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Text
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URL Address
<a href="http://doi.org/10.1016/j.bmcl.2014.03.021" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.bmcl.2014.03.021</a>
Pages
2163–2167
Issue
9
Volume
24
Dublin Core
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Title
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A novel Lipoprotein lipase (LPL) agonist rescues the enzyme from inhibition by angiopoietin-like 4 (ANGPTL4).
Publisher
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Bioorganic & medicinal chemistry letters
Date
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2014
2014-05
Subject
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Angiopoietin-like 4 Protein; Angiopoietins/*metabolism; ANGPTL4; Atherosclerosis; Benzamides/pharmacology; Drug Discovery; Enzyme Activation/*drug effects; High-throughput screen; Homology model; Humans; Ibrolipim; Lipoprotein Lipase/*metabolism; LPL; Molecular Docking Simulation; NO-1886; Organophosphorus Compounds/pharmacology
Creator
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Geldenhuys Werner J; Aring Danielle; Sadana Prabodh
Description
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Lipoprotein lipase (LPL) is a key physiological regulator of triglycerides and atherosclerosis risk. Random screening identified a compound designated C10, showing greater LPL agonist activity than NO-1886, a known LPL agonist. Structure-activity relationship (SAR) exploration of C10 led to the identification of C10d exhibiting at least two fold greater LPL activation than
Identifier
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<a href="http://doi.org/10.1016/j.bmcl.2014.03.021" target="_blank" rel="noreferrer noopener">10.1016/j.bmcl.2014.03.021</a>
Rights
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2014
Angiopoietin-like 4 Protein
Angiopoietins/*metabolism
ANGPTL4
Aring Danielle
Atherosclerosis
Benzamides/pharmacology
Bioorganic & medicinal chemistry letters
Department of Pharmaceutical Sciences
Department of Pharmacy Practice
Drug Discovery
Enzyme Activation/*drug effects
Geldenhuys Werner J
High-throughput screen
Homology model
Humans
Ibrolipim
Lipoprotein Lipase/*metabolism
LPL
Molecular Docking Simulation
NEOMED College of Graduate Studies
NEOMED College of Pharmacy
NO-1886
Organophosphorus Compounds/pharmacology
Sadana Prabodh