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Text
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URL Address
<a href="http://doi.org/10.3109/10611861003639796" target="_blank" rel="noreferrer noopener">http://doi.org/10.3109/10611861003639796</a>
Pages
665–674
Issue
9
Volume
18
Dublin Core
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Title
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Brain-targeted delivery of Tempol-loaded nanoparticles for neurological disorders.
Publisher
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Journal of drug targeting
Date
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2010
2010-11
Subject
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Animals; Rats; Cell Line; Nanoparticles; Polylactic Acid-Polyglycolic Acid Copolymer; Particle Size; Delayed-Action Preparations; Antibodies; Polyethylene Glycols; Blood-Brain Barrier/metabolism; *Lactic Acid; *Polyglycolic Acid; Antioxidants/chemistry/*metabolism; Cross-Linking Reagents/chemistry; Cyclic N-Oxides/chemistry/*metabolism; Free Radical Scavengers/chemistry/*metabolism; Maleimides/chemistry; Spin Labels; Transferrin/*immunology; Tumor; Monoclonal/chemistry/*metabolism
Creator
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Carroll Richard T; Bhatia Deepak; Geldenhuys Werner; Bhatia Ruchi; Miladore Nicholas; Bishayee Anupam; Sutariya Vijaykumar
Description
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Brain-targeted Tempol-loaded poly-(lactide-co-glycolide) (PLGA) nanoparticles (NPs) conjugated with a transferrin antibody (OX 26) were developed using the nanoprecipitation method. These NPs may have utility in treating neurodegenerative diseases such as Parkinson's disease and Alzheimer's disease. Central to these diseases is an increased production of reactive oxygen and nitrogen species which may take part in the development of these conditions. As proof of principle, the NPs were loaded with Tempol, a free radical scavenger that has been shown to be protective against oxidative insults. To enhance the delivery of NPs to the central nervous system (CNS), we conjugated the transferrin receptor antibody covalently to PLGA NPs using the
Identifier
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<a href="http://doi.org/10.3109/10611861003639796" target="_blank" rel="noreferrer noopener">10.3109/10611861003639796</a>
Rights
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Lactic Acid
*Polyglycolic Acid
2010
Animals
Antibodies
Antioxidants/chemistry/*metabolism
Bhatia Deepak
Bhatia Ruchi
Bishayee Anupam
Blood-Brain Barrier/metabolism
Carroll Richard T
Cell Line
Cross-Linking Reagents/chemistry
Cyclic N-Oxides/chemistry/*metabolism
Delayed-Action Preparations
Free Radical Scavengers/chemistry/*metabolism
Geldenhuys Werner
Journal of drug targeting
Maleimides/chemistry
Miladore Nicholas
Monoclonal/chemistry/*metabolism
Nanoparticles
Particle Size
Polyethylene Glycols
Polylactic Acid-Polyglycolic Acid Copolymer
Rats
Spin Labels
Sutariya Vijaykumar
Transferrin/*immunology
Tumor