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Text
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<a href="http://doi.org/10.1152/ajpheart.1997.273.3.H1606" target="_blank" rel="noreferrer noopener">http://doi.org/10.1152/ajpheart.1997.273.3.H1606</a>
Pages
H1606–1610
Issue
3
Volume
273
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Title
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Daily exercise attenuates the sympathetic nerve response to exercise by enhancing cardiac afferents.
Publisher
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The American journal of physiology
Date
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1997
1997-09
Subject
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Afferent Pathways; Animal/*physiology; Animals; Baroreflex; Blood Pressure; Femoral Artery/physiology; Femoral Vein/physiology; Heart Rate; Heart/innervation/*physiology; Kidney/innervation; Physical Conditioning; Rabbits; Sympathetic Nervous System/*physiology
Creator
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DiCarlo S E; Stahl L K; Bishop V S
Description
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"Central command" may initiate the sympathoexcitatory responses at the onset of exercise by shifting the operating point of the arterial baroreflex toward higher pressures. Daily exercise (DE) attenuates the sympathoexcitatory responses to submaximal exercise. This DE-induced adaptation may be due, in part, to an enhanced inhibitory influence of cardiac afferents. This is suggested because cardiac afferents exert a tonic inhibitory influence on the arterial baroreflex which is enhanced by DE. Therefore, the influence of cardiac afferents on the regulation of renal sympathetic nerve activity (RSNA) during exercise was examined in a group of sedentary and age-matched DE rabbits. The rabbits were instrumented with a Silastic catheter inserted into the pericardial sac, electrodes around the renal sympathetic nerves, and catheters in the femoral artery and vein. In the sedentary rabbits, treadmill exercise (12 m/min, 20% grade) significantly increased mean arterial pressure (delta 18 +/- 3 mmHg), heart rate (delta 36 +/- 3 beats/min), and RSNA (delta 295 +/- 23%). More importantly, cardiac afferent blockade (2% intrapericardial procainamide) did not significantly alter the RSNA response to exercise in the sedentary rabbits. DE did not alter the mean arterial pressure (delta 15 +/- 1 mmHg) or heart rate (delta 55 +/- 8 beats/min) response to exercise; however, RSNA (delta 252 +/- 9%) was significantly reduced. In contrast to the sedentary rabbits, cardiac afferent blockade in the DE rabbits significantly increased the RSNA response to exercise (delta 417 +/- 30%). These results suggest that DE attenuates the RSNA response to dynamic exercise due, in part, to an enhanced inhibitory influence of cardiac afferents.
Identifier
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<a href="http://doi.org/10.1152/ajpheart.1997.273.3.H1606" target="_blank" rel="noreferrer noopener">10.1152/ajpheart.1997.273.3.H1606</a>
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1997
Afferent Pathways
Animal/*physiology
Animals
Baroreflex
Bishop V S
Blood Pressure
DiCarlo S E
Femoral Artery/physiology
Femoral Vein/physiology
Heart Rate
Heart/innervation/*physiology
Kidney/innervation
Physical Conditioning
Rabbits
Stahl L K
Sympathetic Nervous System/*physiology
The American journal of physiology