1
40
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Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1152/jn.01148.2005" target="_blank" rel="noreferrer noopener">http://doi.org/10.1152/jn.01148.2005</a>
Pages
2179–2192
Issue
4
Volume
95
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Roles of inhibition in complex auditory responses in the inferior colliculus: inhibited combination-sensitive neurons.
Publisher
An entity responsible for making the resource available
Journal of neurophysiology
Date
A point or period of time associated with an event in the lifecycle of the resource
2006
2006-04
Subject
The topic of the resource
Acoustic Stimulation; Action Potentials/drug effects/physiology; Afferent/drug effects/*physiology; Animals; Auditory; Auditory Pathways/drug effects/*physiology; Bicuculline/pharmacology; Brain Stem/drug effects/*physiology; Chiroptera; Electrophysiology; Evoked Potentials; GABA-A Receptor Antagonists; GABA-A/physiology; Glycine/antagonists & inhibitors/physiology; Inferior Colliculi/*physiology; Neural Inhibition/drug effects/*physiology; Neurons; Receptors; Strychnine/pharmacology
Creator
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Nataraj Kiran; Wenstrup Jeffrey J
Description
An account of the resource
We studied the functional properties and underlying neural mechanisms associated with inhibitory combination-sensitive neurons in the mustached bat's inferior colliculus (IC). In these neurons, the excitatory response to best frequency tones was suppressed by lower frequency signals (usually in the range of 12-30 kHz) in a time-dependant manner. Of 143 inhibitory units, the majority (71%) were type I, in which low-frequency sounds evoked inhibition only. In the remainder, however, the low-frequency inhibitory signal also evoked excitation. Of these, excitation preceded the inhibition in type E/I units (16%), whereas in type I/E units (13%), excitation followed the inhibition. Type E/I and I/E units were distinct in the tuning and threshold sensitivity of low-frequency responses, whereas type I units overlapped the other types in these features. In 71 neurons, antagonists to receptors for glycine [strychnine (STRY)] or GABA [bicuculline (BIC)] were applied microiontophoretically. These antagonists failed to eliminate combination-sensitive inhibition in 92% (STRY), 93% (BIC), and 87% (BIC + STRY) of the type I units tested. However, inhibition was reduced in many neurons. Results were similar for type E/I and I/E inhibitory neurons. The results indicate that there are distinct populations of combination-sensitive inhibited neurons in the IC and that these populations are at least partly independent of glycine or GABAA receptors in the IC. We propose that these populations originate in different brain stem auditory nuclei, that they may be modified by interactions within the IC, and that they may perform different spectrotemporal analyses of vocal signals.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1152/jn.01148.2005" target="_blank" rel="noreferrer noopener">10.1152/jn.01148.2005</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2006
Acoustic Stimulation
Action Potentials/drug effects/physiology
Afferent/drug effects/*physiology
Animals
Auditory
Auditory Pathways/drug effects/*physiology
Bicuculline/pharmacology
Brain Stem/drug effects/*physiology
Chiroptera
College of Anatomy & Neurobiology
Department of Anatomy & Neurobiology
Electrophysiology
Evoked Potentials
GABA-A Receptor Antagonists
GABA-A/physiology
Glycine/antagonists & inhibitors/physiology
Inferior Colliculi/*physiology
Journal of neurophysiology
Nataraj Kiran
NEOMED College of Medicine
Neural Inhibition/drug effects/*physiology
Neurons
Receptors
Strychnine/pharmacology
Wenstrup Jeffrey J
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1152/jappl.1993.75.1.114" target="_blank" rel="noreferrer noopener">http://doi.org/10.1152/jappl.1993.75.1.114</a>
Pages
114–120
Issue
1
Volume
75
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Cardiac afferents attenuate the muscle metaboreflex in the rat.
Publisher
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Journal of applied physiology (Bethesda, Md. : 1985)
Date
A point or period of time associated with an event in the lifecycle of the resource
1993
1993-07
Subject
The topic of the resource
Afferent/drug effects/*physiology; Animals; Aorta/drug effects/physiology; Blood Pressure/drug effects/physiology; Blood Volume/drug effects/physiology; Heart Rate/drug effects/physiology; Heart/drug effects/*innervation/physiology; Muscles/drug effects/*metabolism; N-Methylscopolamine; Neurons; Parasympatholytics/pharmacology; Physical Exertion/physiology; Procainamide/pharmacology; Propranolol/pharmacology; Rats; Reflex/drug effects/*physiology; Scopolamine Derivatives/pharmacology; Specimen Handling
Creator
An entity primarily responsible for making the resource
Collins H L; DiCarlo S E
Description
An account of the resource
The influence of cardiac afferents on the muscle metaboreflex was examined in 16 rats instrumented with a Silastic-tipped catheter in the pericardial space and right atrium, Doppler ultrasonic flow probe and a pneumatic vascular occluder around the terminal aorta, and a Teflon catheter in the thoracic aorta. In protocol I (cardiac efferent and afferent blockade), the muscle metaboreflex was examined under three experimental conditions: 1) control, 2) cardiac autonomic efferent blockade [intrapericardial methylscopolamine (10 micrograms/kg) and propranolol (50 micrograms/kg)], and 3) combined cardiac autonomic efferent and afferent blockade (intrapericardial procainamide, 2%). In protocol II (blood volume expansion), the muscle metaboreflex was examined before and after 15% blood volume expansion. Mild treadmill exercise (9 m/min, 10% grade) increased heart rate (71 +/- 9.4 beats/min), mean arterial pressure (12 +/- 2.0 mmHg), and terminal aortic blood flow velocity (6 +/- 1.0 kHz). During exercise, a reduction of terminal aortic blood flow velocity (10.5 +/- 1.1%) reduced mixed venous PO2 18 +/- 6%. The gain of the muscle metaboreflex in the control condition was 14.6 +/- 2.9 mmHg/kHz. Efferent blockade reduced the gain 51 +/- 7%. However, combined cardiac efferent and afferent blockade increased the gain 207 +/- 64% above the efferent blocked condition and restored the gain to levels above those obtained in the control condition (18.3 +/- 4.6 mmHg/kHz). In addition, 15% blood volume expansion reduced the gain of the muscle metaboreflex regulation of mean arterial pressure and heart rate (44 +/- 9.5% and 41 +/- 12.0%, respectively). Thus cardiac afferents tonically inhibit the pressor response to a reduction in terminal aortic blood flow velocity during exercise.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1152/jappl.1993.75.1.114" target="_blank" rel="noreferrer noopener">10.1152/jappl.1993.75.1.114</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1993
Afferent/drug effects/*physiology
Animals
Aorta/drug effects/physiology
Blood Pressure/drug effects/physiology
Blood Volume/drug effects/physiology
Collins H L
DiCarlo S E
Heart Rate/drug effects/physiology
Heart/drug effects/*innervation/physiology
Journal of applied physiology (Bethesda, Md. : 1985)
Muscles/drug effects/*metabolism
N-Methylscopolamine
Neurons
Parasympatholytics/pharmacology
Physical Exertion/physiology
Procainamide/pharmacology
Propranolol/pharmacology
Rats
Reflex/drug effects/*physiology
Scopolamine Derivatives/pharmacology
Specimen Handling