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<a href="http://doi.org/10.1016/j.vaccine.2019.04.087" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.vaccine.2019.04.087</a>
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Pages
3352-3361
Issue
25
Volume
37
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Title
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Pneumococcal epidemiology among us adults hospitalized for community-acquired pneumonia
Publisher
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Vaccine
Date
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2019
2019-05
Subject
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Community; Pneumococcus; Pneumonia; Streptococcus
Creator
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Isturiz Raul E; Ramirez Julio; Self Wesley H; Grijalva Carlos G; Counselman Francis L; Volturo Gregory; Ostrosky-Zeichner Luis; Peyrani Paula; Wunderink Richard G; Sherwin Robert; Overcash J Scott; Oliva Senen Pena; File Thomas; Wiemken Timothy L; McLaughlin John M; Pride Michael W; Gray Sharon; Alexander Ronika; Ford Kimbal D; Jiang Qin; Jodar Luis
Description
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BACKGROUND: Few studies have measured the burden of adult pneumococcal disease after the introduction of 13-valent pneumococcal conjugate vaccine (PCV13) into the US infant vaccination schedule. Further, most data regarding pneumococcal serotypes are derived from invasive pneumococcal disease (IPD), which represents only a fraction of all adult pneumococcal disease burden. Understanding which pneumococcal serotypes cause pneumonia in adults is critical for informing current immunization policy. The objective of this study was to measure the proportion of radiographically-confirmed (CXR+) community-acquired pneumonia (CAP) caused by PCV13 serotypes in hospitalized US adults. METHODS: This observational, prospective surveillance study recruited hospitalized adults aged ≥18 years from 21 acute care hospitals across 10 geographically-dispersed cities in the United States between October 2013 and September 2016. Clinical and demographic data were collected during hospitalization. Vital status was ascertained 30 days after enrollment. Pneumococcal serotypes were detected via culture from the respiratory tract and normally-sterile sites (including blood and pleural fluid). Additionally, a novel, Luminex-based serotype-specific urinary antigen detection (UAD) assay was used to detect serotypes included in PCV13. RESULTS: Of 15,572 enrolled participants, 12,055 eligible patients with CXR+CAP were included in the final analysis population. Mean age was 64.1 years and 52.7% were aged ≥65 years. Common comorbidities included chronic obstructive pulmonary disease (43.0%) and diabetes mellitus (28.6%). PCV13 serotypes were detected in 552/12,055 (4.6%) of all patients and 265/6347 (4.2%) of those aged ≥65 years. Among patients aged 18-64 years PCV13 serotypes were detected in 3.8-5.3% of patients depending on their risk status. CONCLUSIONS: After implementation of a pneumococcal conjugate vaccination program in US children, and despite the herd protection observed in US adults, a persistent burden of PCV13-type CAP remains in this population.
Identifier
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<a href="http://doi.org/10.1016/j.vaccine.2019.04.087" target="_blank" rel="noreferrer noopener">10.1016/j.vaccine.2019.04.087</a>
2019
Alexander Ronika
Community
Counselman Francis L
Department of Internal Medicine
File Thomas
Ford Kimbal D
Gray Sharon
Grijalva Carlos G
Isturiz Raul E
Jiang Qin
Jodar Luis
June 2019 Update
McLaughlin John M
NEOMED College of Medicine
Oliva Senen Pena
Ostrosky-Zeichner Luis
Overcash J Scott
Peyrani Paula
Pneumococcus
Pneumonia
Pride Michael W
Ramirez Julio
Self Wesley H
Sherwin Robert
Streptococcus
Vaccine
Volturo Gregory
Wiemken Timothy L
Wunderink Richard G