1
40
18
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1152/jn.00422.2011" target="_blank" rel="noreferrer noopener">http://doi.org/10.1152/jn.00422.2011</a>
Pages
1047–1057
Issue
4
Volume
107
Dublin Core
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Title
A name given to the resource
A novel coding mechanism for social vocalizations in the lateral amygdala.
Publisher
An entity responsible for making the resource available
Journal of neurophysiology
Date
A point or period of time associated with an event in the lifecycle of the resource
2012
2012-02
Subject
The topic of the resource
*Social Behavior; Acoustic Stimulation; Action Potentials/*physiology; Amygdala/*cytology/physiology; Animal/*physiology; Animals; Auditory Pathways/*physiology; Chiroptera; Dextrans/metabolism; Echolocation/physiology; Female; Male; Neurons/*physiology; Reaction Time/physiology; Rhodamines/metabolism; Time Factors; Vocalization
Creator
An entity primarily responsible for making the resource
Gadziola Marie A; Grimsley Jasmine M S; Shanbhag Sharad J; Wenstrup Jeffrey J
Description
An account of the resource
The amygdala plays a central role in evaluating the significance of acoustic signals and coordinating the appropriate behavioral responses. To understand how amygdalar responses modulate auditory processing and drive emotional expression, we assessed how neurons respond to and encode information that is carried within complex acoustic stimuli. We characterized responses of single neurons in the lateral nucleus of the amygdala to social vocalizations and synthetic acoustic stimuli in awake big brown bats. Neurons typically responded to most of the social vocalizations presented (mean = nine of 11 vocalizations) but differentially modulated both firing rate and response duration. Surprisingly, response duration provided substantially more information about vocalizations than did spike rate. In most neurons, variation in response duration depended, in part, on persistent excitatory discharge that extended beyond stimulus duration. Information in persistent firing duration was significantly greater than in spike rate, and the majority of neurons displayed more information in persistent firing, which was more likely to be observed in response to aggressive vocalizations (64%) than appeasement vocalizations (25%), suggesting that persistent firing may relate to the behavioral context of vocalizations. These findings suggest that the amygdala uses a novel coding strategy for discriminating among vocalizations and underscore the importance of persistent firing in the general functioning of the amygdala.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1152/jn.00422.2011" target="_blank" rel="noreferrer noopener">10.1152/jn.00422.2011</a>
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Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Social Behavior
2012
Acoustic Stimulation
Action Potentials/*physiology
Amygdala/*cytology/physiology
Animal/*physiology
Animals
Auditory Pathways/*physiology
Chiroptera
College of Anatomy & Neurobiology
Department of Anatomy & Neurobiology
Dextrans/metabolism
Echolocation/physiology
Female
Gadziola Marie A
Grimsley Jasmine M S
Journal of neurophysiology
Male
NEOMED College of Medicine
Neurons/*physiology
Reaction Time/physiology
Rhodamines/metabolism
Shanbhag Sharad J
Time Factors
Vocalization
Wenstrup Jeffrey J
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1152/jn.00657.2016" target="_blank" rel="noreferrer noopener">http://doi.org/10.1152/jn.00657.2016</a>
Pages
2550–2563
Issue
6
Volume
116
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
L-type calcium channels refine the neural population code of sound level.
Publisher
An entity responsible for making the resource available
Journal of neurophysiology
Date
A point or period of time associated with an event in the lifecycle of the resource
2016
2016-12
Subject
The topic of the resource
*auditory midbrain; *dynamic range; *inferior colliculus; *level tuning; *local circuits; *rate-level functions; *Sound; 4-Aminopyridine/analogs & derivatives/pharmacology; Acoustic Stimulation; Action Potentials/drug effects/*physiology; Amifampridine; Animals; Biophysical Phenomena/drug effects; Calcium Channel Blockers/pharmacology; Calcium Channels; Calcium/metabolism; Excitatory Amino Acid Antagonists/pharmacology; In Vitro Techniques; Inbred CBA; Inferior Colliculi/*cytology; L-Type/*metabolism; Mice; Neurons/*physiology; Nimodipine/pharmacology; omega-Conotoxin GVIA/pharmacology; Potassium Channel Blockers/pharmacology; Quinoxalines/pharmacology; Wakefulness
Creator
An entity primarily responsible for making the resource
Grimsley Calum Alex; Green David Brian; Sivaramakrishnan Shobhana
Description
An account of the resource
The coding of sound level by ensembles of neurons improves the accuracy with which listeners identify how loud a sound is. In the auditory system, the rate at which neurons fire in response to changes in sound level is shaped by local networks. Voltage-gated conductances alter local output by regulating neuronal firing, but their role in modulating responses to sound level is unclear. We tested the effects of L-type calcium channels (CaL: CaV1.1-1.4) on sound-level coding in the central nucleus of the inferior colliculus (ICC) in the auditory midbrain. We characterized the contribution of CaL to the total calcium current in brain slices and then examined its effects on rate-level functions (RLFs) in vivo using single-unit recordings in awake mice. CaL is a high-threshold current and comprises approximately 50% of the total calcium current in ICC neurons. In vivo, CaL activates at sound levels that evoke high firing rates. In RLFs that increase monotonically with sound level, CaL boosts spike rates at high sound levels and increases the maximum firing rate achieved. In different populations of RLFs that change nonmonotonically with sound level, CaL either suppresses or enhances firing at sound levels that evoke maximum firing. CaL multiplies the gain of monotonic RLFs with dynamic range and divides the gain of nonmonotonic RLFs with the width of the RLF. These results suggest that a single broad class of calcium channels activates enhancing and suppressing local circuits to regulate the sensitivity of neuronal populations to sound level.
Identifier
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<a href="http://doi.org/10.1152/jn.00657.2016" target="_blank" rel="noreferrer noopener">10.1152/jn.00657.2016</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*auditory midbrain
*dynamic range
*Inferior colliculus
*level tuning
*local circuits
*rate-level functions
*Sound
2016
4-Aminopyridine/analogs & derivatives/pharmacology
Acoustic Stimulation
Action Potentials/drug effects/*physiology
Amifampridine
Animals
Biophysical Phenomena/drug effects
Calcium Channel Blockers/pharmacology
Calcium Channels
Calcium/metabolism
Excitatory Amino Acid Antagonists/pharmacology
Green David Brian
Grimsley Calum Alex
In Vitro Techniques
Inbred CBA
Inferior Colliculi/*cytology
Journal of neurophysiology
L-Type/*metabolism
Mice
Neurons/*physiology
Nimodipine/pharmacology
omega-Conotoxin GVIA/pharmacology
Potassium Channel Blockers/pharmacology
Quinoxalines/pharmacology
Sivaramakrishnan Shobhana
Wakefulness
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.3389/fncir.2013.00174" target="_blank" rel="noreferrer noopener">http://doi.org/10.3389/fncir.2013.00174</a>
Pages
174–174
Volume
7
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Midbrain local circuits shape sound intensity codes.
Publisher
An entity responsible for making the resource available
Frontiers in neural circuits
Date
A point or period of time associated with an event in the lifecycle of the resource
2013
1905-7
Subject
The topic of the resource
inferior colliculus; Animals; Mice; Neurons/physiology; Acoustic Stimulation; Auditory Perception/*physiology; Inferior Colliculi/*physiology; Auditory Pathways/*physiology; Auditory Threshold/physiology; high divalents; local circuits; monosynaptic; Neural Inhibition/*physiology; sound intensity
Creator
An entity primarily responsible for making the resource
Grimsley Calum Alex; Sanchez Jason Tait; Sivaramakrishnan Shobhana
Description
An account of the resource
Hierarchical processing of sensory information requires interaction at multiple levels along the peripheral to central pathway. Recent evidence suggests that interaction between driving and modulating components can shape both top down and bottom up processing of sensory information. Here we show that a component inherited from extrinsic sources combines with local components to code sound intensity. By applying high concentrations of divalent cations to neurons in the nucleus of the inferior colliculus in the auditory midbrain, we show that as sound intensity increases, the source of synaptic efficacy changes from inherited inputs to local circuits. In neurons with a wide dynamic range response to intensity, inherited inputs increase firing rates at low sound intensities but saturate at mid-to-high intensities. Local circuits activate at high sound intensities and widen dynamic range by continuously increasing their output gain with intensity. Inherited inputs are necessary and sufficient to evoke tuned responses, however local circuits change peak output. Push-pull driving inhibition and excitation create net excitatory drive to intensity-variant neurons and tune neurons to intensity. Our results reveal that dynamic range and tuning re-emerge in the auditory midbrain through local circuits that are themselves variable or tuned.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.3389/fncir.2013.00174" target="_blank" rel="noreferrer noopener">10.3389/fncir.2013.00174</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2013
Acoustic Stimulation
Animals
Auditory Pathways/*physiology
Auditory Perception/*physiology
Auditory Threshold/physiology
Frontiers in neural circuits
Grimsley Calum Alex
high divalents
Inferior Colliculi/*physiology
inferior colliculus
local circuits
Mice
monosynaptic
Neural Inhibition/*physiology
Neurons/physiology
Sanchez Jason Tait
Sivaramakrishnan Shobhana
sound intensity
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1523/jneurosci.20-22-08533.2000" target="_blank" rel="noreferrer noopener">http://doi.org/10.1523/jneurosci.20-22-08533.2000</a>
Pages
8533–8541
Issue
22
Volume
20
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Spectral integration in the inferior colliculus of the mustached bat.
Publisher
An entity responsible for making the resource available
The Journal of neuroscience : the official journal of the Society for Neuroscience
Date
A point or period of time associated with an event in the lifecycle of the resource
2000
2000-11
Subject
The topic of the resource
Animals; Chiroptera/*physiology; Neurons/physiology; Acoustic Stimulation; Inferior Colliculi/*physiology; Action Potentials/physiology; Auditory Threshold/physiology; Brain Mapping; Reaction Time/physiology; Pitch Perception/*physiology; Auditory Pathways/physiology; Animal Communication; Sound Spectrography; Stereotaxic Techniques; Electrodes; Animal/physiology; Vocalization; Implanted
Creator
An entity primarily responsible for making the resource
Leroy S A; Wenstrup J J
Description
An account of the resource
Acoustic behaviors including orientation and social communication depend on neural integration of information across the sound spectrum. In many species, spectral integration is performed by combination-sensitive neurons, responding best when distinct spectral elements in sounds are combined. These are generally considered a feature of information processing in the auditory forebrain. In the mustached bat's inferior colliculus (IC), they are common in frequency representations associated with sonar signals but have not been reported elsewhere in this bat's IC or the IC of other species. We examined the presence of combination-sensitive neurons in frequency representations of the mustached bat's IC not associated with biosonar. Seventy-five single-unit responses were recorded with the best frequencies in 10-23 or 32-47 kHz bands. Twenty-six displayed single excitatory tuning curves in one band with no additional responsiveness to a second signal in another band. The remaining 49 responded to sounds in both 10-23 and 32-47 kHz bands, but response types varied. Sounds in the higher band were usually excitatory, whereas sounds in the lower band either facilitated or inhibited responses to the higher frequency signal. Interactions were usually strongest when the higher and lower frequency stimuli were presented simultaneously, but the strength of interactions varied. Over one-third of the neurons formed a distinct subset; they responded most sensitively to bandpass noise, and all were combination sensitive. We suggest that these combination-sensitive interactions are activated by elements of mustached bat social vocalizations. If so, neuronal integration characterizing analysis of social vocalizations in many species occurs in the IC.
Identifier
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<a href="http://doi.org/10.1523/jneurosci.20-22-08533.2000" target="_blank" rel="noreferrer noopener">10.1523/jneurosci.20-22-08533.2000</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2000
Acoustic Stimulation
Action Potentials/physiology
Animal Communication
Animal/physiology
Animals
Auditory Pathways/physiology
Auditory Threshold/physiology
Brain Mapping
Chiroptera/*physiology
College of Anatomy & Neurobiology
Department of Anatomy & Neurobiology
Electrodes
Implanted
Inferior Colliculi/*physiology
Leroy S A
NEOMED College of Medicine
Neurons/physiology
Pitch Perception/*physiology
Reaction Time/physiology
Sound Spectrography
Stereotaxic Techniques
The Journal of neuroscience : the official journal of the Society for Neuroscience
Vocalization
Wenstrup J J
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0378-5955(95)00164-x" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0378-5955(95)00164-x</a>
Pages
185–191
Issue
1
Volume
90
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Combination-sensitive neurons in the inferior colliculus.
Publisher
An entity responsible for making the resource available
Hearing research
Date
A point or period of time associated with an event in the lifecycle of the resource
1995
1995-10
Subject
The topic of the resource
Acoustic Stimulation; Animals; Auditory Cortex/metabolism; Chiroptera; Doppler; Inferior Colliculi/*cytology/metabolism; Neurons/cytology/*physiology; Sound Localization; Transcranial; Ultrasonography
Creator
An entity primarily responsible for making the resource
Mittmann D H; Wenstrup J J
Description
An account of the resource
We examined whether neurons in the inferior colliculus of the mustached bat (Pteronotus parnellii) are combination sensitive, responding to both low- and high-frequency components of the bat's sonar signal. These neurons, previously reported in the thalamus and cortex, analyze sonar target features including distance. Of 82 single units and 36 multiple units from the 58-112 kHz representations of the inferior colliculus, most (86%) displayed sensitivity to low-frequency sounds that was tuned in the range of the fundamental biosonar component (24-31 kHz). All histologically localized units were in the central nucleus of the inferior colliculus (ICC). There were two major types of combination-sensitive influences. Many neurons were facilitated by low-frequency sounds and selective for particular delays between the low- and high-frequency components. In other neurons, the low-frequency signal was inhibitory if presented simultaneously or a few milliseconds prior to the high-frequency signal. The results indicate that mechanisms creating specialized frequency comparisons and delay sensitivity in combination-sensitive neurons operate at the ICC or below. Since combination sensitivity or multipeaked tuning curves occur in the auditory systems of many species, ICC neurons in these animals may also respond to species-specific frequency combinations.
Identifier
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<a href="http://doi.org/10.1016/0378-5955(95)00164-x" target="_blank" rel="noreferrer noopener">10.1016/0378-5955(95)00164-x</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1995
Acoustic Stimulation
Animals
Auditory Cortex/metabolism
Chiroptera
College of Anatomy & Neurobiology
Department of Anatomy & Neurobiology
Doppler
Hearing research
Inferior Colliculi/*cytology/metabolism
Mittmann D H
NEOMED College of Medicine
Neurons/cytology/*physiology
Sound Localization
Transcranial
Ultrasonography
Wenstrup J J
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1152/jn.01148.2005" target="_blank" rel="noreferrer noopener">http://doi.org/10.1152/jn.01148.2005</a>
Pages
2179–2192
Issue
4
Volume
95
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Roles of inhibition in complex auditory responses in the inferior colliculus: inhibited combination-sensitive neurons.
Publisher
An entity responsible for making the resource available
Journal of neurophysiology
Date
A point or period of time associated with an event in the lifecycle of the resource
2006
2006-04
Subject
The topic of the resource
Acoustic Stimulation; Action Potentials/drug effects/physiology; Afferent/drug effects/*physiology; Animals; Auditory; Auditory Pathways/drug effects/*physiology; Bicuculline/pharmacology; Brain Stem/drug effects/*physiology; Chiroptera; Electrophysiology; Evoked Potentials; GABA-A Receptor Antagonists; GABA-A/physiology; Glycine/antagonists & inhibitors/physiology; Inferior Colliculi/*physiology; Neural Inhibition/drug effects/*physiology; Neurons; Receptors; Strychnine/pharmacology
Creator
An entity primarily responsible for making the resource
Nataraj Kiran; Wenstrup Jeffrey J
Description
An account of the resource
We studied the functional properties and underlying neural mechanisms associated with inhibitory combination-sensitive neurons in the mustached bat's inferior colliculus (IC). In these neurons, the excitatory response to best frequency tones was suppressed by lower frequency signals (usually in the range of 12-30 kHz) in a time-dependant manner. Of 143 inhibitory units, the majority (71%) were type I, in which low-frequency sounds evoked inhibition only. In the remainder, however, the low-frequency inhibitory signal also evoked excitation. Of these, excitation preceded the inhibition in type E/I units (16%), whereas in type I/E units (13%), excitation followed the inhibition. Type E/I and I/E units were distinct in the tuning and threshold sensitivity of low-frequency responses, whereas type I units overlapped the other types in these features. In 71 neurons, antagonists to receptors for glycine [strychnine (STRY)] or GABA [bicuculline (BIC)] were applied microiontophoretically. These antagonists failed to eliminate combination-sensitive inhibition in 92% (STRY), 93% (BIC), and 87% (BIC + STRY) of the type I units tested. However, inhibition was reduced in many neurons. Results were similar for type E/I and I/E inhibitory neurons. The results indicate that there are distinct populations of combination-sensitive inhibited neurons in the IC and that these populations are at least partly independent of glycine or GABAA receptors in the IC. We propose that these populations originate in different brain stem auditory nuclei, that they may be modified by interactions within the IC, and that they may perform different spectrotemporal analyses of vocal signals.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1152/jn.01148.2005" target="_blank" rel="noreferrer noopener">10.1152/jn.01148.2005</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2006
Acoustic Stimulation
Action Potentials/drug effects/physiology
Afferent/drug effects/*physiology
Animals
Auditory
Auditory Pathways/drug effects/*physiology
Bicuculline/pharmacology
Brain Stem/drug effects/*physiology
Chiroptera
College of Anatomy & Neurobiology
Department of Anatomy & Neurobiology
Electrophysiology
Evoked Potentials
GABA-A Receptor Antagonists
GABA-A/physiology
Glycine/antagonists & inhibitors/physiology
Inferior Colliculi/*physiology
Journal of neurophysiology
Nataraj Kiran
NEOMED College of Medicine
Neural Inhibition/drug effects/*physiology
Neurons
Receptors
Strychnine/pharmacology
Wenstrup Jeffrey J
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.neuroscience.2012.04.069" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.neuroscience.2012.04.069</a>
Pages
154–171
Volume
217
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Selectivity and persistent firing responses to social vocalizations in the basolateral amygdala.
Publisher
An entity responsible for making the resource available
Neuroscience
Date
A point or period of time associated with an event in the lifecycle of the resource
2012
2012-08
Subject
The topic of the resource
Acoustic Stimulation; Action Potentials/*physiology; Amygdala/*physiology; Animal/*physiology; Animals; Auditory/physiology; Chiroptera/*physiology; Echolocation/physiology; Evoked Potentials; Neurons/*physiology; Vocalization
Creator
An entity primarily responsible for making the resource
Peterson D C; Wenstrup J J
Description
An account of the resource
This study examined responsiveness to acoustic stimuli among neurons of the basolateral amygdala. While recording from single neurons in awake mustached bats (Pteronotus parnellii), we presented a wide range of acoustic stimuli including tonal, noise, and vocal signals. While many neurons displayed phasic or sustained responses locked to effective auditory stimuli, the majority of neurons (n=58) displayed a persistent excitatory discharge that lasted well beyond stimulus duration and filled the interval between successive stimuli. Persistent firing usually began seconds (median value, 5.4 s) after the initiation of a train of repeated stimuli and lasted, in the majority of neurons, for at least 2 min after the end of the stimulus train. Auditory-responsive amygdalar neurons were generally excited by one stimulus or very few stimuli. Most neurons did not respond well to synthetic stimuli including tones, noise bursts or frequency-modulated sweeps, but instead responded only to vocal stimuli (82 of 87 neurons). Furthermore, most neurons were highly selective among vocal stimuli. On average, neurons responded to 1.7 of 15 different syllables or syllable sequences. The largest percentage of neurons responded to a hiss-like rectangular broadband noise burst (rBNB) call associated with aggressive interactions. Responsiveness to effective vocal stimuli was reduced or eliminated when the spectrotemporal features of the stimuli were altered in a subset of neurons. Chemical activation of the medial geniculate body (MG) increased both background and evoked firing. Among 39 histologically localized recording sites, we saw no evidence of topographic organization in terms of temporal response pattern, habituation, or the affect of calls to which neurons responded. Overall, these studies demonstrate that amygdalar neurons in the mustached bat show high selectivity to vocal stimuli, and suggest that persistent firing may be an important feature of amygdalar responses to social vocalizations.
Identifier
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<a href="http://doi.org/10.1016/j.neuroscience.2012.04.069" target="_blank" rel="noreferrer noopener">10.1016/j.neuroscience.2012.04.069</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2012
Acoustic Stimulation
Action Potentials/*physiology
Amygdala/*physiology
Animal/*physiology
Animals
Auditory/physiology
Chiroptera/*physiology
College of Anatomy & Neurobiology
Department of Anatomy & Neurobiology
Echolocation/physiology
Evoked Potentials
NEOMED College of Medicine
Neurons/*physiology
Neuroscience
Peterson D C
Vocalization
Wenstrup J J
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1152/jn.00040.2009" target="_blank" rel="noreferrer noopener">http://doi.org/10.1152/jn.00040.2009</a>
Pages
1004–1016
Issue
2
Volume
102
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Glycinergic inhibition creates a form of auditory spectral integration in nuclei of the lateral lemniscus.
Publisher
An entity responsible for making the resource available
Journal of neurophysiology
Date
A point or period of time associated with an event in the lifecycle of the resource
2009
2009-08
Subject
The topic of the resource
Acoustic Stimulation; Action Potentials/drug effects; Animals; Auditory Perception/drug effects/*physiology; Bicuculline/pharmacology; Brain Stem/drug effects/*physiology; Chiroptera; GABA Antagonists/pharmacology; GABA-A Receptor Antagonists; GABA-A/metabolism; gamma-Aminobutyric Acid/metabolism; Glycine Agents/pharmacology; Glycine/*physiology; Glycine/antagonists & inhibitors/metabolism; Microelectrodes; Neural Inhibition/drug effects/*physiology; Neurons/drug effects/*physiology; Receptors; Strychnine/pharmacology
Creator
An entity primarily responsible for making the resource
Peterson Diana Coomes; Nataraj Kiran; Wenstrup Jeffrey
Description
An account of the resource
For analyses of complex sounds, many neurons integrate information across different spectral elements via suppressive effects that are distant from the neurons' excitatory tuning. In the mustached bat, suppression evoked by sounds within the first sonar harmonic (23-30 kHz) or in the subsonar band (\textless23 kHz) alters responsiveness to the higher best frequencies of many neurons. This study examined features and mechanisms associated with low-frequency (LF) suppression among neurons of the lateral lemniscal nuclei (NLL). We obtained extracellular recordings from neurons in the intermediate and ventral nuclei of the lateral lemniscus, observing different forms of LF suppression related to the two above-cited frequency bands. To understand the mechanisms underlying this suppression in NLL neurons, we examined the roles of glycinergic and GABAergic input through local microiontophoretic application of strychnine, an antagonist to glycine receptors (GlyRs), or bicuculline, an antagonist to gamma-aminobutyric acid type A receptors (GABA(A)Rs). With blockade of GABA(A)Rs, neurons showed an increase in firing rate to best frequency (BF) and/or LF tones but retained LF suppression of BF sounds. For neurons that displayed LF suppression tuned to
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1152/jn.00040.2009" target="_blank" rel="noreferrer noopener">10.1152/jn.00040.2009</a>
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Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2009
Acoustic Stimulation
Action Potentials/drug effects
Animals
Auditory Perception/drug effects/*physiology
Bicuculline/pharmacology
Brain Stem/drug effects/*physiology
Chiroptera
College of Anatomy & Neurobiology
Department of Anatomy & Neurobiology
GABA Antagonists/pharmacology
GABA-A Receptor Antagonists
GABA-A/metabolism
gamma-Aminobutyric Acid/metabolism
Glycine Agents/pharmacology
Glycine/*physiology
Glycine/antagonists & inhibitors/metabolism
Journal of neurophysiology
Microelectrodes
Nataraj Kiran
NEOMED College of Medicine
Neural Inhibition/drug effects/*physiology
Neurons/drug effects/*physiology
Peterson Diana Coomes
Receptors
Strychnine/pharmacology
Wenstrup Jeffrey
-
Text
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URL Address
<a href="http://doi.org/10.1016/s0378-5955(00)00214-8" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/s0378-5955(00)00214-8</a>
Pages
95–105
Issue
1
Volume
151
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Topographical distribution of delay-tuned responses in the mustached bat inferior colliculus.
Publisher
An entity responsible for making the resource available
Hearing research
Date
A point or period of time associated with an event in the lifecycle of the resource
2001
2001-01
Subject
The topic of the resource
Acoustic Stimulation; Animals; Auditory Cortex/anatomy & histology/physiology; Chiroptera/*anatomy & histology/*physiology; Echolocation/physiology; Inferior Colliculi/*anatomy & histology/*physiology; Neurons/physiology; Ultrasonics
Creator
An entity primarily responsible for making the resource
Portfors C V; Wenstrup J J
Description
An account of the resource
In the mustached bat, delay-tuned neurons respond best to specific delays between the first harmonic frequency modulated (FM) component (FM1; 24-29 kHz) of the emitted biosonar pulse and a higher harmonic FM component in returning echoes (e.g. FM3, 72-89 kHz). These delay-tuned, combinatorial responses predominate in the inferior colliculus (IC) of the mustached bat. This study examined the topographical distribution of delay-tuned neurons in the 72-89 kHz frequency representation of the IC. We recorded and histologically localized 163 single units. Ninety units were facilitated and 41 were inhibited by the combination of two frequencies in the 24-29 kHz and 72-89 kHz ranges. The facilitatory responses were selective for delays up to 20 ms between the two signals. To determine if delay-tuned neurons were topographically organized, we plotted the dorsomedio-ventrolateral and caudo-rostral positions of each unit versus its best delay. Best delay was not correlated with either location. Response latency to best frequency tones was topographically organized, but was not correlated with best delay. This indicates that the latency axis in the IC is unrelated to the delay tuning of these combinatorial neurons. Because delay-tuned neurons are not topographically organized in the IC but are in the auditory cortex, our findings suggest that the creation and organization of delay-tuned neurons occur at different stages in the ascending auditory system.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/s0378-5955(00)00214-8" target="_blank" rel="noreferrer noopener">10.1016/s0378-5955(00)00214-8</a>
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Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2001
Acoustic Stimulation
Animals
Auditory Cortex/anatomy & histology/physiology
Chiroptera/*anatomy & histology/*physiology
College of Anatomy & Neurobiology
Department of Anatomy & Neurobiology
Echolocation/physiology
Hearing research
Inferior Colliculi/*anatomy & histology/*physiology
NEOMED College of Medicine
Neurons/physiology
Portfors C V
Ultrasonics
Wenstrup J J
-
Text
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URL Address
<a href="http://doi.org/10.1016/s0378-5955(02)00376-3" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/s0378-5955(02)00376-3</a>
Pages
131–138
Issue
1
Volume
168
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Excitatory and facilitatory frequency response areas in the inferior colliculus of the mustached bat.
Publisher
An entity responsible for making the resource available
Hearing research
Date
A point or period of time associated with an event in the lifecycle of the resource
2002
2002-06
Subject
The topic of the resource
Acoustic Stimulation; Animal; Animals; Auditory; Auditory Perception/*physiology; Brain Stem; Chiroptera/*physiology; Echolocation; Evoked Potentials; Inferior Colliculi/*physiology; Neurons/physiology; Vocalization
Creator
An entity primarily responsible for making the resource
Portfors Christine V; Wenstrup Jeffrey J
Description
An account of the resource
In the mustached bat's central nucleus of the inferior colliculus (ICC), many neurons display facilitatory or inhibitory responses when presented with two tones of distinctly different frequencies. Our previous studies have focused on spectral interactions between specific frequency bands contained in the bat's sonar vocalization. In this study, we describe excitatory and facilitatory frequency response areas across all frequencies in the mustached bat's audible range. We show that many neurons in the ICC have more extensive frequency interactions than previously documented. We recorded responses of 96 single units to single tones and combinations of two tones. Best frequencies of the units ranged from 59-15 kHz. Forty-one units had a single, excitatory frequency response area. The rest of the units had more complex frequency tuning that included multiple excitatory frequency response areas and facilitatory frequency response areas. Some of the facilitatory frequency interactions were between one sound with energy in a sonar frequency band and a second sound with energy in a non-sonar frequency band. We also found that neurons could be facilitated by more than one additional frequency band. Our findings of extensive frequency interactions in the ICC of the mustached bat suggest that some neurons may be well suited for the analysis of complex sounds, possibly including social communication sounds.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/s0378-5955(02)00376-3" target="_blank" rel="noreferrer noopener">10.1016/s0378-5955(02)00376-3</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2002
Acoustic Stimulation
Animal
Animals
Auditory
Auditory Perception/*physiology
Brain Stem
Chiroptera/*physiology
College of Anatomy & Neurobiology
Department of Anatomy & Neurobiology
Echolocation
Evoked Potentials
Hearing research
Inferior Colliculi/*physiology
NEOMED College of Medicine
Neurons/physiology
Portfors Christine V
Vocalization
Wenstrup Jeffrey J
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.3389/fncir.2013.00175" target="_blank" rel="noreferrer noopener">http://doi.org/10.3389/fncir.2013.00175</a>
Pages
175–175
Volume
7
Dublin Core
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Title
A name given to the resource
High concentrations of divalent cations isolate monosynaptic inputs from local circuits in the auditory midbrain.
Publisher
An entity responsible for making the resource available
Frontiers in neural circuits
Date
A point or period of time associated with an event in the lifecycle of the resource
2013
1905-07
Subject
The topic of the resource
inferior colliculus; Animals; Mice; Acoustic Stimulation; Neural Inhibition/drug effects/*physiology; high divalents; local circuits; monosynaptic; first spike latency; Inferior Colliculi/drug effects/*physiology; Reaction Time/drug effects/physiology; Synapses/drug effects/*physiology; Cations; Divalent/*pharmacology
Creator
An entity primarily responsible for making the resource
Sivaramakrishnan Shobhana; Sanchez Jason Tait; Grimsley Calum Alex
Description
An account of the resource
Hierarchical processing of sensory information occurs at multiple levels between the peripheral and central pathway. Different extents of convergence and divergence in top down and bottom up projections makes it difficult to separate the various components activated by a sensory input. In particular, hierarchical processing at sub-cortical levels is little understood. Here we have developed a method to isolate extrinsic inputs to the inferior colliculus (IC), a nucleus in the midbrain region of the auditory system, with extensive ascending and descending convergence. By applying a high concentration of divalent cations (HiDi) locally within the IC, we isolate a HiDi-sensitive from a HiDi-insensitive component of responses evoked by afferent input in brain slices and in vivo during a sound stimulus. Our results suggest that the HiDi-sensitive component is a monosynaptic input to the IC, while the HiDi-insensitive component is a local polysynaptic circuit. Monosynaptic inputs have short latencies, rapid rise times, and underlie first spike latencies. Local inputs have variable delays and evoke long-lasting excitation. In vivo, local circuits have variable onset times and temporal profiles. Our results suggest that high concentrations of divalent cations should prove to be a widely useful method of isolating extrinsic monosynaptic inputs from local circuits in vivo.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.3389/fncir.2013.00175" target="_blank" rel="noreferrer noopener">10.3389/fncir.2013.00175</a>
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Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2013
Acoustic Stimulation
Animals
Cations
Divalent/*pharmacology
first spike latency
Frontiers in neural circuits
Grimsley Calum Alex
high divalents
Inferior Colliculi/drug effects/*physiology
inferior colliculus
local circuits
Mice
monosynaptic
Neural Inhibition/drug effects/*physiology
Reaction Time/drug effects/physiology
Sanchez Jason Tait
Sivaramakrishnan Shobhana
Synapses/drug effects/*physiology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.neuroscience.2008.06.031" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.neuroscience.2008.06.031</a>
Pages
923–936
Issue
3
Volume
155
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Timing of sound-evoked potentials and spike responses in the inferior colliculus of awake bats.
Publisher
An entity responsible for making the resource available
Neuroscience
Date
A point or period of time associated with an event in the lifecycle of the resource
2008
2008-08
Subject
The topic of the resource
*Wakefulness; Acoustic Stimulation; Action Potentials/*physiology; Animals; Auditory Perception; Auditory/*physiology; Chiroptera/physiology; Electroencephalography; Evoked Potentials; Functional Laterality/physiology; Inferior Colliculi/*cytology; Neural Inhibition/physiology; Neurons/*physiology; Psychoacoustics; Reaction Time/*physiology/radiation effects
Creator
An entity primarily responsible for making the resource
Voytenko S V; Galazyuk A V
Description
An account of the resource
Neurons in the inferior colliculus (IC), one of the major integrative centers of the auditory system, process acoustic information converging from almost all nuclei of the auditory brain stem. During this integration, excitatory and inhibitory inputs arrive to auditory neurons at different time delays. Result of this integration determines timing of IC neuron firing. In the mammalian IC, the range of the first spike latencies is very large (5-50 ms). At present, a contribution of excitatory and inhibitory inputs in controlling neurons' firing in the IC is still under debate. In the present study we assess the role of excitation and inhibition in determining first spike response latency in the IC. Postsynaptic responses were recorded to pure tones presented at neuron's characteristic frequency or to downward frequency modulated sweeps in awake bats. There are three main results emerging from the present study: (1) the most common response pattern in the IC is hyperpolarization followed by depolarization followed by hyperpolarization, (2) latencies of depolarizing or hyperpolarizing responses to tonal stimuli are short (3-7 ms) whereas the first spike latencies may vary to a great extent (4-26 ms) from one neuron to another, and (3) high threshold hyperpolarization preceded long latency spikes in IC neurons exhibiting paradoxical latency shift. Our data also show that the onset hyperpolarizing potentials in the IC have very small jitter (\textless100 micros) across repeated stimulus presentations. The results of this study suggest that inhibition, arriving earlier than excitation, may play a role as a mechanism for delaying the first spike latency in IC neurons.
Identifier
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<a href="http://doi.org/10.1016/j.neuroscience.2008.06.031" target="_blank" rel="noreferrer noopener">10.1016/j.neuroscience.2008.06.031</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Wakefulness
2008
Acoustic Stimulation
Action Potentials/*physiology
Animals
Auditory Perception
Auditory/*physiology
Chiroptera/physiology
Department of Anatomy & Neurobiology
Electroencephalography
Evoked Potentials
Functional Laterality/physiology
Galazyuk A V
Inferior Colliculi/*cytology
NEOMED College of Medicine
Neural Inhibition/physiology
Neurons/*physiology
Neuroscience
Psychoacoustics
Reaction Time/*physiology/radiation effects
Voytenko S V
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1152/jn.00976.2006" target="_blank" rel="noreferrer noopener">http://doi.org/10.1152/jn.00976.2006</a>
Pages
1368–1378
Issue
2
Volume
97
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Intracellular recording reveals temporal integration in inferior colliculus neurons of awake bats.
Publisher
An entity responsible for making the resource available
Journal of neurophysiology
Date
A point or period of time associated with an event in the lifecycle of the resource
2007
2007-02
Subject
The topic of the resource
Acoustic Stimulation; Animals; Chiroptera/*physiology; Data Interpretation; Electrophysiology; Excitatory Postsynaptic Potentials/physiology; Inferior Colliculi/cytology/*physiology; Inhibitory Postsynaptic Potentials/physiology; Microelectrodes; Neurons/*physiology; Pitch Perception; Statistical
Creator
An entity primarily responsible for making the resource
Voytenko S V; Galazyuk A V
Description
An account of the resource
The central nucleus of the inferior colliculus (IC) is a major integrative center in the central auditory system. It receives information from both the ascending and descending auditory pathways. To determine how single IC neurons integrate information over a wide range of sound frequencies and sound levels, we examined their intracellular responses to frequency-modulated (FM) sounds in awake little brown bats (Myotis lucifugus). Postsynaptic potentials were recorded in response to downward FM sweeps of the range typical for little brown bats (80-20 kHz) and to three FM subcomponents (80-60, 60-40, and 40-20 kHz). The majority of recorded neurons responded to the 80- to 20-kHz downward FM sweep with a complex response. In this response an initial hyperpolarization was followed by depolarization with or without spike followed by hyperpolarization. Intracellular recordings in response to three FM subcomponents revealed that these neurons receive excitatory and inhibitory inputs from a wide range of sound frequencies. One third of IC neurons performed nearly linear temporal summation across a wide range of sound frequencies, whereas two thirds of IC neurons exhibited nonlinear summation with different degrees of nonlinearity. Some IC neurons showed different latencies of postsynaptic potentials in response to different FM subcomponents. Often responses to the later FM subcomponent occurred before responses to the earlier ones. This phenomenon may be responsible for response selectivity of IC neurons to FM sweeps.
Identifier
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<a href="http://doi.org/10.1152/jn.00976.2006" target="_blank" rel="noreferrer noopener">10.1152/jn.00976.2006</a>
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Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2007
Acoustic Stimulation
Animals
Chiroptera/*physiology
Data Interpretation
Department of Anatomy & Neurobiology
Electrophysiology
Excitatory Postsynaptic Potentials/physiology
Galazyuk A V
Inferior Colliculi/cytology/*physiology
Inhibitory Postsynaptic Potentials/physiology
Journal of neurophysiology
Microelectrodes
NEOMED College of Medicine
Neurons/*physiology
Pitch Perception
Statistical
Voytenko S V
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1523/jneurosci.15-06-04693.1995" target="_blank" rel="noreferrer noopener">http://doi.org/10.1523/jneurosci.15-06-04693.1995</a>
Pages
4693–4711
Issue
6
Volume
15
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Inputs to combination-sensitive neurons in the medial geniculate body of the mustached bat: the missing fundamental.
Publisher
An entity responsible for making the resource available
The Journal of neuroscience : the official journal of the Society for Neuroscience
Date
A point or period of time associated with an event in the lifecycle of the resource
1995
1995-06
Subject
The topic of the resource
Animals; Chiroptera/*physiology; Axonal Transport; Acoustic Stimulation; Neurons/*physiology; Wheat Germ Agglutinin-Horseradish Peroxidase Conjugate; Echolocation; *Brain Mapping; Horseradish Peroxidase; Cholera Toxin; Geniculate Bodies/anatomy & histology/*physiology; Inferior Colliculi/anatomy & histology/*physiology; Lysine/analogs & derivatives; Wheat Germ Agglutinins
Creator
An entity primarily responsible for making the resource
Wenstrup J J; Grose C D
Description
An account of the resource
This study examined projections to combination-sensitive neurons in the medial geniculate body of the mustached bat. These specialized neurons respond to the combination of two temporally and spectrally distinct components of the bat's sonar pulse and echo, encoding target information. Combination-sensitive neurons respond to the bat's sonar fundamental, between 24-31 kHz, in conjunction with a higher harmonic signal. They are thought to be formed in the medial geniculate body (MGB) by convergent input from inferior colliculus representations of 24-31 kHz and higher frequencies. This study used anterograde and retrograde tract-tracing methods in conjunction with physiological recording to test this MGB convergence hypothesis. In anterograde tracing experiments, multiple deposits of two different tracers were placed in the central nucleus of the inferior colliculus (ICC), one tracer in the 24-31 kHz region and another in an ICC representation responding to a higher sonar harmonic. We found only limited overlap in the MGB labeling patterns of the two tracers, and little in many areas where combination-sensitive neurons are common. In retrograde tracing experiments, a single deposit of tracer was placed at a combination-sensitive recording site in the MGB. With the deposit mostly limited to combination-sensitive MGB areas, labeling in 24-31 kHz representations of the ICC was absent or minor. These results suggest that many combination-sensitive neurons in the MGB do not receive 24-31 kHz ICC input. The strongest inputs to combination-sensitive MGB regions originate in high-frequency representations of the ICC and combination-sensitive regions of auditory cortex. Additional projections arrive from the thalamic reticular nucleus, external nucleus of the inferior colliculus, and pericollicular tegmentum. Each projection may contribute to the 24-31 kHz sensitivity of combination-sensitive neurons in the medial geniculate body.
Identifier
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<a href="http://doi.org/10.1523/jneurosci.15-06-04693.1995" target="_blank" rel="noreferrer noopener">10.1523/jneurosci.15-06-04693.1995</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Brain Mapping
1995
Acoustic Stimulation
Animals
Axonal Transport
Chiroptera/*physiology
Cholera Toxin
College of Anatomy & Neurobiology
Department of Anatomy & Neurobiology
Echolocation
Geniculate Bodies/anatomy & histology/*physiology
Grose C D
Horseradish Peroxidase
Inferior Colliculi/anatomy & histology/*physiology
Lysine/analogs & derivatives
NEOMED College of Medicine
Neurons/*physiology
The Journal of neuroscience : the official journal of the Society for Neuroscience
Wenstrup J J
Wheat Germ Agglutinin-Horseradish Peroxidase Conjugate
Wheat Germ Agglutinins
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1002/cne.903460204" target="_blank" rel="noreferrer noopener">http://doi.org/10.1002/cne.903460204</a>
Pages
207–236
Issue
2
Volume
346
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Projections of physiologically defined subdivisions of the inferior colliculus in the mustached bat: targets in the medial geniculate body and extrathalamic nuclei.
Publisher
An entity responsible for making the resource available
The Journal of comparative neurology
Date
A point or period of time associated with an event in the lifecycle of the resource
1994
1994-08
Subject
The topic of the resource
Acoustic Stimulation; Animals; Axons/ultrastructure; Brain Mapping; Chiroptera/*physiology; Geniculate Bodies/*physiology; Inferior Colliculi/*physiology; Neural Pathways/*physiology; Synaptic Transmission; Thalamic Nuclei/*physiology
Creator
An entity primarily responsible for making the resource
Wenstrup J J; Larue D T; Winer J A
Description
An account of the resource
This study examined the output of the central nucleus of the inferior colliculus to the medial geniculate body and other parts of the nervous system in the mustached bat (Pteronotus parnellii). Small deposits of anterograde tracers (horseradish peroxidase, [3H]leucine, Phaseolus vulgaris leucoagglutinin, wheat germ agglutinin conjugated to horseradish peroxidase, or biocytin) were made at physiologically defined sites in the central nucleus representing major components of the bat's echolocation signal. The topography, frequency specificity, and axonal morphology of these outputs were studied. The medial geniculate body was a major target of inferior collicular neurons, with three distinct input patterns. The projection to the ventral division was tonotopically organized, but had a relatively sparse contribution from neurons representing frequency modulated components of the biosonar pulse. The second input was to the rostral medial geniculate body, in which projections from inferior collicular neurons representing constant frequency sonar components were separated from those representing frequency modulated components. A third input was to the suprageniculate nucleus, which received strong, topographically arranged projections. Inputs to the dorsal nucleus and medial division were also observed. Extrathalamic regions receiving input included the pontine gray, external nucleus of the inferior colliculus, pericollicular tegmentum, nucleus of the brachium of the inferior colliculus, and pretectum. These central nucleus projections differed in organization and the structure of axon terminals, suggesting different physiological influences on their target nuclei. These results demonstrate that the central nucleus has divergent projections to various sensory and premotor nuclei, besides its well-established projection to the medial geniculate body.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1002/cne.903460204" target="_blank" rel="noreferrer noopener">10.1002/cne.903460204</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1994
Acoustic Stimulation
Animals
Axons/ultrastructure
Brain Mapping
Chiroptera/*physiology
College of Anatomy & Neurobiology
Department of Anatomy & Neurobiology
Geniculate Bodies/*physiology
Inferior Colliculi/*physiology
Larue D T
NEOMED College of Medicine
Neural Pathways/*physiology
Synaptic Transmission
Thalamic Nuclei/*physiology
The Journal of comparative neurology
Wenstrup J J
Winer J A
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1002/(sici)1096-9861(19990712)409:4%3C509::aid-cne1%3E3.0.co;2-s" target="_blank" rel="noreferrer noopener">http://doi.org/10.1002/(sici)1096-9861(19990712)409:4%3C509::aid-cne1%3E3.0.co;2-s</a>
Pages
509–528
Issue
4
Volume
409
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Inputs to combination-sensitive neurons of the inferior colliculus.
Publisher
An entity responsible for making the resource available
The Journal of comparative neurology
Date
A point or period of time associated with an event in the lifecycle of the resource
1999
1999-07
Subject
The topic of the resource
*Brain Mapping; Acoustic Stimulation; Animals; Auditory; Brain Stem/*physiology; Chiroptera/*physiology; Evoked Potentials; Inferior Colliculi/*physiology; Neurons/*physiology
Creator
An entity primarily responsible for making the resource
Wenstrup J J; Mittmann D H; Grose C D
Description
An account of the resource
In the mustached bat, combination-sensitive neurons display integrative responses to combinations of acoustic elements in biosonar or social vocalizations. One type of combination-sensitive neuron responds to multiple harmonics of the frequency-modulated (FM) components in the sonar pulse and echo of the bat. These neurons, termed FM-FM neurons, are sensitive to the pulse-echo delay and may encode the distance of sonar targets. FM-FM neurons are common in high-frequency regions of the central nucleus of the inferior colliculus (ICC) and may be created there. If so, they must receive low-frequency inputs in addition to the expected high-frequency inputs. We placed single deposits of a tracer at FM-FM recording sites in the ICC and then analyzed retrograde labeling in the brainstem and midbrain. We were particularly interested in labeling patterns suggestive of low-frequency input to these FM-FM neurons. In most nuclei containing labeled cells, there was a single focus of labeling in regions thought to be responsive to high-frequency sounds. More complex labeling patterns were observed in three nuclei. In the anteroventral cochlear nucleus, labeling in the anterior and marginal cell divisions occurred in regions thought to respond to low-frequency sounds. This labeling comprised 6% of total brainstem labeled cells. Labeling in the intermediate nucleus of the lateral lemniscus and the magnocellular part of the ventral nucleus of the lateral lemniscus together comprised nearly 40% of all labeled cells. In both nuclei, multiple foci of labeling occurred. These different foci may represent groups of cells tuned to different frequency bands. Thus, one or more of these three nuclei may provide low-frequency input to high-frequency-sensitive cells in the ICC, creating FM-FM responses. We also examined whether ICC neurons responsive to lower frequencies project to high-frequency-sensitive ICC regions; only 0.15% of labeling originated from these lower frequency representations. If the spectral integration of FM-FM neurons is created at the level of the ICC, these results suggest that neurons of the anteroventral cochlear nucleus or monaural nuclei of the lateral lemniscus may provide the essential low-frequency input. In contrast, there is little evidence that the low-frequency representation of the ICC contributes to these integrative responses.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1002/(sici)1096-9861(19990712)409:4%3C509::aid-cne1%3E3.0.co;2-s" target="_blank" rel="noreferrer noopener">10.1002/(sici)1096-9861(19990712)409:4%3C509::aid-cne1%3E3.0.co;2-s</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Brain Mapping
1999
Acoustic Stimulation
Animals
Auditory
Brain Stem/*physiology
Chiroptera/*physiology
College of Anatomy & Neurobiology
Department of Anatomy & Neurobiology
Evoked Potentials
Grose C D
Inferior Colliculi/*physiology
Mittmann D H
NEOMED College of Medicine
Neurons/*physiology
The Journal of comparative neurology
Wenstrup J J
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.neuroscience.2010.04.073" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.neuroscience.2010.04.073</a>
Pages
906–919
Issue
2
Volume
169
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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Substrates of auditory frequency integration in a nucleus of the lateral lemniscus.
Publisher
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Neuroscience
Date
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2010
2010-08
Subject
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Acoustic Stimulation; Action Potentials; Animals; Auditory Pathways/*physiology; Brain Stem/anatomy & histology/*physiology; Chiroptera/*physiology; Glycine/physiology
Creator
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Yavuzoglu A; Schofield B R; Wenstrup J J
Description
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In the intermediate nucleus of the lateral lemniscus (INLL), some neurons display a form of spectral integration in which excitatory responses to sounds at their best frequency are inhibited by sounds within a frequency band at least one octave lower. Previous work showed that this response property depends on low-frequency-tuned glycinergic input. To identify all sources of inputs to these INLL neurons, and in particular the low-frequency glycinergic input, we combined retrograde tracing with immunohistochemistry for the neurotransmitter glycine. We deposited a retrograde tracer at recording sites displaying either high best frequencies (\textgreater75 kHz) in conjunction with combination-sensitive inhibition, or at sites displaying low best frequencies (23-30 kHz). Most retrogradely labeled cells were located in the ipsilateral medial nucleus of the trapezoid body (MNTB) and contralateral anteroventral cochlear nucleus. Consistent labeling, but in fewer numbers, was observed in the ipsilateral lateral nucleus of the trapezoid body (LNTB), contralateral posteroventral cochlear nucleus, and a few other brainstem nuclei. When tracer deposits were combined with glycine immunohistochemistry, most double-labeled cells were observed in the ipsilateral MNTB (84%), with fewer in LNTB (13%). After tracer deposits at combination-sensitive recording sites, a striking result was that MNTB labeling occurred in both medial and lateral regions. This labeling appeared to overlap the MNTB labeling that resulted from tracer deposits in low-frequency recording sites of INLL. These findings suggest that MNTB is the most likely source of low-frequency glycinergic input to INLL neurons with high best frequencies and combination-sensitive inhibition. This work establishes an anatomical basis for frequency integration in the auditory brainstem.
Identifier
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<a href="http://doi.org/10.1016/j.neuroscience.2010.04.073" target="_blank" rel="noreferrer noopener">10.1016/j.neuroscience.2010.04.073</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2010
Acoustic Stimulation
Action Potentials
Animals
Auditory Pathways/*physiology
Brain Stem/anatomy & histology/*physiology
Chiroptera/*physiology
College of Anatomy & Neurobiology
Department of Anatomy & Neurobiology
Glycine/physiology
NEOMED College of Medicine
Neuroscience
Schofield B R
Wenstrup J J
Yavuzoglu A
-
Text
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URL Address
<a href="http://doi.org/10.1016/j.jneumeth.2017.08.029" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.jneumeth.2017.08.029</a>
Pages
227–237
Volume
291
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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An operant-based detection method for inferring tinnitus in mice.
Publisher
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Journal of neuroscience methods
Date
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2017
2017-11
Subject
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*Conditioning; *Disease Models; *Inferior colliculus; *Mouse model; *Noise-induced hearing loss; *Operant conditioning; *Sodium salicylate; *Tinnitus; Acoustic Stimulation; Analysis of Variance; Animal; Animals; Auditory; Avoidance Learning; Brain Stem/physiology; Electroshock; Equipment Design; Evoked Potentials; Female; Inbred C57BL; Inferior Colliculi/physiopathology; Male; Mice; Motor Activity; Neurons/physiology; Operant; Otoacoustic Emissions; Sodium Salicylate; Spontaneous/physiology; Tinnitus/*diagnosis/physiopathology; Tissue Culture Techniques; Voltage-Sensitive Dye Imaging
Creator
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Zuo Hongyan; Lei Debin; Sivaramakrishnan Shobhana; Howie Benjamin; Mulvany Jessica; Bao Jianxin
Description
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BACKGROUND: Subjective tinnitus is a hearing disorder in which a person perceives sound when no external sound is present. It can be acute or chronic. Because our current understanding of its pathology is incomplete, no effective cures have yet been established. Mouse models are useful for studying the pathophysiology of tinnitus as well as for developing therapeutic treatments. NEW METHOD: We have developed a new method for determining acute and chronic tinnitus in mice, called sound-based avoidance detection (SBAD). The SBAD method utilizes one paradigm to detect tinnitus and another paradigm to monitor possible confounding factors, such as motor impairment, loss of motivation, and deficits in learning and memory. RESULTS: The SBAD method has succeeded in monitoring both acute and chronic tinnitus in mice. Its detection ability is further validated by functional studies demonstrating an abnormal increase in neuronal activity in the inferior colliculus of mice that had previously been identified as having tinnitus by the SBAD method. COMPARISON WITH EXISTING METHODS: The SBAD method provides a new means by which investigators can detect tinnitus in a single mouse accurately and with more control over potential confounding factors than existing methods. CONCLUSION: This work establishes a new behavioral method for detecting tinnitus in mice. The detection outcome is consistent with functional validation. One key advantage of mouse models is they provide researchers the opportunity to utilize an extensive array of genetic tools. This new method could lead to a deeper understanding of the molecular pathways underlying tinnitus pathology.
Identifier
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<a href="http://doi.org/10.1016/j.jneumeth.2017.08.029" target="_blank" rel="noreferrer noopener">10.1016/j.jneumeth.2017.08.029</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Conditioning
*Disease Models
*Inferior colliculus
*Mouse model
*Noise-induced hearing loss
*Operant conditioning
*Sodium salicylate
*Tinnitus
2017
Acoustic Stimulation
Analysis of Variance
Animal
Animals
Auditory
Avoidance Learning
Bao Jianxin
Brain Stem/physiology
Department of Anatomy & Neurobiology
Electroshock
Equipment Design
Evoked Potentials
Female
Howie Benjamin
Inbred C57BL
Inferior Colliculi/physiopathology
Journal of neuroscience methods
Lei Debin
Male
Mice
Motor Activity
Mulvany Jessica
NEOMED College of Medicine
Neurons/physiology
Operant
Otoacoustic Emissions
Sivaramakrishnan Shobhana
Sodium Salicylate
Spontaneous/physiology
Tinnitus/*diagnosis/physiopathology
Tissue Culture Techniques
Voltage-Sensitive Dye Imaging
Zuo Hongyan