1
40
2
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Pages
210–211
Issue
3
Volume
20
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Characterization of the early events in vitamin C and K3-induced death of human bladder tumor cells.
Publisher
An entity responsible for making the resource available
Scanning
Date
A point or period of time associated with an event in the lifecycle of the resource
1998
1998-04
Subject
The topic of the resource
Humans; Time Factors; Drug Synergism; Microscopy; Antineoplastic Combined Chemotherapy Protocols/*pharmacology; Ascorbic Acid/administration & dosage/pharmacology; Carcinoma/*drug therapy/ultrastructure; Cell Death/*drug effects; Urinary Bladder Neoplasms/*drug therapy/ultrastructure; Vitamin K 1/administration & dosage/pharmacology; Electron; Electron/methods; Cultured/drug effects; Tumor Cells; Scanning/methods
Creator
An entity primarily responsible for making the resource
Ervin E; Jamison J M; Gilloteaux J; Docherty J J; Jasso J; Summers J L
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1998
Antineoplastic Combined Chemotherapy Protocols/*pharmacology
Ascorbic Acid/administration & dosage/pharmacology
Carcinoma/*drug therapy/ultrastructure
Cell Death/*drug effects
Cultured/drug effects
Docherty J J
Drug Synergism
Electron
Electron/methods
Ervin E
Gilloteaux J
Humans
Jamison J M
Jasso J
Microscopy
Scanning
Scanning/methods
Summers J L
Time Factors
Tumor Cells
Urinary Bladder Neoplasms/*drug therapy/ultrastructure
Vitamin K 1/administration & dosage/pharmacology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/s0040-8166(96)80072-3" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/s0040-8166(96)80072-3</a>
Pages
687–701
Issue
6
Volume
28
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Flow cytometric and ultrastructural aspects of the synergistic antitumor activity of vitamin C-vitamin K3 combinations against human prostatic carcinoma cells.
Publisher
An entity responsible for making the resource available
Tissue & cell
Date
A point or period of time associated with an event in the lifecycle of the resource
1996
1996-12
Subject
The topic of the resource
*Prostatic Neoplasms; Antineoplastic Combined Chemotherapy Protocols/*pharmacology; Ascorbic Acid/administration & dosage; Cultured/drug effects/metabolism/ultrastructure; DNA/biosynthesis; Drug Synergism; Electron; Flow Cytometry; Hemostatics/administration & dosage; Humans; Male; Microscopy; Scanning; Thymidine/metabolism; Tritium; Tumor Cells; Vitamin K/administration & dosage
Creator
An entity primarily responsible for making the resource
Jamison J M; Gilloteaux J; Venugopal M; Koch J A; Sowick C; Shah R; Summers J L
Description
An account of the resource
Transmission and scanning electron microscopy and flow cytometry were employed to characterize the cytotoxic effects of vitamin C (VC), vitamin K3 (VK3), or VC-VK3 combinations on a human prostate carcinoma cell line (DU145) following a 1-h vitamin treatment and a 24-h incubation in culture medium. Cells exposed to VC exhibited membranous blebs, aberrant microvillar morphology, mitochondria with swollen cristae and intramitochondrial deposits, as well as nucleoli with segregated components. VK3-treated cells displayed a damaged cytoskeleton and membranes, a cytoplasm which contained large lumen, condensed polysomes, and severely damaged mitochondria with residual bodies, and nuclei which exhibited chromatic condensation, pyknosis, and karyolysis. VC-VK3-treated cells exhibited characteristics consistent with necrosis, i.e. swollen mitochondria and swollen, achromatic nuclei with marginated chromatin and intact envelopes, while other cells displayed characteristics consistent with apoptosis, i.e. expulsion of organelle-containing blebs, margination of nuclear chromatin, and segregation of nucleolar components. Vitamin treatment also decreased DNA synthesis, induced a S/G2 block in the cell cycle, and resulted in the accumulation of fragmented DNA. These results suggested that increased oxidative stress, subsequent membrane damage, and DNA fragmentation were responsible for enhanced cytotoxicity of the vitamin combination.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/s0040-8166(96)80072-3" target="_blank" rel="noreferrer noopener">10.1016/s0040-8166(96)80072-3</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Prostatic Neoplasms
1996
Antineoplastic Combined Chemotherapy Protocols/*pharmacology
Ascorbic Acid/administration & dosage
Cultured/drug effects/metabolism/ultrastructure
Department of Anatomy & Neurobiology
DNA/biosynthesis
Drug Synergism
Electron
Flow Cytometry
Gilloteaux J
Hemostatics/administration & dosage
Humans
Jamison J M
Koch J A
Male
Microscopy
NEOMED College of Medicine
Scanning
Shah R
Sowick C
Summers J L
Thymidine/metabolism
Tissue & cell
Tritium
Tumor Cells
Venugopal M
Vitamin K/administration & dosage