1
40
4
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0091-3057(90)90083-t" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0091-3057(90)90083-t</a>
Pages
817–820
Issue
4
Volume
36
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Dopaminergic nature of acute cathine tolerance.
Publisher
An entity responsible for making the resource available
Pharmacology, biochemistry, and behavior
Date
A point or period of time associated with an event in the lifecycle of the resource
1990
1990-08
Subject
The topic of the resource
Male; Animals; Rats; Drug Tolerance; Dopamine/*physiology; Discrimination (Psychology)/drug effects; Discrimination Learning/drug effects; Alkaloids/pharmacology; Thiazepines/pharmacology; Antipsychotic Agents/pharmacology; Appetite Depressants/*pharmacology; Phenylpropanolamine/*pharmacology; Generalization (Psychology)/drug effects; Dose-Response Relationship; Drug; Inbred Strains
Creator
An entity primarily responsible for making the resource
Schechter M D
Description
An account of the resource
Cathine is a psychoactive constituent in the leaves of the Khat shrub which are habitually ingested for their stimulatory effects in many parts of the world. Rats were trained to discriminate the stimulus effect of intraperitoneally administered 4.8 mg/kg d-cathine and, once trained, administration of another Khat constituent, cathinone, was shown to produce cathine-like effects. This generalization to cathinone was dose-responsive when testing occurred 24 hr after vehicle administration, whereas prior administration of cathine resulted in a diminished discriminative response to subsequent cathinone administration possibly as a result of the development of acute tolerance. CGS 10746B, a compound that blocks presynaptic release of dopamine, significantly decreased rats' ability to discriminate cathine when it was administered 25 min prior to cathine testing and it reversed the acute tolerance observed when cathine was tested 24 hr after cathine administration. These results indicate that a previously reported acute tolerance effect to cathine after cathinone administration in cathinone-trained rats appears to be symmetrical in that there is acute tolerance to cathinone after cathine in these cathine-trained rats. The results with CGS 10746B would suggest that both the cathine-induced discriminative cue and cathine's ability to produce acute tolerance are mediated by presynaptic dopamine release.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0091-3057(90)90083-t" target="_blank" rel="noreferrer noopener">10.1016/0091-3057(90)90083-t</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1990
Alkaloids/pharmacology
Animals
Antipsychotic Agents/pharmacology
Appetite Depressants/*pharmacology
Discrimination (Psychology)/drug effects
Discrimination Learning/drug effects
Dopamine/*physiology
Dose-Response Relationship
Drug
Drug Tolerance
Generalization (Psychology)/drug effects
Inbred Strains
Male
Pharmacology, biochemistry, and behavior
Phenylpropanolamine/*pharmacology
Rats
Schechter M D
Thiazepines/pharmacology
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0091-3057(91)90595-s" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0091-3057(91)90595-s</a>
Pages
99–104
Issue
1
Volume
38
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Inverse agonist properties of the FG 7142 discriminative stimulus.
Publisher
An entity responsible for making the resource available
Pharmacology, biochemistry, and behavior
Date
A point or period of time associated with an event in the lifecycle of the resource
1991
1991-01
Subject
The topic of the resource
Male; Animals; Rats; Discrimination (Psychology)/*drug effects; Discrimination Learning/drug effects; Reinforcement Schedule; Appetite Depressants/*pharmacology; Carbolines/antagonists & inhibitors/*pharmacology; Dose-Response Relationship; Drug; Inbred Strains; Receptors; Generalization; Stimulus/drug effects; GABA-A/drug effects
Creator
An entity primarily responsible for making the resource
Leidenheimer N J; Schechter M D
Description
An account of the resource
A two-lever, food-motivated discrimination was established between the benzodiazepine receptor partial inverse agonist FG 7142 (5.0 mg/kg) and its vehicle. The FG 7142 discriminative stimulus was pharmacologically characterized by testing trained rats with a variety of benzodiazepine receptor ligands. Administration of the inverse agonist DMCM (0.15-0.30 mg/kg) dose-dependently mimicked the FG 7142 stimulus. In contrast, the benzodiazepine receptor agonist chlordiazepoxide, partial agonist ZK 91 296, mixed agonist/antagonist CGS 9896 and antagonist RO 15-1788 blocked the FG 7142 cue. These results indicate that the FG 7142 discriminative stimulus is based on its inverse agonist activity. The generalization of FG 7142 to the anxiogenic/convulsant compound pentylenetetrazole (PTZ), but not to the anorectic agent norfenfluramine, indicates that the anxiogenic properties of FG 7142, rather than its anorectic actions, may underlie the FG 7142 discriminative stimulus.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0091-3057(91)90595-s" target="_blank" rel="noreferrer noopener">10.1016/0091-3057(91)90595-s</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1991
Animals
Appetite Depressants/*pharmacology
Carbolines/antagonists & inhibitors/*pharmacology
Discrimination (Psychology)/*drug effects
Discrimination Learning/drug effects
Dose-Response Relationship
Drug
GABA-A/drug effects
Generalization
Inbred Strains
Leidenheimer N J
Male
Pharmacology, biochemistry, and behavior
Rats
Receptors
Reinforcement Schedule
Schechter M D
Stimulus/drug effects
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
Pages
351–355
Issue
2
Volume
30
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Discriminative stimulus control by the anxiogenic beta-carboline FG 7142: generalization to a physiological stressor.
Publisher
An entity responsible for making the resource available
Pharmacology, biochemistry, and behavior
Date
A point or period of time associated with an event in the lifecycle of the resource
1988
1988-06
Subject
The topic of the resource
Male; Animals; Rats; Discrimination Learning/*drug effects; Avoidance Learning/drug effects; Appetite Depressants/*pharmacology; Carbolines/*pharmacology; Stress; Inbred Strains; Generalization; Stimulus/*drug effects; Physiological/*psychology
Creator
An entity primarily responsible for making the resource
Leidenheimer N J; Schechter M D
Description
An account of the resource
Drug discrimination was employed to investigate the similarities between FG
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1988
Animals
Appetite Depressants/*pharmacology
Avoidance Learning/drug effects
Carbolines/*pharmacology
Discrimination Learning/*drug effects
Generalization
Inbred Strains
Leidenheimer N J
Male
Pharmacology, biochemistry, and behavior
Physiological/*psychology
Rats
Schechter M D
Stimulus/*drug effects
Stress
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/0091-3057(92)90641-r" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/0091-3057(92)90641-r</a>
Pages
77–83
Issue
1
Volume
43
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Evidence for noradrenergic involvement in mediating the FG 7142 discriminative stimulus.
Publisher
An entity responsible for making the resource available
Pharmacology, biochemistry, and behavior
Date
A point or period of time associated with an event in the lifecycle of the resource
1992
1992-09
Subject
The topic of the resource
Adrenergic alpha-Antagonists/pharmacology; Animals; Appetite Depressants/*pharmacology; Carbolines/*pharmacology; Clonidine/pharmacology; Dioxanes/pharmacology; Discrimination (Psychology)/*drug effects; Electroshock; Generalization; Idazoxan; Male; Norepinephrine/*physiology; Psychological/psychology; Rats; Sprague-Dawley; Stimulus/drug effects; Stress; Yohimbine/pharmacology
Creator
An entity primarily responsible for making the resource
Leidenheimer N J; Schechter M D
Description
An account of the resource
Rats were trained to discriminate the stimulus properties of the benzodiazepine receptor partial inverse agonist beta-carboline-3-carboxylate acid methyl amide (FG 7142) (5.0 mg/kg) or the alpha 2-adrenergic receptor antagonist 17 alpha-hydroxyyohimban-16 alpha-carboxylic acid methyl ester (yohimbine) (3.0 mg/kg) from vehicle in a two-lever, food-motivated operant task. These compounds have in common a beta-carboline structure and anxiogenic behavioral profiles. The yohimbine discriminative stimulus was mimicked by the alpha 2-adrenergic receptor antagonist idazoxan and antagonized by the alpha 2-adrenergic receptor agonist clonidine, indicating that the yohimbine stimulus was mediated through the alpha
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/0091-3057(92)90641-r" target="_blank" rel="noreferrer noopener">10.1016/0091-3057(92)90641-r</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
1992
Adrenergic alpha-Antagonists/pharmacology
Animals
Appetite Depressants/*pharmacology
Carbolines/*pharmacology
Clonidine/pharmacology
Dioxanes/pharmacology
Discrimination (Psychology)/*drug effects
Electroshock
Generalization
Idazoxan
Leidenheimer N J
Male
Norepinephrine/*physiology
Pharmacology, biochemistry, and behavior
Psychological/psychology
Rats
Schechter M D
Sprague-Dawley
Stimulus/drug effects
Stress
Yohimbine/pharmacology