the resource
2004
2004
Subject
The topic of the resource
3; 4-Dihydroxyphenylacetic Acid/metabolism; Animal/*drug effects; Animals; Behavior; Brain Chemistry/drug effects; Dopamine/*metabolism; Dose-Response Relationship; Drug; Drug Interactions; Estrogen Antagonists/pharmacology; Estrogens/*pharmacology; Female; Methamphetamine/*toxicity; Mice; Movement/drug effects; Neostriatum/*drug effects/physiology; Neurotoxins/*toxicity; Organ Size/drug effects; Ovariectomy/methods; Stereotyped Behavior/drug effects; Substantia Nigra/drug effects/physiology; Tamoxifen/*pharmacology; Uterus
Creator
An entity primarily responsible for making the resource
Mickley Katherine R; Dluzen Dean E
Description
An account of the resource
In the present experiment we evaluated the dose-response effects of estrogen (estradiol benzoate; EB) and tamoxifen (TMX) in modulating the acute behavioral and chronic effects of methamphetamine (MA) upon the nigrostriatal dopaminergic (NSDA) system in ovariectomized (OVX) mice. EB over a range of doses from 1-40 microg resulted in a neuroprotective effect upon the NSDA system as defined by both a preservation of striatal dopamine (DA) concentrations and a decrease in DOPAC/DA ratios. Interestingly, the neuroprotective effect of the 1-microg EB dose occurred in the absence of any statistically significant effect upon the bioassay parameter of uterine weight. With the exception of an increase in stereotypy time as a response to the 40-microg dose, EB at any of the doses tested failed to alter any acute behavioral responses evoked by MA. In response to TMX, a statistically significant NSDA neuroprotectant response was obtained for DOPAC/DA ratios, but not DA concentrations, to doses ranging from 12.5 to 500 microg. No statistically significant effects upon uterine weights were obtained for any of the doses of TMX tested. Behaviorally, TMX at 500 microg had the effect of increasing the amount of time spent in the center of the cage. Taken together these results demonstrate: (1) EB and TMX at relatively low doses can exert a neuroprotective effect against MA; (2) these neuroprotective effects of EB and TMX can occur in the absence of an effect upon the bioassay parameter–uterine weights; (3) the parameter of DOPAC/DA ratio may indicate a more sensitive index of NSDA neuroprotection, and (4) modulatory effects of EB and TMX upon acute behavioral responses of the NSDA system to MA can be distinguished from their neuroprotective actions.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1159/000079710" target="_blank" rel="noreferrer noopener">10.1159/000079710</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2004
3
4-Dihydroxyphenylacetic Acid/metabolism
Animal/*drug effects
Animals
Behavior
Brain Chemistry/drug effects
Dluzen Dean E
Dopamine/*metabolism
Dose-Response Relationship
Drug
Drug Interactions
Estrogen Antagonists/pharmacology
Estrogens/*pharmacology
Female
Methamphetamine/*toxicity
Mice
Mickley Katherine R
Movement/drug effects
Neostriatum/*drug effects/physiology
Neuroendocrinology
Neurotoxins/*toxicity
Organ Size/drug effects
Ovariectomy/methods
Stereotyped Behavior/drug effects
Substantia Nigra/drug effects/physiology
Tamoxifen/*pharmacology
Uterus
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1046/j.1471-4159.1996.66020658.x" target="_blank" rel="noreferrer noopener">http://doi.org/10.1046/j.1471-4159.1996.66020658.x</a>
Pages
658–666
Issue
2
Volume
66
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Estrogen alters MPTP-induced neurotoxicity in female mice: effects on striatal dopamine concentrations and release.
Publisher
An entity responsible for making the resource available
Journal of neurochemistry
Date
A point or period of time associated with an event in the lifecycle of the resource
1996
1996-02
Subject
The topic of the resource
*MPTP Poisoning; 3; 4-Dihydroxyphenylacetic Acid/metabolism; Animals; Corpus Striatum/*drug effects/*metabolism; Dopamine/*metabolism; Estradiol/*pharmacology; Female; Inbred C57BL; Inbred Strains; Levodopa/pharmacology; Mice; Osmolar Concentration; Ovariectomy
Creator
An entity primarily responsible for making the resource
Dluzen D E; McDermott J L; Liu B
Description
An account of the resource
The effects of estrogen on MPTP-induced neurotoxicity of the nigrostriatal dopaminergic system were examined in C57Bl and CD-1 mice. Ovariectomized mice with and without estrogen were treated with MPTP or its vehicle. The effects of these treatments on striatal dopamine concentrations and L-DOPA-stimulated dopamine and L-3,4-dihydroxyphenylacetic acid (DOPAC) release in vitro were determined. Dopamine concentrations of C57Bl mice receiving estrogen before MPTP were significantly greater than those of non-estrogen-treated MPTP mice as well as estrogen-treated mice receiving the MPTP vehicle. Dopamine concentrations of the CD-1 mice did not differ with these treatments. L-DOPA-evoked dopamine release values of estrogen-treated C57Bl mice were significantly increased compared with non-estrogen-treated mice. No such differences were observed in the
Identifier
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<a href="http://doi.org/10.1046/j.1471-4159.1996.66020658.x" target="_blank" rel="noreferrer noopener">10.1046/j.1471-4159.1996.66020658.x</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*MPTP Poisoning
1996
3
4-Dihydroxyphenylacetic Acid/metabolism
Animals
Corpus Striatum/*drug effects/*metabolism
Dluzen D E
Dopamine/*metabolism
Estradiol/*pharmacology
Female
Inbred C57BL
Inbred Strains
Journal of neurochemistry
Levodopa/pharmacology
Liu B
McDermott J L
Mice
Osmolar Concentration
Ovariectomy
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/s0006-8993(00)02329-5" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/s0006-8993(00)02329-5</a>
Pages
95–104
Issue
1
Volume
868
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Estrogen reduces acute striatal dopamine responses in vivo to the neurotoxin MPP+ in female, but not male rats.
Publisher
An entity responsible for making the resource available
Brain research
Date
A point or period of time associated with an event in the lifecycle of the resource
2000
2000-06
Subject
The topic of the resource
*Sex Characteristics; 1-Methyl-4-phenylpyridinium/*toxicity; 3; 4-Dihydroxyphenylacetic Acid/metabolism; Animals; Corpus Striatum/*metabolism; Dopamine/*metabolism; Estrogens/*pharmacology; Extracellular Space/metabolism; Female; Herbicides/*toxicity; Male; Microdialysis; Nerve Degeneration/chemically induced/metabolism; Parkinson Disease; Rats; Secondary/chemically induced/metabolism; Sprague-Dawley
Creator
An entity primarily responsible for making the resource
Disshon K A; Dluzen D E
Description
An account of the resource
The effects of in vivo estrogen treatment upon MPP(+)-induced dopamine (DA) release were determined using in vivo microdialysis in female and male rats. Ovariectomized female rats were implanted or not with an estrogen pellet (0.1 mg, 17beta estradiol) and subjected to microdialysis 6 days later. After baseline DA release was determined, 5 mM MPP(+) was infused through the microdialysis probe for one 20-min interval. Perfusion resumed with normal medium for the duration of the experiment. A significant attenuation of MPP(+)-induced DA release was obtained in estrogen-treated females. One week later, striatal DA and dihydroxyphenylacetic acid (DOPAC) concentrations were determined for the lesioned and non-lesioned striata of each animal. MPP(+) infusion significantly decreased striatal DA concentrations, however, there was no effect of estrogen treatment on striatal DA depletion. This experiment was repeated using orchidectomized male rats treated with 0, 0.1, or 5 mg estradiol. In contrast to the females, no differences in MPP(+)-induced DA release were seen among these males, and there was no significant effect of the varying estrogen treatments on striatal DA or DOPAC concentrations. These results demonstrate that in vivo estrogen treatment attenuates MPP(+)-induced striatal DA release in gonadectomized female, but not male, rats.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/s0006-8993(00)02329-5" target="_blank" rel="noreferrer noopener">10.1016/s0006-8993(00)02329-5</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Sex Characteristics
1-Methyl-4-phenylpyridinium/*toxicity
2000
3
4-Dihydroxyphenylacetic Acid/metabolism
Animals
Brain research
Corpus Striatum/*metabolism
Disshon K A
Dluzen D E
Dopamine/*metabolism
Estrogens/*pharmacology
Extracellular Space/metabolism
Female
Herbicides/*toxicity
Male
Microdialysis
Nerve Degeneration/chemically induced/metabolism
Parkinson Disease
Rats
Secondary/chemically induced/metabolism
Sprague-Dawley
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.neuroscience.2010.02.076" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.neuroscience.2010.02.076</a>
Pages
985–993
Issue
4
Volume
167
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Relationships among gender, age, time, and temperature in methamphetamine-induced striatal dopaminergic neurotoxicity.
Publisher
An entity responsible for making the resource available
Neuroscience
Date
A point or period of time associated with an event in the lifecycle of the resource
2010
2010-06
Subject
The topic of the resource
3; 4-Dihydroxyphenylacetic Acid/metabolism; Age Factors; Animals; Body Temperature/drug effects; Central Nervous System Stimulants/*toxicity; Corpus Striatum/*drug effects/metabolism; Dopamine/*metabolism; Female; In Vitro Techniques; Male; Methamphetamine/*toxicity; Mice; Neurotoxicity Syndromes/etiology/*metabolism/physiopathology; Sex Factors; Time Factors
Creator
An entity primarily responsible for making the resource
Dluzen D E; McDermott J L; Darvesh A S
Description
An account of the resource
A neurotoxic regimen of methamphetamine (MA-40 mg/kg ip) administered at 0 (control-MA vehicle), 0.5 and 72 h prior to determinations of striatal dopamine (DA) and DOPAC (3,4-dihydroxyphenylacetic acid)/DA ratios were compared among juvenile and adult female and male mice. Adult females and males showed similar depletions in striatal DA at 0.5 h post-MA, but males showed greater DA depletions and DOPAC/DA ratios at 72 h post-MA. Juvenile mice showed neither sex differences, nor any MA neurotoxicity upon striatal DA or DOPAC/DA ratios. Following MA, body temperatures increased in all mice, but increases in adult males were greater than adult females; juveniles showed no sex differences and body temperature increases were similar to that of adult males. MA-evoked DA output was greater in adult compared to juvenile males and a biologically effective regimen of testosterone to juvenile males neither increased MA-evoked DA output nor decreased MA-induced striatal DA like that observed in adult males. These results demonstrate: (1) Unlike adults, juvenile mice show neither a sex difference for MA-induced neurotoxicity or body temperature increases, nor MA neurotoxicity, (2) Initial effects of MA (0.5 h) in adult females and males are similar, but at 72 h post-MA females show no further striatal DA depletion, (3) Increased striatal DA depletion within adult versus juvenile males may be related to initially higher MA-evoked DA responses, and (4) Testosterone fails to convert juvenile males into adults with regard to MA effects.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/j.neuroscience.2010.02.076" target="_blank" rel="noreferrer noopener">10.1016/j.neuroscience.2010.02.076</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2010
3
4-Dihydroxyphenylacetic Acid/metabolism
Age Factors
Animals
Body Temperature/drug effects
Central Nervous System Stimulants/*toxicity
Corpus Striatum/*drug effects/metabolism
Darvesh A S
Department of Pharmaceutical Sciences
Dluzen D E
Dopamine/*metabolism
Female
In Vitro Techniques
Male
McDermott J L
Methamphetamine/*toxicity
Mice
NEOMED College of Pharmacy
Neuroscience
Neurotoxicity Syndromes/etiology/*metabolism/physiopathology
Sex Factors
Time Factors
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.neuroscience.2007.06.058" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.neuroscience.2007.06.058</a>
Pages
401–408
Issue
2
Volume
149
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Aging and sex differences in striatal dopaminergic function.
Publisher
An entity responsible for making the resource available
Neuroscience
Date
A point or period of time associated with an event in the lifecycle of the resource
2007
2007-10
Subject
The topic of the resource
3; 4-Dihydroxyphenylacetic Acid/metabolism; Aging/*physiology; Amphetamine/pharmacology; Animals; Chemical; Dopamine Uptake Inhibitors/pharmacology; Dopamine/metabolism/*physiology; Female; In Vitro Techniques; Male; Mice; Neostriatum/metabolism/*physiology; Organ Size/physiology; Potassium/pharmacology; Sex Characteristics; Stimulation; Uterus/physiology
Creator
An entity primarily responsible for making the resource
McDermott J L; Dluzen D E
Description
An account of the resource
In this report the potassium- (30 mM) and amphetamine- (10 microM) stimulated responses of dopamine (DA) and 3,4-dihydroxy phenylacetic acid (DOPAC) from superfused striatal tissue of female and male mice as sampled at 2, 6, 18 and 24 months of age were compared. When assessed relative to responses obtained from
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/j.neuroscience.2007.06.058" target="_blank" rel="noreferrer noopener">10.1016/j.neuroscience.2007.06.058</a>
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Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2007
3
4-Dihydroxyphenylacetic Acid/metabolism
Aging/*physiology
Amphetamine/pharmacology
Animals
Chemical
Dluzen D E
Dopamine Uptake Inhibitors/pharmacology
Dopamine/metabolism/*physiology
Female
In Vitro Techniques
Male
McDermott J L
Mice
Neostriatum/metabolism/*physiology
Neuroscience
Organ Size/physiology
Potassium/pharmacology
Sex Characteristics
Stimulation
Uterus/physiology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.neuro.2016.04.008" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.neuro.2016.04.008</a>
Pages
40–47
Volume
55
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
MPTP neurotoxicity is highly concordant between the sexes among BXD recombinant inbred mouse strains.
Publisher
An entity responsible for making the resource available
Neurotoxicology
Date
A point or period of time associated with an event in the lifecycle of the resource
2016
2016-07
Subject
The topic of the resource
*QTL; *Recombinant inbred mice; *Sex Characteristics; *Sex differences; 1-Methyl-4-phenyl-1; 2; 3; 4-Dihydroxyphenylacetic Acid/metabolism; 6-tetrahydropyridine/pharmacology; Animal; Animals; Corpus Striatum/drug effects/*metabolism; Disease Models; Dopamine/metabolism; Female; Gene Expression Regulation/drug effects/*genetics; Glial Fibrillary Acidic Protein/*metabolism; Homovanillic Acid/metabolism; Inbred Strains; Male; Mice; MPTP Poisoning/chemically induced/*pathology; Serotonin/metabolism; Species Specificity; Tyrosine 3-Monooxygenase/metabolism
Creator
An entity primarily responsible for making the resource
Alam Gelareh; Miller Diane B; O'Callaghan James P; Lu Lu; Williams Robert W; Jones Byron C
Description
An account of the resource
Continuing our previous work in which we showed wide-ranging strain differences in MPTP neurotoxicity in male mice among ten BXD recombinant inbred strains, we replicated our work in females from nine of the same strains. Mice received a single s.c. injection of 12.5mg/kg MPTP or saline. Forty-eight hours later the striatum was dissected for neurochemical analysis. Striatal dopamine (DA) and its metabolites, DOPAC and HVA, striatal serotonin (5-HT) and its metabolite, 5-HIAA, were analyzed using HPLC. Tyrosine hydroxylase (TH) and glial fibrillary acidic protein (GFAP), an astrocytic protein that increases during the astroglial response to neural injury, were measured using ELISA. There were wide genetic variations in the DA, DOPAC, HVA, TH and GFAP responses to MPTP. We also performed principal component analysis (PCA) on the difference values, saline minus MPTP, for DA, DOPAC, HVA and TH and mapped the dominant principal component to a suggestive QTL on chromosome 1 at the same location that we observed previously for males. Moreover, there were significant correlations between the sexes for the effect of MPTP on DA, HVA, and TH. Our findings suggest that the systems genetic approach as utilized here can help researchers understand the role of sex in individual differences. The same approach can pave the way to understand and pinpoint the genetic bases for individual differences in pathology attributable to toxicants. Such systems genetics approach has broad implications for elucidating gene-environment contributions to neurodegenerative diseases.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/j.neuro.2016.04.008" target="_blank" rel="noreferrer noopener">10.1016/j.neuro.2016.04.008</a>
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Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*QTL
*Recombinant inbred mice
*Sex Characteristics
*Sex differences
1-Methyl-4-phenyl-1
2
2016
3
4-Dihydroxyphenylacetic Acid/metabolism
6-tetrahydropyridine/pharmacology
Alam Gelareh
Animal
Animals
Corpus Striatum/drug effects/*metabolism
Department of Family & Community Medicine
Disease Models
Dopamine/metabolism
Female
Gene Expression Regulation/drug effects/*genetics
Glial Fibrillary Acidic Protein/*metabolism
Homovanillic Acid/metabolism
Inbred Strains
Jones Byron C
Lu Lu
Male
Mice
Miller Diane B
MPTP Poisoning/chemically induced/*pathology
NEOMED College of Medicine
Neurotoxicology
O'Callaghan James P
Serotonin/metabolism
Species Specificity
Tyrosine 3-Monooxygenase/metabolism
Williams Robert W
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.jneumeth.2011.02.031" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.jneumeth.2011.02.031</a>
Pages
23–28
Issue
1
Volume
198
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
The effect of freezing and extraction upon striatal dopaminergic function.
Publisher
An entity responsible for making the resource available
Journal of neuroscience methods
Date
A point or period of time associated with an event in the lifecycle of the resource
2011
2011-05
Subject
The topic of the resource
*Freezing; 3; 4-Dihydroxyphenylacetic Acid/metabolism; Analysis of Variance; Animals; Chemical Fractionation/methods; Corpus Striatum/*metabolism; Cryopreservation/methods; Dopamine/*metabolism; Male; Mice; Time Factors
Creator
An entity primarily responsible for making the resource
Dluzen Dean E
Description
An account of the resource
Determinations of striatal dopamine (DA) and 3,4-dihydroxyphenylacetic acid (DOPAC) concentrations were compared under conditions where tissue was either frozen followed by extraction (FE) or extracted followed by freezing (EF). In Experiment 1, these determinations were performed at 0 (control), 0.5, 1 or 2h postmortem. In Experiment 2, these two protocols were compared at 0 (control), 0.5 or 72 h after a neurotoxic regimen of methamphetamine. In Experiment 3, potassium-stimulated DA release from superfused striatal tissue was compared between frozen and fresh tissue. The results from the 0 h (control) groups of Experiments 1 and 2 revealed that FE results in significant reductions in DA concentrations as compared with the EF procedure. However, FE diminishes the time-dependent reductions in striatal DA and increases in DOPAC present in the EF group, as obtained under conditions of natural (Experiment 1) or neurotoxin-induced (Experiment 2) degradation. Potassium-stimulated DA release from superfused striatal tissue is significantly decreased when measured from frozen versus fresh tissue. While freezing seems to produce an initial detrimental effect upon measuring striatal DA concentrations and potassium-stimulated release, there appears to be a capacity for preservation of striatal DA and diminution in DOPAC production by freezing when tissue is undergoing degradation. Such results demonstrate the significance of the protocol used for determination of neurotransmitters in postmortem tissue and suggest a potential means for diminishing the adverse effects of insult to striatal tissue that may result from conditions like stroke and exposure to neurotoxins.
Identifier
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<a href="http://doi.org/10.1016/j.jneumeth.2011.02.031" target="_blank" rel="noreferrer noopener">10.1016/j.jneumeth.2011.02.031</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Freezing
2011
3
4-Dihydroxyphenylacetic Acid/metabolism
Analysis of Variance
Animals
Chemical Fractionation/methods
Corpus Striatum/*metabolism
Cryopreservation/methods
Dluzen Dean E
Dopamine/*metabolism
Journal of neuroscience methods
Male
Mice
Time Factors
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.brainres.2004.12.013" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.brainres.2004.12.013</a>
Pages
188–195
Issue
2
Volume
1035
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Dopamine transporter function differences between male and female CD-1 mice.
Publisher
An entity responsible for making the resource available
Brain research
Date
A point or period of time associated with an event in the lifecycle of the resource
2005
2005-02
Subject
The topic of the resource
*Sex Characteristics; 3; 4-Dihydroxyphenylacetic Acid/metabolism; Animals; Corpus Striatum/physiology; Dopamine Plasma Membrane Transport Proteins; Dopamine/physiology; Female; Male; Membrane Glycoproteins/*physiology; Membrane Transport Proteins/*physiology; Mice; Nerve Tissue Proteins/*physiology
Creator
An entity primarily responsible for making the resource
Bhatt Sandeep D; Dluzen Dean E
Description
An account of the resource
It has been reported that male mice are more susceptible to the neurotoxic effects of methamphetamine (MA) upon the nigrostriatal dopaminergic (NSDA) system. Since MA utilizes the dopamine transporter (DAT) to exert its effects, in the present study, we tested for differences in the dynamics of DAT function between male and female mice as an approach to understand some of the bases for this sex difference in MA-induced NSDA neurotoxicity. To accomplish this goal, in Experiment 1, the amount of dopamine (DA) obtained following DA infusion into the superfused striatal tissue fragments of male and female mice was measured while in Experiment 2 responses to the DA uptake blocker, nomifensine (NMF), were assessed in these preparations. The differences obtained to these treatments demonstrate that marked differences in DA transporter activity exist between male and female mice. When combining the DA and DOPAC measures from these two experiments, the data suggest that the female mice show a more active and efficient recovery and vesicular packaging of extracellular DA. These findings have important implications for sex differences in NSDA functions and responses to neurotoxins which enter the neurons via the DAT.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/j.brainres.2004.12.013" target="_blank" rel="noreferrer noopener">10.1016/j.brainres.2004.12.013</a>
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Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Sex Characteristics
2005
3
4-Dihydroxyphenylacetic Acid/metabolism
Animals
Bhatt Sandeep D
Brain research
Corpus Striatum/physiology
Dluzen Dean E
Dopamine Plasma Membrane Transport Proteins
Dopamine/physiology
Female
Male
Membrane Glycoproteins/*physiology
Membrane Transport Proteins/*physiology
Mice
Nerve Tissue Proteins/*physiology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0165-3806(91)90175-i" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0165-3806(91)90175-i</a>
Pages
273–276
Issue
2
Volume
62
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Striatal dopamine release in vitro from immature male rats shows enhanced responsiveness to pulsatile, but not continuous, infusions of L-dopa.
Publisher
An entity responsible for making the resource available
Brain research. Developmental brain research
Date
A point or period of time associated with an event in the lifecycle of the resource
1991
1991-10
Subject
The topic of the resource
3; 4-Dihydroxyphenylacetic Acid/metabolism; Aging/*metabolism; Animals; Corpus Striatum/*metabolism; Dopamine/*metabolism; Inbred Strains; Levodopa/*administration & dosage/pharmacology; Male; Pulsatile Flow; Rats
Creator
An entity primarily responsible for making the resource
Dluzen D; McDermott J
Description
An account of the resource
In the present experiment we compared the effects of continuous versus pulsed infusions of L-beta-3,4,dihydroxyphenylalanine (L-DOPA) upon dopamine and 3,4-dihydroxyphenylacetic acid (DOPAC) release in vitro from superfused corpus striatal tissue fragments of immature (25-32 day) and adult (90-120 day) male rats. In response to two pulse infusions of L-DOPA (5 microM) a significantly greater amount of dopamine and DOPAC was released from the striatal fragments of immature vs adult males. In contrast, when L-DOPA was infused continuously throughout the superfusion virtually identical amounts of dopamine and DOPAC were obtained for immature and adult male rats. No differences in postsuperfusion dopamine tissue content were obtained between adult and immature rats following the two pulses or continuous infusion of L-DOPA. These results suggest that the corpus striatum of the immature rat has an enhanced capacity to convert and release dopamine in response to a submaximal pulsatile infusion of L-DOPA.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0165-3806(91)90175-i" target="_blank" rel="noreferrer noopener">10.1016/0165-3806(91)90175-i</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1991
3
4-Dihydroxyphenylacetic Acid/metabolism
Aging/*metabolism
Animals
Brain research. Developmental brain research
Corpus Striatum/*metabolism
Dluzen D
Dopamine/*metabolism
Inbred Strains
Levodopa/*administration & dosage/pharmacology
Male
McDermott J
Pulsatile Flow
Rats
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0091-3057(94)90562-2" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0091-3057(94)90562-2</a>
Pages
515–519
Issue
2
Volume
48
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
L-dopa reverses castration-induced disruption of dishabituation responses to female chemical cues in male rats.
Publisher
An entity responsible for making the resource available
Pharmacology, biochemistry, and behavior
Date
A point or period of time associated with an event in the lifecycle of the resource
1994
1994-06
Subject
The topic of the resource
*Cues; *Orchiectomy; 3; 4-Dihydroxyphenylacetic Acid/metabolism; Animal/*drug effects/physiology; Animals; Brain Chemistry/drug effects/physiology; Catecholamines/metabolism; Discrimination (Psychology)/drug effects; Female; Habituation; Levodopa/*pharmacology; Male; Olfactory Bulb/drug effects/metabolism/physiology; Psychophysiologic/*drug effects; Rats; Sexual Behavior; Sprague-Dawley; Urine/physiology
Creator
An entity primarily responsible for making the resource
Guan X; Dluzen D E
Description
An account of the resource
In the present experiment, habituation/dishabituation behavioral tests were conducted to measure discriminatory olfactory recognition responses to chemical cues among control, castrated, and castrated+L-3,4-dihydroxyphenylalanine (L-DOPA)-treated male rats. Castration produced a disruption of dishabituation responses to female urine, and this effect was reversed by treatment with L-DOPA. In the posterior olfactory bulb, 3,4-dihydroxyphenlacetic acid (DOPAC) levels were significantly increased in L-DOPA-treated animals compared with the vehicle-treated control and castrated groups. No significant differences in olfactory bulb norepinephrine or dopamine concentrations among the three treatment groups were obtained. The restoration of behavioral dishabituation responses following L-DOPA treatment suggests that the catecholaminergic system of the olfactory bulb may play a critical role in the recognition and possibly attractions for or preferences to female chemical cues.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0091-3057(94)90562-2" target="_blank" rel="noreferrer noopener">10.1016/0091-3057(94)90562-2</a>
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Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Cues
*Orchiectomy
1994
3
4-Dihydroxyphenylacetic Acid/metabolism
Animal/*drug effects/physiology
Animals
Brain Chemistry/drug effects/physiology
Catecholamines/metabolism
Discrimination (Psychology)/drug effects
Dluzen D E
Female
Guan X
Habituation
Levodopa/*pharmacology
Male
Olfactory Bulb/drug effects/metabolism/physiology
Pharmacology, biochemistry, and behavior
Psychophysiologic/*drug effects
Rats
Sexual Behavior
Sprague-Dawley
Urine/physiology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0047-6374(96)01774-5" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0047-6374(96)01774-5</a>
Pages
37–45
Issue
1
Volume
91
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Age-related changes in monoamines within the olfactory bulbs of the Fischer 344 male rat.
Publisher
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Mechanisms of ageing and development
Date
A point or period of time associated with an event in the lifecycle of the resource
1996
1996-10
Subject
The topic of the resource
3; 4-Dihydroxyphenylacetic Acid/metabolism; Aging/*metabolism; Animals; Biogenic Monoamines/*metabolism; Dopamine/metabolism; Inbred F344; Male; Olfactory Bulb/*metabolism; Rats; Serotonin/metabolism
Creator
An entity primarily responsible for making the resource
Dluzen D E
Description
An account of the resource
In this report the olfactory bulbs (OB) were removed from 5-6 month, 15-16 month and 25-26 month male Fischer 344 rats and assayed for concentrations of monoamines and their metabolites using HPLC-EC. Concentrations of norepinephrine were significantly greater in 25-26 and 15-16 compared to the 5-6 month old rats. By contrast, the norepinephrine metabolite, 3-methoxy-4-hydroxyphenyl glycol (MHPG), was significantly lower in the 25-26 vs. the 15-16 and 5-6 month old animals. While OB concentrations of dopamine and serotonin did not differ among the three age groups, their respective metabolites, 3,4-dihydroxyphenylacetic acid (DOPAC) and 5-hydroxyindole-3-acetic acid (5-HIAA), were significantly reduced in the 15-16 and 25-26 month old animals compared to the 5-6 month old animals. These data show some of the age related changes which occur in the monoamines of the OB of the Fischer 344 rat. The salient bi-directional changes which are observed between norepinephrine and its metabolite, MHPG, are particularly intriguing since they reveal some of the mechanistic alterations that occur in the OB noradrenergic system, which may underlie the age related changes in olfactory related memory/recognition processes.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0047-6374(96)01774-5" target="_blank" rel="noreferrer noopener">10.1016/0047-6374(96)01774-5</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1996
3
4-Dihydroxyphenylacetic Acid/metabolism
Aging/*metabolism
Animals
Biogenic Monoamines/*metabolism
Dluzen D E
Dopamine/metabolism
Inbred F344
Male
Mechanisms of ageing and development
Olfactory Bulb/*metabolism
Rats
Serotonin/metabolism
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0028-3908(92)90050-y" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0028-3908(92)90050-y</a>
Pages
1223–1229
Issue
12
Volume
31
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
The aromatic amino acid decarboxylase inhibitor, NSD-1015, increases release of dopamine: response characteristics.
Publisher
An entity responsible for making the resource available
Neuropharmacology
Date
A point or period of time associated with an event in the lifecycle of the resource
1992
1992-12
Subject
The topic of the resource
*Aromatic Amino Acid Decarboxylase Inhibitors; 3; 4-Dihydroxyphenylacetic Acid/metabolism; Animals; Brain/*drug effects/metabolism; Dopamine/*metabolism; Hydrazines/*pharmacology; Male; Rats; Sprague-Dawley
Creator
An entity primarily responsible for making the resource
Dluzen D; Reddy A; McDermott J
Description
An account of the resource
Addition of the aromatic amino acid decarboxylase inhibitor, NSD-1015 (10 microM), to Krebs'-Ringer phosphate (KRP) superfusion medium, significantly increased the release of dopamine in vitro from superfused corpus striatum tissue fragments of male rats. A dose-dependent increase in release of dopamine was obtained in response to increasing concentrations of NSD-1015, with 1.0 microM being the minimally effective dose. In addition to the striatum, NSD-1015 also increased the release of dopamine from superfused hypothalamic tissue fragments. This capacity of NSD-1015 to increase release of dopamine was calcium-independent, appeared to be somewhat specific and could apparently increase the release of dopamine in vivo, as indicated by increases in the release of the metabolite of dopamine, DOPAC, under conditions of push-pull perfusion. Although the putative role of NSD-1015 is as an aromatic amino acid decarboxylase inhibitor, the present results demonstrate that, either as a result of this function and/or in addition to this role, NSD-1015 is a potent activator of the release of dopamine.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0028-3908(92)90050-y" target="_blank" rel="noreferrer noopener">10.1016/0028-3908(92)90050-y</a>
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Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Aromatic Amino Acid Decarboxylase Inhibitors
1992
3
4-Dihydroxyphenylacetic Acid/metabolism
Animals
Brain/*drug effects/metabolism
Dluzen D
Dopamine/*metabolism
Hydrazines/*pharmacology
Male
McDermott J
Neuropharmacology
Rats
Reddy A
Sprague-Dawley
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0006-8993(95)01566-3" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0006-8993(95)01566-3</a>
Pages
113–118
Issue
1
Volume
715
Dublin Core
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Title
A name given to the resource
Effects of testosterone upon MPTP-induced neurotoxicity of the nigrostriatal dopaminergic system of C57/B1 mice.
Publisher
An entity responsible for making the resource available
Brain research
Date
A point or period of time associated with an event in the lifecycle of the resource
1996
1996-04
Subject
The topic of the resource
*MPTP Poisoning; 1-Methyl-4-phenyl-1; 2; 3; 4-Dihydroxyphenylacetic Acid/metabolism; 6-tetrahydropyridine/*antagonists & inhibitors; Animals; Catecholamines/metabolism; Dopamine Agents/*toxicity; Dopamine/metabolism/*physiology; Female; Inbred C57BL; Male; Mice; Neostriatum/drug effects/metabolism/*pathology; Nervous System Diseases/chemically induced/*pathology/*prevention & control; Olfactory Bulb/drug effects/metabolism; Orchiectomy; Substantia Nigra/drug effects/metabolism/*pathology; Testosterone/*pharmacology
Creator
An entity primarily responsible for making the resource
Dluzen D E
Description
An account of the resource
We have recently reported that treatment of gonadectomized female and male C57/B1 mice with the gonadal steroid hormone, estrogen, reduced nigrostriatal dopaminergic neurotoxicity resulting from the Parkinson's-like inducing agent
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0006-8993(95)01566-3" target="_blank" rel="noreferrer noopener">10.1016/0006-8993(95)01566-3</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*MPTP Poisoning
1-Methyl-4-phenyl-1
1996
2
3
4-Dihydroxyphenylacetic Acid/metabolism
6-tetrahydropyridine/*antagonists & inhibitors
Animals
Brain research
Catecholamines/metabolism
Dluzen D E
Dopamine Agents/*toxicity
Dopamine/metabolism/*physiology
Female
Inbred C57BL
Male
Mice
Neostriatum/drug effects/metabolism/*pathology
Nervous System Diseases/chemically induced/*pathology/*prevention & control
Olfactory Bulb/drug effects/metabolism
Orchiectomy
Substantia Nigra/drug effects/metabolism/*pathology
Testosterone/*pharmacology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1007/s00702-007-0017-0" target="_blank" rel="noreferrer noopener">http://doi.org/10.1007/s00702-007-0017-0</a>
Pages
809–817
Issue
6
Volume
115
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Sex differences in striatal dopaminergic function within heterozygous mutant dopamine transporter knock-out mice.
Publisher
An entity responsible for making the resource available
Journal of neural transmission (Vienna, Austria : 1996)
Date
A point or period of time associated with an event in the lifecycle of the resource
2008
2008-06
Subject
The topic of the resource
*Sex Characteristics; 3; 4-Dihydroxyphenylacetic Acid/metabolism; Animals; Brain/drug effects/*metabolism; Corpus Striatum/drug effects/*metabolism; Dopamine Plasma Membrane Transport Proteins/*genetics; Dopamine Uptake Inhibitors/pharmacology; Dopamine/*metabolism; Down-Regulation/drug effects/genetics; Female; Gene Expression Regulation/drug effects/genetics; Heterozygote; Knockout; Male; Methamphetamine/pharmacology; Mice; Mutation/*genetics; Neural Pathways/drug effects/metabolism; Potassium Chloride/metabolism/pharmacology; Substantia Nigra/drug effects/metabolism; Synaptic Transmission/drug effects/genetics; Up-Regulation/drug effects/genetics
Creator
An entity primarily responsible for making the resource
Ji Jing; Dluzen Dean E
Description
An account of the resource
The issue of whether a deletion of the dopamine transporter (DAT) allele (+/- DAT) would differentially alter striatal dopamine (DA) and dihydroxyphenylacetic acid (DOPAC) concentrations and DA release upon potassium and methamphetamine (MA) stimulation between male and female mice was examined. Striatal DA and DOPAC concentrations of female +/- DAT mice were significantly decreased as compared with wild type (+/+) controls and male +/- DAT mice. No such changes were obtained from the olfactory tubercle suggesting that these effects might be specific for the striatum. Potassium-stimulated DA was increased in male and female +/- DAT mice and maximally stimulated DA was obtained from +/- DAT females, although these mice showed the lowest DA concentrations. MA-evoked DA was increased in male and female +/- mice. While MA-evoked DA was significantly increased in +/+ males versus +/+ females, the +/- females showed the highest DA responses, thereby showing a reversal in the results seen in wild-type conditions. These findings indicate: (1) that a deficiency in the DAT interacts with the sex of the subject, (2)+/- DAT females show more extreme changes in dopaminergic responses, and (3) the importance for considering such variables such as sex when examining differences among knock-out conditions.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1007/s00702-007-0017-0" target="_blank" rel="noreferrer noopener">10.1007/s00702-007-0017-0</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Sex Characteristics
2008
3
4-Dihydroxyphenylacetic Acid/metabolism
Animals
Brain/drug effects/*metabolism
Corpus Striatum/drug effects/*metabolism
Dluzen Dean E
Dopamine Plasma Membrane Transport Proteins/*genetics
Dopamine Uptake Inhibitors/pharmacology
Dopamine/*metabolism
Down-Regulation/drug effects/genetics
Female
Gene Expression Regulation/drug effects/genetics
Heterozygote
Ji Jing
Journal of neural transmission (Vienna, Austria : 1996)
Knockout
Male
Methamphetamine/pharmacology
Mice
Mutation/*genetics
Neural Pathways/drug effects/metabolism
Potassium Chloride/metabolism/pharmacology
Substantia Nigra/drug effects/metabolism
Synaptic Transmission/drug effects/genetics
Up-Regulation/drug effects/genetics
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1007/s00702-003-0045-3" target="_blank" rel="noreferrer noopener">http://doi.org/10.1007/s00702-003-0045-3</a>
Pages
1215–1224
Issue
11
Volume
110
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Acute effects of estrogen upon methamphetamine induced neurotoxicity of the nigrostriatal dopaminergic system.
Publisher
An entity responsible for making the resource available
Journal of neural transmission (Vienna, Austria : 1996)
Date
A point or period of time associated with an event in the lifecycle of the resource
2003
2003-11
Subject
The topic of the resource
3; 4-Dihydroxyphenylacetic Acid/metabolism; Animals; Dopamine/metabolism; Drug Interactions; Estrogens/metabolism/*pharmacology; Female; Methamphetamine/antagonists & inhibitors/*toxicity; Mice; Neostriatum/*drug effects/metabolism/physiopathology; Neural Pathways/*drug effects/metabolism/physiopathology; Neuroprotective Agents/metabolism/pharmacology; Neurotoxins/antagonists & inhibitors/toxicity; Ovariectomy; Parkinson Disease/drug therapy/metabolism/physiopathology; Presynaptic Terminals/drug effects/metabolism; Reaction Time/drug effects/physiology; Sex Factors; Substantia Nigra/*drug effects/metabolism/physiopathology
Creator
An entity primarily responsible for making the resource
Gajjar T M; Anderson L I; Dluzen D E
Description
An account of the resource
Estrogen acts as a neuroprotectant of the nigrostriatal dopaminergic system when given chronically to female mice prior to Methamphetamine (MA) insult. In this report, we tested the acute effects of Estradiol Benzoate (EB-10 microg in Oil) in ovariectomized CD-1 mice to function as a neuroprotectant when administered prior to (Experiment 1) or after (Experiment 2) MA treatment. Striatal dopamine (DA) concentrations and DOPAC/DA ratios were measured to assess the neuroprotective effects of EB. In Experiment 1, we observed that EB exerted a neuroprotective effect upon striatal dopamine concentrations when administered at 24 and 12, but not at 0.5, hours prior to MA injection and upon DOPAC/DA ratios when administered at 24, 12 and 0.5 hours prior to MA. In Experiment 2, no evidence for estrogen to protect the striatum from MA insult was obtained when EB was administered at 15, 30, 60 or 120 minutes after MA. These results show that EB can act as a modulator of MA-induced nigrostriatal dopaminergic neurotoxicity suggestive of a neuroprotectant, when administered within 0.5 hour of MA insult as assessed by measures of DOPAC/DA, but fails to prevent depletion of DA when given after MA insult. The data suggest that estrogen may exert this rapid neuroprotective effect through a non-genomic mechanism.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1007/s00702-003-0045-3" target="_blank" rel="noreferrer noopener">10.1007/s00702-003-0045-3</a>
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Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2003
3
4-Dihydroxyphenylacetic Acid/metabolism
Anderson L I
Animals
Dluzen D E
Dopamine/metabolism
Drug Interactions
Estrogens/metabolism/*pharmacology
Female
Gajjar T M
Journal of neural transmission (Vienna, Austria : 1996)
Methamphetamine/antagonists & inhibitors/*toxicity
Mice
Neostriatum/*drug effects/metabolism/physiopathology
Neural Pathways/*drug effects/metabolism/physiopathology
Neuroprotective Agents/metabolism/pharmacology
Neurotoxins/antagonists & inhibitors/toxicity
Ovariectomy
Parkinson Disease/drug therapy/metabolism/physiopathology
Presynaptic Terminals/drug effects/metabolism
Reaction Time/drug effects/physiology
Sex Factors
Substantia Nigra/*drug effects/metabolism/physiopathology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1007/bf03033303" target="_blank" rel="noreferrer noopener">http://doi.org/10.1007/bf03033303</a>
Pages
15–21
Issue
1
Volume
9
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Rotenone produces opposite effects upon mouse striatal dopamine function as a result of environmental temperature.
Publisher
An entity responsible for making the resource available
Neurotoxicity research
Date
A point or period of time associated with an event in the lifecycle of the resource
2006
2006-01
Subject
The topic of the resource
*Temperature; 3; 4-Dihydroxyphenylacetic Acid/metabolism; Analysis of Variance; Animals; Brain Chemistry/drug effects/physiology/radiation effects; Corpus Striatum/*drug effects/metabolism; Dopamine/*metabolism; Dose-Response Relationship; Drug; Insecticides/*pharmacology; Methamphetamine/pharmacology; Mice; Rotenone/*pharmacology
Creator
An entity primarily responsible for making the resource
Crutchfield Karla C; Dluzen Dean E
Description
An account of the resource
Rotenone is a commonly used pesticide that can function as an environmental neurotoxin. Rotenone is a known mitochondrial complex I inhibitor which can lead to oxidative stress and results in dopaminergic cell death. Another environmental factor known to exacerbate oxidative stress and result in striatal dopaminergic cell death is elevated environmental temperature. In this study we evaluated the effects of a single injection of various doses of rotenone (0.65, 1.3 and 2.6 mg/kg) on striatal dopamine (DA) and 3,4-dihydroxyphenylacetic acid (DOPAC) concentrations in CD-1 mice and compared this with a single injection of two doses of methamphetamine (MA - 10 or 20 mg/kg), a known striatal DA depleting agent, as administered to mice maintained at 21 degrees C (Experiment 1). These results were then compared to striatal DA and DOPAC concentrations of mice treated with rotenone (1.3 or 2.6 mg/kg) or MA (10 or 20 mg/kg) administered to mice maintained at 28 degrees C (Experiment 2). A single injection of rotenone to mice maintained at 21 degrees C resulted in a significant increase in DA and decrease in DOPAC concentrations for all doses tested compared to controls, whereas a single injection of MA at the same temperature resulted in a significant decrease in DA and no change in DOPAC concentrations. At a temperature of 28 degrees C, a single injection of rotenone resulted in a significant decrease in both DA and DOPAC concentrations similar to that seen with the MA-treated mice. Collectively, these results indicate that rotenone interacts with environmental temperature to produce opposite effects upon striatal DA concentrations – significantly increasing striatal DA when administered at 21 degrees C and significantly decreasing striatal DA when administered at 28 degrees C, while producing similar decreases in striatal DOPAC under both temperatures.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1007/bf03033303" target="_blank" rel="noreferrer noopener">10.1007/bf03033303</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*temperature
2006
3
4-Dihydroxyphenylacetic Acid/metabolism
Analysis of Variance
Animals
Brain Chemistry/drug effects/physiology/radiation effects
Corpus Striatum/*drug effects/metabolism
Crutchfield Karla C
Dluzen Dean E
Dopamine/*metabolism
Dose-Response Relationship
Drug
Insecticides/*pharmacology
Methamphetamine/pharmacology
Mice
Neurotoxicity research
Rotenone/*pharmacology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1006/exnr.2000.7515" target="_blank" rel="noreferrer noopener">http://doi.org/10.1006/exnr.2000.7515</a>
Pages
450–457
Issue
2
Volume
166
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
The effect of GDNF on nigrostriatal dopaminergic function in response to a two-pulse K(+) stimulation.
Publisher
An entity responsible for making the resource available
Experimental neurology
Date
A point or period of time associated with an event in the lifecycle of the resource
2000
2000-12
Subject
The topic of the resource
*Nerve Growth Factors; 3; 4-Dihydroxyphenylacetic Acid/metabolism; Animals; Corpus Striatum/*drug effects/metabolism; Dopamine/*metabolism; Dose-Response Relationship; Drug; Extracellular Space/metabolism; Glial Cell Line-Derived Neurotrophic Factor; Male; Microdialysis; Nerve Tissue Proteins/*pharmacology; Neuroprotective Agents/*pharmacology; Parkinson Disease/drug therapy/metabolism; Potassium/*pharmacology; Rats; Sprague-Dawley; Substantia Nigra/*drug effects/metabolism
Creator
An entity primarily responsible for making the resource
Xu K; Dluzen D E
Description
An account of the resource
We examined the effect of glial cell line-derived neurotrophic factor (GDNF) upon nigrostriatal dopaminergic function in response to two-pulse potassium (K(+)) stimulation in rats under in vivo microdialysis conditions. The two-pulse infusion protocol permits us to focus upon the role of this neurotrophin as related to vesicular storage and release of dopamine (DA). The effects of two
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1006/exnr.2000.7515" target="_blank" rel="noreferrer noopener">10.1006/exnr.2000.7515</a>
Rights
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Nerve Growth Factors
2000
3
4-Dihydroxyphenylacetic Acid/metabolism
Animals
Corpus Striatum/*drug effects/metabolism
Dluzen D E
Dopamine/*metabolism
Dose-Response Relationship
Drug
Experimental neurology
Extracellular Space/metabolism
Glial Cell Line-Derived Neurotrophic Factor
Male
Microdialysis
Nerve Tissue Proteins/*pharmacology
Neuroprotective Agents/*pharmacology
Parkinson Disease/drug therapy/metabolism
Potassium/*pharmacology
Rats
Sprague-Dawley
Substantia Nigra/*drug effects/metabolism
Xu K
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1002/syn.21554" target="_blank" rel="noreferrer noopener">http://doi.org/10.1002/syn.21554</a>
Pages
686–693
Issue
8
Volume
66
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Nomifensine alters sex differences in striatal dopaminergic function.
Publisher
An entity responsible for making the resource available
Synapse (New York, N.Y.)
Date
A point or period of time associated with an event in the lifecycle of the resource
2012
2012-08
Subject
The topic of the resource
*Sex Characteristics; 3; 4-Dihydroxyphenylacetic Acid/metabolism; Animals; Dopamine Plasma Membrane Transport Proteins/drug effects/metabolism; Dopamine Uptake Inhibitors/*pharmacology; Dopamine/*metabolism; Female; Inbred Strains; Male; Methamphetamine/pharmacology; Mice; Neostriatum/drug effects/metabolism; Nomifensine/*pharmacology
Creator
An entity primarily responsible for making the resource
Poth Luke S; O'Connell Bryan P; McDermott Janet L; Dluzen Dean E
Description
An account of the resource
A series of three experiments are presented in which the acute effects of the catecholamine reuptake inhibitor, nomifensine, upon striatal dopaminergic function are compared in female and male mice. In Experiment 1, treatment with nomifensine (5 mg kg(-)(1)), at 30 min prior to injection of methamphetamine (40 mg kg(-)(1)) significantly decreased the amount of striatal dopamine depletion in male, but not female, mice, thereby abolishing the sex difference in methamphetamine-induced neurotoxicity (males \textgreater females). In Experiment 2, the methamphetamine-evoked sex differences in dopamine and DOPAC output from superfused striatal tissue (males \textgreater females) were abolished in mice treated with nomifensine at 30 min prior to tissue removal. In Experiment 3, the potassium chloride-evoked sex differences in dopamine and DOPAC output from superfused striatal tissue (females \textgreater males) were reversed in mice treated with nomifensine at 30 min prior to tissue removal. Taken together these results demonstrate the critical role played by catecholamine transporters in sex differences of dopaminergic function and suggest that this may involve the dopamine transporter, due to its high concentrations within the striatum. Such findings highlight the need for gender-specific considerations in use of treatments that target reuptake transporters function.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1002/syn.21554" target="_blank" rel="noreferrer noopener">10.1002/syn.21554</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Sex Characteristics
2012
3
4-Dihydroxyphenylacetic Acid/metabolism
Animals
Dluzen Dean E
Dopamine Plasma Membrane Transport Proteins/drug effects/metabolism
Dopamine Uptake Inhibitors/*pharmacology
Dopamine/*metabolism
Female
Inbred Strains
Male
McDermott Janet L
Methamphetamine/pharmacology
Mice
Neostriatum/drug effects/metabolism
Nomifensine/*pharmacology
O'Connell Bryan P
Poth Luke S
Synapse (New York, N.Y.)
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1002/syn.20307" target="_blank" rel="noreferrer noopener">http://doi.org/10.1002/syn.20307</a>
Pages
354–361
Issue
5
Volume
60
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Effect of estrogen upon methamphetamine-induced neurotoxicity within the impaired nigrostriatal dopaminergic system.
Publisher
An entity responsible for making the resource available
Synapse (New York, N.Y.)
Date
A point or period of time associated with an event in the lifecycle of the resource
2006
2006-10
Subject
The topic of the resource
3; 4-Dihydroxyphenylacetic Acid/metabolism; Adrenergic Uptake Inhibitors/antagonists & inhibitors/toxicity; Animal; Animals; Corpus Striatum/*drug effects/metabolism/physiopathology; Disease Models; Dopamine/metabolism; Estrogens/metabolism/*pharmacology/therapeutic use; Female; Male; Methamphetamine/*antagonists & inhibitors/toxicity; Mice; Nerve Degeneration/chemically induced/*drug therapy/prevention & control; Neural Pathways/drug effects/metabolism/physiopathology; Neuroprotective Agents/metabolism/*pharmacology/therapeutic use; Neurotoxins/antagonists & inhibitors/toxicity; Orchiectomy; Ovariectomy; Parkinsonian Disorders/*drug therapy/physiopathology/prevention & control; Substantia Nigra/*drug effects/metabolism/physiopathology
Creator
An entity primarily responsible for making the resource
Liu Bin; Dluzen Dean E
Description
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In the present study, we investigated whether estrogen remains effective as a neuroprotectant within an impaired nigrostriatal dopaminergic (NSDA) system of gonadectomized female and male mice. In Experiment 1, mice were treated with four different regimens of methamphetamine (MA) to establish a protocol for an impaired NSDA system to be used in subsequent experiments. Based upon the results of Experiment 1, in Experiment 2 gonadectomized female mice received a treatment with either control (saline), low- or high-dose of MA to produce an initial NSDA impairment. At one week post-MA, mice received either estradiol benzoate (10 microg) or vehicle followed 24 h later with low-MA or saline. Estrogen altered the toxic effects of the second invasion of MA as indicated by a significant decrease in striatal dopamine (DA) and 3,4-dihydroxyphenylacetic acid (DOPAC) concentrations. In addition, DA and DOPAC depletion was greater in high- vs. low-dose MA. In gonadectomized male mice (Experiment 3), striatal DA and DOPAC concentrations showed greater decreases following high-, vs. low-doses of MA; however, estrogen did not alter these responses. These results demonstrate that the capacity for estrogen to protect or worsen MA-induced neurotoxicity of dopaminergic neurons is limited to female mice and depends on the condition of the NSDA system.
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<a href="http://doi.org/10.1002/syn.20307" target="_blank" rel="noreferrer noopener">10.1002/syn.20307</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2006
3
4-Dihydroxyphenylacetic Acid/metabolism
Adrenergic Uptake Inhibitors/antagonists & inhibitors/toxicity
Animal
Animals
Corpus Striatum/*drug effects/metabolism/physiopathology
Disease Models
Dluzen Dean E
Dopamine/metabolism
Estrogens/metabolism/*pharmacology/therapeutic use
Female
Liu Bin
Male
Methamphetamine/*antagonists & inhibitors/toxicity
Mice
Nerve Degeneration/chemically induced/*drug therapy/prevention & control
Neural Pathways/drug effects/metabolism/physiopathology
Neuroprotective Agents/metabolism/*pharmacology/therapeutic use
Neurotoxins/antagonists & inhibitors/toxicity
Orchiectomy
Ovariectomy
Parkinsonian Disorders/*drug therapy/physiopathology/prevention & control
Substantia Nigra/*drug effects/metabolism/physiopathology
Synapse (New York, N.Y.)