Browse Items · NEOMED Bibliography Database

Concurrent treatment of chronic psoriasis and asthma with ustekinumab.

A 56-year-old woman with a 40-year history of guttate flares of psoriasis associated with stress and infection as well as chronic asthma was treated with subcutaneous injections of ustekinumab, repeated after 1 month and then every 3 months. Her…

THROMBOCYTOPENIA IN INTENSIVE-CARE PATIENTS - A COMPREHENSIVE ANALYSIS OF RISK-FACTORS IN 314 PATIENTS

OBJECTIVE: To define the incidence and severity of thrombocytopenia in a mixed medical-surgical population of critically ill patients and to examine factors that may be related to the development of thrombocytopenia. DESIGN: Retrospective chart…

Tags: 1995, Annals of Pharmacotherapy, Antibodies, Bonfiglio M F, heparin-associated thrombocytopenia, Hulisz D T, intravascular coagulation, Journal Article or Conference Abstract Publication, Kier K L, Martin B R, Pharmacology & Pharmacy, respiratory-distress syndrome, septicemia, Traeger S M, vancomycin, Verbeck S R

Recent developments in the treatment of rheumatoid arthritis.

The introduction of biologic response modifiers has revolutionized treatment approaches in rheumatoid arthritis. The ideal treatment approach to induce remission and minimize joint destruction is yet to be determined, however. The guidelines for the…

Tags: 2009, Antibodies, Antirheumatic Agents – Administration and Dosage, Arthritis, Biological Response Modifiers – Administration and Dosage, Bruce SP, Department of Pharmaceutical Sciences, Department of Pharmacy Practice, Immunosuppressive Agents, Journal of pharmacy practice, Monoclonal – Administration and Dosage, NEOMED College of Pharmacy, rheumatoid, Rheumatoid – Complications, Rheumatoid – Drug Therapy, Rheumatoid – Epidemiology, Rheumatoid – Physiopathology

Brain-targeted delivery of Tempol-loaded nanoparticles for neurological disorders.

Brain-targeted Tempol-loaded poly-(lactide-co-glycolide) (PLGA) nanoparticles (NPs) conjugated with a transferrin antibody (OX 26) were developed using the nanoprecipitation method. These NPs may have utility in treating neurodegenerative diseases…

CEL-1000 - a peptide with adjuvant activity or Th1 immune responses

CEL-1000 (derG, DGQEEKAGVVSTGLIGGG) is a small immunomodulatory peptide which delivers demonstrated protective activity in two infectious disease challenge models (HSV and malaria) and an allogenic tumor vaccine model. CEL-1000 and other activators…

Scalp Angiosarcoma Remission with Bevacizumab and Radiotherapy without Surgery: A Case Report and Review of the Literature.

Angiosarcoma (AS) is a rare and aggressive vascular neoplasm with very poor prognosis. Patients with extensive cutaneous AS who are not surgical candidates have very limited options since there is no standard treatment. Treatment options include…

Herpes simplex virus type 1 that exhibits herpes simplex virus type 2 sensitivity to (E)-5-(2-bromovinyl)-2'-deoxyuridine.

A clinical isolate, designated 145, of herpes simplex virus (HSV) had type 1 characteristics as determined by monoclonal antibody immunofluorescence, heat stability of viral thymidine kinase (TK), BamHI restriction endonuclease pattern, and absence…

Ten-year outcomes: the clinical utility of single photon emission computed tomography/computed tomography capromab pendetide (Prostascint) in a cohort diagnosed with localized prostate cancer.

Purpose: To evaluate the clinical utility of capromab pendetide imaging with single photon emission computed tomography coregistration with computed tomography (SPECT/CT) in primary prostate cancer (CaP) for pretreatment prognostic staging and…

Clinical characteristics of Chlamydia pneumoniae infection as the sole cause of community-acquired pneumonia.

The clinical characteristics of 26 patients with community-acquired pneumonia due to Chlamydia pneumoniae as the only identified pathogen who required hospitalization were evaluated. Most patients (18) had reinfection based on serological results.…

Par-4 is a synaptic protein that regulates neurite outgrowth by altering calcium homeostasis and transcription factor AP-1 activation.

Although Par-4 (prostate apoptosis response-4) is involved in initiation of neurodegenerative cascades associated with certain neurodegenerative disorders, normal physiological roles of Par-4 in neurons have remained elusive. It was recently reported…

Infliximab-induced headache and infliximab-induced meningitis: two ends of the same spectrum?

This report describes a case of aseptic meningitis induced by the tumor necrosis factor-alpha inhibitor infliximab. The patient, a 51-year-old female, was being treated for Crohn's disease. After an infliximab infusion, she had headache, fever,…

Tags: 2005, Antibodies, Aseptic/*chemically induced/diagnosis, Crohn Disease/drug therapy, Department of Internal Medicine, Female, Gayomali Charina, Headache/*chemically induced, Hegde Nikita, Humans, Infliximab, Meningitis, Middle Aged, Monoclonal/*adverse effects, NEOMED College of Medicine, Rich Michael W, Serum Sickness/*etiology, Southern medical journal

Type VI collagen increases cell survival and prevents anti-beta 1 integrin-mediated apoptosis.

Cell-matrix interactions are important in the development of the avian cornea. Type VI collagen is present within the periocular mesenchyme prior to the migration of cells into the corneal stroma and is abundant in the mature stroma. Whether the…

Postmortem vitreous bevacizumab levels of an infant treated for retinopathy of prematurity.

We report the vitreous concentration of bevacizumab after injection for the treatment of retinopathy of prematurity (ROP). A premature neonate diagnosed with type 1 ROP was treated in both eyes with 0.625 mg intravitreal bevacizumab injection at 32…

Tromantadine inhibits a late step in herpes simplex virus type 1 replication and syncytium formation.

Addition of tromantadine after virus penetration inhibited HSV-1 induced syncytium formation and virus production in HEp-2 and VERO cells and acted additively with neutralizing antibody in blocking virus spread and cytopathology. Inhibition of…

Herpes-simplex Virus - A Possible Etiologic Agent In Some Gastroduodenal Ulcer Disease

There is increasing evidence that the herpes simplex virus may account for some gastric ulcer disease. To examine this possibility, 62 tissue biopsies from 21 patients were obtained during esophagogastroduodenoscopy for gastroduodenal ulcer disease…

Tags: 1992, American Surgeon, Antibodies, DeLucia A, DNA, Docherty J J, Journal Article or Conference Abstract Publication, Kemker B P, Lewis R D, peptic-ulcer, Ruf W, Surgery, type-1

The use of eculizumab in gemcitabine induced thrombotic microangiopathy.

BACKGROUND: Thrombotic microangiopathy (TMA) secondary to gemcitabine therapy (GiTMA) is a very rare pathology that carries a poor prognosis, with nearly half of the cases progressing to end stage renal disease. GiTMA is most commonly associated with…

Tags: *Gemcitabine, *Hemolytic uremic syndrome, *Pancreatic cancer, *Renal failure, *Thrombotic microangiopathy, 2018, Antibodies, Antimetabolites, Antineoplastic – Adverse Effects, Antineoplastic/*adverse effects, BMC nephrology, Das Abhijit, Deoxycytidine, Deoxycytidine – Adverse Effects, Deoxycytidine/adverse effects/*analogs & derivatives, Department of Internal Medicine, Female, Gupta Mohit, Humanized/*therapeutic use, Humans, Krishnappa Vinod, Middle Age, Middle Aged, Monoclonal, Monoclonal – Therapeutic Use, NEOMED College of Graduate Studies Student, NEOMED College of Medicine, Novak Robert, Raina Rupesh, Scales, Shah Haikoo, Tanphaichitr Natthavat, Thrombocytopenia – Chemically Induced, Thrombocytopenia – Diagnosis, Thrombocytopenia – Drug Therapy, Thrombotic Microangiopathies/*chemically induced/diagnosis/*drug therapy

Mice transgenic for simian immunodeficiency virus nef are immunologically compromised.

An intact nef gene is essential for rapid development of immunodeficiency in human immunodeficiency virus and simian immunodeficiency virus infections. To assess the role of nef in the immune response, mice transgenic for SIV nef were constructed and…

Antiphospholipids antibodies in a 12-month-old presenting with idiopathic thrombocytopenic purpura.

A 12-month-old Caucasian female with a history of recurrent ear infections presented to the emergency room with petechiae, severe thrombocytopenia (4000/microL), and abnormally prolonged activated partial thromboplastin time. Further autoantibody…

Tags: 2008, Antibodies, Antinuclear/blood/immunology, Antiphospholipid/*blood/immunology, Female, Humans, Idiopathic/*blood/*drug therapy/immunology, Immunoglobulins, Immunologic Factors/*administration & dosage, Infant, Intravenous/*administration & dosage, Nseir Bacel, Panicker Jyoti, Pediatric hematology and oncology, Purpura, Thrombocytopenic

Modern outcomes of inflammatory breast cancer.

Purpose: To report contemporary outcomes for inflammatory breast cancer (IBC) patients treated in the modern era of trastuzumab and taxane-based chemotherapy. Methods and Materials: We retrospectively reviewed the charts of 104 patients with…

SEROLOGIC REACTIVITY AGAINST MYCOBACTERIUM-PARATUBERCULOSIS ANTIGENS IN PATIENTS WITH SARCOIDOSIS

Although sarcoidosis has clinical and histopathologic similarities to some forms of tuberculosis and other mycobacterial infections, attempts to establish a mycobacterial etiology have not been successful. Using cytoplasmic antigens derived from a…

Tags: 1993, Antibodies, Chiodini R J, crohns-disease, elisa, elisa assay, inflammatory bowel disease, Journal Article, linked immunosorbent-assay, mycobacterium-paratuberculosis, Reid J D, Respiratory System, Sarcoidosis, Tuberculosis

Why Don't We Have a Vaccine Against..........? Part 3. Bacteria, Too

Despite the large number of vaccines, this review asks the question "Why don'twe have vaccines for all infectious diseases?" The first and second parts of this series discussed basics of vaccine immunology and new approaches and outlined some of the…

Immunohistochemical localization of serotonin, leu-enkephalin, tyrosine hydroxylase, and substance P within the visceral sensory area of cartilaginous fish.

We examined the distribution of immunoreactivity to serotonin (5-HT), leu-enkephalin (LENK), tyrosine-hydroxylase (TH), and substance P (SP) within the primary visceral sensory region of cartilaginous fish. Two genera of sharks, Squalus and…

Tags: *Brain Chemistry, 1992, Animals, Antibodies, Brain Stem/cytology, Cell and tissue research, Cruce W L, Enkephalin, Fishes, Immunohistochemistry, Leucine/*analysis, Medulla Oblongata/cytology, Serotonin/*analysis, Stuesse D C, Stuesse S L, Substance P/*analysis, Tyrosine 3-Monooxygenase/*analysis

Efficacy and safety of ustekinumab and etanercept for the treatment of psoriasis.

IMPORTANCE OF THE FIELD: TNF-alpha inhibitors such as etanercept have been used for psoriasis for years. A fairly well defined efficacy and safety profile has developed. A new biologic agent, ustekinumab, an IL-12 and IL-23 inhibitor, has recently…

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