1
40
2
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Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.4037/ajcc2015335" target="_blank" rel="noreferrer noopener">http://doi.org/10.4037/ajcc2015335</a>
Pages
440–445
Issue
5
Volume
24
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Mechanical Ventilation Antioxidant Trial.
Publisher
An entity responsible for making the resource available
American journal of critical care : an official publication, American Association of Critical-Care Nurses
Date
A point or period of time associated with an event in the lifecycle of the resource
2015
2015-09
Subject
The topic of the resource
Adult; Female; Humans; Male; Middle Aged; Time Factors; Aged; Length of Stay; Treatment Outcome; Prospective Studies; Oxidative Stress; Double-Blind Method; Intensive Care Units; Antioxidants/*therapeutic use; Antioxidants; Oxidative Stress/*drug effects; Critical Care/*methods; Human; Chi Square Test; Funding Source; Data Analysis Software; Middle Age; T-Tests; Ascorbic Acid/therapeutic use; Critical Illness; Cystine/analogs & derivatives/therapeutic use; Inflammation/*drug therapy/*etiology; Vitamin E/therapeutic use; Vitamins/therapeutic use; 80 and over; Artificial; Respiration; Artificial/*adverse effects; Randomized Controlled Trials; Double-Blind Studies; Acetylcysteine; Critically Ill Patients; Dietary Supplementation; Log-Rank Test; Mantel-Haenszel Test; Ventilator Weaning; Vitamin E; 80 and Over; Ascorbic Acid – Administration and Dosage
Creator
An entity primarily responsible for making the resource
Howe Kimberly P; Clochesy John M; Goldstein Lawrence S; Owen Hugh
Description
An account of the resource
BACKGROUND: Many patients each year require prolonged mechanical ventilation. Inflammatory processes may prevent successful weaning, and evidence indicates that mechanical ventilation induces oxidative stress in the diaphragm, resulting in atrophy and contractile dysfunction of diaphragmatic myofibers. Antioxidant supplementation might mitigate the harmful effects of the oxidative stress induced by mechanical ventilation. OBJECTIVE: To test the clinical effectiveness of antioxidant supplementation in reducing the duration of mechanical ventilation. METHODS: A randomized, prospective, placebo-controlled double-blind design was used to test whether enterally administered antioxidant supplementation would decrease the duration of mechanical ventilation, all-cause mortality, and length of stay in the intensive care unit and hospital. Patients received vitamin C 1000 mg plus vitamin E 1000 IU, vitamin C 1000 mg plus vitamin E 1000 IU plus N-acetylcysteine 400 mg, or placebo solution as a bolus injection via their enteral feeding tube every 8 hours. RESULTS: Clinical and statistically significant differences in duration of mechanical ventilation were seen among the 3 groups (Mantel-Cox log rank statistic = 5.69, df = 1, P = .017). The 3 groups did not differ significantly in all-cause mortality during hospitalization or in the length of stay in the intensive care unit or hospital. CONCLUSIONS: Enteral administration of antioxidants is a simple, safe, inexpensive, and effective intervention that decreases the duration of mechanical ventilation in critically ill adults.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.4037/ajcc2015335" target="_blank" rel="noreferrer noopener">10.4037/ajcc2015335</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2015
80 and over
Acetylcysteine
Adult
Aged
American journal of critical care : an official publication, American Association of Critical-Care Nurses
Antioxidants
Antioxidants/*therapeutic use
Artificial
Artificial/*adverse effects
Ascorbic Acid – Administration and Dosage
Ascorbic Acid/therapeutic use
Chi Square Test
Clochesy John M
Critical Care/*methods
Critical Illness
Critically Ill Patients
Cystine/analogs & derivatives/therapeutic use
Data Analysis Software
Department of Internal Medicine
Dietary Supplementation
Double-Blind Method
Double-Blind Studies
Female
Funding Source
Goldstein Lawrence S
Howe Kimberly P
Human
Humans
Inflammation/*drug therapy/*etiology
Intensive Care Units
Length of Stay
Log-Rank Test
Male
Mantel-Haenszel Test
Middle Age
Middle Aged
NEOMED College of Medicine
Owen Hugh
Oxidative Stress
Oxidative Stress/*drug effects
Prospective Studies
RANDOMIZED controlled trials
Respiration
T-Tests
Time Factors
Treatment Outcome
Ventilator Weaning
Vitamin E
Vitamin E/therapeutic use
Vitamins/therapeutic use
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.2146/ajhp100214" target="_blank" rel="noreferrer noopener">http://doi.org/10.2146/ajhp100214</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
69-72
Issue
1
Volume
68
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Stability Of Extemporaneously Prepared Acetylcysteine 1% And 10% Solutions For Treatment Of Meconium Ileus
Publisher
An entity responsible for making the resource available
American Journal of Health-System Pharmacy
Date
A point or period of time associated with an event in the lifecycle of the resource
2011
2011-01
Subject
The topic of the resource
Acetylcysteine; Chromatography; Color; Compounding; Concentration; cystic fibrosis; Diluents; edta; equivalent; Hydrogen ion concentration; Hydrogen sulfide; Ileus; Infant; liquid; management; Mucolytic agents; n-acetylcysteine; nonoperative treatment; obstruction; Odors; Pharmacology & Pharmacy; Sodium chloride; Stability; Storage
Creator
An entity primarily responsible for making the resource
Fohl A L; Johnson C E; Cober M P
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.2146/ajhp100214" target="_blank" rel="noreferrer noopener">10.2146/ajhp100214</a>
Format
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Journal Article or Conference Abstract Publication
2011
Acetylcysteine
American Journal of Health-System Pharmacy
Chromatography
Cober M P
Color
compounding
Concentration
CYSTIC fibrosis
Department of Pharmacy Practice
Diluents
edta
equivalent
Fohl A L
hydrogen ion concentration
Hydrogen sulfide
Ileus
Infant
Johnson C E
Liquid
Management
Mucolytic agents
n-acetylcysteine
NEOMED College of Pharmacy
nonoperative treatment
obstruction
Odors
Pharmacology & Pharmacy
Sodium chloride
Stability
Storage