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<a href="http://doi.org/10.1161/circ.142.suppl_3.17248" target="_blank" rel="noreferrer noopener">http://doi.org/10.1161/circ.142.suppl_3.17248</a>
Pages
A17248-A17248
Issue
Suppl 3
Volume
142
ISSN
0009-7322
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Update Year & Number
December 2020 List
NEOMED College
NEOMED College of Medicine Student
NEOMED College of Medicine
NEOMED Department
Department of Integrative Medical Sciences
NEOMED Student Publications
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Abstract 17248: The role of microRNA-21 in regulating the coronary microcirculation in diabetes
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Circulation
Date
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2020
2020-11-17
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Juguilon C; Wang Z; Gadd J;Ohanyan VA; Anurag J; Molly E; Wang T; Kolz C; William MC; Yin L
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Introduction: Coronary microvascular dysfunction is prevalent among diabetics and intersects with deficits in endothelial-dependent vasodilation. These deficits occur early in the progression of the disease, but the mechanisms remain incompletely understood. Nitric oxide (NO) is the major endothelial-dependent mediator of vasodilation in the healthy coronary circulation, but the mediator switches to hydrogen peroxide (H2O2) in coronary artery disease (CAD) patients. Diabetes is a risk factor for CAD, so we hypothesized that a similar switch would occur.Methods: Coronary arteries were isolated and endothelial-dependent vasodilation was assessed using myography. Quantitative polymerase chain reaction (qPCR) was performed for gene expression analysis and myocardial blood flow (MBF) was measured by contrast echocardiography.Results: Nitric oxide synthase inhibitor (L-NAME) inhibited vasodilation in wild type (WT) mice, but the H2O2 scavenger (PEG-catalase) had no effect. In contrast, vasodilation in diabetic mice was blunted by PEG-catalase, but not L-NAME. This suggests that the mediator of coronary vasodilation switched from NO to H2O2 in diabetes. Importantly, we found that microRNA-21 (miR-21) is upregulated in diabetes and the deficiency modulates the mediator switch from NO to H2O2 in diabetic mice.Conclusions: The switch in the mediator of coronary vasodilation from NO to H2O2 contributes to microvascular dysfunction in diabetes and miR-21 regulates this switch. Further genetic profiling will elucidate the pathways and mechanisms converging with miR-21 to regulate microvascular function in diabetes. This is the first mouse model that recapitulates the switch in mediator of coronary vasodilation from NO to H2O2 seen in CAD patients.
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<a href="http://doi.org/10.1161/circ.142.suppl_3.17248" target="_blank" rel="noreferrer noopener">10.1161/circ.142.suppl_3.17248</a>
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journalArticle
2020
Anurag J
Circulation
December 2020 List
Department of Integrative Medical Sciences
Gadd J
journalArticle
Juguilon C
Kolz C
Molly E
NEOMED College of Graduate Studies
NEOMED College of Medicine
NEOMED Student Publications
Ohanyan VA
Wang T
Wang Z
William MC
Yin L