1
40
4
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0091-3057(92)90007-3" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0091-3057(92)90007-3</a>
Pages
619–623
Issue
4
Volume
42
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Direct microinjection of cathinone into the rat brain produces discriminative stimuli.
Publisher
An entity responsible for making the resource available
Pharmacology, biochemistry, and behavior
Date
A point or period of time associated with an event in the lifecycle of the resource
1992
1992-08
Subject
The topic of the resource
*Brain/anatomy & histology; Alkaloids/administration & dosage/*pharmacology; Animals; Discrimination (Psychology)/*drug effects; Discrimination Learning/drug effects; Dose-Response Relationship; Drug; Inbred Strains; Injections; Intraventricular; Male; Microinjections; Nucleus Accumbens/anatomy & histology; Psychotropic Drugs/*pharmacology; Rats
Creator
An entity primarily responsible for making the resource
Schechter M D; Schechter J B; Calcagnetti D J
Description
An account of the resource
Rats were trained to discriminate IP administration of 800 micrograms/kg cathinone using a food-motivated, two-lever discrimination procedure. Following training, 800 micrograms/kg cathinone discrimination was produced (generalized) by lower cathinone doses in a dose-responsive manner after IP administration; an ED50 value of 330 micrograms/kg was calculated. Subsequently, guide cannulae were implanted into the lateral ventricle and bilaterally into the nucleus accumbens. After recovery, injections were made via cannulae that extended 0.5 mm past the tip of the guide cannulae. ICV administration of 256 micrograms cathinone/rat produced discriminative responding on the cathinone-appropriate lever to the same degree as did the peripherally administered training dose of cathinone. Decreasing ICV doses produced decreased discriminative performance and allowed the calculation of an ED50 value of 90.5 micrograms. Likewise, administration of 64 micrograms cathinone/nucleus accumbens (for a total of 128 micrograms/rat) substituted for the IP training dose of cathinone. These results evidence the central mediation of the cathinone-induced discriminative stimulus cue and show that administration of cathinone into the nucleus accumbens is sufficient to produce these stimuli. Thus, these data suggest that receptors in the nucleus accumbens are important for the discrimination of this psychostimulant.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0091-3057(92)90007-3" target="_blank" rel="noreferrer noopener">10.1016/0091-3057(92)90007-3</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Brain/anatomy & histology
1992
Alkaloids/administration & dosage/*pharmacology
Animals
Calcagnetti D J
Discrimination (Psychology)/*drug effects
Discrimination Learning/drug effects
Dose-Response Relationship
Drug
Inbred Strains
Injections
Intraventricular
Male
Microinjections
Nucleus Accumbens/anatomy & histology
Pharmacology, biochemistry, and behavior
Psychotropic Drugs/*pharmacology
Rats
Schechter J B
Schechter M D
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0014-2999(93)90739-5" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0014-2999(93)90739-5</a>
Pages
135–138
Issue
1
Volume
232
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Conditioned place preference produced by the psychostimulant cathinone.
Publisher
An entity responsible for making the resource available
European journal of pharmacology
Date
A point or period of time associated with an event in the lifecycle of the resource
1993
1993-02
Subject
The topic of the resource
Alkaloids/administration & dosage/*pharmacology; Animals; Central Nervous System Stimulants/administration & dosage/*pharmacology; Choice Behavior/drug effects; Conditioning (Psychology)/drug effects; Dose-Response Relationship; Drug; Habituation; Male; Motor Activity/*drug effects; Psychophysiologic; Rats; Sprague-Dawley
Creator
An entity primarily responsible for making the resource
Schechter M D; Meehan S M
Description
An account of the resource
Previous work has indicated that the psychostimulant cathinone produces a location preference in the conditioned place preference task. The present study expanded upon this earlier work by examining the dose-response nature of cathinone-induced conditioned place preference, as well as testing its effect upon spontaneous locomotor activity. At doses ranging from 0.2 to 1.6 mg/kg, cathinone produced a conditioned place preference at all but the lowest dose, and the highest dose but not the lowest dose increased locomotor activity. Results are discussed in terms of dopaminergic mediation of conditioned place preference and the relationship between conditioned place preference and locomotion being subserved by the same neuronal system.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0014-2999(93)90739-5" target="_blank" rel="noreferrer noopener">10.1016/0014-2999(93)90739-5</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1993
Alkaloids/administration & dosage/*pharmacology
Animals
Central Nervous System Stimulants/administration & dosage/*pharmacology
Choice Behavior/drug effects
Conditioning (Psychology)/drug effects
Dose-Response Relationship
Drug
European journal of pharmacology
Habituation
Male
Meehan S M
Motor Activity/*drug effects
Psychophysiologic
Rats
Schechter M D
Sprague-Dawley
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0361-9230(92)90153-o" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0361-9230(92)90153-o</a>
Pages
843–846
Issue
6
Volume
29
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Increases in the locomotor activity of rats after intracerebral administration of cathinone.
Publisher
An entity responsible for making the resource available
Brain research bulletin
Date
A point or period of time associated with an event in the lifecycle of the resource
1992
1992-12
Subject
The topic of the resource
Alkaloids/administration & dosage/*pharmacology; Animals; Cerebral Ventricles/drug effects/*physiology; Dose-Response Relationship; Drug; Injections; Intraventricular; Male; Motor Activity/*drug effects; Nucleus Accumbens/drug effects/*physiology; Psychotropic Drugs/administration & dosage/*pharmacology; Rats; Sprague-Dawley; Stereotaxic Techniques; Substantia Nigra/drug effects/*physiology
Creator
An entity primarily responsible for making the resource
Calcagnetti D J; Schechter M D
Description
An account of the resource
There is a widespread practice among people living in Eastern Africa and Southern Arabia of chewing the leaves of the Khat shrub so as to produce pharmacological effects that are practically indistinguishable from those produced by amphetamine (AMPH). Cathinone (CATH) has been identified as the psychostimulant constituent of this plant and, although the locomotor elevating effects of centrally administered AMPH and cocaine (COC) in rats are well known, there is a paucity of data regarding CATH. Three experiments were, therefore, conducted to measure locomotor activity following central administration of CATH in rats. The first experiment determined the dose-dependent effects of CATH on activity following intracerebroventricular (ICV) administration. As psychostimulant effects are believed, at least in part, to be mediated by dopaminergic systems, in Experiment 2 CATH was injected into the dopamine nerve terminals of the nucleus accumbens. Experiment 3 examined the effects of CATH injection into the dopamine cell body region of the substantia nigra, and activity was measured. Results of the ICV injection of CATH revealed a dose-dependent increase of activity. The highest dose tested (64 micrograms) yielded a 117% increase in activity when compared to baseline, whereas a 20 micrograms bilateral nucleus accumbens (NA) injection of CATH increased activity fivefold. These findings evidence the hypothesis that the effects of CATH are dopaminergically mediated. Substantia nigra (SN) injections of CATH were without effect.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0361-9230(92)90153-o" target="_blank" rel="noreferrer noopener">10.1016/0361-9230(92)90153-o</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1992
Alkaloids/administration & dosage/*pharmacology
Animals
Brain research bulletin
Calcagnetti D J
Cerebral Ventricles/drug effects/*physiology
Dose-Response Relationship
Drug
Injections
Intraventricular
Male
Motor Activity/*drug effects
Nucleus Accumbens/drug effects/*physiology
Psychotropic Drugs/administration & dosage/*pharmacology
Rats
Schechter M D
Sprague-Dawley
Stereotaxic Techniques
Substantia Nigra/drug effects/*physiology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0278-5846(93)90011-g" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0278-5846(93)90011-g</a>
Pages
637–649
Issue
4
Volume
17
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Place preference for the psychostimulant cathinone is blocked by pretreatment with a dopamine release inhibitor.
Publisher
An entity responsible for making the resource available
Progress in neuro-psychopharmacology & biological psychiatry
Date
A point or period of time associated with an event in the lifecycle of the resource
1993
1993-07
Subject
The topic of the resource
*Dopamine Antagonists; Alkaloids/administration & dosage/*pharmacology; Animals; Antipsychotic Agents/pharmacology; Central Nervous System Stimulants/administration & dosage/*pharmacology; Conditioning; Discrimination (Psychology)/drug effects; Dose-Response Relationship; Drug; Injections; Intraventricular; Male; Operant/*drug effects; Rats; Sprague-Dawley; Thiazepines/pharmacology
Creator
An entity primarily responsible for making the resource
Calcagnetti D J; Schechter M D
Description
An account of the resource
1. The objective of Exp. 1 was to determine whether intracerebroventricular (ICV) injection of cathinone CATH (8.0-32 micrograms) would produce a dose-dependent conditioned place preference (CPP) and/or activation in rats. Results indicate that rats conditioned with 16 or 32 micrograms doses of CATH significantly increased the time spent in their less preferred side, whereas rats conditioned with the 8.0 micrograms dose failed to show any shift from baseline preference. The 16 and 32 micrograms doses of CATH also significantly (p \textless .004) increased activity by more than 65% of baseline. 2. Exp. 2 was designed to determine whether ICV pretreatment with a dopamine release inhibitor CGS 10746B (CGS; 15 micrograms/rat) would block place conditioning produced by CATH. The results demonstrate that CGS pretreatment effectively blocked CATH-induced place conditioning and the CATH-induced elevation of activity.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0278-5846(93)90011-g" target="_blank" rel="noreferrer noopener">10.1016/0278-5846(93)90011-g</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Dopamine Antagonists
1993
Alkaloids/administration & dosage/*pharmacology
Animals
Antipsychotic Agents/pharmacology
Calcagnetti D J
Central Nervous System Stimulants/administration & dosage/*pharmacology
Conditioning
Discrimination (Psychology)/drug effects
Dose-Response Relationship
Drug
Injections
Intraventricular
Male
Operant/*drug effects
Progress in neuro-psychopharmacology & biological psychiatry
Rats
Schechter M D
Sprague-Dawley
Thiazepines/pharmacology