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40
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Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Pages
211–217
Issue
2
Volume
160
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Spinal beta-endorphin analgesia involves an interaction with local monoaminergic systems.
Publisher
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European journal of pharmacology
Date
A point or period of time associated with an event in the lifecycle of the resource
1989
1989-01
Subject
The topic of the resource
Male; Animals; Rats; Adrenergic alpha-Antagonists/pharmacology; Injections; Serotonin Antagonists/pharmacology; Naltrexone/pharmacology; Spinal Cord/*drug effects; Biogenic Monoamines/*physiology; Analgesics/administration & dosage/antagonists & inhibitors/*pharmacology; beta-Endorphin/administration & dosage/antagonists & inhibitors/*pharmacology; Norepinephrine/physiology; Serotonin/physiology; Inbred Strains; Spinal
Creator
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Crisp T; Stafinsky J L; Hess J E; Uram M
Description
An account of the resource
beta-Endorphin administered intrathecally (i.t.) in rats produced a dose-dependent elevation in tail-flick latency. Naltrexone administered i.t. as a pretreatment reversed the spinal antinociceptive action of beta-endorphin, suggesting that the opioid interacts directly with spinal opiate receptors. Spinal administration of the alpha 1-adrenoceptor antagonist WB-4101 failed to alter the analgesic effects of the opioid, whereas the alpha 2-adrenoceptor antagonist yohimbine completely blocked beta-endorphin-induced elevations in tail-flick latency. Thus, there is an apparent specificity for the alpha
Rights
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1989
Adrenergic alpha-Antagonists/pharmacology
Analgesics/administration & dosage/antagonists & inhibitors/*pharmacology
Animals
beta-Endorphin/administration & dosage/antagonists & inhibitors/*pharmacology
Biogenic Monoamines/*physiology
Crisp T
European journal of pharmacology
Hess J E
Inbred Strains
Injections
Male
Naltrexone/pharmacology
Norepinephrine/physiology
Rats
Serotonin Antagonists/pharmacology
Serotonin/physiology
Spinal
Spinal Cord/*drug effects
Stafinsky J L
Uram M