1 40 1 Text A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text. URL Address <a href="http://doi.org/10.1016/s0014-2999(98)00700-6" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/s0014-2999(98)00700-6</a> Pages 207–216 Issue 2 Volume 361 Dublin Core The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/. Title A name given to the resource Sex differences in extracellular and intracellular calcium-mediated vascular reactivity to vasopressin in rat aorta. Publisher An entity responsible for making the resource available European journal of pharmacology Date A point or period of time associated with an event in the lifecycle of the resource 1998 1998-11 Subject The topic of the resource *Sex Characteristics; 1; 3-Pyridinecarboxylic acid; 4-dihydro-2; 6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-; Animals; Aorta/drug effects/*metabolism; Calcium Channel Agonists/*pharmacology; Calcium Channel Blockers/*pharmacology; Calcium/*metabolism; Diltiazem/pharmacology; Dose-Response Relationship; Drug; Female; In Vitro Techniques; Male; Methyl ester/pharmacology; Potassium Chloride/pharmacology; Rats; Simvastatin/pharmacology; Sprague-Dawley; Vasoconstriction/*drug effects; Vasopressins/*metabolism Creator An entity primarily responsible for making the resource Eatman D; Stallone J N; Rutecki G W; Whittier F C Description An account of the resource In rat thoracic aorta, contractile responses to arginine vasopressin are two-fold higher in females than in males. To determine the roles of extracellular and intracellular Ca2+ in this sexual dimorphism in vascular function, vascular reactivity and Ca2+ channel function were examined in thoracic aortae of male and female rats. In the presence of diltiazem (10 microM), maximal contraction to vasopressin was reduced to a greater extent in male (65+/-2%) than in female aortae (38+/-1%). Maximal contractile responses to KCl and Bay K 8644 were similar in male and female aortae. Sensitivity to KCI was slightly but significantly higher in male than in female aorta; in contrast, sensitivity to Bay K 8644 was nearly three-fold higher in males than in females. Removal of the endothelium enhanced sensitivity to KCl similarly in male and female aortae. In the presence of simvastatin (60 microM; an inhibitor of intracellular Ca2+ release), reactivity to vasopressin was reduced substantially in female (42+/-1%) but unaltered in male aortae. Removal of the endothelium enhanced the inhibitory effect of simvastatin in both female (73+/-2%) and male aortae (41+/-2%). These findings demonstrate that male aortae depend more upon extracellular Ca2+ influx, whereas female aortae depend more upon intracellular Ca2+ release for vasopressin-induced contraction. Identifier An unambiguous reference to the resource within a given context <a href="http://doi.org/10.1016/s0014-2999(98)00700-6" target="_blank" rel="noreferrer noopener">10.1016/s0014-2999(98)00700-6</a> Rights Information about rights held in and over the resource Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s). *Sex Characteristics 1 1998 3-Pyridinecarboxylic acid 4-dihydro-2 6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)- Animals Aorta/drug effects/*metabolism Calcium Channel Agonists/*pharmacology Calcium Channel Blockers/*pharmacology Calcium/*metabolism Department of Internal Medicine Diltiazem/pharmacology Dose-Response Relationship Drug Eatman D European journal of pharmacology Female In Vitro Techniques Male Methyl ester/pharmacology NEOMED College of Medicine Potassium Chloride/pharmacology Rats Rutecki G W Simvastatin/pharmacology Sprague-Dawley Stallone J N Vasoconstriction/*drug effects Vasopressins/*metabolism Whittier F C