1
40
6
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1523/JNEUROSCI.2205-13.2013" target="_blank" rel="noreferrer noopener">http://doi.org/10.1523/JNEUROSCI.2205-13.2013</a>
Pages
17538–17548
Issue
44
Volume
33
Dublin Core
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Title
A name given to the resource
Coding the meaning of sounds: contextual modulation of auditory responses in the basolateral amygdala.
Publisher
An entity responsible for making the resource available
The Journal of neuroscience : the official journal of the Society for Neuroscience
Date
A point or period of time associated with an event in the lifecycle of the resource
2013
2013-10
Subject
The topic of the resource
Female; Male; Animals; Mice; Acoustic Stimulation/*methods; Auditory Perception/*physiology; Action Potentials/*physiology; Amygdala/*physiology; Cats; Animal/*physiology; Inbred CBA; Vocalization
Creator
An entity primarily responsible for making the resource
Grimsley Jasmine M S; Hazlett Emily G; Wenstrup Jeffrey J
Description
An account of the resource
Female mice emit a low-frequency harmonic (LFH) call in association with distinct behavioral contexts: mating and physical threat or pain. Here we report the results of acoustic, behavioral, and neurophysiological studies of the contextual analysis of these calls in CBA/CaJ mice. We first show that the acoustical features of the LFH call do not differ between contexts. We then show that male mice avoid the LFH call in the presence of a predator cue (cat fur) but are more attracted to the same exemplar of the call in the presence of a mating cue (female urine). The males thus use nonauditory cues to determine the meaning of the LFH call, but these cues do not generalize to noncommunication sounds, such as noise bursts. We then characterized neural correlates of contextual meaning of the LFH call in responses of basolateral amygdala (BLA) neurons from awake, freely moving mice. There were two major findings. First, BLA neurons typically displayed early excitation to all tested behaviorally aversive stimuli. Second, the nonauditory context modulates the BLA population response to the LFH call but not to the noncommunication sound. These results suggest that the meaning of communication calls is reflected in the spike discharge patterns of BLA neurons.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1523/JNEUROSCI.2205-13.2013" target="_blank" rel="noreferrer noopener">10.1523/JNEUROSCI.2205-13.2013</a>
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Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2013
Acoustic Stimulation/*methods
Action Potentials/*physiology
Amygdala/*physiology
Animal/*physiology
Animals
Auditory Perception/*physiology
Cats
College of Anatomy & Neurobiology
Department of Anatomy & Neurobiology
Female
Grimsley Jasmine M S
Hazlett Emily G
Inbred CBA
Male
Mice
NEOMED College of Medicine
The Journal of neuroscience : the official journal of the Society for Neuroscience
Vocalization
Wenstrup Jeffrey J
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1152/jn.01152.2004" target="_blank" rel="noreferrer noopener">http://doi.org/10.1152/jn.01152.2004</a>
Pages
3294–3312
Issue
6
Volume
93
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Roles of inhibition in creating complex auditory responses in the inferior colliculus: facilitated combination-sensitive neurons.
Publisher
An entity responsible for making the resource available
Journal of neurophysiology
Date
A point or period of time associated with an event in the lifecycle of the resource
2005
2005-06
Subject
The topic of the resource
Acoustic Stimulation/methods; Action Potentials/*physiology; Animals; Auditory Pathways/physiology; Bicuculline/pharmacology; Cell Count; Drug Interactions; GABA Antagonists/pharmacology; Glycine Agents/pharmacology; Inferior Colliculi/*cytology; Iontophoresis/methods; Models; Neural Inhibition/drug effects/*physiology; Neurological; Neurons/classification/drug effects/*physiology/radiation effects; Otters; Reaction Time/*physiology/radiation effects; Regression Analysis; Strychnine/pharmacology; Time Factors; Wakefulness/physiology
Creator
An entity primarily responsible for making the resource
Nataraj Kiran; Wenstrup Jeffrey J
Description
An account of the resource
We studied roles of inhibition on temporally sensitive facilitation in combination-sensitive neurons from the mustached bat's inferior colliculus (IC). In these integrative neurons, excitatory responses to best frequency (BF) tones are enhanced by much lower frequency signals presented in a specific temporal relationship. Most facilitated neurons (76%) showed inhibition at delays earlier than or later than the delays causing facilitation. The timing of inhibition at earlier delays was closely related to the best delay of facilitation, but the inhibition had little influence on the duration or strength of the facilitatory interaction. Local iontophoretic application of antagonists to receptors for glycine (strychnine, STRY) and gamma-aminobutyric acid (GABA) (bicuculline, BIC) showed that STRY abolished facilitation in 96% of tested units, but BIC eliminated facilitation in only 28%. This suggests that facilitatory interactions are created in IC and reveals a differential role for these neurotransmitters. The facilitation may be created by coincidence of a postinhibitory rebound excitation activated by the low-frequency signal with the BF-evoked excitation. Unlike facilitation, inhibition at earlier delays was not eliminated by application of antagonists, suggesting an origin in lower brain stem nuclei. However, inhibition at delays later than facilitation, like facilitation itself, appears to originate within IC and to be more dependent on glycinergic than GABAergic mechanisms. Facilitatory and inhibitory interactions displayed by these combination-sensitive neurons encode information within sonar echoes and social vocalizations. The results indicate that these complex response properties arise through a series of neural interactions in the auditory brain stem and midbrain.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1152/jn.01152.2004" target="_blank" rel="noreferrer noopener">10.1152/jn.01152.2004</a>
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Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2005
Acoustic Stimulation/methods
Action Potentials/*physiology
Animals
Auditory Pathways/physiology
Bicuculline/pharmacology
Cell Count
College of Anatomy & Neurobiology
Department of Anatomy & Neurobiology
Drug Interactions
GABA Antagonists/pharmacology
Glycine Agents/pharmacology
Inferior Colliculi/*cytology
Iontophoresis/methods
Journal of neurophysiology
Models
Nataraj Kiran
NEOMED College of Medicine
Neural Inhibition/drug effects/*physiology
Neurological
Neurons/classification/drug effects/*physiology/radiation effects
Otters
Reaction Time/*physiology/radiation effects
Regression Analysis
Strychnine/pharmacology
Time Factors
Wakefulness/physiology
Wenstrup Jeffrey J
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1152/jn.00634.2005" target="_blank" rel="noreferrer noopener">http://doi.org/10.1152/jn.00634.2005</a>
Pages
88–105
Issue
1
Volume
95
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Auditory responses in the cochlear nucleus of awake mustached bats: precursors to spectral integration in the auditory midbrain.
Publisher
An entity responsible for making the resource available
Journal of neurophysiology
Date
A point or period of time associated with an event in the lifecycle of the resource
2006
2006-01
Subject
The topic of the resource
Acoustic Stimulation/methods; Action Potentials/*physiology; Animals; Auditory; Brain Mapping; Brain Stem/*physiology; Chiroptera/*physiology; Cochlear Nucleus/*physiology; Evoked Potentials; Mesencephalon/physiology; Nerve Net/*physiology; Pitch Perception/*physiology; Wakefulness/physiology
Creator
An entity primarily responsible for making the resource
Marsh Robert A; Nataraj Kiran; Gans Donald; Portfors Christine V; Wenstrup Jeffrey J
Description
An account of the resource
In the cochlear nucleus (CN) of awake mustached bats, single- and two-tone stimuli were used to examine how responses in major CN subdivisions contribute to spectrotemporal integrative features in the inferior colliculus (IC). Across CN subdivisions, the proportional representation of frequencies differed. A striking result was the substantial number of units tuned to frequencies \textless23 kHz. Across frequency bands, temporal response patterns, latency, and spontaneous discharge differed. For example, the 23- to 30-kHz representation, which comprises the fundamental of the sonar call, had an unusually high proportion of units with onset responses (39%) and low spontaneous rates (53%). Units tuned to 58-59 kHz, corresponding to the sharply tuned cochlear resonance, had slightly but significantly longer latencies than other bands. In units tuned to frequencies \textgreater30 kHz, 31% displayed a secondary excitatory peak, usually between 10 and 22 kHz. The secondary peak may originate in cochlear mechanisms for some units, but in others it may result from convergent input onto CN neurons. In 20% of units tested with two-tone stimuli, suppression of best frequency (BF) responses was tuned at least an octave below BF. These properties may underlie similar IC responses. However, other forms of spectral interaction present in IC were absent in CN: we found no facilitatory combination-sensitive interactions and very few combination-sensitive inhibitory interactions of the dominant IC type in which inhibition was tuned to 23-30 kHz. Such interactions arise above CN. Distinct forms of spectral integration thus originate at different levels of the ascending auditory pathway.
Identifier
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<a href="http://doi.org/10.1152/jn.00634.2005" target="_blank" rel="noreferrer noopener">10.1152/jn.00634.2005</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2006
Acoustic Stimulation/methods
Action Potentials/*physiology
Animals
Auditory
Brain Mapping
Brain Stem/*physiology
Chiroptera/*physiology
Cochlear Nucleus/*physiology
College of Anatomy & Neurobiology
Department of Anatomy & Neurobiology
Evoked Potentials
Gans Donald
Journal of neurophysiology
Marsh Robert A
Mesencephalon/physiology
Nataraj Kiran
NEOMED College of Medicine
Nerve Net/*physiology
Pitch Perception/*physiology
Portfors Christine V
Wakefulness/physiology
Wenstrup Jeffrey J
-
Text
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URL Address
<a href="http://doi.org/10.1152/jn.00422.2011" target="_blank" rel="noreferrer noopener">http://doi.org/10.1152/jn.00422.2011</a>
Pages
1047–1057
Issue
4
Volume
107
Dublin Core
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Title
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A novel coding mechanism for social vocalizations in the lateral amygdala.
Publisher
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Journal of neurophysiology
Date
A point or period of time associated with an event in the lifecycle of the resource
2012
2012-02
Subject
The topic of the resource
*Social Behavior; Acoustic Stimulation; Action Potentials/*physiology; Amygdala/*cytology/physiology; Animal/*physiology; Animals; Auditory Pathways/*physiology; Chiroptera; Dextrans/metabolism; Echolocation/physiology; Female; Male; Neurons/*physiology; Reaction Time/physiology; Rhodamines/metabolism; Time Factors; Vocalization
Creator
An entity primarily responsible for making the resource
Gadziola Marie A; Grimsley Jasmine M S; Shanbhag Sharad J; Wenstrup Jeffrey J
Description
An account of the resource
The amygdala plays a central role in evaluating the significance of acoustic signals and coordinating the appropriate behavioral responses. To understand how amygdalar responses modulate auditory processing and drive emotional expression, we assessed how neurons respond to and encode information that is carried within complex acoustic stimuli. We characterized responses of single neurons in the lateral nucleus of the amygdala to social vocalizations and synthetic acoustic stimuli in awake big brown bats. Neurons typically responded to most of the social vocalizations presented (mean = nine of 11 vocalizations) but differentially modulated both firing rate and response duration. Surprisingly, response duration provided substantially more information about vocalizations than did spike rate. In most neurons, variation in response duration depended, in part, on persistent excitatory discharge that extended beyond stimulus duration. Information in persistent firing duration was significantly greater than in spike rate, and the majority of neurons displayed more information in persistent firing, which was more likely to be observed in response to aggressive vocalizations (64%) than appeasement vocalizations (25%), suggesting that persistent firing may relate to the behavioral context of vocalizations. These findings suggest that the amygdala uses a novel coding strategy for discriminating among vocalizations and underscore the importance of persistent firing in the general functioning of the amygdala.
Identifier
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<a href="http://doi.org/10.1152/jn.00422.2011" target="_blank" rel="noreferrer noopener">10.1152/jn.00422.2011</a>
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Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Social Behavior
2012
Acoustic Stimulation
Action Potentials/*physiology
Amygdala/*cytology/physiology
Animal/*physiology
Animals
Auditory Pathways/*physiology
Chiroptera
College of Anatomy & Neurobiology
Department of Anatomy & Neurobiology
Dextrans/metabolism
Echolocation/physiology
Female
Gadziola Marie A
Grimsley Jasmine M S
Journal of neurophysiology
Male
NEOMED College of Medicine
Neurons/*physiology
Reaction Time/physiology
Rhodamines/metabolism
Shanbhag Sharad J
Time Factors
Vocalization
Wenstrup Jeffrey J
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.neuroscience.2012.04.069" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.neuroscience.2012.04.069</a>
Pages
154–171
Volume
217
Dublin Core
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Title
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Selectivity and persistent firing responses to social vocalizations in the basolateral amygdala.
Publisher
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Neuroscience
Date
A point or period of time associated with an event in the lifecycle of the resource
2012
2012-08
Subject
The topic of the resource
Acoustic Stimulation; Action Potentials/*physiology; Amygdala/*physiology; Animal/*physiology; Animals; Auditory/physiology; Chiroptera/*physiology; Echolocation/physiology; Evoked Potentials; Neurons/*physiology; Vocalization
Creator
An entity primarily responsible for making the resource
Peterson D C; Wenstrup J J
Description
An account of the resource
This study examined responsiveness to acoustic stimuli among neurons of the basolateral amygdala. While recording from single neurons in awake mustached bats (Pteronotus parnellii), we presented a wide range of acoustic stimuli including tonal, noise, and vocal signals. While many neurons displayed phasic or sustained responses locked to effective auditory stimuli, the majority of neurons (n=58) displayed a persistent excitatory discharge that lasted well beyond stimulus duration and filled the interval between successive stimuli. Persistent firing usually began seconds (median value, 5.4 s) after the initiation of a train of repeated stimuli and lasted, in the majority of neurons, for at least 2 min after the end of the stimulus train. Auditory-responsive amygdalar neurons were generally excited by one stimulus or very few stimuli. Most neurons did not respond well to synthetic stimuli including tones, noise bursts or frequency-modulated sweeps, but instead responded only to vocal stimuli (82 of 87 neurons). Furthermore, most neurons were highly selective among vocal stimuli. On average, neurons responded to 1.7 of 15 different syllables or syllable sequences. The largest percentage of neurons responded to a hiss-like rectangular broadband noise burst (rBNB) call associated with aggressive interactions. Responsiveness to effective vocal stimuli was reduced or eliminated when the spectrotemporal features of the stimuli were altered in a subset of neurons. Chemical activation of the medial geniculate body (MG) increased both background and evoked firing. Among 39 histologically localized recording sites, we saw no evidence of topographic organization in terms of temporal response pattern, habituation, or the affect of calls to which neurons responded. Overall, these studies demonstrate that amygdalar neurons in the mustached bat show high selectivity to vocal stimuli, and suggest that persistent firing may be an important feature of amygdalar responses to social vocalizations.
Identifier
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<a href="http://doi.org/10.1016/j.neuroscience.2012.04.069" target="_blank" rel="noreferrer noopener">10.1016/j.neuroscience.2012.04.069</a>
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Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2012
Acoustic Stimulation
Action Potentials/*physiology
Amygdala/*physiology
Animal/*physiology
Animals
Auditory/physiology
Chiroptera/*physiology
College of Anatomy & Neurobiology
Department of Anatomy & Neurobiology
Echolocation/physiology
Evoked Potentials
NEOMED College of Medicine
Neurons/*physiology
Neuroscience
Peterson D C
Vocalization
Wenstrup J J
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.neuroscience.2008.06.031" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.neuroscience.2008.06.031</a>
Pages
923–936
Issue
3
Volume
155
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Timing of sound-evoked potentials and spike responses in the inferior colliculus of awake bats.
Publisher
An entity responsible for making the resource available
Neuroscience
Date
A point or period of time associated with an event in the lifecycle of the resource
2008
2008-08
Subject
The topic of the resource
*Wakefulness; Acoustic Stimulation; Action Potentials/*physiology; Animals; Auditory Perception; Auditory/*physiology; Chiroptera/physiology; Electroencephalography; Evoked Potentials; Functional Laterality/physiology; Inferior Colliculi/*cytology; Neural Inhibition/physiology; Neurons/*physiology; Psychoacoustics; Reaction Time/*physiology/radiation effects
Creator
An entity primarily responsible for making the resource
Voytenko S V; Galazyuk A V
Description
An account of the resource
Neurons in the inferior colliculus (IC), one of the major integrative centers of the auditory system, process acoustic information converging from almost all nuclei of the auditory brain stem. During this integration, excitatory and inhibitory inputs arrive to auditory neurons at different time delays. Result of this integration determines timing of IC neuron firing. In the mammalian IC, the range of the first spike latencies is very large (5-50 ms). At present, a contribution of excitatory and inhibitory inputs in controlling neurons' firing in the IC is still under debate. In the present study we assess the role of excitation and inhibition in determining first spike response latency in the IC. Postsynaptic responses were recorded to pure tones presented at neuron's characteristic frequency or to downward frequency modulated sweeps in awake bats. There are three main results emerging from the present study: (1) the most common response pattern in the IC is hyperpolarization followed by depolarization followed by hyperpolarization, (2) latencies of depolarizing or hyperpolarizing responses to tonal stimuli are short (3-7 ms) whereas the first spike latencies may vary to a great extent (4-26 ms) from one neuron to another, and (3) high threshold hyperpolarization preceded long latency spikes in IC neurons exhibiting paradoxical latency shift. Our data also show that the onset hyperpolarizing potentials in the IC have very small jitter (\textless100 micros) across repeated stimulus presentations. The results of this study suggest that inhibition, arriving earlier than excitation, may play a role as a mechanism for delaying the first spike latency in IC neurons.
Identifier
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<a href="http://doi.org/10.1016/j.neuroscience.2008.06.031" target="_blank" rel="noreferrer noopener">10.1016/j.neuroscience.2008.06.031</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Wakefulness
2008
Acoustic Stimulation
Action Potentials/*physiology
Animals
Auditory Perception
Auditory/*physiology
Chiroptera/physiology
Department of Anatomy & Neurobiology
Electroencephalography
Evoked Potentials
Functional Laterality/physiology
Galazyuk A V
Inferior Colliculi/*cytology
NEOMED College of Medicine
Neural Inhibition/physiology
Neurons/*physiology
Neuroscience
Psychoacoustics
Reaction Time/*physiology/radiation effects
Voytenko S V