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40
6
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Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
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<a href="http://doi.org/10.1111/nan.12711" target="_blank" rel="noreferrer noopener">http://doi.org/10.1111/nan.12711</a>
ISSN
1365-2990 0305-1846
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April 2021 List
NEOMED College
NEOMED College of Pharmacy
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Department of Pharmaceutical Sciences
NEOMED Student Publications
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Title
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Irisin treatment lowers levels of phosphorylated tau in the hippocampus of pre-symptomatic female but not male htau mice.
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Neuropathology And Applied Neurobiology
Date
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2021
2021-03-26
Subject
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Alzheimer disease; anti-inflammatory agents; Dementia; metabolic diseases; neurofibrillary tangles; physical exertion; tauopathies
Creator
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Bretland KA; Lin Li; Bretland KM; Smith MA; Fleming SM; Dengler-Crish CM
Description
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AIMS: Irisin is a hormone cleaved from fibronectin type-III domain-containing protein 5 in response to exercise and may be therapeutic in Alzheimer's disease (AD). Irisin is shown to repair damage caused by midlife cardiometabolic risk factors for AD (i.e., diabetes mellitus; hypertension), prevent neural amyloid beta aggregation, and reduce neuroinflammation. However, there are no investigations of irisin's effect on AD-associated tauopathy in the brain. This study begins to address this gap in knowledge. METHODS: Transgenic htau mice that selectively develop age-related tauopathy were treated with recombinant irisin (100 ug/kg weekly i.p.) beginning at a pre-symptomatic age (4 months) to determine if irisin could prevent emergence of early neuropathology. One month later, mice were sacrificed to collect brain tissue and serum. Protein levels of ptau (serine 202), inflammatory cytokine tumour necrosis factor alpha (TNFα) and FNDC5 were quantified using capillary-based western blotting (Wes). RESULTS: Our data show that irisin treatment significantly reduced ptau and TNFα in hippocampus and serum of female htau mice compared to vehicle-treated controls. Irisin treatment did not alter ptau levels in male htau hippocampus and appeared to enhance both neural and systemic TNFα levels. CONCLUSIONS: This study provides the first evidence that enhancing the endogenous hormone irisin may be therapeutic against emerging neuropathology in a tauopathy-selective AD model. This is important because there are currently no disease-modifying therapeutics available for AD, and few agents in development address the multiple disease targets irisin appears to-making irisin an intriguing therapeutic candidate for further investigation.
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<a href="http://doi.org/10.1111/nan.12711" target="_blank" rel="noreferrer noopener">10.1111/nan.12711</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
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journalArticle
2021
Alzheimer disease
Anti-Inflammatory Agents
April 2021 List
Bretland KA
Bretland KM
dementia
Dengler-Crish CM
Department of Pharmaceutical Sciences
Fleming SM
journalArticle
Lin Li
metabolic diseases
NEOMED College of Pharmacy
NEOMED College of Pharmacy Student
NEOMED Student Publications
neurofibrillary tangles
Neuropathology And Applied Neurobiology
Physical Exertion
Smith MA
Tauopathies
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<table width="91" style="border-collapse:collapse;width:68pt;"><colgroup><col width="91" style="width:68pt;" /></colgroup><tbody><tr style="height:15pt;"><td width="91" height="20" class="xl18" style="width:68pt;height:15pt;"><a href="http://doi.org/10.1111/nan.12711">http://doi.org/10.1111/nan.12711</a></td>
</tr></tbody></table>
NEOMED College
NEOMED College of Medicine
NEOMED Department
Department of Pharmaceutical Sciences
Update Year & Number
Jan to Aug list 2021
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Irisin treatment lowers levels of phosphorylated tau in the hippocampus of pre-symptomatic female but not male htau mice.
Creator
An entity primarily responsible for making the resource
Bretland KA; Lin Li; Bretland KM; Smith MA; Fleming SM; Dengler-Crish CM
Publisher
An entity responsible for making the resource available
Neuropathology And Applied Neurobiology
Date
A point or period of time associated with an event in the lifecycle of the resource
2021
2021-05-05
Description
An account of the resource
Irisin is a hormone cleaved from fibronectin type-III domain-containing protein 5 in response to exercise and may be therapeutic in Alzheimer's disease (AD). Irisin is shown to repair damage caused by midlife cardiometabolic risk factors for AD (i.e., diabetes mellitus; hypertension), prevent neural amyloid beta aggregation and reduce neuroinflammation. However, there are no investigations of irisin's effect on AD-associated tauopathy in the brain. This study begins to address this gap in knowledge.
Subject
The topic of the resource
Transgenic htau mice that selectively develop age-related tauopathy were treated with recombinant irisin (100 µg/kg weekly i.p.) beginning at a pre-symptomatic age (4 months) to determine if irisin could prevent emergence of early neuropathology. One month later, mice were sacrificed to collect brain tissue and serum. Protein levels of ptau (serine 202), inflammatory cytokine tumour necrosis factor alpha (TNFα) and FNDC5 were quantified using capillary-based western blotting (Wes).
Identifier
An unambiguous reference to the resource within a given context
<table width="91" style="border-collapse:collapse;width:68pt;"><colgroup><col width="91" style="width:68pt;" /></colgroup><tbody><tr style="height:15pt;"><td width="91" height="20" class="xl18" style="width:68pt;height:15pt;"><a href="http://doi.org/10.1111/nan.12711">http://doi.org/10.1111/nan.12711</a></td>
</tr></tbody></table>
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© 2021 The Authors. Neuropathology and Applied Neurobiology published by John Wiley & Sons Ltd on behalf of British Neuropathological Society.
Format
The file format, physical medium, or dimensions of the resource
Journal Article
2021
Alzheimer disease
Anti-Inflammatory Agents
dementia
metabolic diseases
Neurofibrillary tangle
Physical Exertion
Tauopathies
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<table width="91" style="border-collapse:collapse;width:68pt;"><colgroup><col width="91" style="width:68pt;" /></colgroup><tbody><tr style="height:15pt;"><td width="91" height="20" class="xl18" style="width:68pt;height:15pt;"><a href="http://doi.org/10.3390/cells10040957">http://doi.org/10.3390/cells10040957</a></td>
</tr></tbody></table>
NEOMED College
NEOMED College of Medicine
NEOMED Department
Department of Pharmaceutical Sciences
Update Year & Number
Jan to Aug list 2021
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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Microglial Function and Regulation during Development, Homeostasis and Alzheimer's Disease
Creator
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Casali BT; Reed-Geaghan EG
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Cells
Date
A point or period of time associated with an event in the lifecycle of the resource
2021
2021-04-20
Description
An account of the resource
Microglia are the resident immune cells of the brain, deriving from yolk sac progenitors that populate the brain parenchyma during development. During development and homeostasis, microglia play critical roles in synaptogenesis and synaptic plasticity, in addition to their primary role as immune sentinels. In aging and neurodegenerative diseases generally, and Alzheimer’s disease (AD) specifically, microglial function is altered in ways that significantly diverge from their homeostatic state, inducing a more detrimental inflammatory environment. In this review, we discuss the receptors, signaling, regulation and gene expression patterns of microglia that mediate their phenotype and function contributing to the inflammatory milieu of the AD brain, as well as strategies that target microglia to ameliorate the onset, progression and symptoms of AD.
Identifier
An unambiguous reference to the resource within a given context
<table width="91" style="border-collapse:collapse;width:68pt;"><colgroup><col width="91" style="width:68pt;" /></colgroup><tbody><tr style="height:15pt;"><td width="91" height="20" class="xl18" style="width:68pt;height:15pt;"><a href="http://doi.org/10.3390/cells10040957">http://doi.org/10.3390/cells10040957</a></td>
</tr></tbody></table>
Format
The file format, physical medium, or dimensions of the resource
Journal Article
2021
Alzheimer disease
Inflammation
Microglia
neurodegenerative disease
Neuroinflammation
TREM2
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1111/joim.13244" target="_blank" rel="noreferrer noopener">http://doi.org/10.1111/joim.13244</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
ISSN
1365-2796 0954-6820
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Locate full-text within NEOMED Library's e-journal collections
<a href="http://neomed.idm.oclc.org/login?url=http://doi.org/10.1111/joim.13244" target="_blank" rel="noreferrer noopener">NEOMED Full-text Holding (if available) - Proxy DOI: 10.1111/joim.13244</a>
<p>Users with a NEOMED Library login can search for full-text journal articles at the following url: <a href="https://libraryguides.neomed.edu/home">https://libraryguides.neomed.edu/home</a></p>
Update Year & Number
February 2021 List
NEOMED College
NEOMED College of Medicine
NEOMED Department
Department of Family & Community Medicine
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Practical Recommendations for Timely, Accurate Diagnosis of Symptomatic Alzheimer's Disease (MCI and Dementia) in Primary Care: A Review and Synthesis.
Date
A point or period of time associated with an event in the lifecycle of the resource
2021
2021-01-18
Subject
The topic of the resource
Alzheimer Disease; Biomarkers; Dementia; Disease-Modifying Therapies; Mild Cognitive Impairment; Primary Health Care
Creator
An entity primarily responsible for making the resource
Liss JL;Seleri MAS;Cummings J;Atri A;Geldmacher DS;Candela SF;Devanand DP;Fillit HM;Susman J;Mintzer J;Bittner T;Brunton SA;Kerwin DR;Clay JW;Small GW;Grossberg GT;Clevenger CK;Cotter V;Stefanacci R;Wise-Brown A;Sabbagh MN
Description
An account of the resource
The critical role of primary care clinicians (PCCs) in Alzheimer's disease (AD) prevention, diagnosis and management must evolve as new treatment paradigms and disease-modifying therapies (DMTs) emerge. Our understanding of AD has grown substantially: No longer conceptualized as a late-in-life syndrome of cognitive and functional impairments, we now recognize that AD pathology builds silently for decades before cognitive impairment is detectable. Clinically, AD first manifests subtly as mild cognitive impairment (MCI) due to AD before progressing to dementia. Emerging optimism for improved outcomes in AD stem from a focus on preventive interventions in mid-life and timely, biomarker-confirmed diagnosis at early signs of cognitive deficits (ie, MCI due to AD and mild AD dementia). A timely AD diagnosis is particularly important for optimizing patient care and enabling the appropriate use of anticipated DMTs. An accelerating challenge for PCCs and AD specialists will be to respond to innovations in diagnostics and therapy for AD in a system that is not currently well positioned to do so. To overcome these challenges, PCCs and AD specialists must collaborate closely to navigate and optimize dynamically evolving AD care in the face of new opportunities. In the spirit of this collaboration, we summarize here some prominent and influential models that inform our current understanding of AD. We also advocate for timely and accurate (ie, biomarker-defined) diagnosis of early AD. In doing so, we consider evolving issues related to prevention, detecting emerging cognitive impairment, and the role of biomarkers in the clinic.
Identifier
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<a href="http://doi.org/10.1111/joim.13244" target="_blank" rel="noreferrer noopener">10.1111/joim.13244</a>
Format
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journalArticle
Publisher
An entity responsible for making the resource available
Journal Of Internal Medicine
2021
Alzheimer disease
Atri A
Biomarkers
Bittner T
Brunton SA
Candela SF
Clay JW
Clevenger CK
Cotter V
Cummings J
dementia
Department of Family & Community Medicine
Devanand DP
Disease-Modifying Therapies
February 2021 List
Fillit HM
Geldmacher DS
Grossberg GT
Journal Of Internal Medicine
journalArticle
Kerwin DR
Liss JL
Mild Cognitive Impairment
Mintzer J
NEOMED College of Medicine
Primary Health Care
Sabbagh MN
Seleri MAS
Small GW
Stefanacci R
Susman J
Wise-Brown A
-
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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Articles Published in 2021
Creator
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Shelley Harrell
Publisher
An entity responsible for making the resource available
Shelley Harrell
Date
A point or period of time associated with an event in the lifecycle of the resource
2021
Description
An account of the resource
Items published in 2021
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<table width="91" style="border-collapse:collapse;width:68pt;"><colgroup><col width="91" style="width:68pt;" /></colgroup><tbody><tr style="height:72pt;"><td width="91" height="96" class="xl18" style="width:68pt;height:72pt;"><a href="http://doi.org/10.1111/joim.13244">http://doi.org/10.1111/joim.13244</a></td>
</tr></tbody></table>
NEOMED College
NEOMED College of Medicine
NEOMED Department
Department of Family & Community Medicine
Update Year & Number
Jan to Aug list 2021
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Practical Recommendations for Timely, Accurate Diagnosis of Symptomatic Alzheimer's Disease (MCI and Dementia) in Primary Care: A Review and Synthesis.
Creator
An entity primarily responsible for making the resource
Liss JL;Seleri MAS;Cummings J;Atri A;Geldmacher DS;Candela SF;Devanand DP;Fillit HM;Susman J;Mintzer J;Bittner T;Brunton SA;Kerwin DR;Clay JW;Small GW;Grossberg GT;Clevenger CK;Cotter V;Stefanacci R;Wise-Brown A;Sabbagh MN
Publisher
An entity responsible for making the resource available
Journal Of Internal Medicine
Date
A point or period of time associated with an event in the lifecycle of the resource
2021
2021-01-18
Description
An account of the resource
The critical role of primary care clinicians (PCCs) in Alzheimer’s disease (AD) prevention, diagnosis and management must evolve as new treatment paradigms and disease-modifying therapies (DMTs) emerge. Our understanding of AD has grown substantially: no longer conceptualized as a late-in-life syndrome of cognitive and functional impairments, we now recognize that AD pathology builds silently for decades before cognitive impairment is detectable. Clinically, AD first manifests subtly as mild cognitive impairment (MCI) due to AD before progressing to dementia. Emerging optimism for improved outcomes in AD stems from a focus on preventive interventions in midlife and timely, biomarker-confirmed diagnosis at early signs of cognitive deficits (i.e. MCI due to AD and mild AD dementia). A timely AD diagnosis is particularly important for optimizing patient care and enabling the appropriate use of anticipated DMTs. An accelerating challenge for PCCs and AD specialists will be to respond to innovations in diagnostics and therapy for AD in a system that is not currently well positioned to do so. To overcome these challenges, PCCs and AD specialists must collaborate closely to navigate and optimize dynamically evolving AD care in the face of new opportunities. In the spirit of this collaboration, we summarize here some prominent and influential models that inform our current understanding of AD. We also advocate for timely and accurate (i.e. biomarker-defined) diagnosis of early AD. In doing so, we consider evolving issues related to prevention, detecting emerging cognitive impairment and the role of biomarkers in the clinic.
Identifier
An unambiguous reference to the resource within a given context
<table width="91" style="border-collapse:collapse;width:68pt;"><colgroup><col width="91" style="width:68pt;" /></colgroup><tbody><tr style="height:72pt;"><td width="91" height="96" class="xl18" style="width:68pt;height:72pt;"><a href="http://doi.org/10.1111/joim.13244">http://doi.org/10.1111/joim.13244</a></td>
</tr></tbody></table>
Type
The nature or genre of the resource
Journal Article
2021
Alzheimer disease
Biomarkers
dementia
Disease-Modifying Therapies
Mild Cognitive Impairment
Primary Health Care
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.3390/microorganisms8040493" target="_blank" rel="noreferrer noopener">http://doi.org/10.3390/microorganisms8040493</a>
Issue
4
Volume
8
ISSN
2076-2607 2076-2607
Search for Full-text
Locate full-text within NEOMED Library's e-journal collections
<a href="http://neomed.idm.oclc.org/login?url=http://doi.org/10.3390/microorganisms8040493" target="_blank" rel="noreferrer noopener">NEOMED Full-text Holding (if available) - Proxy DOI: 10.3390/microorganisms8040493</a>
<p>Users with a NEOMED Library login can search for full-text journal articles at the following url: <a href="https://libraryguides.neomed.edu/home">https://libraryguides.neomed.edu/home</a></p>
Update Year & Number
June 2020 Update I
NEOMED College
NEOMED College of Medicine
NEOMED Department
NEOMED Student Publications
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
The Microbiota-Gut-Brain Axis-Heart Shunt Part II: Prosaic Foods and the Brain-Heart Connection in Alzheimer Disease.
Publisher
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Microorganisms
Date
A point or period of time associated with an event in the lifecycle of the resource
2020
2020-03-31
Subject
The topic of the resource
Alzheimer disease; brain; cerebrovascular; co-metabolism; French paradox; heart; microbiota-gut-brain axis; Parkinson's disease; polyphenol; prosaic foods; red wine; trimethylamine-N-oxide (TMANO/TMAO)
Creator
An entity primarily responsible for making the resource
Obrenovich Mark; Tabrez Shams; Siddiqui Bushra; McCloskey Benjamin; Perry George
Description
An account of the resource
There is a strong cerebrovascular component to brain aging, Alzheimer disease, and vascular dementia. Foods, common drugs, and the polyphenolic compounds contained in wine modulate health both directly and through the gut microbiota. This observation and novel findings centered on nutrition, biochemistry, and metabolism, as well as the newer insights we gain into the microbiota-gut-brain axis, now lead us to propose a shunt to this classic triad, which involves the heart and cerebrovascular systems. The French paradox and prosaic foods, as they relate to the microbiota-gut-brain axis and neurodegenerative diseases, are discussed in this manuscript, which is the second part of a two-part series of concept papers addressing the notion that the microbiota and host liver metabolism all play roles in brain and heart health.
Identifier
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<a href="http://doi.org/10.3390/microorganisms8040493" target="_blank" rel="noreferrer noopener">10.3390/microorganisms8040493</a>
Rights
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Format
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journalArticle
2020
Alzheimer disease
Brain
cerebrovascular
co-metabolism
French paradox
heart
Journal Article
journalArticle
June 2020 Update I
McCloskey Benjamin
microbiota-gut-brain axis
microorganisms
NEOMED College of Medicine Student
NEOMED Student Publications
Obrenovich Mark
Parkinson's disease
Perry George
polyphenol
prosaic foods
red wine
Siddiqui Bushra
Tabrez Shams
trimethylamine-N-oxide (TMANO/TMAO)