1
40
2
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1007/BF01271190" target="_blank" rel="noreferrer noopener">http://doi.org/10.1007/BF01271190</a>
Pages
1295–1305
Issue
11
Volume
103
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
L-DOPA modulation of corpus striatal dopamine and dihydroxyphenylacetic acid output from intact and 6-OHDA lesioned rats.
Publisher
An entity responsible for making the resource available
Journal of neural transmission (Vienna, Austria : 1996)
Date
A point or period of time associated with an event in the lifecycle of the resource
1996
1905-06
Subject
The topic of the resource
*Sympathectomy; 3; 4-Dihydroxyphenylacetic Acid/*metabolism; Animals; Antiparkinson Agents/*pharmacology; Chemical; Corpus Striatum/drug effects/*metabolism; Dopamine/*metabolism; Levodopa/*pharmacology; Male; Oxidopamine; Rats; Sprague-Dawley; Substantia Nigra/drug effects/metabolism
Creator
An entity primarily responsible for making the resource
Xu K; Dluzen D E
Description
An account of the resource
In the present report we examined the differences in in vitro dopamine (DA) and dihydroxyphenylacetic acid (DOPAC) efflux from the corpus striatum (CS) of intact versus 6-hydroxydopamine (6-OHDA) lesioned (in substantia nigra) male rats in response to different doses of two pulse infusions of L-dihydroxyphenylalanine (L-DOPA). In the first experiment, we tested the effects of two 20-min infusions of 5 uM L-DOPA. In the second experiment we repeated this protocol using 50 uM
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1007/BF01271190" target="_blank" rel="noreferrer noopener">10.1007/BF01271190</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Sympathectomy
1996
3
4-Dihydroxyphenylacetic Acid/*metabolism
Animals
Antiparkinson Agents/*pharmacology
Chemical
Corpus Striatum/drug effects/*metabolism
Dluzen D E
Dopamine/*metabolism
Journal of neural transmission (Vienna, Austria : 1996)
Levodopa/*pharmacology
Male
Oxidopamine
Rats
Sprague-Dawley
Substantia Nigra/drug effects/metabolism
Xu K
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.expneurol.2018.07.005" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.expneurol.2018.07.005</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
111-119
Volume
308
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
The anti-parkinsonian drug zonisamide reduces neuroinflammation: Role of microglial Nav 1.6.
Publisher
An entity responsible for making the resource available
Experimental neurology
Date
A point or period of time associated with an event in the lifecycle of the resource
2018
2018-10
Subject
The topic of the resource
Female; Humans; Male; Animals; Mice; Aged; *gp91(phox); *Microglia; *MPTP; *Na(v)1.6; *Neuroinflammation; *Parkinson's disease; *TNF-alpha; *Voltage-gated sodium channels; *Zonisamide; Inflammation/metabolism; Neuroprotective Agents/pharmacology; Antiparkinson Agents/*pharmacology; Inbred C57BL; Microglia/drug effects/*metabolism; NAV1.6 Voltage-Gated Sodium Channel/*biosynthesis; Parkinsonian Disorders/*metabolism/pathology; Zonisamide/*pharmacology
Creator
An entity primarily responsible for making the resource
Hossain Muhammad M; Weig Blair; Reuhl Kenneth; Gearing Marla; Wu Long-Jun; Richardson Jason R
Description
An account of the resource
Parkinson's disease (PD), the second most common age-related progressive neurodegenerative disorder, is characterized by dopamine depletion and the loss of dopaminergic (DA) neurons with accompanying neuroinflammation. Zonisamide is an-anti-convulsant drug that has recently been shown to improve clinical symptoms of PD through its inhibition of monoamine oxidase B (MAO-B). However, zonisamide has additional targets, including voltage-gated sodium channels (Nav), which may contribute to its reported neuroprotective role in preclinical models of PD. Here, we report that Nav1.6 is highly expressed in microglia of post-mortem PD brain and of mice treated with the parkinsonism-inducing neurotoxin MPTP. Administration of zonisamide (20mg/kg, i.p. every 4hx3) following a single injection of MPTP (12.5mg/kg, s.c.) reduced microglial Nav 1.6 and microglial activation in the striatum, as indicated by Iba-1 staining and mRNA expression of F4/80. MPTP increased the levels of the pro-inflammatory cytokine TNF-alpha and gp91(phox), and this was significantly reduced by zonisamide. Together, these findings suggest that zonisamide may reduce neuroinflammation through the down-regulation of microglial Nav 1.6. Thus, in addition to its effects on parkinsonian symptoms through inhibition of MAO-B, zonisamide may have disease modifying potential through the inhibition of Nav 1.6 and neuroinflammation.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/j.expneurol.2018.07.005" target="_blank" rel="noreferrer noopener">10.1016/j.expneurol.2018.07.005</a>
*gp91(phox)
*Microglia
*MPTP
*Na(v)1.6
*Neuroinflammation
*Parkinson's disease
*TNF-alpha
*Voltage-gated sodium channels
*Zonisamide
2018
Aged
Animals
Antiparkinson Agents/*pharmacology
Experimental neurology
Female
Gearing Marla
Hossain Muhammad M
Humans
Inbred C57BL
Inflammation/metabolism
Male
Mice
Microglia/drug effects/*metabolism
NAV1.6 Voltage-Gated Sodium Channel/*biosynthesis
Neuroprotective Agents/pharmacology
Parkinsonian Disorders/*metabolism/pathology
Reuhl Kenneth
Richardson Jason R
Weig Blair
Wu Long-Jun
Zonisamide/*pharmacology