Comment on: Periarticular osteoporosis: a useful feature in the diagnosis of early rheumatoid arthritis? Reliability and validity in a cross-sectional diagnostic study using dual-energy X-ray absorptiometry.
Validity; Arthritis; Absorptiometry; Diagnostic Reasoning; Osteoporosis – Risk Factors; Photon – Utilization; Rheumatoid – Diagnosis
Rothschild Bruce
Rheumatology
2012
2012-07
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
<a href="http://doi.org/10.1093/rheumatology/kes044" target="_blank" rel="noreferrer noopener">10.1093/rheumatology/kes044</a>
Findings from a 10-year follow-up of bone mineral density in competitive perimenopausal runners.
Adult; Female; Humans; Middle Aged; Surveys and Questionnaires; Follow-Up Studies; Prospective Studies; Case-Control Studies; Bone Density/*physiology; Running/*physiology; Hip Joint/diagnostic imaging/*physiology; Lumbar Vertebrae/diagnostic imaging/*physiology; Perimenopause; Osteoporosis; Human; Questionnaires; Clinical Trials; Middle Age; Case Control Studies; Absorptiometry; Photon; Postmenopausal/*diagnostic imaging; Menopause; Bone Density – Physiology; Hip Joint – Physiology; Hip Joint – Radiography; Lumbar Vertebrae – Physiology; Lumbar Vertebrae – Radiography; Osteoporosis – Radiography; Running – Physiology
OBJECTIVE: To evaluate bone mineral density (BMD) in perimenopausal competitive runners with long-term follow-up. STUDY DESIGN: Fifteen master female runners between 40 and 50 years old who ran at least 20 miles per week were evaluated. BMD was measured by dual-energy x-ray absorptiometry (DEXA) at baseline and at the 10-year follow-up. RESULTS: The median age was 46 and median miles run per week, 25. At baseline, after a median of 11 years of competitive running, hip BMD was above peak bone mass (T-score = 0.8) and that of age-matched controls (Z-score = 1.6), while lumbar spine BMD was below peak bone mass (T-score = -0.8) and equal to that of age-matched controls (Z-score = -0.1). At the 10-year follow-up, hip BMD fell below peak bone mass (T-score = -0.2, p = 0.0004) but was still above that of age-matched controls (Z-score = 0.5, p = 0.002), while there was little change in lumbar spine BMD. CONCLUSION: Competitive running prior to the perimenopausal period seems to be associated with improved hip BMD. However, continued competitive running during the perimenopausal period is not associated with prevention of a perimenopausal hip BMD decline. In contrast, competitive running had little effect on peri-menopausal lumbar spine BMD.
Fanning James; Larrick Lori; Weinstein Louis; Horrigan Terrence J; Marcotte Michael P; Flora Robert F
The Journal of reproductive medicine
2007
2007-10
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Longitudinal assessment of bone growth and development in a facility-based population of young adults with cerebral palsy.
Absorptiometry; Adolescence; Adolescent; Adult; Bone Density – Physiology; Bone Density/*physiology; Cerebral Palsy – Physiopathology; Cerebral Palsy/*physiopathology; Child; Cross Sectional Studies; Cross-Sectional Studies; Female; Human; Humans; Long Term Care – Statistics and Numerical Data; Long-Term Care/*statistics & numerical data; Longitudinal Studies; Male; Photon; Preschool; Prospective Studies; Risk Factors; Young Adult
AIM: Osteoporosis is a significant clinical problem in persons with moderate to severe cerebral palsy (CP), causing fractures with minimal trauma. Over the past decade, most studies examining osteoporosis and CP have been cross-sectional in nature, focused exclusively on children and adolescents and only involving one evaluation of bone mineral density (BMD). The purpose of this study was to assess BMD in a group including adults with CP, and changes in each individual's BMD over a 5- to 6-year period. METHOD: The study group included 40 residents of a long-term care facility aged 6 to 26 years at the time of their initial evaluation. Twenty-one patients (52.5%) were male, 35 (88%) were white, and 38 (95%) were in Gross Motor Function Classification System level V. BMD was assessed by dual-energy X-ray absorptiometry on the right and left distal femurs for three distinct regions of interest. RESULTS: Five residents had a fracture that occurred during the study period; this represented a fracture rate of 2.1% per year in the study group. Longitudinally, annualized change in the median BMD was 0.7% to 1.0% per year in the different regions of the distal femur, but ranged widely among the study group, with both increases and decreases in BMD. Increase in BMD over time was negatively correlated with age and positively correlated with change in weight. INTERPRETATION: Changes in BMD over time in profoundly involved persons with CP can range widely, which is important to recognize when evaluating potential interventions to improve BMD. Age and changes in body weight appear the most relevant factors.
Grossberg Richard; Blackford Martha G; Kecskemethy Heidi H; Henderson Richard; Reed Michael D
Developmental medicine and child neurology
2015
2015-11
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
<a href="http://doi.org/10.1111/dmcn.12790" target="_blank" rel="noreferrer noopener">10.1111/dmcn.12790</a>