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Text
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URL Address
<a href="http://doi.org/10.1006/cbir.1996.0102" target="_blank" rel="noreferrer noopener">http://doi.org/10.1006/cbir.1996.0102</a>
Pages
787–797
Issue
12
Volume
20
Dublin Core
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Title
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Synergistic antitumour activity of vitamins C and K3 against human prostate carcinoma cell lines.
Publisher
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Cell biology international
Date
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1996
1996-12
Subject
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Adenosine Triphosphate/biosynthesis; Antineoplastic Agents/*pharmacology/toxicity; Antineoplastic Combined Chemotherapy Protocols/pharmacology; Ascorbic Acid/*pharmacology/toxicity; Carcinoma/*metabolism; Catalase/pharmacology; Cultured; DNA; Humans; Hydrogen Peroxide/metabolism; Lipid Peroxidation; Male; Neoplasm Proteins/biosynthesis; Neoplasm/biosynthesis; Prostatic Neoplasms/*metabolism; Sulfhydryl Compounds/analysis; Tumor Cells; Vitamin K/*pharmacology/toxicity
Creator
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Venugopal M; Jamison J M; Gilloteaux J; Koch J A; Summers M; Hoke J; Sowick C; Summers J L
Description
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Vitamins C, K3 (VC, VK3) and a VC/VK3 combination with a VC:VK3 ratio of 100:1 were assayed for their antitumour activity against two human prostatic carcinoma cell lines. Co-administration of the vitamins enhanced the antitumour activity 5- to 20-fold even with a 1 h exposure time. While exogenous catalase destroyed the antitumour activity, hydrogen peroxide-induced lipid peroxidation was negligible. Analysis of cellular ATP and thiol levels as well as DNA and protein synthesis revealed: a transient increase in ATP production, a decrease in DNA synthesis, an increase in protein synthesis and a decrease in thiol levels. These results suggested that the increased cytotoxicity of the vitamin combination was due to redox cycling and increased oxidative stress.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1006/cbir.1996.0102" target="_blank" rel="noreferrer noopener">10.1006/cbir.1996.0102</a>
Rights
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1996
Adenosine Triphosphate/biosynthesis
Antineoplastic Agents/*pharmacology/toxicity
Antineoplastic Combined Chemotherapy Protocols/pharmacology
Ascorbic Acid/*pharmacology/toxicity
Carcinoma/*metabolism
Catalase/pharmacology
Cell biology international
Cultured
Department of Anatomy & Neurobiology
DNA
Gilloteaux J
Hoke J
Humans
Hydrogen Peroxide/metabolism
Jamison J M
Koch J A
Lipid Peroxidation
Male
NEOMED College of Medicine
Neoplasm Proteins/biosynthesis
Neoplasm/biosynthesis
Prostatic Neoplasms/*metabolism
Sowick C
Sulfhydryl Compounds/analysis
Summers J L
Summers M
Tumor Cells
Venugopal M
Vitamin K/*pharmacology/toxicity