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Text
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<a href="http://doi.org/10.1093/ofid/ofz360.308" target="_blank" rel="noreferrer noopener">http://doi.org/10.1093/ofid/ofz360.308</a>
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Pages
S133-S134
Volume
6
ISSN
23288957
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Title
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233. The Epidemiology, Genomics, and Evolution of Staphylococcus aureus in Northeast Ohio.
Publisher
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Open Forum Infectious Diseases
Date
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2019
2019-10-02
Subject
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mortality; epidemiology; prevention; Community; OHIO; inpatients; morbidity; infection; OHIO; genomics; institutional review board; risk reduction; METHICILLIN-resistant staphylococcus aureus; genomics; epidemiology; staphylococcus aureus; AKRON (Ohio); CLEVELAND Clinic Foundation; databases; disclosure; FOOD poisoning; HUMAN ecology; meca gene; methicillin; METHICILLIN-resistant staphylococcus aureus; MICROCOCCACEAE; polymerase chain reaction; staphylococcal protein a; staphylococcus; staphylococcus aureus
Creator
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Watkins Richard R; Thapaliya Dipendra; Savri Rami; Smith Tara
Description
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Background Infections due to S. aureus result in significant morbidity, mortality, and healthcare expense. We sought to identify the strains of S. aureus causing infections in hospitalized patients in Northeast Ohio and determine whether they are reflective of the S. aureus strains present in the surrounding environment. Methods The study was approved by the Institutional Review Board at Cleveland Clinic Akron General. Clinical S. aureus isolates (n = 300) were cultured and PCR was used to amplify the staphylococcus protein A (spa), Panton–Valentine Leukocidin (PVL), and mecA genes. The clinical spa types were compared with ones from our data base of S. aureus strains previously collected and sequenced from the community and environment in Northeast Ohio. Results A total of 51 spa types were detected from 129 S. aureus clinical isolates (discriminatory index, 0.876; 95% confidence interval [CI], 0.827–0.925; Table 1). The most common spa types were t008 (42/129, 32.6%), t002 (16/129, 12.4%), and t334 (6/129, 4.7%). In comparison, the most frequently detected spa types from the environmental samples were t189 (40/257, 15.6%), t002 (16/257, 6.2%), and t008 (11/257, 4.3%). Among the S. aureus isolates (n = 146), 45 were PVL-positive (30.8%) and 94 (66.7%) carried mecA. Of the 42 t008 (ST8/USA300; a common community-associated strain) isolates, 35 (83.3%) were methicillin-resistant S. aureus (MRSA) (based on the presence of the mecA gene) and 25 (59.5%) were PVL-positive. Thirteen of the sixteen (81.2%) t002 (ST5/USA100; a common hospital-associated strain) were MRSA and only one (6.2%) was PVL-positive. Conclusion There is considerable overlap of S. aureus strains present in clinical samples with those found in the environment. This finding should draw attention to the need for more effective prevention strategies to reduce the risk of transmission of S. aureus, including MRSA, in the environment to humans. Disclosures All authors: No reported disclosures. [ABSTRACT FROM AUTHOR]
Identifier
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<a href="http://doi.org/10.1093/ofid/ofz360.308" target="_blank" rel="noreferrer noopener">10.1093/ofid/ofz360.308</a>
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Journal Article
2019
AKRON (Ohio)
CLEVELAND Clinic Foundation
Community
Databases
Department of Internal Medicine
Disclosure
Epidemiology
FOOD poisoning
Genomics
HUMAN ecology
Infection
Inpatients
institutional review board
Journal Article
meca gene
methicillin
Methicillin-Resistant Staphylococcus aureus
MICROCOCCACEAE
Morbidity
Mortality
NEOMED College of Medicine
NEOMED College of Medicine Student
NEOMED Student Publications
November 2019 Update
Ohio
Open forum infectious diseases
Polymerase Chain Reaction
Prevention
risk reduction
Savri Rami
Smith Tara
staphylococcal protein a
staphylococcus
Staphylococcus aureus
Thapaliya Dipendra
Watkins Richard R