1
40
2
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Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1002/(SICI)1096-8644(199906)109:2%3C259::AID-AJPA10%3E3.0.CO;2-3" target="_blank" rel="noreferrer noopener">http://doi.org/10.1002/(SICI)1096-8644(199906)109:2%3C259::AID-AJPA10%3E3.0.CO;2-3</a>
Pages
259–267
Issue
2
Volume
109
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Spondyloarthropathy identified as the etiology of Nubian erosive arthritis.
Publisher
An entity responsible for making the resource available
American journal of physical anthropology
Date
A point or period of time associated with an event in the lifecycle of the resource
1999
1999-06
Subject
The topic of the resource
Africa; African Continental Ancestry Group; Ancient; Arthritis; Bone and Bones/pathology; Diagnosis; Differential; Egypt; Ethnic Groups; History; Humans; Museums; Northern; Paleopathology; Rheumatoid/diagnosis/*history; Spinal Osteophytosis/diagnosis/*history; Sudan
Creator
An entity primarily responsible for making the resource
Rothschild B M; Arriaza B; Woods R J; Dutour O
Description
An account of the resource
Slight variation in manifestation of different diseases may allow a single individual with one disease to mimic the "classic" appearance of another, as evidenced by the frequent confusion of spondyloarthropathy with rheumatoid arthritis. Analysis of population occurrence of arthritis (rather than isolated skeletons) facilitates more precise diagnosis. Northeast Africans living around 2,000 years before present were clearly afflicted with a form of spondyloarthropathy. Lack of inclusion of spondyloarthropathy in the differential diagnosis of erosive arthritis led to past misclassification of Nubians as having rheumatoid arthritis. While evidence of spondyloarthropathy abounds in the literature of human skeletal disease, pre-Columbian Old World rheumatoid arthritis is still elusive. The current study further documents the absence of rheumatoid arthritis in Nubians, supporting the hypothesis that rheumatoid arthritis began in the New World.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1002/(SICI)1096-8644(199906)109:2%3C259::AID-AJPA10%3E3.0.CO;2-3" target="_blank" rel="noreferrer noopener">10.1002/(SICI)1096-8644(199906)109:2%3C259::AID-AJPA10%3E3.0.CO;2-3</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1999
Africa
African Continental Ancestry Group
American journal of physical anthropology
Ancient
Arriaza B
Arthritis
Bone and Bones/pathology
Diagnosis
Differential
Dutour O
Egypt
Ethnic Groups
History
Humans
Museums
Northern
Paleopathology
Rheumatoid/diagnosis/*history
Rothschild B M
Spinal Osteophytosis/diagnosis/*history
Sudan
Woods R J
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.bone.2015.04.029" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.bone.2015.04.029</a>
Pages
94–101
Volume
78
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
The associations of 25-hydroxyvitamin D levels, vitamin D binding protein gene polymorphisms, and race with risk of incident fracture-related hospitalization: Twenty-year follow-up in a bi-ethnic cohort (the ARIC Study).
Publisher
An entity responsible for making the resource available
Bone
Date
A point or period of time associated with an event in the lifecycle of the resource
2015
2015-09
Subject
The topic of the resource
*Polymorphism; African Continental Ancestry Group; Aged; Alleles; Epidemiology; Ethnic Groups; European Continental Ancestry Group; Female; Follow-Up Studies; Fracture; Fracture Healing; Genetic Variation; Genotype; Hip Fractures/blood/*ethnology/*genetics; Hospitalization; Humans; Incidence; Male; Middle Aged; Proportional Hazards Models; Prospective Studies; Race; Risk Factors; Single Nucleotide; Vitamin D; Vitamin D binding protein polymorphisms; Vitamin D-Binding Protein/*genetics; Vitamin D/*analogs & derivatives/blood
Creator
An entity primarily responsible for making the resource
Takiar Radhika; Lutsey Pamela L; Zhao Di; Guallar Eliseo; Schneider Andrea L C; Grams Morgan E; Appel Lawrence J; Selvin Elizabeth; Michos Erin D
Description
An account of the resource
BACKGROUND: Deficient levels of 25-hydroxyvitamin D [25(OH)D] have been associated with increased fracture risk. Racial differences in fracture risk may be related to differences in bioavailable vitamin D due to single nucleotide polymorphism (SNP) variations in the vitamin D binding protein (DBP). METHODS: We measured 25(OH)D levels in 12,781 middle-aged White and Black participants [mean age 57 years (SD 5.7), 25% Black] in the ARIC Study who attended the second examination from 1990-1992. Participants were genotyped for two DBP SNPs (rs4588 and rs7041). Incident hospitalized fractures were measured by abstracting hospital records for ICD-9 codes. We used Cox proportional hazards models to evaluate the association between 25(OH)D levels and risk of fracture with adjustment for possible confounders. Interactions were tested by race and DBP genotype. RESULTS: There were 1122 incident fracture-related hospitalizations including 267 hip fractures over a median of 19.6 years of follow-up. Participants with deficient 25(OH)D (\textless20 ng/mL) had a higher risk of any fracture hospitalization [HR=1.21 (95% CI 1.05-1.39)] and hospitalization for hip fracture [HR=1.35 (1.02-1.79)]. No significant racial interaction was noted (p-interaction=0.20 for any fracture; 0.74 for hip fracture). There was no independent association of rs4588 and rs7041 with fracture. However, there was a marginal interaction for 25(OH)D deficiency with rs7041 among Whites (p-interaction=0.065). Whites with both 25(OH)D deficiency and the GG genotype [i.e., with predicted higher levels of DBP and lower bioavailable vitamin D] were at the greatest risk for any fracture [HR=1.48 (1.10-2.00)] compared to Whites with the TT genotype and replete 25(OH)D (reference group). CONCLUSIONS: Deficient 25(OH)D levels are associated with higher incidence of hospitalized fractures. Marginal effects were seen in Whites for the DBP genotype associated with lower bioavailable vitamin D, but result inconclusive. Further investigation is needed to more directly evaluate the association between bioavailable vitamin D and fracture risk.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/j.bone.2015.04.029" target="_blank" rel="noreferrer noopener">10.1016/j.bone.2015.04.029</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Polymorphism
2015
African Continental Ancestry Group
Aged
Alleles
Appel Lawrence J
Bone
Epidemiology
Ethnic Groups
European Continental Ancestry Group
Female
Follow-Up Studies
Fracture
Fracture Healing
Genetic Variation
Genotype
Grams Morgan E
Guallar Eliseo
Hip Fractures/blood/*ethnology/*genetics
Hospitalization
Humans
Incidence
Lutsey Pamela L
Male
Michos Erin D
Middle Aged
Proportional Hazards Models
Prospective Studies
Race
Risk Factors
Schneider Andrea L C
Selvin Elizabeth
Single Nucleotide
Takiar Radhika
Vitamin D
Vitamin D binding protein polymorphisms
Vitamin D-Binding Protein/*genetics
Vitamin D/*analogs & derivatives/blood
Zhao Di