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Text
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URL Address
<a href="http://doi.org/10.1002/syn.20309" target="_blank" rel="noreferrer noopener">http://doi.org/10.1002/syn.20309</a>
Pages
347–353
Issue
5
Volume
60
Dublin Core
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Title
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Testosterone modulation of striatal dopamine output in orchidectomized mice.
Publisher
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Synapse (New York, N.Y.)
Date
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2006
2006-10
Subject
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Adrenergic Uptake Inhibitors/pharmacology; Animals; Corpus Striatum/drug effects/*metabolism; Dopamine/*metabolism/pharmacology; Male; Mice; Neural Pathways/drug effects/*metabolism; Orchiectomy; Potassium Chloride/pharmacology; Presynaptic Terminals/drug effects/metabolism; Reserpine/pharmacology; Sex Characteristics; Substantia Nigra/drug effects/*metabolism; Synaptic Transmission/drug effects/physiology; Synaptic Vesicles/drug effects/metabolism; Testosterone/*metabolism; Vesicular Monoamine Transport Proteins/drug effects/metabolism
Creator
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Shemisa Kamal; Kunnathur Vidhya; Liu Bin; Salvaterra Ty J; Dluzen Dean E
Description
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Three experiments are presented in which dopamine (DA) responses from superfused striatal tissue of orchidectomized (ORCH) mice treated or not with testosterone (T) are compared. In experiment 1, potassium-stimulated DA output was significantly greater in ORCH vs. ORCH+T mice. This profile was reversed when reserpine was infused in experiment 2, with DA output being significantly greater in ORCH+T vs. ORCH mice. In experiment 3, the amount of DA recovered following infusion of DA indicated no statistically significant differences in DA recoveries between ORCH and ORCH+T mice as tested in this paradigm. The findings that both potassium- and reserpine-induced DA responses are altered significantly by T suggests that one potential site of T action might involve the storage/uptake of DA within the vesicles of these neurons. Such results have important implications with regard to understanding the sex differences that are present in nigrostriatal dopaminergic function within health and diseased states.
Identifier
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<a href="http://doi.org/10.1002/syn.20309" target="_blank" rel="noreferrer noopener">10.1002/syn.20309</a>
Rights
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2006
Adrenergic Uptake Inhibitors/pharmacology
Animals
Corpus Striatum/drug effects/*metabolism
Dluzen Dean E
Dopamine/*metabolism/pharmacology
Kunnathur Vidhya
Liu Bin
Male
Mice
Neural Pathways/drug effects/*metabolism
Orchiectomy
Potassium Chloride/pharmacology
Presynaptic Terminals/drug effects/metabolism
Reserpine/pharmacology
Salvaterra Ty J
Sex Characteristics
Shemisa Kamal
Substantia Nigra/drug effects/*metabolism
Synapse (New York, N.Y.)
Synaptic Transmission/drug effects/physiology
Synaptic Vesicles/drug effects/metabolism
Testosterone/*metabolism
Vesicular Monoamine Transport Proteins/drug effects/metabolism