1
40
3
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/s0091-3057(97)00415-2" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/s0091-3057(97)00415-2</a>
Pages
265–270
Issue
2
Volume
59
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
MDMA-like stimulus effects of hallucinogens in male Fawn-Hooded rats.
Publisher
An entity responsible for making the resource available
Pharmacology, biochemistry, and behavior
Date
A point or period of time associated with an event in the lifecycle of the resource
1998
1998-02
Subject
The topic of the resource
4-methylenedioxyamphetamine/*pharmacology; Animals; Central Nervous System Stimulants/*pharmacology; Conditioning; Cues; Discrimination (Psychology)/drug effects; Dopamine Agents/pharmacology; Dose-Response Relationship; Drug; Generalization; Hallucinogens/*pharmacology; Inbred Strains; Male; N-Methyl-3; Operant/drug effects; Rats; Serotonin Agents/pharmacology; Serotonin/genetics/physiology; Sprague-Dawley; Stimulus/drug effects
Creator
An entity primarily responsible for making the resource
Schechter M D
Description
An account of the resource
A two-lever, food-motivated, operant technique was employed to train the purportedly serotonergically dysfunctional Fawn-Hooded (FH) rat to discriminate 1.5 mg/kg MDMA. Once all 10 male subjects learned the MDMA-vehicle discrimination at criterion performance level, doses different than the training dose were used to generate a dose-response discrimination gradient. The ED50 value of MDMA was shown to be 0.136 mg/kg, not significantly different from that of previously trained Sprague-Dawley male rats. Thus, the Fawn-Hooded rat appears to not differ in its sensitivity to lower doses of MDMA. Testing for MDMA-like stimulus generalizations with other drugs indicated that the MDMA derivative MDE produced generalization at a dose of 2.25 mg/kg and allowed for an ED50 value of 0.496 mg/kg. Like MDE, the testing of alpha-ethyltryptamine was shown to produce
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/s0091-3057(97)00415-2" target="_blank" rel="noreferrer noopener">10.1016/s0091-3057(97)00415-2</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1998
4-methylenedioxyamphetamine/*pharmacology
Animals
Central Nervous System Stimulants/*pharmacology
Conditioning
Cues
Discrimination (Psychology)/drug effects
Dopamine Agents/pharmacology
Dose-Response Relationship
Drug
Generalization
Hallucinogens/*pharmacology
Inbred Strains
Male
N-Methyl-3
Operant/drug effects
Pharmacology, biochemistry, and behavior
Rats
Schechter M D
Serotonin Agents/pharmacology
Serotonin/genetics/physiology
Sprague-Dawley
Stimulus/drug effects
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/s0014-2999(97)85404-0" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/s0014-2999(97)85404-0</a>
Pages
113–118
Issue
2
Volume
326
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Discrete versus cumulative dosing in dose-response discrimination studies.
Publisher
An entity responsible for making the resource available
European journal of pharmacology
Date
A point or period of time associated with an event in the lifecycle of the resource
1997
1997-05
Subject
The topic of the resource
4-methylenedioxyamphetamine/*pharmacology; Animals; Chemical; Cocaine/*pharmacology; Discrimination Learning/*drug effects; Dose-Response Relationship; Drug; Drug Administration Schedule; Drug Evaluation; Male; N-Methyl-3; Preclinical; Rats; Sprague-Dawley; Stimulation
Creator
An entity primarily responsible for making the resource
Schechter M D
Description
An account of the resource
This study describes the results of a 'side-by-side' comparison of two measurement techniques and two dosing regimens in a discrimination study using rats trained to either 10 mg/kg cocaine or 2 mg/kg 3,4-methylenedioxymethamphetamine (MDMA). The measurements employed were either quantal or quantitative; the former an all-or-none correct lever selection measure and the latter a measure of all responses made at the time that the criterion for selection was met. The dosing regimens were either a discrete single injection of lower doses than used in training or a cumulative dose administration sequence, in an ascending order, during one session on two separate occasions. Results indicate that the cumulative dose-response relationships, as indicated by both the slope of the curve or the generated ED50 value, for the discrete and cumulative dose response curves do not significantly differ. In addition, both the quantal and quantitative measurements yield almost identical ED50 values, thus allowing for accurate comparability of drug-discrimination data using different techniques. The present experimentation employed two drugs known to produce heightened response rates which would not allow for behavioral suppression at the highest doses used either in discrete or cumulative regimens. The pharmacokinetics of the two drugs employed in the discrimination tests are considered and discussed in light of the advantages and disadvantages of each of the two methods employed.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/s0014-2999(97)85404-0" target="_blank" rel="noreferrer noopener">10.1016/s0014-2999(97)85404-0</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1997
4-methylenedioxyamphetamine/*pharmacology
Animals
Chemical
Cocaine/*pharmacology
Discrimination Learning/*drug effects
Dose-Response Relationship
Drug
Drug Administration Schedule
Drug Evaluation
European journal of pharmacology
Male
N-Methyl-3
Preclinical
Rats
Schechter M D
Sprague-Dawley
Stimulation
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0741-8329(95)02004-7" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0741-8329(95)02004-7</a>
Pages
569–572
Issue
6
Volume
12
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
MDMA (Ecstasy) substitutes for the ethanol discriminative cue in HAD but not LAD rats.
Publisher
An entity responsible for making the resource available
Alcohol (Fayetteville, N.Y.)
Date
A point or period of time associated with an event in the lifecycle of the resource
1995
1995-12
Subject
The topic of the resource
4-methylenedioxyamphetamine/*pharmacology; Alcohol Drinking/*genetics/psychology; Animals; Central Nervous System Depressants/*pharmacology; Cues; Discrimination (Psychology)/*drug effects; Discrimination Learning/drug effects; Dose-Response Relationship; Drug; Ethanol/*pharmacology; Generalization; Male; N-Methyl-3; Piperazines/pharmacology; Rats; Serotonin Agents/*pharmacology; Serotonin Receptor Agonists/pharmacology; Stimulus
Creator
An entity primarily responsible for making the resource
Meehan S M; Gordon T L; Schechter M D
Description
An account of the resource
Selectively bred high- and low-alcohol-drinking (HAD/LAD) rats were trained to discriminate the interoceptive stimuli produced by IP-administered 600 mg/kg ethanol (10% w/v in a two-lever, food-motivated operant task. Once criterion discrimination was attained, animals were tested with 3.0, 1.5, 1.0, and 0.5 mg/kg MDMA. Although no differences in alcohol discrimination were observed between the HAD and LAD animals, the HAD line was significantly more sensitive than the LAD line to the effects of MDMA. These results provide additional information to the growing body of evidence suggesting serotonergic mediation of some of the behavioral effects of ethanol.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0741-8329(95)02004-7" target="_blank" rel="noreferrer noopener">10.1016/0741-8329(95)02004-7</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1995
4-methylenedioxyamphetamine/*pharmacology
Alcohol (Fayetteville, N.Y.)
Alcohol Drinking/*genetics/psychology
Animals
Central Nervous System Depressants/*pharmacology
Cues
Discrimination (Psychology)/*drug effects
Discrimination Learning/drug effects
Dose-Response Relationship
Drug
Ethanol/*pharmacology
Generalization
Gordon T L
Male
Meehan S M
N-Methyl-3
Piperazines/pharmacology
Rats
Schechter M D
Serotonin Agents/*pharmacology
Serotonin Receptor Agonists/pharmacology
Stimulus