1
40
3
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Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1152/physrev.00003.2002" target="_blank" rel="noreferrer noopener">http://doi.org/10.1152/physrev.00003.2002</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
569-600
Issue
3
Volume
82
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Lung epithelial fluid transport and the resolution of pulmonary edema
Publisher
An entity responsible for making the resource available
Physiological Reviews
Date
A point or period of time associated with an event in the lifecycle of the resource
2002
2002-07
Subject
The topic of the resource
Physiology; sodium transport; tumor-necrosis-factor; alveolar liquid clearance; respiratory-distress syndrome; adenovirus-mediated transfer; active; aquaporin water channels; beta-adrenergic receptors; pseudomonas-aeruginosa pneumonia; sensitive na+ channel; surface fluorescence method
Creator
An entity primarily responsible for making the resource
Matthay M A; Folkesson H G; Clerici C
Description
An account of the resource
The discovery of mechanisms that regulate salt and water transport by the alveolar and distal airway epithelium of the lung has generated new insights into the regulation of lung fluid balance under both normal and pathological conditions. There is convincing evidence that active sodium and chloride transporters are expressed in the distal lung epithelium and are responsible for the ability of the lung to remove alveolar fluid at the time of birth as well as in the mature lung when pathological conditions lead to the development of pulmonary edema. Currently, the best described molecular transporters are the epithelial sodium channel, the cystic fibrosis transmembrane conductance regulator, Na+-K+-ATPase, and several aquaporin water channels. Both catecholamine-dependent and -independent mechanisms can upregulate isosmolar fluid transport across the distal lung epithelium. Experimental and clinical studies have made it possible to examine the role of these transporters in the resolution of pulmonary edema.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1152/physrev.00003.2002" target="_blank" rel="noreferrer noopener">10.1152/physrev.00003.2002</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
2002
Active
adenovirus-mediated transfer
alveolar liquid clearance
aquaporin water channels
beta-adrenergic receptors
Clerici C
Folkesson H G
Journal Article or Conference Abstract Publication
Matthay M A
Physiological Reviews
Physiology
pseudomonas-aeruginosa pneumonia
respiratory-distress syndrome
sensitive na+ channel
sodium transport
surface fluorescence method
tumor-necrosis-factor
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Pages
173–180
Issue
3
Volume
48
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Nephrologists' subjective attitudes towards end-of-life issues and the conduct of terminal care.
Publisher
An entity responsible for making the resource available
Clinical nephrology
Date
A point or period of time associated with an event in the lifecycle of the resource
1997
1997-09
Subject
The topic of the resource
Adult; Humans; Middle Aged; Pilot Projects; *Attitude of Health Personnel; Data Collection; *Attitude to Death; Empirical Approach; *Euthanasia; *Terminal Care; Advance Directive Adherence; Advance Directives; Death and Euthanasia; Nephrology; Withholding Treatment; Ethics; Medical; Active
Creator
An entity primarily responsible for making the resource
Rutecki G W; Cugino A; Jarjoura D; Kilner J F; Whittier F C
Description
An account of the resource
Decisions which determine the duration and outcome of terminal care should be influenced by patient autonomy. Studies suggest, however, that end-of-life decision-making is more complex than a single principle and that physicians may be responsible for selected aspects of terminal care independent of patient choice. To study how nephrologists' perceptions toward end-of-life issues may affect decision-making, we anonymously surveyed 125 of them. The study employed the straightforward terminology of "hastening death" rather than adopting the ambiguous term "euthanasia" or the narrow term "assisted suicide." Subjective physician profiles demonstrated that nephrologists who are less comfortable with dying patients were significantly less likely to report that they omitted life-prolonging measures (p = 0.02) and more likely to report that they would not initiate measures in order to hasten death even were it legal (p = 0.04). Ninety-eight percent of nephrologists reported omissions in terminal care with patient knowledge and 80% without patient knowledge. In contrast, forty-three percent of the nephrologists said that were it to become legal to initiate measures in order to hasten death, they would "never" do so. The ethical framework utilized for discontinuation of dialysis decisions incorporated medical benefit (cancer as criterion, 48%; multisystem complications, 84%; dementia 79%) and quality of life criteria. Twenty-five percent of nephrologists admitted difficulty with advance directives if the directives clashed with heir beliefs. ESRD end-of-life decision-making in the USA may be altered by the subjective characteristics of nephrologists. In particular, nephrologists' level of discomfort with patient mortality is linked with their reported management of terminal patients.
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Attitude of Health Personnel
*Attitude to Death
*Euthanasia
*Terminal Care
1997
Active
Adult
Advance Directive Adherence
Advance Directives
Clinical nephrology
Cugino A
Data Collection
Death and Euthanasia
Department of Internal Medicine
Empirical Approach
Ethics
Humans
Jarjoura D
Kilner J F
Medical
Middle Aged
NEOMED College of Medicine
Nephrology
Pilot Projects
Rutecki G W
Whittier F C
Withholding Treatment
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1080/13550280600970417" target="_blank" rel="noreferrer noopener">http://doi.org/10.1080/13550280600970417</a>
Pages
365–374
Issue
5
Volume
12
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Innate and adaptive host response during the initial phase of herpes simplex virus encephalitis in the neonatal mouse.
Publisher
An entity responsible for making the resource available
Journal of neurovirology
Date
A point or period of time associated with an event in the lifecycle of the resource
2006
2006-10
Subject
The topic of the resource
*Immunity; Active; Animal; Animals; B-Lymphocytes/immunology; Brain/pathology/*virology; Cell Line; Disease Models; Encephalitis; Herpes Simplex/*immunology; Innate; Mice; Microglia/pathology/virology; Newborn; Simplexvirus/*isolation & purification/physiology; T-Lymphocytes/immunology; Virus Replication
Creator
An entity primarily responsible for making the resource
Kumaraswamy Guttalu K; Fu Ming Ming; Docherty John J
Description
An account of the resource
To study early events of neonatal herpes simplex virus (HSV) encephalitis and its sequelae, the authors induced a controlled infection in the brains of mice using HSVgH, a genetically modified Disabled Infective Single Cycle virus. Neonatal Balb/C mice were infected with various amounts of HSVgH- virus by intracerebral injection. Results showed that the survival of infected mice was dependent on the amount of virus injected. Infection with 200,000 plaque forming units (pfu) of HSVgH-, virus resulted in 0% survival, whereas 25,000 pfu resulted in 75% survival. If the mice died, 98% of the deaths occurred between 3 and 7 days after infection. Replication competent virus was recovered from 20% of mice brains infected with 25,000 pfu of HSVgH-. Neutralizing antibodies were not detected 6 weeks post infection in sera of mice, which survived infection with 25,000 pfu of HSVgH-. LacZ histochemistry and immunoperoxidase staining using anti-HSV and anti- beta-galactosidase antibodies revealed that the infection was limited to the site of injection. Tissue destruction was observed at the site of inoculation 3 days post infection using cresyl violet staining. At 3 days post infection adjacent sections showed positive cells for viral antigens and apoptotic cells in the infected area. Immunoperoxidase staining using antibodies to surface markers showed microglial activation beginning on day 1 and astrocyte proliferation beginning on day 3 post infection. B and T lymphocytes were not detected on day 1 through 7 post infection. This controlled experimental HSV infection suggests a limited non-specific early host response in the neonate to HSV encephalitis.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1080/13550280600970417" target="_blank" rel="noreferrer noopener">10.1080/13550280600970417</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Immunity
2006
Active
Animal
Animals
B-Lymphocytes/immunology
Brain/pathology/*virology
Cell Line
Disease Models
Docherty John J
Encephalitis
Fu Ming Ming
Herpes Simplex/*immunology
Innate
Journal of neurovirology
Kumaraswamy Guttalu K
Mice
Microglia/pathology/virology
Newborn
Simplexvirus/*isolation & purification/physiology
T-Lymphocytes/immunology
Virus Replication