1
40
2
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Text
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URL Address
<a href="http://doi.org/10.1152/jappl.1992.73.6.2662" target="_blank" rel="noreferrer noopener">http://doi.org/10.1152/jappl.1992.73.6.2662</a>
Pages
2662–2667
Issue
6
Volume
73
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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Reduced vascular responsiveness after a single bout of dynamic exercise in the conscious rabbit.
Publisher
An entity responsible for making the resource available
Journal of applied physiology (Bethesda, Md. : 1985)
Date
A point or period of time associated with an event in the lifecycle of the resource
1992
1992-12
Subject
The topic of the resource
Adenosine/pharmacology; Adrenergic/physiology; Animals; Blood Vessels/*physiology; Dose-Response Relationship; Drug; Hindlimb/physiology; In Vitro Techniques; Isoproterenol/pharmacology; Phenylephrine/pharmacology; Physical Exertion/*physiology; Pressoreceptors/physiology; Purinergic/physiology; Rabbits; Receptors; Reflex/physiology; Regional Blood Flow/physiology
Creator
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Howard M G; DiCarlo S E
Description
An account of the resource
We measured agonist-induced changes in the iliac artery blood flow velocity (IFV) independent of baroreflex-mediated compensatory mechanisms in chronically instrumented New Zealand White rabbits (n = 8). Animals were instrumented with a Doppler flow probe around the right common iliac artery. A Teflon catheter was inserted into the right iliolumbar artery for local infusion of the vasoactive agonists. Another Teflon catheter was inserted in the left femoral artery for the measurement of pulsatile and mean arterial (MAP) blood pressures and heart rate (HR). The alpha-adrenergic receptor agonist phenylephrine (PE, 1.32-10.0 micrograms), the beta 1- and beta 2-adrenergic receptor agonist isoproterenol (IP, 0.022-0.11 micrograms), and the purinergic receptor agonist adenosine (AD, 10.0-100.0 micrograms) were injected into the functionally isolated hindlimb, and dose-response curves were generated. Changes in IFV were obtained without changes in MAP or HR. Exercise increased HR, MAP, and IFV (65.3 +/- 7.1 beats/min, 11.1 +/- 2.2 mmHg, and 2.2 +/- 0.3 kHz, respectively). The maximum responses to PE, AD, and IP were reduced 29.0 +/- 6.7, 50.7 +/- 8.5, and 61.0 +/- 8.1%, respectively, after exercise. In conclusion, exercise attenuated adrenergic and purinergic receptor-mediated vascular responses in the intact conscious rabbit.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1152/jappl.1992.73.6.2662" target="_blank" rel="noreferrer noopener">10.1152/jappl.1992.73.6.2662</a>
Rights
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1992
Adenosine/pharmacology
Adrenergic/physiology
Animals
Blood Vessels/*physiology
DiCarlo S E
Dose-Response Relationship
Drug
Hindlimb/physiology
Howard M G
In Vitro Techniques
Isoproterenol/pharmacology
Journal of applied physiology (Bethesda, Md. : 1985)
Phenylephrine/pharmacology
Physical Exertion/*physiology
Pressoreceptors/physiology
Purinergic/physiology
Rabbits
Receptors
Reflex/physiology
Regional Blood Flow/physiology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0014-2999(91)90801-v" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0014-2999(91)90801-v</a>
Pages
129–131
Issue
1
Volume
203
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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Cholinergic disinhibition in area CA1 of the rat hippocampus is not mediated by receptors located on inhibitory neurons.
Publisher
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European journal of pharmacology
Date
A point or period of time associated with an event in the lifecycle of the resource
1991
1991-10
Subject
The topic of the resource
2-Amino-5-phosphonovalerate/pharmacology; Action Potentials/drug effects; Adenosine/pharmacology; Animals; Baclofen/pharmacology; Carbachol/pharmacology; Cholinergic/*drug effects; Evoked Potentials/drug effects; GABA-A Receptor Antagonists; Hippocampus/*drug effects; In Vitro Techniques; Membrane Potentials/drug effects; Neurons/*drug effects; Parasympathetic Nervous System/*drug effects; Phorbol Esters/pharmacology; Quinoxalines/pharmacology; Rats; Receptors; Synaptic Transmission/physiology
Creator
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Lambert N A; Teyler T J
Description
An account of the resource
We studied the effects of carbamylcholine (carbachol; CCh) on monosynaptic inhibitory postsynaptic potentials (IPSPs) evoked in the presence of the excitatory amino acid receptor antagonists 6,7-dinitroquinoxaline-2,3-dione (DNQX) and D,L-2-amino-5-phosphonovalerate (APV). CCh (30 microM) blocked late afterhyperpolarizations but did not depress GABAA receptor-mediated fast monosynaptic IPSPs or GABAB receptor-mediated late monosynaptic IPSPs. In the presence of CCh the GABAB receptor agonist (+/- )-baclofen (2 microM) reversibly hyperpolarized pyramidal neurons and depressed monosynaptic IPSPs as under control conditions. Phorbol-12,13-diacetate (PDAc; 10 microM) increased fast and depressed late monosynaptic IPSPs, and prevented depression of IPSPs by baclofen. These results suggest that cholinergic disinhibition in area CA1 of the hippocampus results from decreased synaptic excitation of inhibitory neurons.
Identifier
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<a href="http://doi.org/10.1016/0014-2999(91)90801-v" target="_blank" rel="noreferrer noopener">10.1016/0014-2999(91)90801-v</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1991
2-Amino-5-phosphonovalerate/pharmacology
Action Potentials/drug effects
Adenosine/pharmacology
Animals
Baclofen/pharmacology
Carbachol/pharmacology
Cholinergic/*drug effects
European journal of pharmacology
Evoked Potentials/drug effects
GABA-A Receptor Antagonists
Hippocampus/*drug effects
In Vitro Techniques
Lambert N A
Membrane Potentials/drug effects
Neurons/*drug effects
Parasympathetic Nervous System/*drug effects
Phorbol Esters/pharmacology
Quinoxalines/pharmacology
Rats
Receptors
Synaptic Transmission/physiology
Teyler T J