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Text
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URL Address
<a href="http://doi.org/10.1177/0897190015621813" target="_blank" rel="noreferrer noopener">http://doi.org/10.1177/0897190015621813</a>
Pages
89–93
Issue
1
Volume
30
Dublin Core
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Title
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Impact of Tranexamic Acid in Total Knee and Total Hip Replacement.
Publisher
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Journal of pharmacy practice
Date
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2017
2017-02
Subject
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Aged; Antifibrinolytic Agents/adverse effects/therapeutic use; Arthroplasty; Blood Transfusion; Blood Transfusion/statistics & numerical data; Case-Control Studies; Descriptive Statistics; Female; Hemoglobins – Analysis; Hemoglobins/metabolism; Hip; Hip/*methods; Human; Humans; Knee; Knee/*methods; Length of Stay – Evaluation; Length of Stay/statistics & numerical data; Male; Outcome Assessment; Replacement; Retrospective Design; Retrospective Studies; total hip replacement; total knee replacement; tranexamic acid; Tranexamic Acid – Administration and Dosage; Tranexamic Acid/adverse effects/*therapeutic use; Venous Thromboembolism – Risk Factors; Venous Thromboembolism/epidemiology
Creator
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Boyle Jaclyn A; Soric Mate M
Description
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OBJECTIVE: To evaluate the net clinical benefit of tranexamic acid use in patients undergoing total knee or total hip replacement. METHODS: This is a retrospective study of patients undergoing total knee or total hip replacement. The primary outcome was the net clinical benefit of tranexamic acid use. Secondary outcomes included length of stay, incidence of venous thromboembolism, change in hemoglobin, and number of units of blood transfused. RESULTS: Four hundred and six patients were screened for inclusion and 327 patients met inclusion criteria; 174 patients received tranexamic acid versus 153 patients who received usual care. Tranexamic acid demonstrated a positive net clinical benefit versus usual care (40.8% vs 13.7%, P \textless .01) but did not affect length of stay (3.39 vs 3.37 days, respectively, P = .76). Venous thromboembolism was comparable between groups (2.3% vs 0.7%, P = .38). Average change in hemoglobin and need for transfusion were lower in the treatment group versus the usual care group, respectively (3.46 vs 4.26 mg/dL, P \textless .01). CONCLUSION: Tranexamic acid demonstrated a significant benefit in decreasing change in hemoglobin as well as the need for blood transfusion with no increase in the risk of venous thromboembolism in patients undergoing total knee or total hip replacement.
Identifier
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<a href="http://doi.org/10.1177/0897190015621813" target="_blank" rel="noreferrer noopener">10.1177/0897190015621813</a>
Rights
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2017
Aged
Antifibrinolytic Agents/adverse effects/therapeutic use
Arthroplasty
Blood Transfusion
Blood Transfusion/statistics & numerical data
Boyle Jaclyn A
Case-Control Studies
Department of Pharmaceutical Sciences
Department of Pharmacy Practice
Descriptive Statistics
Female
Hemoglobins – Analysis
Hemoglobins/metabolism
Hip
Hip/*methods
Human
Humans
Journal of pharmacy practice
Knee
Knee/*methods
Length of Stay – Evaluation
Length of Stay/statistics & numerical data
Male
NEOMED College of Pharmacy
Outcome Assessment
Replacement
Retrospective Design
Retrospective Studies
Soric Mate M
total hip replacement
total knee replacement
tranexamic acid
Tranexamic Acid – Administration and Dosage
Tranexamic Acid/adverse effects/*therapeutic use
Venous Thromboembolism – Risk Factors
Venous Thromboembolism/epidemiology