Minocycline pigmentation of the cardiac valves and aorta in a 29-year survivor of liver transplant.
*Liver Transplantation; Adult; Anti-Bacterial Agents/*adverse effects; Aorta/*drug effects; Aortic Aneurysm/diagnosis/surgery; Heart Valve Prosthesis Implantation; Heart Valves/*drug effects; Humans; Incidental Findings; Male; Minocycline/*adverse effects; Pigmentation Disorders/*chemically induced; Survivors
Cohen Maria A; Owens Scott R; Yang Bo
The Journal of thoracic and cardiovascular surgery
2016
2016-12
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
<a href="http://doi.org/10.1016/j.jtcvs.2016.03.046" target="_blank" rel="noreferrer noopener">10.1016/j.jtcvs.2016.03.046</a>
Role of endothelium in sexual dimorphism in vasopressin-induced contraction of rat aorta.
*Sex Characteristics; *Vasoconstriction; Animals; Aorta/*drug effects; Arginine Vasopressin/*pharmacology; Arginine/analogs & derivatives/pharmacology; Endothelium; Female; Indomethacin/pharmacology; Male; Nitric Oxide/antagonists & inhibitors; omega-N-Methylarginine; Osmolar Concentration; Phenylephrine/pharmacology; Rats; Sprague-Dawley; Vascular/*physiology
In rat thoracic aorta, contractile responses to arginine vasopressin (AVP) are twofold higher in females than in males. To determine the role of the endothelium in this phenomenon, the effects of endothelium removal and inhibition of nitric oxide (NO) synthase and cyclooxygenase were examined in thoracic aortas prepared from male and female Sprague-Dawley rats and mounted for isometric tension recording. Maximal contractile response to AVP was substantially higher in female (4,232 +/- 316 mg/mg ring dry wt) than in male aortas (1,365 +/- 239; P \textless 0.01). Removal of the endothelium markedly potentiated maximal response to AVP in male aortas (4,100 +/- 422 mg/mg ring wt; P \textless 0.01); endothelium removal increased sensitivity but not maximal response in female aortas. Inhibition of NO synthase with NG-monomethyl-L-arginine (L-NMMA, 250 microM) doubled maximal contraction to AVP in male aortas (3,175 +/- 193 mg/mg ring wt; P \textless 0.01); L-NMMA increased sensitivity but not maximal response in female aortas. Inhibition of cyclooxygenase with indomethacin (10 microM) did not alter maximal response to AVP in male aortas but significantly attenuated responses of female aortas (2,816 +/- 306 mg/mg ring wt; P \textless 0.01). In contrast, maximal contractile response to phenylephrine hydrochloride (PE) was 40% higher in males than in females (P \textless 0.01); L-NMMA increased both the sensitivity and maximal response to PE to a greater extent in female (3,061 +/- 121 vs. 4,971 +/- 135 mg/mg ring wt; P \textless 0.01) than in male aortas (4,317 +/- 227 vs. 4,899 +/- 104 mg/mg ring wt; P \textless 0.01). (ABSTRACT TRUNCATED AT 250 WORDS)
Stallone J N
The American journal of physiology
1993
1993-12
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
<a href="http://doi.org/10.1152/ajpheart.1993.265.6.H2073" target="_blank" rel="noreferrer noopener">10.1152/ajpheart.1993.265.6.H2073</a>
Sexual dimorphism in vasopressin-induced contraction of rat aorta.
*Sex Characteristics; *Vasoconstriction; Animals; Aorta/*drug effects; Arginine Vasopressin/*pharmacology; Dose-Response Relationship; Drug; Female; Male; Osmolar Concentration; Phenylephrine/pharmacology; Rats
Previously, we reported that, in the rat, pressor responsiveness to vasopressin (VP) is higher in males than in females during most phases of the estrous cycle. To explore the role of the vasculature in this phenomenon, we examined vascular reactivity to VP in thoracic aortas of male rats and female rats during each phase of the estrous cycle. Aortic rings were prepared from age-matched male and female Sprague-Dawley rats and mounted for isometric tension recording. Maximal response of female aortas to VP (4,246 +/- 163 mg/mg ring dry wt) was more than twice (P less than 0.001) that of male aortas (1,877 +/- 215 mg/mg ring wt). Sensitivity of female aortas to VP was substantially higher (P less than 0.001) than that of male aortas (EC50: 10.9 +/- 0.7 vs. 19.0 +/- 1.6 nM, respectively). Maximal rate of tension development (dT/dtmax) during contraction with VP was nearly twofold higher (P less than 0.01) in female aortas (536 +/- 23 mg/min) than in male aortas (300 +/- 19 mg/min). Maximal response, sensitivity, and dT/dtmax of female aortas did not vary significantly during the estrous cycle. Maximal response of female aortas to phenylephrine (PE; 1,251 +/- 93 mg/mg ring wt) was half that (P less than 0.001) of male aortas (2,546 +/- 194 mg/mg ring wt); sensitivity to PE did not differ significantly (EC50: 0.33 +/- 0.02 vs. 0.38 +/- 0.06 microM, respectively).(ABSTRACT TRUNCATED AT 250 WORDS)
Stallone J N; Crofton J T; Share L
The American journal of physiology
1991
1991-02
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
<a href="http://doi.org/10.1152/ajpheart.1991.260.2.H453" target="_blank" rel="noreferrer noopener">10.1152/ajpheart.1991.260.2.H453</a>