1 40 2 Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. URL Address <a href="http://doi.org/10.1186/s12891-018-2311-4" target="_blank" rel="noreferrer noopener">http://doi.org/10.1186/s12891-018-2311-4</a> Pages 393–393 Issue 1 Volume 19 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Contributions of symptomatic osteoarthritis and physical function to incident cardiovascular disease. Publisher An entity responsible for making the resource available BMC musculoskeletal disorders Date A point or period of time associated with an event in the lifecycle of the resource 2018 2018-11 Subject The topic of the resource Cardiovascular disease; Function; Osteoarthritis Creator An entity primarily responsible for making the resource Corsi Michela; Alvarez Carolina; Callahan Leigh F; Cleveland Rebecca J; Golightly Yvonne M; Jordan Joanne M; Nelson Amanda E; Renner Jordan; Tsai Allen; Allen Kelli D Description An account of the resource BACKGROUND: Osteoarthritis (OA) is associated with worsening physical function and a high prevalence of comorbid health conditions. In particular, cardiovascular disease (CVD) risk is higher in individuals with OA than the general population. Limitations in physical function may be one pathway to the development of CVD among individuals with OA. This study evaluated associations of symptomatic knee OA (sxKOA), baseline physical function and worsening of function over time with self-reported incident CVD in a community-based cohort. METHODS: Our sample consisted of individuals from the Johnston County Osteoarthritis Project who did not report having CVD at baseline. Variables used to evaluate physical function were the Health Assessment Questionnaire (HAQ), time to complete 5 chair stands, and the 8-ft walk. Worsening function for these variables was defined based on previous literature and cutoffs from our sample. Logistic regression analyses examined associations of sxKOA, baseline function and worsening of function over time with self-reported incident CVD, unadjusted and adjusted for relevant demographic and clinical characteristics. RESULTS: Among 1709 participants included in these analyses, the mean age was 59.5 +/- 9.5 years, 63.6% were women, 15% had sxKOA, and the follow up time was 5.9 +/- 1.2 years. About a third of participants reported worsening HAQ score, about two-fifths had worsened chair stand time, half had worsened walking speed during the 8-ft walk, and 16% self-reported incident CVD. In unadjusted analyses, sxKOA, baseline function, and worsening function were all associated with self-reported incident CVD. In multivariable models including all of these variables, sxKOA was not associated with incident CVD, but worsening function was significantly associated with increased CVD risk, for all three functional measures: HAQ odds ratio (OR) = 2.49 (95% confidence interval (CI) 1.90-3.25), chair stands OR = 1.58 (95% CI 1.20-2.08), 8-ft walk OR = 1.53 (95%CI 1.15-2.04). These associations for worsening function remained in models additionally adjusted for demographic and clinical characteristics related to CVD risk. CONCLUSIONS: The association between symptomatic knee osteoarthritis and cardiovascular disease risk was explained by measures of physical function. This highlights the importance of physical activity and other strategies to prevent functional loss among individuals with symptomatic knee osteoarthritis. Identifier An unambiguous reference to the resource within a given context <a href="http://doi.org/10.1186/s12891-018-2311-4" target="_blank" rel="noreferrer noopener">10.1186/s12891-018-2311-4</a> Rights Information about rights held in and over the resource Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s). 2018 Allen Kelli D Alvarez Carolina BMC musculoskeletal disorders Callahan Leigh F CARDIOVASCULAR DISEASE Cleveland Rebecca J Corsi Michela Function Golightly Yvonne M Jordan Joanne M Nelson Amanda E Osteoarthritis Renner Jordan Tsai Allen Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. URL Address <a href="http://doi.org/10.1186/s12891-018-2311-4" target="_blank" rel="noreferrer noopener">http://doi.org/10.1186/s12891-018-2311-4</a> Rights Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s). Pages 393-393 Issue 1 Volume 19 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Contributions of symptomatic osteoarthritis and physical function to incident cardiovascular disease. Publisher An entity responsible for making the resource available BMC musculoskeletal disorders Date A point or period of time associated with an event in the lifecycle of the resource 2018 2018-11 Subject The topic of the resource Female; Humans; Male; Middle Aged; Cardiovascular disease; Function; *Osteoarthritis; Aged; Incidence; Cohort Studies; Risk Factors; Exercise/*physiology; Cardiovascular Diseases/diagnosis/*epidemiology/physiopathology; Health Surveys/methods/trends; Independent Living/trends; North Carolina/epidemiology; Walk Test/methods/trends; Knee/diagnosis/*epidemiology/physiopathology Creator An entity primarily responsible for making the resource Corsi Michela; Alvarez Carolina; Callahan Leigh F; Cleveland Rebecca J; Golightly Yvonne M; Jordan Joanne M; Nelson Amanda E; Renner Jordan; Tsai Allen; Allen Kelli D Description An account of the resource BACKGROUND: Osteoarthritis (OA) is associated with worsening physical function and a high prevalence of comorbid health conditions. In particular, cardiovascular disease (CVD) risk is higher in individuals with OA than the general population. Limitations in physical function may be one pathway to the development of CVD among individuals with OA. This study evaluated associations of symptomatic knee OA (sxKOA), baseline physical function and worsening of function over time with self-reported incident CVD in a community-based cohort. METHODS: Our sample consisted of individuals from the Johnston County Osteoarthritis Project who did not report having CVD at baseline. Variables used to evaluate physical function were the Health Assessment Questionnaire (HAQ), time to complete 5 chair stands, and the 8-ft walk. Worsening function for these variables was defined based on previous literature and cutoffs from our sample. Logistic regression analyses examined associations of sxKOA, baseline function and worsening of function over time with self-reported incident CVD, unadjusted and adjusted for relevant demographic and clinical characteristics. RESULTS: Among 1709 participants included in these analyses, the mean age was 59.5 +/- 9.5 years, 63.6% were women, 15% had sxKOA, and the follow up time was 5.9 +/- 1.2 years. About a third of participants reported worsening HAQ score, about two-fifths had worsened chair stand time, half had worsened walking speed during the 8-ft walk, and 16% self-reported incident CVD. In unadjusted analyses, sxKOA, baseline function, and worsening function were all associated with self-reported incident CVD. In multivariable models including all of these variables, sxKOA was not associated with incident CVD, but worsening function was significantly associated with increased CVD risk, for all three functional measures: HAQ odds ratio (OR) = 2.49 (95% confidence interval (CI) 1.90-3.25), chair stands OR = 1.58 (95% CI 1.20-2.08), 8-ft walk OR = 1.53 (95%CI 1.15-2.04). These associations for worsening function remained in models additionally adjusted for demographic and clinical characteristics related to CVD risk. CONCLUSIONS: The association between symptomatic knee osteoarthritis and cardiovascular disease risk was explained by measures of physical function. This highlights the importance of physical activity and other strategies to prevent functional loss among individuals with symptomatic knee osteoarthritis. Identifier An unambiguous reference to the resource within a given context <a href="http://doi.org/10.1186/s12891-018-2311-4" target="_blank" rel="noreferrer noopener">10.1186/s12891-018-2311-4</a> *OSTEOARTHRITIS 2018 Aged Allen Kelli D Alvarez Carolina BMC musculoskeletal disorders Callahan Leigh F CARDIOVASCULAR DISEASE Cardiovascular Diseases/diagnosis/*epidemiology/physiopathology Cleveland Rebecca J Cohort Studies Corsi Michela Exercise/*physiology Female Function Golightly Yvonne M Health Surveys/methods/trends Humans Incidence Independent Living/trends Jordan Joanne M Knee/diagnosis/*epidemiology/physiopathology Male Middle Aged Nelson Amanda E North Carolina/epidemiology Renner Jordan Risk Factors Tsai Allen Walk Test/methods/trends