1
40
12
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0304-3940(91)90576-f" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0304-3940(91)90576-f</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
229-232
Issue
2
Volume
133
Search for Full-text
Locate full-text within NEOMED Library's e-journal collections
<p>Users with a NEOMED Library login can search for full-text journal articles at the following url: <a href="https://libraryguides.neomed.edu/home">https://libraryguides.neomed.edu/home</a></p>
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
EVALUATION OF THE INTERACTIONS OF SEROTONERGIC AND ADRENERGIC-DRUGS WITH MU, DELTA, AND KAPPA OPIOID BINDING-SITES
Publisher
An entity responsible for making the resource available
Neuroscience Letters
Date
A point or period of time associated with an event in the lifecycle of the resource
1991
1991-12
Subject
The topic of the resource
receptor; Neurosciences & Neurology; involvement; rat-brain; morphine; dorsal horn; adrenergic; cord; mu opioid; nociceptive; periaqueductal gray; phentolamine; raphe magnus stimulation; reflexes; serotonergic; spinal antinociceptive action; spiroxatrine; delta opioid; kappa opioid
Creator
An entity primarily responsible for making the resource
Monroe P J; Perschke S E; Crisp T; Smith D J
Description
An account of the resource
Several serotonergic and adrenergic agents were tested for an ability to interact with mu, delta, and kappa opioid binding sites. Spiroxatrine interacted nearly equipotently with all three opioid subtypes, yielding K(i) values near 110 nM. A number of other serotonergic and adrenergic agents interacted with affinities in the 1-50-mu-M range. Most of the other compounds tested in this study were found to compete for opioid binding to some degree, though not achieving a 50% inhibition of binding at concentrations up to 100-mu-M. If this interaction between monoaminergic agents and opioid receptors is found to have functional significance, it must be considered in the interpretation of results from studies using these agents to evaluate the contribution of monoaminergic systems to opioid-mediated events.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0304-3940(91)90576-f" target="_blank" rel="noreferrer noopener">10.1016/0304-3940(91)90576-f</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
1991
Adrenergic
cord
Crisp T
delta opioid
dorsal horn
involvement
Journal Article or Conference Abstract Publication
kappa opioid
Monroe P J
MORPHINE
mu opioid
Neuroscience letters
Neurosciences & Neurology
nociceptive
periaqueductal gray
Perschke S E
phentolamine
raphe magnus stimulation
rat-brain
Receptor
reflexes
serotonergic
Smith D J
spinal antinociceptive action
spiroxatrine
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Pages
20–31
Volume
309
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Discriminative stimulus effect of phenylephrine.
Publisher
An entity responsible for making the resource available
Archives internationales de pharmacodynamie et de therapie
Date
A point or period of time associated with an event in the lifecycle of the resource
1991
1991-02
Subject
The topic of the resource
Male; Animals; Rats; Cues; Adrenergic alpha-Antagonists/pharmacology; Discrimination (Psychology)/*drug effects; Reinforcement Schedule; Phenylephrine/*pharmacology; Adrenergic alpha-Agonists/pharmacology; Dose-Response Relationship; Drug; Inbred Strains; Receptors; Generalization; Stimulus/drug effects; Adrenergic; alpha/drug effects
Creator
An entity primarily responsible for making the resource
Schechter M D
Description
An account of the resource
Rats were trained to discriminate phenylephrine in a two-lever, food-motivated operant task by increasing the i.p. administered training dose from 0.8 to 2 mg/kg. Stable discrimination to 2 mg/kg phenylephrine was established and testing of 0.5-2.5 mg/kg was shown to be dose-responsive and allowed for a calculated ED50 value of 0.87 mg/kg. Administration of methoxamine (0.5-6 mg/kg), another alpha 1-adrenoceptor agonist, produced a dose-responsive generalization, whereas only the lowest (0.04 mg/kg) and highest (0.12 mg/kg) doses of the alpha
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1991
Adrenergic
Adrenergic alpha-Agonists/pharmacology
Adrenergic alpha-Antagonists/pharmacology
alpha/drug effects
Animals
Archives internationales de pharmacodynamie et de therapie
Cues
Discrimination (Psychology)/*drug effects
Dose-Response Relationship
Drug
Generalization
Inbred Strains
Male
Phenylephrine/*pharmacology
Rats
Receptors
Reinforcement Schedule
Schechter M D
Stimulus/drug effects
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Pages
760–766
Issue
2
Volume
12
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Oxytocin induces preservation of social recognition in male rats by activating alpha-adrenoceptors of the olfactory bulb.
Publisher
An entity responsible for making the resource available
The European journal of neuroscience
Date
A point or period of time associated with an event in the lifecycle of the resource
2000
2000-02
Subject
The topic of the resource
Male; Animals; *Social Behavior; Rats; Adrenergic beta-Antagonists/pharmacology; Adrenergic beta-Agonists/pharmacology; Microdialysis; Adrenergic alpha-Antagonists/pharmacology; Phentolamine/pharmacology; Isoproterenol/pharmacology; Clonidine/pharmacology; Norepinephrine/pharmacology; Social Dominance; Adrenergic alpha-Agonists/pharmacology; Memory/*drug effects/physiology; Olfactory Bulb/*drug effects/physiology; Oxytocin/*pharmacology; Timolol/pharmacology; Receptors; Adrenergic; Wistar; alpha/*drug effects/physiology; Oxytocin/drug effects/*physiology
Creator
An entity primarily responsible for making the resource
Dluzen D E; Muraoka S; Engelmann M; Ebner K; Landgraf R
Description
An account of the resource
In this report, a series of four experiments was performed to evaluate the relationship between the olfactory bulb norepinephrine system and intra-olfactory bulb infusion of oxytocin in the preservation of social memory responses. The present data indicate that oxytocin exerts this preservation of social recognition through a specific, receptor-mediated mechanism within the olfactory bulb (experiment 1). The involvement of the olfactory bulb norepinephrine system is revealed by the demonstration that retrodialysis of oxytocin into the olfactory bulb increases norepinephrine release (experiment 4). Our data suggest that the increased output of olfactory bulb norepinephrine resulting from oxytocin appears to activate alpha-adrenoceptors to produce this preservation in recognition because infusions of clonidine into the olfactory bulb preserve recognition responses in a manner similar to that observed with oxytocin (experiment 2). In addition, a co-infusion of oxytocin with phentolamine abolishes recognition responses (experiment 3). Accordingly, this model affords the opportunity to study neuropeptide-catecholamine interactions, link these interactions with a specific behavioural outcome and identify a novel function/site of action for oxytocin in the male.
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Social Behavior
2000
Adrenergic
Adrenergic alpha-Agonists/pharmacology
Adrenergic alpha-Antagonists/pharmacology
Adrenergic beta-Agonists/pharmacology
Adrenergic beta-Antagonists/pharmacology
alpha/*drug effects/physiology
Animals
Clonidine/pharmacology
Dluzen D E
Ebner K
Engelmann M
Isoproterenol/pharmacology
Landgraf R
Male
Memory/*drug effects/physiology
Microdialysis
Muraoka S
Norepinephrine/pharmacology
Olfactory Bulb/*drug effects/physiology
Oxytocin/*pharmacology
Oxytocin/drug effects/*physiology
Phentolamine/pharmacology
Rats
Receptors
Social Dominance
The European journal of neuroscience
Timolol/pharmacology
Wistar
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1249/00005768-199210000-00006" target="_blank" rel="noreferrer noopener">http://doi.org/10.1249/00005768-199210000-00006</a>
Pages
1102–1107
Issue
10
Volume
24
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Acute exercise attenuates phenylephrine-induced contraction of rabbit isolated aortic rings.
Publisher
An entity responsible for making the resource available
Medicine and science in sports and exercise
Date
A point or period of time associated with an event in the lifecycle of the resource
1992
1992-10
Subject
The topic of the resource
Animals; Rabbits; In Vitro Techniques; Phenylephrine/*pharmacology; Aorta/physiology; Muscle Contraction/*drug effects; Dose-Response Relationship; Drug; Muscle; Receptors; Animal; Smooth; Adrenergic; *Physical Conditioning; alpha/physiology; Vascular/*drug effects/physiology
Creator
An entity primarily responsible for making the resource
Howard M G; DiCarlo S E; Stallone J N
Description
An account of the resource
Factors associated with a single bout of dynamic exercise (increased circulating catecholamines, increased body temperature, and decreased pH) are known to attenuate the vascular response to alpha-adrenergic receptor activation. Therefore, we postulate that an acute bout of dynamic exercise may decrease the vascular response to catecholamines. To test this hypothesis, we evaluated contractile responsiveness to phenylephrine (PE) in aortae of two groups of New Zealand white rabbits, a control group (no exercise) and an exercise group (treadmill running, 24m.min-1; 16 +/- 2.0 min). Aortic rings were prepared from age-matched control (N = 6) and exercise rabbits (N = 5) and mounted for isometric tension recording (in Krebs-Henseleit-bicarbonate solution, 37 degrees C, 1.5 g passive tension). After equilibration (2 h) a cumulative concentration-response curve to PE (10(-7) M-10(-2) M) was obtained. The results demonstrate that a single bout of dynamic exercise attenuates (P \textless 0.05) the maximal contractile tension (2,457 +/- 120 vs 3,620 +/- 321 mg tension.mg-1 ring wt), gain (602 +/- 31 vs 878 +/- 87 mg.M-1 PE), and rate of contraction (6.2 +/- 0.3 vs 4.7 +/- 0.3 mg tension.s-1). In addition, contraction threshold was significantly increased in exercise (2.6 +/- 0.4 x 10(-6) M) vs control aortae (1.03 +/- 0.4 x 10(-6) M). A single bout of dynamic exercise did not alter the contractile response to 70 mM KCl (3,555 +/- 270 vs 3,083 +/- 233 mg tension.mg-1 ring weight). These data suggest that an acute bout of dynamic exercise significantly attenuates alpha-adrenergic receptor-mediated contraction of vascular smooth muscle.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1249/00005768-199210000-00006" target="_blank" rel="noreferrer noopener">10.1249/00005768-199210000-00006</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Physical Conditioning
1992
Adrenergic
alpha/physiology
Animal
Animals
Aorta/physiology
DiCarlo S E
Dose-Response Relationship
Drug
Howard M G
In Vitro Techniques
Medicine and science in sports and exercise
Muscle
Muscle Contraction/*drug effects
Phenylephrine/*pharmacology
Rabbits
Receptors
Smooth
Stallone J N
Vascular/*drug effects/physiology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1152/jappl.1999.87.2.611" target="_blank" rel="noreferrer noopener">http://doi.org/10.1152/jappl.1999.87.2.611</a>
Pages
611–618
Issue
2
Volume
87
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Effect of epinephrine on alveolar liquid clearance in the rat.
Publisher
An entity responsible for making the resource available
Journal of applied physiology (Bethesda, Md. : 1985)
Date
A point or period of time associated with an event in the lifecycle of the resource
1999
1999-08
Subject
The topic of the resource
Adrenergic; Adrenergic beta-Agonists/*pharmacology; Amiloride/pharmacology; Animals; beta/metabolism; Bronchoalveolar Lavage Fluid/chemistry; Epinephrine/blood/*pharmacology; Male; Norepinephrine/blood; Propranolol/pharmacology; Pulmonary Alveoli/*drug effects; Rats; Receptors; Serum Albumin/metabolism; Sprague-Dawley; Time Factors
Creator
An entity primarily responsible for making the resource
Charron P D; Fawley J P; Maron M B
Description
An account of the resource
Endogenous epinephrine has been found to increase alveolar liquid clearance (ALC) in several pulmonary edema models. In this study, we infused epinephrine intravenously for 1 h in anesthetized rats to produce plasma epinephrine concentrations commonly observed in this species under stressful conditions and measured ALC by mass balance. Epinephrine increased ALC from 31.5 +/- 3.2 to 48.9 +/- 1.1 (SE)% of the instilled volume (P \textless 0.05). The increased ALC was prevented by either propranolol or amiloride. To determine whether ALC returns to normal after plasma epinephrine concentration normalizes, we measured ALC 2 h after stopping an initial 1-h epinephrine infusion and found ALC to be at baseline values. Finally, to determine whether desensitization of the liquid clearance response occurs, we evaluated the effects of both repeated 1-h infusions and a continuous 4-h infusion of epinephrine on ALC and found no reduction in ALC under either condition. We conclude that epinephrine increases ALC by stimulating beta-adrenoceptors and sodium transport, that the increase is reversible once plasma epinephrine concentration normalizes, and that desensitization of the ALC response does not appear to occur after 4 h of continuous epinephrine exposure.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1152/jappl.1999.87.2.611" target="_blank" rel="noreferrer noopener">10.1152/jappl.1999.87.2.611</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1999
Adrenergic
Adrenergic beta-Agonists/*pharmacology
Amiloride/pharmacology
Animals
beta/metabolism
Bronchoalveolar Lavage Fluid/chemistry
Charron P D
Epinephrine/blood/*pharmacology
Fawley J P
Journal of applied physiology (Bethesda, Md. : 1985)
Male
Maron M B
Norepinephrine/blood
Propranolol/pharmacology
Pulmonary Alveoli/*drug effects
Rats
Receptors
Serum Albumin/metabolism
Sprague-Dawley
Time Factors
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1152/ajplung.90629.2008" target="_blank" rel="noreferrer noopener">http://doi.org/10.1152/ajplung.90629.2008</a>
Pages
L487–495
Issue
3
Volume
297
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Beta-adrenoceptor stimulation of alveolar fluid clearance is increased in rats with heart failure.
Publisher
An entity responsible for making the resource available
American journal of physiology. Lung cellular and molecular physiology
Date
A point or period of time associated with an event in the lifecycle of the resource
2009
2009-09
Subject
The topic of the resource
Adrenergic; Animals; beta/*metabolism; Body Fluids/*metabolism; Epithelial Cells/drug effects/metabolism/pathology; Gene Expression Regulation/drug effects; Heart Failure/blood/diagnostic imaging/*metabolism/*pathology; Hormones/blood; Hyperplasia; Ion Channels/genetics/metabolism; Male; Messenger/genetics/metabolism; Myocardial Infarction/blood/diagnostic imaging/pathology; Pulmonary Alveoli/drug effects/*pathology; Rats; Receptors; RNA; Sprague-Dawley; Terbutaline/pharmacology; Ultrasonography
Creator
An entity primarily responsible for making the resource
Maron Michael B; Luther Daniel J; Pilati Charles F; Ohanyan Vahagn; Li Tianbo; Koshy Shyny; Horne Walter I; Meszaros J Gary; Walro Jon M; Folkesson Hans G
Description
An account of the resource
The alveolar epithelium plays a critical role in resolving pulmonary edema. We thus hypothesized that its function might be upregulated in rats with heart failure, a condition that severely challenges the lung's ability to maintain fluid balance. Heart failure was induced by left coronary artery ligation. Echocardiographic and cardiovascular hemodynamics confirmed its development at 16 wk postligation. At that time, alveolar fluid clearance was measured by an increase in protein concentration over 1 h of a 5% albumin solution instilled into the lungs. Baseline alveolar fluid clearance was similar in heart failure and age-matched control rats. Terbutaline was added to the instillate to determine whether heart failure rats responded to beta-adrenoceptor stimulation. Alveolar fluid clearance in heart failure rats was increased by 194% after terbutaline stimulation compared with a 153% increase by terbutaline in control rats. To determine the mechanisms responsible for this accelerated alveolar fluid clearance, we measured ion transporter expression (ENaC, Na-K- ATPase, CFTR). No significant upregulation was observed for these ion transporters in the heart failure rats. Lung morphology showed significant alveolar epithelial type II cell hyperplasia in heart failure rats. Thus, alveolar epithelial type II cell hyperplasia is the likely explanation for the increased terbutaline-stimulated alveolar fluid clearance in heart failure rats. These data provide evidence for previously unrecognized mechanisms that can protect against or hasten resolution of alveolar edema in heart failure.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1152/ajplung.90629.2008" target="_blank" rel="noreferrer noopener">10.1152/ajplung.90629.2008</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2009
Adrenergic
American journal of physiology. Lung cellular and molecular physiology
Animals
beta/*metabolism
Body Fluids/*metabolism
Department of Integrative Medical Sciences
Epithelial Cells/drug effects/metabolism/pathology
Folkesson Hans G
Gene Expression Regulation/drug effects
Heart Failure/blood/diagnostic imaging/*metabolism/*pathology
Hormones/blood
Horne Walter I
Hyperplasia
Ion Channels/genetics/metabolism
Koshy Shyny
Li Tianbo
Luther Daniel J
Male
Maron Michael B
Messenger/genetics/metabolism
Meszaros J Gary
Myocardial Infarction/blood/diagnostic imaging/pathology
NEOMED College of Medicine
Ohanyan Vahagn
Pilati Charles F
Pulmonary Alveoli/drug effects/*pathology
Rats
Receptors
RNA
Sprague-Dawley
Terbutaline/pharmacology
Ultrasonography
Walro Jon M
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1152/ajplung.00381.2001" target="_blank" rel="noreferrer noopener">http://doi.org/10.1152/ajplung.00381.2001</a>
Pages
L666–674
Issue
4
Volume
282
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Prolonged isoproterenol infusion impairs the ability of beta(2)-agonists to increase alveolar liquid clearance.
Publisher
An entity responsible for making the resource available
American journal of physiology. Lung cellular and molecular physiology
Date
A point or period of time associated with an event in the lifecycle of the resource
2002
2002-04
Subject
The topic of the resource
Adrenergic; Adrenergic beta-Agonists/*pharmacology; Animals; beta/metabolism; Down-Regulation/drug effects; Drug Interactions; Epithelial Cells/metabolism; Extravascular Lung Water/*metabolism; Isoproterenol/*pharmacology; Male; Pulmonary Alveoli/cytology/*metabolism; Pulmonary Circulation/physiology; Pulmonary Edema/metabolism; Rats; Receptors; Respiratory Mucosa/cytology/*metabolism; Sprague-Dawley; Terbutaline/pharmacology
Creator
An entity primarily responsible for making the resource
Morgan Eric E; Hodnichak Cheryl M; Stader Sonya M; Maender Kay C; Boja John W; Folkesson Hans G; Maron Michael B
Description
An account of the resource
We determined if prolonged isoproterenol (Iso) infusion in rats impaired the ability of the beta(2)-adrenergic agonist terbutaline to increase alveolar liquid clearance (ALC). We infused rats with Iso (at rates of 4, 40, or 400 microg.kg(-1).h(-1)) or vehicle (0.001 N HCl) for 48 h using subcutaneously implanted miniosmotic pumps. After this time, the rats were anesthetized, and ALC was determined (by mass-balance after instillation of Ringer lactate containing albumin into the lungs) under baseline conditions and after terbutaline administration. Baseline and terbutaline-stimulated ALC in vehicle-infused rats averaged, respectively, 19.6 +/- 1.2% (SE) and 44.7 +/- 1.5%/h. The ability of terbutaline to increase ALC was eliminated at 400 microg.kg(-1).h(-1)Iso, inhibited by 26% at 40 microg.kg(-1).h(-1) Iso, and was not affected by 4 microg.kg(-1).h(-1) Iso. beta-adrenergic receptor (betaAR) density of freshly isolated alveolar epithelial type II (ATII) cells from Iso-infused rats was reduced by the 40 and 400 microg.kg(-1).h(-1) infusion rates. These data demonstrate that prolonged exposure to beta-agonists can impair the ability of beta(2)-agonists to stimulate ALC and produce ATII cell betaAR downregulation.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1152/ajplung.00381.2001" target="_blank" rel="noreferrer noopener">10.1152/ajplung.00381.2001</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2002
Adrenergic
Adrenergic beta-Agonists/*pharmacology
American journal of physiology. Lung cellular and molecular physiology
Animals
beta/metabolism
Boja John W
Down-Regulation/drug effects
Drug Interactions
Epithelial Cells/metabolism
Extravascular Lung Water/*metabolism
Folkesson Hans G
Hodnichak Cheryl M
Isoproterenol/*pharmacology
Maender Kay C
Male
Maron Michael B
Morgan Eric E
Pulmonary Alveoli/cytology/*metabolism
Pulmonary Circulation/physiology
Pulmonary Edema/metabolism
Rats
Receptors
Respiratory Mucosa/cytology/*metabolism
Sprague-Dawley
Stader Sonya M
Terbutaline/pharmacology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1152/ajplung.00339.2002" target="_blank" rel="noreferrer noopener">http://doi.org/10.1152/ajplung.00339.2002</a>
Pages
L578–583
Issue
3
Volume
285
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Postreceptor defects in alveolar epithelial beta-adrenergic signaling after prolonged isoproterenol infusion.
Publisher
An entity responsible for making the resource available
American journal of physiology. Lung cellular and molecular physiology
Date
A point or period of time associated with an event in the lifecycle of the resource
2003
2003-09
Subject
The topic of the resource
8-Bromo Cyclic Adenosine Monophosphate/pharmacology; Adenylyl Cyclases/metabolism; Adrenergic; Adrenergic beta-Agonists/*pharmacology; Animals; beta/*metabolism; Colforsin/pharmacology; Cyclic AMP-Dependent Protein Kinase Type II; Cyclic AMP-Dependent Protein Kinases/metabolism; Cyclic AMP/metabolism; Extravascular Lung Water/metabolism; Isoproterenol/*pharmacology; Male; Pulmonary Alveoli/*drug effects/*metabolism; Pulmonary Edema/metabolism; Rats; Receptors; Respiratory Mucosa/drug effects/metabolism; Signal Transduction/drug effects; Sprague-Dawley
Creator
An entity primarily responsible for making the resource
Morgan Eric E; Stader Sonya M; Hodnichak Cheryl M; Mavrich Kate E; Folkesson Hans G; Maron Michael B
Description
An account of the resource
We previously found that prolonged isoproterenol (Iso) infusion in rats impaired the ability of beta-adrenoceptor (beta-AR) agonists to increase alveolar liquid clearance (ALC). Here, we determined if postreceptor defects in beta-AR signaling contribute to this impairment. Iso was infused using subcutaneous miniosmotic pumps (4, 40, or 400 microg. kg-1. h-1) in rats for 48 h. At this time, forskolin-stimulated ALC was measured by mass balance. Forskolin-stimulated ALC [33.4 +/- 2.1%/h (mean +/- SE) in vehicle-infused rats] was reduced by 25 and 38%, respectively, after the 40 and 400 microg. kg-1. h-1 Iso infusions. The ability of forskolin to increase cAMP was reduced by 70% in alveolar type II (ATII) cells isolated from rats infused with 400 microg. kg-1. h-1 Iso. Additionally, the ability of the stable cAMP analog 8-bromoadenosine-3',5'-cyclic monophosphorothioate, Sp-isomer, to increase ALC (48.7 +/- 3.0% in vehicle-infused rats) was reduced by 25 and 51%, respectively, after the 40 and 400 microg. kg-1. h-1 infusions. Finally, the ability of cAMP to increase protein kinase A activity was eliminated in ATII cells isolated from rats infused with Iso at 400 microg. kg-1. h-1. These data demonstrate that prolonged beta-AR agonist exposure can impair alveolar epithelial beta-AR signaling downstream of the beta-AR.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1152/ajplung.00339.2002" target="_blank" rel="noreferrer noopener">10.1152/ajplung.00339.2002</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2003
8-Bromo Cyclic Adenosine Monophosphate/pharmacology
Adenylyl Cyclases/metabolism
Adrenergic
Adrenergic beta-Agonists/*pharmacology
American journal of physiology. Lung cellular and molecular physiology
Animals
beta/*metabolism
Colforsin/pharmacology
Cyclic AMP-Dependent Protein Kinase Type II
Cyclic AMP-Dependent Protein Kinases/metabolism
Cyclic AMP/metabolism
Extravascular Lung Water/metabolism
Folkesson Hans G
Hodnichak Cheryl M
Isoproterenol/*pharmacology
Male
Maron Michael B
Mavrich Kate E
Morgan Eric E
Pulmonary Alveoli/*drug effects/*metabolism
Pulmonary Edema/metabolism
Rats
Receptors
Respiratory Mucosa/drug effects/metabolism
Signal Transduction/drug effects
Sprague-Dawley
Stader Sonya M
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1152/ajplung.00022.2006" target="_blank" rel="noreferrer noopener">http://doi.org/10.1152/ajplung.00022.2006</a>
Pages
L252–256
Issue
2
Volume
291
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Impaired alveolar liquid clearance after 48-h isoproterenol infusion spontaneously recovers by 96 h of continuous infusion.
Publisher
An entity responsible for making the resource available
American journal of physiology. Lung cellular and molecular physiology
Date
A point or period of time associated with an event in the lifecycle of the resource
2006
2006-08
Subject
The topic of the resource
*Pulmonary Alveoli/drug effects/metabolism; Adrenergic; Adrenergic beta-Antagonists/pharmacology; Animals; beta-2/metabolism; Bronchodilator Agents/administration & dosage/*pharmacology; Isoproterenol/administration & dosage/*pharmacology; Lung/drug effects/metabolism; Male; Propranolol/pharmacology; Rats; Receptors; Sprague-Dawley; Terbutaline/pharmacology; Time Factors
Creator
An entity primarily responsible for making the resource
Maron Michael B; Folkesson Hans G; Stader Sonya M; Hodnichak Cheryl M
Description
An account of the resource
We previously demonstrated that 48-h isoproterenol (Iso) infusion in rats impaired the ability of beta-adrenoceptor (beta-AR) agonists to increase alveolar liquid clearance (ALC). In this study, we determined whether this impairment persisted over longer time periods by infusing 400 mug.kg(-1).h(-1) Iso by osmotic minipump for 24-144 h (n = 6-7/group). ALC in control rats was 19.0 +/- 2.4 (SD)% of instilled volume absorbed per hour. In Iso-infused rats, ALC was elevated at 24 h (34.9 +/- 2.4%) and decreased at 48 h (15.2 +/- 4.4%) and had recovered to 24 h values at 96 h (37.3 +/- 3.8%) and 144 h (35.2 +/- 3.3%). Plasma Iso concentrations remained elevated at all Iso infusion times. Peripheral lung beta(2)-AR expression exhibited a parallel time course, with a reduction in expression observed at 48 h, followed by an increase to 24 h values at 96 and 144 h. Propranolol prevented the increase in ALC observed at 96 and 144 h, indicating that the recovery in ALC was mediated by a recovery of beta-AR function and beta-AR signaling. ALC at 96 and 144 h could not be further increased by terbutaline, indicating that ALC was maximally stimulated. These data indicate that recovery of beta-AR-stimulated ALC can occur in the continued presence of Iso and is mediated by a recovery of the ability of the distal lung epithelium to respond to beta-AR stimulation.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1152/ajplung.00022.2006" target="_blank" rel="noreferrer noopener">10.1152/ajplung.00022.2006</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Pulmonary Alveoli/drug effects/metabolism
2006
Adrenergic
Adrenergic beta-Antagonists/pharmacology
American journal of physiology. Lung cellular and molecular physiology
Animals
beta-2/metabolism
Bronchodilator Agents/administration & dosage/*pharmacology
Folkesson Hans G
Hodnichak Cheryl M
Isoproterenol/administration & dosage/*pharmacology
Lung/drug effects/metabolism
Male
Maron Michael B
Propranolol/pharmacology
Rats
Receptors
Sprague-Dawley
Stader Sonya M
Terbutaline/pharmacology
Time Factors
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1124/jpet.106.111369" target="_blank" rel="noreferrer noopener">http://doi.org/10.1124/jpet.106.111369</a>
Pages
877–884
Issue
2
Volume
320
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
A noninflammatory interleukin-1beta fragment stimulates fetal lung fluid absorption in guinea pigs.
Publisher
An entity responsible for making the resource available
The Journal of pharmacology and experimental therapeutics
Date
A point or period of time associated with an event in the lifecycle of the resource
2007
2007-02
Subject
The topic of the resource
Absorption; Adrenergic; Adrenocorticotropic Hormone/blood; Animals; beta/analysis; Body Fluids/drug effects/metabolism; Epithelial Sodium Channels/genetics; Female; Fetus/drug effects; Guinea Pigs; Hydrocortisone/biosynthesis; Interleukin-1beta/*pharmacology; Lung/*drug effects/metabolism; Messenger/analysis; Oxytocin/pharmacology; Peptide Fragments/*pharmacology; Pregnancy; Receptors; RNA
Creator
An entity primarily responsible for making the resource
Li Tianbo; Varadarajulu Shilpa; Beard LaMonta L; Yun June; Folkesson Hans G
Description
An account of the resource
We have previously demonstrated that full-length interleukin (IL)-1beta can induce and stimulate lung fluid absorption in near-term guinea pig fetuses via stimulation of fetal cortisol synthesis and release. To develop a potentially clinically useful drug, we tested the hypothesis that maternal administration of a noninflammatory IL-1beta-fragment (IL-1beta(Fr)) induced cortisol synthesis and stimulated lung fluid absorption in preterm fetuses. IL-1beta(Fr) was administered s.c. daily to timed-pregnant guinea pigs for 3 days with and without simultaneous cortisol synthesis inhibition by metyrapone. Fetuses were obtained by abdominal hysterotomy at 61 and 68 days gestation and instilled with isosmolar 5% albumin into the lungs, and lung fluid absorption was measured over 1 h by mass balance. Lung fluid absorption was induced at 61 days and stimulated at 68 days gestation by IL-1beta(Fr), which both were attenuated by cortisol synthesis inhibition. Moreover, induction of labor by oxytocin stimulated lung fluid absorption at 61 days but had no stimulatory effect at 68 days gestation when given with the IL-1beta(Fr). Plasma adrenocorticotropin and cortisol concentrations were increased by IL-1beta(Fr) at 61 days gestation and remained high but unstimulated by IL-1beta(Fr) at 68 days gestation, and metyrapone always reduced cortisol concentrations. Prenatal lung fluid absorption, when present as well as IL-1beta(Fr)-induced, was always propranolol- and amiloride-sensitive, suggesting that beta-adrenoceptor stimulation and the epithelial Na(+) channel (ENaC) were critical for the induced/stimulated lung fluid absorption. ENaC expression was increased by IL-1beta(Fr) and attenuated by cortisol synthesis inhibition. Thus, our results suggest a potential clinical use of IL-1beta(Fr) therapeutically to induce lung fluid absorption in fetuses at risk of preterm delivery.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1124/jpet.106.111369" target="_blank" rel="noreferrer noopener">10.1124/jpet.106.111369</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2007
Absorption
Adrenergic
Adrenocorticotropic Hormone/blood
Animals
Beard LaMonta L
beta/analysis
Body Fluids/drug effects/metabolism
Department of Integrative Medical Sciences
Epithelial Sodium Channels/genetics
Female
Fetus/drug effects
Folkesson Hans G
Guinea Pigs
Hydrocortisone/biosynthesis
Interleukin-1beta/*pharmacology
Li Tianbo
Lung/*drug effects/metabolism
Messenger/analysis
NEOMED College of Medicine
Oxytocin/pharmacology
Peptide Fragments/*pharmacology
Pregnancy
Receptors
RNA
The Journal of pharmacology and experimental therapeutics
Varadarajulu Shilpa
Yun June
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/s0306-4522(01)00120-8" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/s0306-4522(01)00120-8</a>
Pages
957–964
Issue
4
Volume
104
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Nisoxetine infusion into the olfactory bulb enhances the capacity for male rats to identify conspecifics.
Publisher
An entity responsible for making the resource available
Neuroscience
Date
A point or period of time associated with an event in the lifecycle of the resource
2001
1905-06
Subject
The topic of the resource
Adrenergic; Adrenergic alpha-Antagonists/pharmacology; alpha/drug effects/metabolism; Animal/*drug effects/physiology; Animal/drug effects/physiology; Animals; Behavior; Drug Interactions/physiology; Female; Fluoxetine/analogs & derivatives/*pharmacology; Hierarchy; Male; Norepinephrine/*antagonists & inhibitors/metabolism; Olfactory Bulb/cytology/*drug effects/metabolism; Phentolamine/pharmacology; Presynaptic Terminals/drug effects/metabolism; Rats; Receptors; Recognition (Psychology)/*drug effects/physiology; Sexual Behavior; Smell/*drug effects/physiology; Social; Social Facilitation; Sprague-Dawley/anatomy & histology/*metabolism/psychology
Creator
An entity primarily responsible for making the resource
Shang Y; Dluzen D E
Description
An account of the resource
In the present report, the norepinephrine uptake inhibitor nisoxetine as well as a cocktail of nisoxetine and the alpha-adrenergic receptor antagonist phentolamine were infused unilaterally into the olfactory bulb during microdialysis to assess their effects upon the capacity of male rats to identify conspecifics. A social discrimination test was conducted while simultaneously measuring olfactory bulb norepinephrine output in the dialysate before, during, and after behavioral testing. Nisoxetine significantly increased norepinephrine levels in the olfactory bulb compared with the Ringer's solution control group. Following such increases in olfactory bulb norepinephrine, identification responses were enhanced compared with that observed in the Ringer's control. In the presence of phentolamine, nisoxetine elevated olfactory bulb norepinephrine to levels similar to that obtained in the nisoxetine alone group, however, investigatory responses directed to the conspecifics indicated an absence of identification capacity similar to that observed in the Ringer's control group. These results reveal a direct link between norepinephrine transmission in the olfactory bulb and enhanced identification via its activation of postsynaptic alpha-adrenergic receptors. These results also show that inhibition of norepinephrine uptake may represent an important mechanism involved with the enhancement of social identification and suggest a possible novel effect for the antidepressant nisoxetine.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/s0306-4522(01)00120-8" target="_blank" rel="noreferrer noopener">10.1016/s0306-4522(01)00120-8</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2001
Adrenergic
Adrenergic alpha-Antagonists/pharmacology
alpha/drug effects/metabolism
Animal/*drug effects/physiology
Animal/drug effects/physiology
Animals
Behavior
Dluzen D E
Drug Interactions/physiology
Female
Fluoxetine/analogs & derivatives/*pharmacology
Hierarchy
Male
Neuroscience
Norepinephrine/*antagonists & inhibitors/metabolism
Olfactory Bulb/cytology/*drug effects/metabolism
Phentolamine/pharmacology
Presynaptic Terminals/drug effects/metabolism
Rats
Receptors
Recognition (Psychology)/*drug effects/physiology
Sexual Behavior
Shang Y
Smell/*drug effects/physiology
Social
Social Facilitation
Sprague-Dawley/anatomy & histology/*metabolism/psychology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.ajog.2003.09.074" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.ajog.2003.09.074</a>
Pages
340–345
Issue
1
Volume
191
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Stimulation of distal airspace fluid clearance in guinea pigs involves bumetanide-sensitive ion transport.
Publisher
An entity responsible for making the resource available
American journal of obstetrics and gynecology
Date
A point or period of time associated with an event in the lifecycle of the resource
2004
2004-07
Subject
The topic of the resource
*Ion Transport; Absorption; Adrenergic; Adrenergic beta-Antagonists/pharmacology; Animals; beta/physiology; Body Fluids/*metabolism; Bumetanide/*pharmacology; Diuretics/*pharmacology; Epinephrine/blood; Epithelium; Fetus/metabolism; Gestational Age; Guinea Pigs; Lung/*embryology/metabolism; Newborn; Propranolol/pharmacology; Receptors
Creator
An entity primarily responsible for making the resource
Ye Xin; Norlin Andreas; Folkesson Hans G
Description
An account of the resource
OBJECTIVE: This study was undertaken to test the hypothesis that beta-adrenoceptor stimulation of fetal lung fluid absorption in near-term guinea pig fetuses involves bumetanide-sensitive ion transport. STUDY DESIGN: Fetuses were obtained from timed-pregnant guinea pigs at 61 to 69 days' gestation with and without oxytocin-induced preterm labor. The fetuses were placed on continuous positive airway pressure oxygenation, and an isosmolar 5% albumin solution was instilled into the lungs. Distal airspace fluid clearance was measured over 1 hour from the increase in distal airspace protein concentration as fluid was reabsorbed with and without the Cl(-) transport inhibitor bumetanide. RESULTS: Fetal lungs began to absorb distal airspace fluid at 64 to 66 days' gestation, and at birth, distal airspace fluid clearance rapidly quadrupled. Labor induction by oxytocin stimulated distal airspace fluid clearance. Distal airspace fluid clearance, when present, was sensitive to propranolol-inhibition and depended on beta-adrenoceptor stimulation. Fluid secretion at 61 days' gestation was reduced by bumetanide instillation. Bumetanide addition was only inhibitory when distal airspace fluid clearance was propranolol-sensitive. CONCLUSION: Beta-adrenoceptor stimulation from endogenous fetal epinephrine increased fetal distal airspace fluid clearance and involved bumetanide-sensitive ion transport.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/j.ajog.2003.09.074" target="_blank" rel="noreferrer noopener">10.1016/j.ajog.2003.09.074</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Ion Transport
2004
Absorption
Adrenergic
Adrenergic beta-Antagonists/pharmacology
American journal of obstetrics and gynecology
Animals
beta/physiology
Body Fluids/*metabolism
Bumetanide/*pharmacology
Diuretics/*pharmacology
Epinephrine/blood
Epithelium
Fetus/metabolism
Folkesson Hans G
Gestational Age
Guinea Pigs
Lung/*embryology/metabolism
Newborn
Norlin Andreas
Propranolol/pharmacology
Receptors
Ye Xin