1 40 6 Hyperlink A link, or reference, to another resource on the Internet. URL https://pubmed.ncbi.nlm.nih.gov/36803818/ Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Role of rodent models in advancing precision medicine for Parkinson's disease Creator An entity primarily responsible for making the resource Emily Simons Sheila M Fleming Date A point or period of time associated with an event in the lifecycle of the resource 2023 Description An account of the resource With a current lack of disease-modifying treatments, an initiative toward implementing a precision medicine approach for treating Parkinson's disease (PD) has emerged. However, challenges remain in how to define and apply precision medicine in PD. To accomplish the goal of optimally targeted and timed treatment for each patient, preclinical research in a diverse population of rodent models will continue to be an essential part of the translational path to identify novel biomarkers for patient diagnosis and subgrouping, understand PD disease mechanisms, identify new therapeutic targets, and screen therapeutics prior to clinical testing. This review highlights the most common rodent models of PD and discusses how these models can contribute to defining and implementing precision medicine for the treatment of PD. Source A related resource from which the described resource is derived Handb Clin Neurol . 2023;193:3-16. Language A language of the resource English 2023 Animal models Neurotoxic models Parkinson's disease Precision medicine Rodent models Transgenic models α-Synuclein Hyperlink A link, or reference, to another resource on the Internet. URL https://doi.org/10.1007/s00455-022-10449-x Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource The Pathway from Anatomy and Physiology to Diagnosis: A Developmental Perspective on Swallowing and Dysphagia Creator An entity primarily responsible for making the resource C J Mayerl Date A point or period of time associated with an event in the lifecycle of the resource 2022 Description An account of the resource Dysphagia results from diverse and distinct etiologies. The pathway from anatomy and physiology to clinical diagnosis is complex and hierarchical. Our approach in this paper is to show the linkages from the underlying anatomy and physiology to the clinical presentation. In particular, the terms performance, function, behavior, and physiology are often used interchangeably, which we argue is an obstacle to clear discussion of mechanism of pathophysiology. We use examples from pediatric populations to highlight the importance of understanding anatomy and physiology to inform clinical practice. We first discuss the importance of understanding anatomy in the context of physiology and performance. We then use preterm infants and swallow-breathe coordination as examples to explicate the hierarchical nature of physiology and its impact on performance. We also highlight where the holes in our knowledge lie, with the ultimate endpoint of providing a framework that could enhance our ability to design interventions to help patients. Clarifying these terms, and the roles they play in the biology of dysphagia will help both the researchers studying the problems as well as the clinicians applying the results of those studies. Source A related resource from which the described resource is derived Dysphagia . 2022 Apr 19;10.1007/s00455-022-10449-x. doi: 10.1007/s00455-022-10449-x. Online ahead of print. Language A language of the resource English 2022 Animal models Deglutition Pathophysiology Pediatric. Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. URL Address <a href="http://doi.org/10.1016/j.otc.2020.03.001" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.otc.2020.03.001</a> ISSN 1557-8259 0030-6665 Search for Full-text Locate full-text within NEOMED Library's e-journal collections <a href="http://neomed.idm.oclc.org/login?url=http://doi.org/10.1016/j.otc.2020.03.001" target="_blank" rel="noreferrer noopener">NEOMED Full-text Holding (if available) - Proxy DOI: 10.1016/j.otc.2020.03.001</a> <p>Users with a NEOMED Library login can search for full-text journal articles at the following url: <a href="https://libraryguides.neomed.edu/home">https://libraryguides.neomed.edu/home</a></p> Update Year & Number June 2020 Update II NEOMED College NEOMED College of Medicine NEOMED Department Department of Anatomy & Neurobiology Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Animal Models of Tinnitus: A Review. Publisher An entity responsible for making the resource available Otolaryngologic clinics of North America Date A point or period of time associated with an event in the lifecycle of the resource 2020 2020-04-20 Subject The topic of the resource Acoustic startle reflex; Animal models; Operant behavioral methods; Psychophysics; Tinnitus Creator An entity primarily responsible for making the resource Galazyuk Alexander; Brozoski Thomas J Description An account of the resource Animal models have significantly contributed to understanding the pathophysiology of chronic subjective tinnitus. They are useful because they control etiology, which in humans is heterogeneous; employ random group assignment; and often use methods not permissible in human studies. Animal models can be broadly categorized as either operant or reflexive, based on methodology. Operant methods use variants of established psychophysical procedures to reveal what an animal hears. Reflexive methods do the same using elicited behavior, for example, the acoustic startle reflex. All methods contrast the absence of sound and presence of sound, because tinnitus cannot by definition be perceived as silence. Identifier An unambiguous reference to the resource within a given context <a href="http://doi.org/10.1016/j.otc.2020.03.001" target="_blank" rel="noreferrer noopener">10.1016/j.otc.2020.03.001</a> Rights Information about rights held in and over the resource Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s). Format The file format, physical medium, or dimensions of the resource journalArticle 2020 Acoustic startle reflex Animal models Brozoski Thomas J Department of Anatomy & Neurobiology Galazyuk Alexander journalArticle June 2020 Update II NEOMED College of Medicine Operant behavioral methods Otolaryngologic clinics of North America Psychophysics Tinnitus Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. URL Address <a href="http://doi.org/10.1046/j.1525-1438.2003.13317.x" target="_blank" rel="noreferrer noopener">http://doi.org/10.1046/j.1525-1438.2003.13317.x</a> Rights Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s). Pages 405-412 Issue 4 Volume 13 Search for Full-text Locate full-text within NEOMED Library's e-journal collections <p>Users with a NEOMED Library login can search for full-text journal articles at the following url: <a href="https://libraryguides.neomed.edu/home">https://libraryguides.neomed.edu/home</a></p> Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Rodent models for ovarian cancer research Publisher An entity responsible for making the resource available International Journal of Gynecological Cancer Date A point or period of time associated with an event in the lifecycle of the resource 2003 2003-07 Subject The topic of the resource animal models; carcinoma cell-line; epithelial; gene-therapy; immunodeficient mice; luteinizing-hormone; lysophosphatidic acid; metastasis in-vivo; mouse models; neoplasms; nude-mice; Obstetrics & Gynecology; Oncology; ovarian-cancer; p53; review; tumor-associated antigens Creator An entity primarily responsible for making the resource Stakleff K D S; Von Gruenigen V E Description An account of the resource Animal models that are biologically and clinically relevant are essential for conducting research to investigate the pathophysiologic progression of disease and to develop diagnostic or therapeutic strategies. Several rodent models that vary in methods of induction allow appropriate in vivo evaluation for ovarian cancer. The types of rodent models discussed include chemically (nonhormonal and hormonal) induced, genetic (knockout and transgenic), xenograft, and syngeneic. A summary of the available rodent models is provided with a discussion of the advantages and disadvantages of each. Optimization and application of these rodent models to future research may benefit the detection and treatment of ovarian cancer. Identifier An unambiguous reference to the resource within a given context <a href="http://doi.org/10.1046/j.1525-1438.2003.13317.x" target="_blank" rel="noreferrer noopener">10.1046/j.1525-1438.2003.13317.x</a> Format The file format, physical medium, or dimensions of the resource Journal Article 2003 Animal models carcinoma cell-line epithelial gene-therapy immunodeficient mice International Journal of Gynecological Cancer Journal Article luteinizing-hormone lysophosphatidic acid metastasis in-vivo mouse models Neoplasms nude-mice Obstetrics & Gynecology oncology ovarian-cancer p53 review Stakleff K D S tumor-associated antigens von Gruenigen V E Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. URL Address <a href="http://doi.org/10.1007/s10067-005-0141-x" target="_blank" rel="noreferrer noopener">http://doi.org/10.1007/s10067-005-0141-x</a> Rights Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s). Pages 645-647 Issue 5 Volume 25 Search for Full-text Locate full-text within NEOMED Library's e-journal collections <p>Users with a NEOMED Library login can search for full-text journal articles at the following url: <a href="https://libraryguides.neomed.edu/home">https://libraryguides.neomed.edu/home</a></p> Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Osteoarthritis is for the birds Publisher An entity responsible for making the resource available Clinical Rheumatology Date A point or period of time associated with an event in the lifecycle of the resource 2006 2006-09 Subject The topic of the resource animal models; birds; classification; guinea-pigs; inflammatory arthritis; knee; monkeys; of-rheumatology criteria; osteoarthritis; pyrophosphate deposition disease; rhesus macaques; Rheumatology; santiago; spondyloarthropathy Creator An entity primarily responsible for making the resource Rothschild B M; Panza R Description An account of the resource The purpose of this study was to assess birds as a potential model for osteoarthritis. Compromised by confounding factors, it has not been possible to clearly delineate causation in humans. Nonhuman mammals manifest osteoarthritis in the natural state too rarely for comparative study. Artificial environments (of captive animals) are associated with higher frequencies, but are still inadequate for comparative study, and surgical and chemical models provide only limited insight. As frequency of pathology (except trauma-related) in birds has not been systematically examined across species lines, several families were selected for examination. Skeletal collections of major museums were examined for presence of osteophytes in hawks and pigeons. Three percent of 2,243 free-ranging hawks and 9.8% of 2,718 pigeons had osteoarthritis, all localized to the ankle. The bird ankle morphologically resembles the human knee. Frequency in pigeons was significantly greater than in hawks (chi(2) = 86.48, p < 0.00001), but was no difference in frequency between wild caught and captive birds (chi(2) = 1.06). While misconceptions have plagued past perspectives, it turns out that the most common form of arthritis in humans (osteoarthritis) is actually for, or at least, is common in the class Aves (birds). The frequency of osteoarthritis and cacophony of bird morphologies and behaviors provides an opportunity to start to understand such causation. Identifier An unambiguous reference to the resource within a given context <a href="http://doi.org/10.1007/s10067-005-0141-x" target="_blank" rel="noreferrer noopener">10.1007/s10067-005-0141-x</a> Format The file format, physical medium, or dimensions of the resource Journal Article 2006 Animal models Birds classification Clinical rheumatology guinea-pigs inflammatory arthritis Journal Article Knee monkeys of-rheumatology criteria Osteoarthritis Panza R pyrophosphate deposition disease rhesus macaques Rheumatology Rothschild B M santiago Spondyloarthropathy Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. URL Address <a href="http://doi.org/10.1007/s00455-019-10033-w" target="_blank" rel="noreferrer noopener">http://doi.org/10.1007/s00455-019-10033-w</a> Rights Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s). Search for Full-text Locate full-text within NEOMED Library's e-journal collections <p>Users with a NEOMED Library login can search for full-text journal articles at the following url: <a href="https://libraryguides.neomed.edu/home">https://libraryguides.neomed.edu/home</a></p> Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Reduced Coordination of Hyolaryngeal Elevation and Bolus Movement in a Pig Model of Preterm Infant Swallowing Publisher An entity responsible for making the resource available Dysphagia Date A point or period of time associated with an event in the lifecycle of the resource 2019 2019-07 Subject The topic of the resource Animal models; Baby foods; Biomechanics; Deglutition; Dysphagia; Feeding; Hogs; Infants; Medical Sciences; Pig; Premature; Suidae; Swallowing Creator An entity primarily responsible for making the resource Catchpole Emily; Bond Laura; German Rebecca; Mayerl Christopher J; Stricklen Bethany; Gould François D H Description An account of the resource Preterm infants often have dysphagia. Because reducing lifetime cumulative exposure to radiation in the context of diagnosis and treatment is a continuing goal of all medical fields which use X-ray imaging, efforts exist to reduce reliance on the gold standard diagnostic tool for dysphagia, VFSS. Alternatives, such as video of external hyolaryngeal movement using video recordings of the anterior surface of the neck, must be evaluated and validated against videofluoroscopy, a task for which non-human animal models are appropriate. In this study, we tested the hypotheses that (1) swallows could be identified equally well from video of external hyolaryngeal movement and bolus movement in videofluoroscopy, and that (2) the two measures would be tightly temporally linked in both term and preterm infant pigs. We recorded 222 swallows in simultaneous and precisely synchronized high-speed videofluoroscopy and high-speed camera films of 4 preterm and 3 term infant pigs drinking milk from a bottle. In term pigs, the two measures consistently identified the same swallows in each image stream. However, in preterm pigs there was a high rate of false positives (~ 10% per feeding sequence) and false negatives (~ 27% per feeding sequence). The timing of hyolaryngeal elevation (external video) and bolus movement (videofluoroscopy) was correlated and consistent in terms pigs, but not in preterm pigs. Magnitude of hyolaryngeal elevation was less in preterm pig swallows than term pig swallows. Absence of epiglottal inversion in preterm pigs was not linked to variation in the timing of the two swallow events. Video of external hyolaryngeal movement, though a reliable swallow indicator in term infant pigs, was unreliable in preterm infant pigs. The coordination of swallowing events differs in preterm and term infant pigs. More research is needed into the distinctive biomechanics of preterm infant pigs. Identifier An unambiguous reference to the resource within a given context <a href="http://doi.org/10.1007/s00455-019-10033-w" target="_blank" rel="noreferrer noopener">10.1007/s00455-019-10033-w</a> 2019 Animal models Baby foods biomechanics Bond Laura Catchpole Emily Deglutition Department of Anatomy & Neurobiology Dysphagia Feeding German Rebecca Gould François D H Hogs Infants Mayerl Christopher J MEDICAL sciences NEOMED College of Medicine pig Premature September 2019 Update Stricklen Bethany Suidae swallowing