1
40
4
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0197-4580(94)90108-2" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0197-4580(94)90108-2</a>
Pages
169–174
Issue
2
Volume
15
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Effects of aging on spinal opioid-induced antinociception.
Publisher
An entity responsible for making the resource available
Neurobiology of aging
Date
A point or period of time associated with an event in the lifecycle of the resource
1994
1994-04
Subject
The topic of the resource
5)-; Aging/*physiology; Ala(2)-MePhe(4)-Gly(5)-; Analgesics; Animals; D-Penicillamine (2; delta/agonists; Dose-Response Relationship; Drug; Enkephalin; Enkephalins/administration & dosage/pharmacology; Hot Temperature; Inbred F344; Injections; Male; mu/agonists; Nociceptors/*drug effects; Opioid; Opioid/administration & dosage/*pharmacology; Pain Measurement/drug effects; Rats; Receptors; Spinal; Spinal Cord/*physiology
Creator
An entity primarily responsible for making the resource
Crisp T; Stafinsky J L; Hoskins D L; Dayal B; Chinrock K M; Uram M
Description
An account of the resource
Initial experiments were conducted to determine whether or not the aging process alters the ability of young, mature, or aged male Fischer 344 rats (5- to 6-, 15- to 16-, and 25- to 26-months-old, respectively) to respond to thermal nociceptive stimuli. Using the tail-flick analgesiometric assay, 25- to 26-month-old rats responded significantly faster to the heat source than 15- to 16-month-old animals, but no significant differences were noted between the 5- to 6-month-old and aged rats. Another series of investigations compared the effects of aging on the spinal antinociceptive properties of the mu opioid agonist [D-Ala2,N-methyl-Phe4,Gly5-ol] enkephalin (DAMPGO) and the delta agonist [D-Pen2,D-Pen5] enkephalin (DPDPE). In these studies, young, mature, and aged rats were injected intrathecally (IT) with different doses of DAMPGO or DPDPE, and opioid-induced antinociception was tested on the tail-flick test. All three age groups responded to IT DAMPGO in a dose-dependent manner but, for the most part, higher spinal doses were required to produce significant elevations in tail-flick latency in the aged cohort of rats. The spinal analgesic effects of DPDPE also declined with advanced age. The aging process apparently alters the pain-inhibitory function of mu and delta opioid receptors in the rat spinal cord.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0197-4580(94)90108-2" target="_blank" rel="noreferrer noopener">10.1016/0197-4580(94)90108-2</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1994
5)-
Aging/*physiology
Ala(2)-MePhe(4)-Gly(5)-
Analgesics
Animals
Chinrock K M
Crisp T
D-Penicillamine (2
Dayal B
delta/agonists
Dose-Response Relationship
Drug
Enkephalin
Enkephalins/administration & dosage/pharmacology
Hoskins D L
Hot Temperature
Inbred F344
Injections
Male
mu/agonists
Neurobiology of aging
Nociceptors/*drug effects
Opioid
Opioid/administration & dosage/*pharmacology
Pain Measurement/drug effects
Rats
Receptors
Spinal
Spinal Cord/*physiology
Stafinsky J L
Uram M
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Pages
282–286
Issue
1
Volume
643
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Age-related changes in the spinal antinociceptive effects of DAGO, DPDPE and beta-endorphin in the rat.
Publisher
An entity responsible for making the resource available
Brain research
Date
A point or period of time associated with an event in the lifecycle of the resource
1994
1994-04
Subject
The topic of the resource
Male; Animals; Rats; Analysis of Variance; Aging/*physiology; Injections; Analgesics/*pharmacology; Pain/*physiopathology; beta-Endorphin/administration & dosage/*pharmacology; Enkephalins/administration & dosage/*pharmacology; Spine/drug effects/growth & development/*physiology; Dose-Response Relationship; Drug; Enkephalin; Inbred F344; Ala(2)-MePhe(4)-Gly(5)-; Spinal; 5)-; D-Penicillamine (2
Creator
An entity primarily responsible for making the resource
Crisp T; Stafinsky J L; Hoskins D L; Perni V C; Uram M; Gordon T L
Description
An account of the resource
These studies were designed to investigate how the aging process alters the spinal antinociceptive efficacy of mu (mu), delta (delta) and epsilon (epsilon) opioid receptor agonists administered intrathecally (i.t.) in rats. Various doses of the mu agonist DAGO, the delta agonist DPDPE or the putative epsilon beta-endorphin were injected i.t. in young (5-6-month-old), mature (15-16-month-old) and aged (25-26-month-old) Fischer 344 rats. Antinociception was measured using the rat tail-flick analgesiometric assay. The data demonstrated a decline in spinal opioid-induced antinociception as a function of age. For instance, the i.t. dose of DPDPE or beta-endorphin needed to produce antinociception in the 25-26-month-old rats was higher than that needed to elevate tail-flick latency in the young and mature animals. We also noted that the i.t. doses of the opioid agonists needed to produce 'antinociception' in the aged cohort were within a range of spinal doses that produced motor impairment. Apparently, the aging process alters the ability of opioid receptors to mediate antinociception. Perhaps an age-related decrease in the number and/or affinity of opioid receptor sites in the rat spinal cord accounts for these observations.
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1994
5)-
Aging/*physiology
Ala(2)-MePhe(4)-Gly(5)-
Analgesics/*pharmacology
Analysis of Variance
Animals
beta-Endorphin/administration & dosage/*pharmacology
Brain research
Crisp T
D-Penicillamine (2
Dose-Response Relationship
Drug
Enkephalin
Enkephalins/administration & dosage/*pharmacology
Gordon T L
Hoskins D L
Inbred F344
Injections
Male
Pain/*physiopathology
Perni V C
Rats
Spinal
Spine/drug effects/growth & development/*physiology
Stafinsky J L
Uram M
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0306-3623(94)00154-f" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0306-3623(94)00154-f</a>
Pages
161–168
Issue
1
Volume
26
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
A lack of supersensitivity to opioid receptor agonists following chronic spinal opioid receptor antagonist administration in the rat.
Publisher
An entity responsible for making the resource available
General pharmacology
Date
A point or period of time associated with an event in the lifecycle of the resource
1995
1995-01
Subject
The topic of the resource
5)-; Ala(2)-MePhe(4)-Gly(5)-; Animals; D-Penicillamine (2; Dose-Response Relationship; Drug; Enkephalin; Enkephalins/*pharmacology; Male; Naltrexone/analogs & derivatives/pharmacology; Narcotic Antagonists/*pharmacology; Opioid/*drug effects; Rats; Receptors; Somatostatin/analogs & derivatives/pharmacology; Species Specificity; Spinal Cord/*drug effects; Sprague-Dawley
Creator
An entity primarily responsible for making the resource
Keck B J; Stafinsky J L; Uram M; Crisp T
Description
An account of the resource
1. Male Sprague-Dawley rats were chronically tested with intrathecal (i.t.) receptor selective opioid antagonists to determine if antinociceptive supersensitivity developed to selective i.t. opioid receptor agonists. 2. A subcutaneously implanted osmotic minipump was used to deliver the mu-opioid receptor antagonist CTOP (0.3 nmol) or the delta-opioid receptor antagonist naltrindole (5.5 nmol) for 7 days. 3. Following a 24 hr washout period, rats received a single i.t. dose (ED50) of either DAMPGO (for CTOP-treated animals) or DPDPE (for naltrindole-treated animals) and the antinociceptive effects of the agents were tested on the tail-flick test. 4. Our findings revealed that chronic spinal treatment with selective opioid receptor antagonists did not induce an antinociceptive supersensitivity to selective opioid receptor agonists. 5. Perhaps this lack of supersensitivity is reflective of difficulties inherent to opioid receptor antagonists that do not possess negative intrinsic activity.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0306-3623(94)00154-f" target="_blank" rel="noreferrer noopener">10.1016/0306-3623(94)00154-f</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1995
5)-
Ala(2)-MePhe(4)-Gly(5)-
Animals
Crisp T
D-Penicillamine (2
Dose-Response Relationship
Drug
Enkephalin
Enkephalins/*pharmacology
General pharmacology
Keck B J
Male
Naltrexone/analogs & derivatives/pharmacology
Narcotic Antagonists/*pharmacology
Opioid/*drug effects
Rats
Receptors
Somatostatin/analogs & derivatives/pharmacology
Species Specificity
Spinal Cord/*drug effects
Sprague-Dawley
Stafinsky J L
Uram M
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0304-3959(89)90046-8" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0304-3959(89)90046-8</a>
Pages
329–335
Issue
3
Volume
39
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
A comparative analysis of monoaminergic involvement in the spinal antinociceptive action of DAMPGO and DPDPE.
Publisher
An entity responsible for making the resource available
Pain
Date
A point or period of time associated with an event in the lifecycle of the resource
1989
1989-12
Subject
The topic of the resource
Male; Animals; Rats; Injections; Enkephalins/*pharmacology; Naloxone/pharmacology; Anesthetics/*pharmacology; Biogenic Monoamines/*physiology; Pain/*metabolism; Spinal Cord/drug effects/metabolism/*physiopathology; Dose-Response Relationship; Drug; Inbred Strains; Receptors; Enkephalin; Ala(2)-MePhe(4)-Gly(5)-; Spinal; 5)-; D-Penicillamine (2; Opioid/drug effects/*physiology; Enkephalins; Intraspinal; Amines – Physiology; Anesthetics – Pharmacodynamics; Cell Surface – Drug Effects; Cell Surface – Physiology; Enkephalins – Pharmacodynamics; Naloxone – Pharmacodynamics; Pain – Metabolism; Spinal Cord – Drug Effects; Spinal Cord – Metabolism; Spinal Cord – Physiopathology
Creator
An entity primarily responsible for making the resource
Spanos L J; Stafinsky J L; Crisp T
Description
An account of the resource
The antinociceptive properties of intrathecally (i.t.) administered [D-Ala2,
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0304-3959(89)90046-8" target="_blank" rel="noreferrer noopener">10.1016/0304-3959(89)90046-8</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1989
5)-
Ala(2)-MePhe(4)-Gly(5)-
Amines – Physiology
Anesthetics – Pharmacodynamics
Anesthetics/*pharmacology
Animals
Biogenic Monoamines/*physiology
Cell Surface – Drug Effects
Cell Surface – Physiology
Crisp T
D-Penicillamine (2
Dose-Response Relationship
Drug
Enkephalin
Enkephalins
Enkephalins – Pharmacodynamics
Enkephalins/*pharmacology
Inbred Strains
Injections
Intraspinal
Male
Naloxone – Pharmacodynamics
Naloxone/pharmacology
Opioid/drug effects/*physiology
Pain
Pain – Metabolism
Pain/*metabolism
Rats
Receptors
Spanos L J
Spinal
Spinal Cord – Drug Effects
Spinal Cord – Metabolism
Spinal Cord – Physiopathology
Spinal Cord/drug effects/metabolism/*physiopathology
Stafinsky J L