Drug-induced acute renal failure: recognizing and treating prerenal, postrenal, and pseudorenal injury.
Female; Male; Aged; Risk Factors; Hemodynamics; Physical Examination; Inpatients; Middle Age; Kidney Function Tests; Kidney Failure; Nephrotoxicity; Antiinflammatory Agents; Acute – Etiology; Angiotensin-Converting Enzyme Inhibitors – Adverse Effects; Antineoplastic Agents – Adverse Effects; Non-Steroidal – Adverse Effects; Acute – Chemically Induced; Acute – Diagnosis; Acute – Therapy; Enzyme Inhibitors – Adverse Effects; Renal Circulation – Drug Effects
Angiotensin-converting enzyme (ACE) inhibitors and NSAIDs are among the drugs most commonly associated with acute renal failure (ARF). Patients at risk for ACE inhibitor-induced ARF include those with congestive heart failure (CHF) or compromised left ventricular (IV) function and those receiving diuretics. In these settings, discontinue the ACE inhibitor and direct therapy toward correcting volume or improving the ineffective circulation (by appropriately reducing afterload, by ensuring adequate IV filling pressures, and by treating ischemia). Risk factors for NSAID-included ARF include CHI, poor renal perfusion, and recent hospitalization. Postrenal ARF may be precipitated by drugs that are highly insoluble in addic urine, such as antineoplastic agents and HmG-CoA reductase inhibitors. Alkalinization of urine and hydration are the cornerstones of management of this type of ARF.
Frazee L A; Rutecki G W; Whittier F C
Consultant (00107069)
1997
1997-05
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Management of the late effects of treatments for gynecological cancer.
Female; Quality of Life; Survivors; Genital Neoplasms; After Care – Methods; Antineoplastic Agents – Adverse Effects; Cognition Disorders – Chemically Induced; Combined Modality Therapy – Adverse Effects; Female – Therapy; Radiotherapy – Adverse Effects
PURPOSE OF REVIEW: As the number of gynecologic cancer survivors grows, there is an increased awareness and need for effective therapy for late side-effects caused by cancer treatments. Several treatment modalities are used to treat gynecologic malignancies, including surgery, radiotherapy, and chemotherapy. Each modality can be responsible for causing late-term side-effects. RECENT FINDINGS: There has been an increased awareness of the late detrimental side-effects of cancer treatment, mostly by the use of patient-generated surveys. Effective ways to treat and ameliorate the late side-effects have lagged behind the ability to describe and categorize these effects on patient's quality of life. SUMMARY: This review will highlight the recent studies to help the clinician caring for gynecologic cancer survivors in recognizing and treating the late effects of cancer therapy.
Andrews Stephen; von Gruenigen Vivian E
Current Opinion in Oncology
2013
2013-09
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
<a href="http://doi.org/10.1097/CCO.0b013e328363e11a" target="_blank" rel="noreferrer noopener">10.1097/CCO.0b013e328363e11a</a>