1
40
3
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1177/095632029000100502" target="_blank" rel="noreferrer noopener">http://doi.org/10.1177/095632029000100502</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
285-292
Issue
5
Volume
1
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Dublin Core
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Title
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Enhancement Of The Antiviral Activity Of Poly (a-u) By Adriamycin And Daunomycin
Publisher
An entity responsible for making the resource available
Antiviral Chemistry & Chemotherapy
Date
A point or period of time associated with an event in the lifecycle of the resource
1990
1990-10
Subject
The topic of the resource
Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Virology
Creator
An entity primarily responsible for making the resource
Jamison J M; Bonilla P J; Tsai C C
Description
An account of the resource
The role of adriamycin (ADR) and daunomycin (DMN) in modulating the antiviral activity of poly (adeylate-uridylate) (poly (A-U)) was examined using a human foreskin fibroblast - vesicular stomatitis virus (HSF-VSV) bioassay in which the concentration of poly (A-U) was fixed at 0.05 mm or 0.2 mm while the ADR or DMN concentration was varied to produce ADR (or DMN)/ribonucleotide ratios ranging from 1:16 to 2:1. Poly (A-U), ADR and DMN were not efficacious antiviral agents when tested individually at the concentrations employed in the ADR (or DMN)/poly (A-U) combinations. When the ADR or DMN was combined with the poly (A-U) to produce ADR (or DMN)/poly (A-U) ratios of 1/6, the 50% effective doses (ED50) of the poly (A-U), ADR and DMN decreased 18, 104, and 185-fold, respectively. However, when ADR or DMN was combined with polyriboinosinic-polyribocytidylic acid [poly (I) . poly (C)], the ED50 of the ADR, DMN and the poly (I) . poly (C) were not affected. Interferon neutralization studies indicated that ADR, DMN, poly (A-U) and the ADR (or DMN)/poly (A-U) combination induced the production of interferon-beta (IFN-beta). The amount of IFN produced by the ADR (or DMN)/poly (A-U) combinations was equal to the sum of the IFN produced by their constituents. These results indicate that the ADR and DMN potentiate the antiviral activity of the poly (A-U) without affecting the amount of IFN induced. The direct viral inactivation study demonstrated that ADR, DMN, poly (A-U) and the ADR (or DMN)/poly (A-U) combinations do not inactivate the VSV at concentrations near the ED50.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1177/095632029000100502" target="_blank" rel="noreferrer noopener">10.1177/095632029000100502</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
1990
Antiviral Chemistry & Chemotherapy
Biochemistry & Molecular Biology
Bonilla P J
Jamison J M
Journal Article or Conference Abstract Publication
Pharmacology & Pharmacy
Tsai C C
Virology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1177/095632029000100109" target="_blank" rel="noreferrer noopener">http://doi.org/10.1177/095632029000100109</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
53-60
Issue
1
Volume
1
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Dublin Core
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Title
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Modulation Of The Antiviral Activity Of Poly (a-u) By Ethidium Bromide And Propidium Iodide
Publisher
An entity responsible for making the resource available
Antiviral Chemistry & Chemotherapy
Date
A point or period of time associated with an event in the lifecycle of the resource
1990
1990-02
Subject
The topic of the resource
Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Virology
Creator
An entity primarily responsible for making the resource
Jamison J M; Bonilla P J; Tsai C C
Description
An account of the resource
The role of ethidium bromide (EB) and propidium iodide (PI) in modulating the antiviral and interferon-inducing activities of poly(adenylate-uridylate) (poly (A-U )) was examined using the human foreskin fibro-blast-vesicular stomatitis virus (HSF-VSV) bioassay system in which the concentration of poly (A-U) was fixed at 0.05 mM or 0.2 mM while the EB or PI concentration was varied to produce variable EB (or PI)/ribonucleotide ratios ranging from 1: 16 to 2:1. EB, PI and poly (A-U) tested individually were not efficacious antiviral agents. When poly (A-U) was combined with the ethidium bromide or propidium iodide the antiviral activity was potentiated 15- to 22-fold at EB (or Pl)/ribonucleotide ratios in the region of 1/4. The interferon-inducing activity of the EB (or Pl)/poly (A-U) combinations were equal to the sum of the interferon-inducing activity of the poly (A-U) and the EB or (PI). These results indicate that the EB and PI potentiate the antiviral activity of the poly (A-U) without superinduction of interferon. The direct viral inactivation study demonstrated that EB, PI, poly (A-U) and the EB (or Pl)/poly (A-U) combinations did not inactivate the VSV at concentrations near the 50% viral inhibitory dose.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1177/095632029000100109" target="_blank" rel="noreferrer noopener">10.1177/095632029000100109</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
1990
Antiviral Chemistry & Chemotherapy
Biochemistry & Molecular Biology
Bonilla P J
Jamison J M
Journal Article or Conference Abstract Publication
Pharmacology & Pharmacy
Tsai C C
Virology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1177/095632029000100601" target="_blank" rel="noreferrer noopener">http://doi.org/10.1177/095632029000100601</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
333-347
Issue
6
Volume
1
Search for Full-text
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Dublin Core
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Title
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Rna-intercalating Agent Interactions: In Vitro Antiviral Activity Studies
Publisher
An entity responsible for making the resource available
Antiviral Chemistry & Chemotherapy
Date
A point or period of time associated with an event in the lifecycle of the resource
1990
1990-12
Subject
The topic of the resource
Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Virology
Creator
An entity primarily responsible for making the resource
Jamison J M; Krabill K; Allen K A; Stuart S H; Tsai C C
Description
An account of the resource
Twenty intercalating agents were tested to examine the effects of intercalating dye-induced perturbations upon the antiviral activity of poly (adenylate-uridylate) [poly (A-U)]. Neither poly (A-U) alone nor each intercalative dye was an efficacious antiviral agent. When poly (A-U) was combined with major groove intercalating dyes (acridine orange or proflavine), no synergism was observed. When poly (A-U) was combined with minor groove intercalating dyes [ethidium (EB), propidium (PI), adriamycin (ADR) or daunomycin (DMN)] or minor/major groove intercalating dyes [9-aminoacridine (9-AA), N-2-methyl-9-hydroxy-ellipticine (NMHE) or N-2,N-6-dimethyl-9-hydroxy-ellipticine (DMHE)] the 50% effective doses (ED50) of the poly (A-U), 9-AA, ADR, DMHE, DMN, EB, NMHE and PI decreased 18-, 22-, 60-, 274-, 61-, 154-, 113- and 299-fold, respectively. When poly (A-U) was combined individually with 11 dyes whose mode of intercalation was not known, the ED50 of ametantrone (HAQ), chloroquine (CHL), mitoxantrone (DHAQ) and quinine (QUI) decreased 125-, 65-, 251- and 32-fold, respectively. These results suggest that the four dyes may intercalate into poly (A-U) from the minor groove. Ten (ADR, CHL, DMN, DHAQ, DMHE, EB, HAQ, NMHE, PI, QUI) of the 20 dyes evaluated exhibited significant synergism with poly (A-U), as quantified by the fractional inhibitory concentration index. Interferon (IFN) neutralization assays demonstrated that the IFN-inducing capability of the dye/poly (A-U) combinations approximated the sum of the capabilities of the poly (A-U) and the dyes employed. These results suggest that the majority of the dyes tested potentiate the antiviral activity of poly (A-U) without affecting the amount of IFN induced.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1177/095632029000100601" target="_blank" rel="noreferrer noopener">10.1177/095632029000100601</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article or Conference Abstract Publication
1990
Allen K A
Antiviral Chemistry & Chemotherapy
Biochemistry & Molecular Biology
Jamison J M
Journal Article or Conference Abstract Publication
Krabill K
Pharmacology & Pharmacy
Stuart S H
Tsai C C
Virology