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Text
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URL Address
<a href="http://doi.org/10.1371/journal.pone.0109663" target="_blank" rel="noreferrer noopener">http://doi.org/10.1371/journal.pone.0109663</a>
Pages
e109663–e109663
Issue
10
Volume
9
Dublin Core
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Title
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Hepatic carboxylesterase 1 is induced by glucose and regulates postprandial glucose levels.
Publisher
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PloS one
Date
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2014
2014
Subject
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Male; Animals; Mice; Blood Glucose/*metabolism; Histones/metabolism; Gene Expression Regulation; Acetylation/drug effects; Glucose/*pharmacology; Homeostasis; Carboxylic Ester Hydrolases/*metabolism; Nutritional Status; *Postprandial Period; ATP Citrate (pro-S)-Lyase/metabolism; Chromatin/metabolism; Liver/*enzymology; Inbred C57BL; Enzymologic/drug effects
Creator
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Xu Jiesi; Yin Liya; Xu Yang; Li Yuanyuan; Zalzala Munaf; Cheng Gang; Zhang Yanqiao
Description
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Metabolic syndrome, characterized by obesity, hyperglycemia, dyslipidemia and hypertension, increases the risks for cardiovascular disease, diabetes and stroke. Carboxylesterase 1 (CES1) is an enzyme that hydrolyzes triglycerides and cholesterol esters, and is important for lipid metabolism. Our previous data show that over-expression of mouse hepatic CES1 lowers plasma glucose levels and improves insulin sensitivity in diabetic ob/ob mice. In the present study, we determined the physiological role of hepatic CES1 in glucose homeostasis. Hepatic CES1 expression was reduced by fasting but increased in diabetic mice. Treatment of mice with glucose induced hepatic CES1 expression. Consistent with the in vivo study, glucose stimulated CES1 promoter activity and increased acetylation of histone 3 and histone 4 in the CES1 chromatin. Knockdown of ATP-citrate lyase (ACL), an enzyme that regulates histone acetylation, abolished glucose-mediated histone acetylation in the CES1 chromatin and glucose-induced hepatic CES1 expression. Finally, knockdown of hepatic CES1 significantly increased postprandial blood glucose levels. In conclusion, the present study uncovers a novel glucose-CES1-glucose pathway which may play an important role in regulating postprandial blood glucose levels.
Identifier
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<a href="http://doi.org/10.1371/journal.pone.0109663" target="_blank" rel="noreferrer noopener">10.1371/journal.pone.0109663</a>
Rights
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Postprandial Period
2014
Acetylation/drug effects
Animals
ATP Citrate (pro-S)-Lyase/metabolism
Blood Glucose/*metabolism
Carboxylic Ester Hydrolases/*metabolism
Cheng Gang
Chromatin/metabolism
Department of Integrative Medical Sciences
Enzymologic/drug effects
Gene Expression Regulation
Glucose/*pharmacology
Histones/metabolism
Homeostasis
Inbred C57BL
Li Yuanyuan
Liver/*enzymology
Male
Mice
NEOMED College of Medicine
Nutritional Status
PloS one
Xu Jiesi
Xu Yang
Yin Liya
Zalzala Munaf
Zhang Yanqiao