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Text
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URL Address
<a href="http://doi.org/10.1586/ern.09.51" target="_blank" rel="noreferrer noopener">http://doi.org/10.1586/ern.09.51</a>
Pages
1073–1085
Issue
7
Volume
9
Dublin Core
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Title
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The serotonin 5-HT6 receptor: a viable drug target for treating cognitive deficits in Alzheimer's disease.
Publisher
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Expert review of neurotherapeutics
Date
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2009
2009-07
Subject
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Humans; Animals; Structure-Activity Relationship; Serotonin/*metabolism; Drug Design; Alzheimer Disease/*complications; Cognition Disorders/*drug therapy/*etiology; Serotonin Antagonists/chemistry/*therapeutic use; Receptors; Biological; Models
Creator
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Geldenhuys Werner J; Van der Schyf Cornelis J
Description
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The serotonin 6 receptor is attracting attention as an etiological contributor in cognition deficits in diseases such as Alzheimer's disease, anxiety/depression and schizophrenia. In this review, we discuss the role of this recently discovered G protein-coupled receptor in cognition and memory, particularly in Alzheimer's disease. A surge in publications that describe the development of ligands for this receptor have recently come to light, underscoring the emerging interest in this receptor as a drug target. We also explore the current status of structure-activity relationship studies that have focused on the design of novel antagonists for the serotonin 6 receptor.
Identifier
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<a href="http://doi.org/10.1586/ern.09.51" target="_blank" rel="noreferrer noopener">10.1586/ern.09.51</a>
Rights
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2009
Alzheimer Disease/*complications
Animals
Biological
Cognition Disorders/*drug therapy/*etiology
Drug Design
Expert review of neurotherapeutics
Geldenhuys Werner J
Humans
Models
Receptors
Serotonin Antagonists/chemistry/*therapeutic use
Serotonin/*metabolism
Structure-Activity Relationship
Van der Schyf Cornelis J