1
40
3
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Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1258/jms.2009.009017" target="_blank" rel="noreferrer noopener">http://doi.org/10.1258/jms.2009.009017</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
55-59
Issue
2
Volume
16
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Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
The Ability Of The Quadruple Test To Predict Adverse Perinatal Outcomes In A High-risk Obstetric Population
Publisher
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Journal of Medical Screening
Date
A point or period of time associated with an event in the lifecycle of the resource
2009
2009
Subject
The topic of the resource
alpha-fetoprotein; association; birth; down-syndrome; Environmental & Occupational Health; human chorionic-gonadotropin; intrauterine growth restriction; markers; maternal; preeclampsia; pregnancy; Public; serum inhibin
Creator
An entity primarily responsible for making the resource
Lao M R; Calhoun B C; Bracero L A; Wang Y; Seybold D J; Brace M; Hatjis C G
Description
An account of the resource
`Objective To determine the ability of the quadruple Down's syndrome screening test (quad screen) to predict other adverse perinatal outcomes (APO) in a high-risk obstetric population. Setting A tertiary medical centre in West Virginia. Methods We retrospectively reviewed 342 obstetric patients with quad screen data from a single clinic. The quad screen included maternal serum levels of alphafetoprotein (AFP), human chorionic gonadotrophin (hCG), uncongjugated oestriol (uE(3)) and inhibin A. The risk of APO was compared between patients with at least one abnormal marker versus no abnormal markers and >= 2 abnormal markers versus <2 abnormal markers. Abnormal markers were determined by cut-off values produced by Receiver Operator Characteristic (ROC) curves and the FASTER trial. Unadjusted and adjusted effects were estimated using logistic regression analysis. Results The risk of having an APO increased significantly for patients with abnormal markers by about three-fold using ROC and two-fold using FASTER trial thresholds. Conclusions The quad screen shows value in predicting risk of APO in high-risk patients.
Identifier
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<a href="http://doi.org/10.1258/jms.2009.009017" target="_blank" rel="noreferrer noopener">10.1258/jms.2009.009017</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
2009
Alpha-fetoprotein
association
birth
Brace M
Bracero L A
Calhoun B C
down-syndrome
Environmental & Occupational Health
Hatjis C G
human chorionic-gonadotropin
intrauterine growth restriction
Journal Article or Conference Abstract Publication
Journal of Medical Screening
Lao M R
markers
maternal
Preeclampsia
Pregnancy
Public
serum inhibin
Seybold D J
Wang Y
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1002/1097-4644(20010601)81:3%3C535::aid-jcb1067%3E3.0.co;2-6" target="_blank" rel="noreferrer noopener">http://doi.org/10.1002/1097-4644(20010601)81:3%3C535::aid-jcb1067%3E3.0.co;2-6</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
535-546
Issue
3
Volume
81
Search for Full-text
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<p>Users with a NEOMED Library login can search for full-text journal articles at the following url: <a href="https://libraryguides.neomed.edu/home">https://libraryguides.neomed.edu/home</a></p>
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Title
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Baculovirus-expressed vitamin D-binding protein-macrophage activating factor (DBP-maf) activates osteoclasts and binding of 25-hydroxyvitamin D-3 does not influence this activity
Publisher
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Journal of Cellular Biochemistry
Date
A point or period of time associated with an event in the lifecycle of the resource
2001
2001
Subject
The topic of the resource
activating factor (DBP-maf); albumin; alpha-fetoprotein; Biochemistry & Molecular Biology; bone resorption; bone resorption; Cell Biology; cells; family; gc-globulin; group-specific component; identification; in-vitro; member; osteoclast activation; recombinant DBP-maf; vitamin D-binding protein (DBP); vitamin D-binding protein macrophage
Creator
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Swamy N; Ghosh S; Schneider G B; Ray R
Description
An account of the resource
Vitamin D-binding protein (DBP) is a multi-functional serum protein that is converted to vitamin D-binding protein-macrophage activating factor (DBP-maf) by post-translational modification. DBP-maf is a new cytokine that mediates bone resorption by activating osteoclasts, which are responsible for resorption of bone. Defective osteoclast activation leads to disorders like osteopetrosis, characterized by excessive accumulation of bone mass. Previous studies demonstrated that two nonallelic mutations in the rat with osteopetrosis have independent defects in the cascade involved in the conversion of DBP to DBP-maf. The skeletal defects associated with osteopetrosis are corrected in these mutants with in vivo DBP-maf treatment. This study evaluates the effects of various forms of DBP-maf (native, recombinant, and 25-hydroxyvitamin D-3 bound) on osteoclast function in vitro in order to determine some of the structural requirements of this protein that relate to bone resorbing activities. Osteoclast activity was determined by evaluating pit formation using osteoclasts, isolated from the long bones of newborn rats, incubated on calcium phosphate coated, thin film, Ostologic MultiTest Slides. Incubation of osteoclasts with ex vivo generated native DBP-maf resulted in a dose dependent, statistically significant, activation of the osteoclasts. The activation was similar whether or not the vitamin D binding site of the DBP-maf was occupied. The level of activity in response to DBP-maf was greater than that elicited by optimal doses of other known stimulators (PTH and 1,25(OH)(2)D-3) of osteoclast function. Furthermore, another potent macrophage activating factor, interferon-gamma, had no effect on osteoclast activity. The activated form of a full length recombinant DBP, expressed in E. coli showed no activity in the in vitro assay. Contrary to this finding, baculovirus-expressed recombinant DBP-maf demonstrated significant osteoclast activating activity. The normal conversion of DBP to DBP-maf requires the selective removal of galactose and sialic acid from the third domain of the protein. Hence, the differential effects of the two recombinant forms of DBP-maf is most likely related to glycosylation; E. coli expressed recombinant DBP is non-glycosylated, whereas the baculovirus expressed form is glycosylated. These data support the essential role of glycosylation for the osteoclast activating property of DBP-mai. J. Cell. Biochem. 81:535-546, 2001. (C) 2001 Wiley-Liss, Inc.
Identifier
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<a href="http://doi.org/10.1002/1097-4644(20010601)81:3%3C535::aid-jcb1067%3E3.0.co;2-6" target="_blank" rel="noreferrer noopener">10.1002/1097-4644(20010601)81:3%3C535::aid-jcb1067%3E3.0.co;2-6</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article
2001
activating factor (DBP-maf)
albumin
Alpha-fetoprotein
Biochemistry & Molecular Biology
Bone resorption
Cell Biology
Cells
Family
gc-globulin
Ghosh S
group-specific component
identification
in-vitro
Journal Article
Journal of cellular biochemistry
member
osteoclast activation
Ray R
recombinant DBP-maf
Schneider G B
Swamy N
vitamin D-binding protein (DBP)
vitamin D-binding protein macrophage
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.gore.2015.06.006" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.gore.2015.06.006</a>
Pages
64–67
Volume
13
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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Hepatoid carcinoma of the ovary: A case report and review of the literature.
Publisher
An entity responsible for making the resource available
Gynecologic oncology reports
Date
A point or period of time associated with an event in the lifecycle of the resource
2015
2015-08
Subject
The topic of the resource
Alpha-fetoprotein; Hepatoid ovarian carcinoma
Creator
An entity primarily responsible for making the resource
Randolph Laura K; Hopkins Maeve K; Hopkins Michael P; Wasdahl Daniel A
Description
An account of the resource
Primary hepatoid carcinoma of the ovary (HCO) is a rare aggressive tumor that typically presents at an advanced stage in postmenopausal women with unilateral or bilateral ovarian masses and elevated AFP and CA125. We report a case of HCO in a 73 year-old woman who presented with abdominal distention, weight loss, and a large lower abdominal mass. Postoperative serum AFP was markedly elevated and trended down with initiation of chemotherapy. Review of the literature revealed thirty-two reported cases with no consensus on histogenesis or consistent immunohistochemical profile other than positive AFP staining in all but one case. Although the optimal treatment has not yet been determined, tumor debulking surgery followed by a platinum and taxane based chemotherapy regimen has shown promise. Both serum AFP and CA125 appear to have prognostic value and can be used to follow response to treatment and screen for recurrence.
Identifier
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<a href="http://doi.org/10.1016/j.gore.2015.06.006" target="_blank" rel="noreferrer noopener">10.1016/j.gore.2015.06.006</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2015
Alpha-fetoprotein
Gynecologic oncology reports
Hepatoid ovarian carcinoma
Hopkins Maeve K
Hopkins Michael P
Randolph Laura K
Wasdahl Daniel A