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Text
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URL Address
<a href="http://doi.org/10.2174/1874467208666150817112109" target="_blank" rel="noreferrer noopener">http://doi.org/10.2174/1874467208666150817112109</a>
Pages
226–236
Issue
3
Volume
10
Dublin Core
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Title
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Signal Transduction Mechanisms of Alcoholic Fatty Liver Disease: Emer ging Role of Lipin-1.
Publisher
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Current molecular pharmacology
Date
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2017
1905-7
Subject
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Humans; Animals; AMP-Activated Protein Kinases/metabolism; Signal Transduction; Lipid Metabolism; Fatty Liver; Liver/metabolism; lipid metabolism; alcoholic fatty liver disease; inflammation; Lipin-1; signal transduction; transcriptional regulators; Phosphatidate Phosphatase/*metabolism; Inflammation/metabolism; Ethanol/chemistry/*metabolism; Sirtuin 1/metabolism; Alcoholic/*metabolism/pathology
Creator
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You Min; Jogasuria Alvin; Lee Kwangwon; Wu Jiashin; Zhang Yanqiao; Lee Yoon-Kwang; Sadana Prabodh
Description
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Lipin-1, a mammalian phosphatidic acid phosphatase (PAP), is a bi-functional molecule involved in various signaling pathways via its function as a PAP enzyme in the triglyceride synthesis pathway and in the nucleus as a transcriptional co-regulator. In the liver, lipin-1 is known to play a vital role in controlling the lipid metabolism and inflammation process at multiple regulatory levels. Alcoholic fatty liver disease (AFLD) is one of the earliest forms of liver injury and approximately 8-20% of patients with simple steatosis can develop into more severe forms of liver injury, including steatohepatitis, fibrosis/ cirrhosis, and eventually hepatocellular carcinoma (HCC). The signal transduction mechanisms for alcohol-induced detrimental effects in liver involves alteration of complex and multiple signaling pathways largely governed by a central and upstream signaling system, namely, sirtuin 1 (SIRT1)-AMP activated kinase (AMPK) axis. Emerging evidence suggests a pivotal role of lipin-1 as a crucial downstream regulator of
Identifier
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<a href="http://doi.org/10.2174/1874467208666150817112109" target="_blank" rel="noreferrer noopener">10.2174/1874467208666150817112109</a>
Rights
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2017
alcoholic fatty liver disease
Alcoholic/*metabolism/pathology
AMP-Activated Protein Kinases/metabolism
Animals
Current molecular pharmacology
Department of Integrative Medical Sciences
Department of Pharmaceutical Sciences
Department of Pharmacy Practice
Ethanol/chemistry/*metabolism
Fatty Liver
Humans
Inflammation
Inflammation/metabolism
Jogasuria Alvin
Lee Kwangwon
Lee Yoon-Kwang
Lipid Metabolism
Lipin-1
Liver/metabolism
NEOMED College of Graduate Studies
NEOMED College of Medicine
NEOMED College of Pharmacy
Phosphatidate Phosphatase/*metabolism
Sadana Prabodh
Signal Transduction
Sirtuin 1/metabolism
transcriptional regulators
Wu Jiashin
You Min
Zhang Yanqiao