1
40
4
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/s0024-3205(00)00658-5" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/s0024-3205(00)00658-5</a>
Pages
643–650
Issue
6
Volume
67
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Phenobarbital pre-treatment prevents kainic acid-induced impairments in acquisition learning.
Publisher
An entity responsible for making the resource available
Life sciences
Date
A point or period of time associated with an event in the lifecycle of the resource
2000
2000-06
Subject
The topic of the resource
Animal/drug effects; Animals; Behavior; Cues; Excitatory Amino Acid Agonists/*toxicity; GABA Modulators/*pharmacology; Kainic Acid/*antagonists & inhibitors/*toxicity; Learning/drug effects; Long-Evans; Male; Maze Learning/*drug effects; Memory/drug effects; Phenobarbital/*pharmacology; Rats; Seizures/chemically induced/prevention & control
Creator
An entity primarily responsible for making the resource
Brown-Croyts L M; Caton P W; Radecki D T; McPherson S L
Description
An account of the resource
This study examined the protective effect of phenobarbital on kainic acid-induced deficits in acquisition learning. A single kainic acid injection (9 mg/kg i.p.) was administered five days prior to testing using the Morris water maze test. Kainic acid produced deficits in the acquisition of spatial information observed as an increase in latency to a hidden escape platform. Daily phenobarbital treatment (20 mg/kg i.p.) initiated 45 minutes prior to the kainic acid injection blocked the kainic acid-induced deficits in acquisition learning. When daily phenobarbital treatment was initiated 2-3 hours after kainic acid seizure development it did not block the kainic acid induced-deficits in water maze performance. Daily administration of phenobarbital alone at the moderate concentration used in this study did not cause alterations in behavioral performance in the Morris water maze. These studies indicate that phenobarbital pre-treatment results in a behavioral neuroprotection against kainic acid-induced neurotoxicity.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/s0024-3205(00)00658-5" target="_blank" rel="noreferrer noopener">10.1016/s0024-3205(00)00658-5</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2000
Animal/drug effects
Animals
Behavior
Brown-Croyts L M
Caton P W
Cues
Excitatory Amino Acid Agonists/*toxicity
GABA Modulators/*pharmacology
Kainic Acid/*antagonists & inhibitors/*toxicity
Learning/drug effects
Life sciences
Long-Evans
Male
Maze Learning/*drug effects
McPherson S L
Memory/drug effects
Phenobarbital/*pharmacology
Radecki D T
Rats
Seizures/chemically induced/prevention & control
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1196/annals.1432.010" target="_blank" rel="noreferrer noopener">http://doi.org/10.1196/annals.1432.010</a>
Pages
140–150
Volume
1139
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Sex differences in dopamine- and vesicular monoamine-transporter functions.
Publisher
An entity responsible for making the resource available
Annals of the New York Academy of Sciences
Date
A point or period of time associated with an event in the lifecycle of the resource
2008
2008-10
Subject
The topic of the resource
3; 4-Dihydroxyphenylacetic Acid/metabolism; Adrenergic Uptake Inhibitors/metabolism; Animal/drug effects; Animals; Behavior; Behavior/drug effects; Corpus Striatum/metabolism; Dopamine Agents/pharmacology; Dopamine Plasma Membrane Transport Proteins/*metabolism; Dopamine Uptake Inhibitors/metabolism; Female; Humans; Male; Methamphetamine/pharmacology; Mice; Nomifensine/metabolism; Reserpine/metabolism; Sex Factors; Vesicular Monoamine Transport Proteins/*metabolism
Creator
An entity primarily responsible for making the resource
Dluzen D E; McDermott J L
Description
An account of the resource
Men and women differ with regard to their use of, and responses to, methamphetamine (MA). Analogous sex differences with regard to MA are observed in animal models. In this report, data from a series of experiments that focus upon dopamine transporter (DAT) and vesicular monoamine transporter2 (VMAT2) function are reviewed by way of providing some understanding for these sex differences to MA. The amount of dopamine (DA) recovered after infusion of DA into superfused striatal tissue was greater in females and an accentuated amount of extracellular DA was obtained from females after infusion of the DAT-blocking drug, nomifensine. These data suggest a higher level of DAT activity in females. To evaluate the implications of this sex difference in DAT function as related to MA, the amount of DA evoked by an infusion of MA into superfused striatal tissue was tested and found to be significantly greater in males. In contrast, potassium chloride-stimulated DA release was greater in females. The results of these
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1196/annals.1432.010" target="_blank" rel="noreferrer noopener">10.1196/annals.1432.010</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2008
3
4-Dihydroxyphenylacetic Acid/metabolism
Adrenergic Uptake Inhibitors/metabolism
Animal/drug effects
Animals
Annals of the New York Academy of Sciences
Behavior
Behavior/drug effects
Corpus Striatum/metabolism
Dluzen D E
Dopamine Agents/pharmacology
Dopamine Plasma Membrane Transport Proteins/*metabolism
Dopamine Uptake Inhibitors/metabolism
Female
Humans
Male
McDermott J L
Methamphetamine/pharmacology
Mice
Nomifensine/metabolism
Reserpine/metabolism
Sex Factors
Vesicular Monoamine Transport Proteins/*metabolism
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1007/s10637-009-9332-7" target="_blank" rel="noreferrer noopener">http://doi.org/10.1007/s10637-009-9332-7</a>
Pages
380–391
Issue
2
Volume
29
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Chemopreventive doses of resveratrol do not produce cardiotoxicity in a rodent model of hepatocellular carcinoma.
Publisher
An entity responsible for making the resource available
Investigational new drugs
Date
A point or period of time associated with an event in the lifecycle of the resource
2011
2011-04
Subject
The topic of the resource
*Chemoprevention; Analysis of Variance; Animal; Animal Studies; Animal/drug effects; Animals; Antioxidants; Behavior; Blotting; Carcinoma; Cardiotoxicity; Cardiotoxins/*toxicity; Chemoprevention; Data Analysis Software; Descriptive Statistics; Disease Models; Doppler; Dose-Response Relationship; Drug; Echocardiography; Feeding Behavior/drug effects; Female; Fisher's Exact Test; Funding Source; Heart – Drug Effects; Heart/drug effects/physiopathology; Hepatocellular – Prevention and Control; Hepatocellular/*drug therapy/pathology/physiopathology; Hepatocytes/drug effects/pathology; Humans; Liver Neoplasms/*drug therapy/pathology/physiopathology; Liver/drug effects/pathology/physiopathology; Polyphenols – Therapeutic Use; Rats; Resveratrol; Sprague-Dawley; Stilbenes/*therapeutic use; Systole/drug effects; Western
Creator
An entity primarily responsible for making the resource
Luther Daniel J; Ohanyan Vahagn; Shamhart Patricia E; Hodnichak Cheryl M; Sisakian Hamayak; Booth Tristan D; Meszaros J Gary; Bishayee Anupam
Description
An account of the resource
Hepatocellular carcinoma (HCC), one of the most lethal cancers, results in more than one million fatalities worldwide every year. In view of the limited therapeutic alternatives and poor prognosis of liver cancer, preventive control approaches, notably chemoprevention, have been considered to be the best strategy in lowering the present prevalence of the disease. Resveratrol, a naturally occurring antioxidant and antiinflammatory agent found in grapes and red wine, inhibits carcinogenesis with a pleiotropic mode of action. Recently, we have reported that dietary resveratrol significantly prevents chemically-induced liver tumorigenesis in rats. One of the mechanisms of resveratrol-mediated chemoprevention of hepatocarcinogenesis could be related to its antiinflammatory action through hepatic cyclooxygenase (COX-2) inhibition. Although several COX-2 inhibitors are known to exert chemopreventive efficacy, not all are considered ideal candidates for chemoprevention due to the risk of adverse cardiovascular events. Accordingly, the objective of the present study was to evaluate the role of resveratrol on cardiac performance during experimental hepatocarcinogenesis initiated with diethylnitrosamine and promoted by phenobarbital. Rats had free access to diet supplemented with resveratrol four weeks before the carcinogen injection and 14 weeks thereafter. The cardiotoxicity of resveratrol was assessed by monitoring the cardiac function using transthoracic echocardiography as well as Western blot analysis of cardiac tissue. Long-term dietary administration of resveratrol dose-dependently suppressed hepatic tumor multiplicity, the principal endpoint for evaluating the chemopreventive potential of a candidate agent. The chemopreventive effects of resveratrol were also reflected in histopathological assessment of hepatic tissues. Resveratrol did not exhibit any cardiotoxicity but rather improved the cardiac function in a dose-responsive fashion. Our results indicate that resveratrol-mediated chemoprevention of rat liver carcinogenesis is devoid of any adverse cardiovascular events. Resveratrol may be developed as a chemopreventive as well as therapeutic drug for human HCC.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1007/s10637-009-9332-7" target="_blank" rel="noreferrer noopener">10.1007/s10637-009-9332-7</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Chemoprevention
2011
Analysis of Variance
Animal
Animal Studies
Animal/drug effects
Animals
Antioxidants
Behavior
Bishayee Anupam
Blotting
Booth Tristan D
Carcinoma
Cardiotoxicity
Cardiotoxins/*toxicity
Chemoprevention
Data Analysis Software
Department of Integrative Medical Sciences
Descriptive Statistics
Disease Models
Doppler
Dose-Response Relationship
Drug
Echocardiography
Feeding Behavior/drug effects
Female
Fisher's Exact Test
Funding Source
Heart – Drug Effects
Heart/drug effects/physiopathology
Hepatocellular – Prevention and Control
Hepatocellular/*drug therapy/pathology/physiopathology
Hepatocytes/drug effects/pathology
Hodnichak Cheryl M
Humans
Investigational new drugs
Liver Neoplasms/*drug therapy/pathology/physiopathology
Liver/drug effects/pathology/physiopathology
Luther Daniel J
Meszaros J Gary
NEOMED College of Medicine
Ohanyan Vahagn
Polyphenols – Therapeutic Use
Rats
Resveratrol
Shamhart Patricia E
Sisakian Hamayak
Sprague-Dawley
Stilbenes/*therapeutic use
Systole/drug effects
Western
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0741-8329(88)90075-4" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0741-8329(88)90075-4</a>
Pages
331–335
Issue
4
Volume
5
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Interaction of ethanol and tetrahydro-beta-carboline (THBC) in a discriminative task.
Publisher
An entity responsible for making the resource available
Alcohol (Fayetteville, N.Y.)
Date
A point or period of time associated with an event in the lifecycle of the resource
1988
1988-08
Subject
The topic of the resource
Male; Animals; Rats; Ethanol/*pharmacology; Behavior; Drug Interactions; Discrimination Learning/*drug effects; Conditioning (Psychology)/drug effects; Carbolines/*pharmacology; Dose-Response Relationship; Drug; Inbred Strains; Animal/drug effects
Creator
An entity primarily responsible for making the resource
Schechter M D; Signs S A
Description
An account of the resource
Rats (n = 10) were trained to discriminate between ethanol (600 mg/kg, IP) and its vehicle, or between THBC (20 mg/kg) and its vehicle in a two-lever food-motivated operant task. Once the discriminative training criterion was attained, rats in each group were administered different doses of both ethanol and THBC. The ED50 of ethanol in the ethanol-trained rats was 298.0 mg/kg and 15 mg/kg THBC produced ethanol-like responding. The ED50 of THBC in the THBC-trained rats was 3.63 mg/kg and 1200 mg/kg ethanol produced THBC-like responding. The cross-generalization between ethanol and THBC is, thus, indicated and relates to previous evidence in which both ethanol- and THBC-trained rats generalize to a common agent, TFMPP, a putatively specific 5HT1B receptor agonist. Taken together, these observations suggest that beta-carbolines may play a role in the discriminative stimulus properties of ethanol.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0741-8329(88)90075-4" target="_blank" rel="noreferrer noopener">10.1016/0741-8329(88)90075-4</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1988
Alcohol (Fayetteville, N.Y.)
Animal/drug effects
Animals
Behavior
Carbolines/*pharmacology
Conditioning (Psychology)/drug effects
Discrimination Learning/*drug effects
Dose-Response Relationship
Drug
Drug Interactions
Ethanol/*pharmacology
Inbred Strains
Male
Rats
Schechter M D
Signs S A