1
40
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Text
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URL Address
<a href="http://doi.org/10.1152/jappl.2001.91.6.2602" target="_blank" rel="noreferrer noopener">http://doi.org/10.1152/jappl.2001.91.6.2602</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
2602-2610
Issue
6
Volume
91
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Dublin Core
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Title
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Androgen-receptor defect abolishes sex differences in nitric oxide and reactivity to vasopressin in rat aorta
Publisher
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Journal of Applied Physiology
Date
A point or period of time associated with an event in the lifecycle of the resource
2001
2001-12
Subject
The topic of the resource
aorta; arginine vasopressin; binding; brain; dependent gender differences; dimorphism; Endothelium; endothelium-derived relaxing factor; estrogen; gonadal steroid hormones; hormones; l-arginine; muscle; Physiology; Sport Sciences; testicular feminized rat; testicular feminized rat; vasoconstriction
Creator
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Stallone J N; Salisbury R L; Fulton C T
Description
An account of the resource
Contractions of rat thoracic aorta to vasopressin WP) are threefold higher in females (F) than in males (M), primarily because nitric oxide (NO) attenuation of contraction is greater in M. To determine the role of the androgen receptor (AR) in this mechanism, vascular reactivity to VP was examined in thoracic aorta of the testicular-feminized male (Tfm) rat, which has an X-linked, recessive defect in AR function in affected M. Maximal contraction of normal aortas to VP was fourfold higher in F (4,128 +/- 291 mg/mg ring wt) than in M (971 +/- 133 mg); maximal response of Tfm (3,967 +/- 253 mg) was similar to that of normal F. N-G-nitro-L-arginine methyl ester increased maximal response to VP threefold in M but had no effect in F or Tfm. In contrast, maximal contraction of normal aortas to phenylephrine was 43% higher in M (4,011 +/- 179 mg) than in F (2,809 +/- 78 mg); maximal response of Tfm (2,716 +/- 126 mg) was similar to that of normal F. N-G-nitro-L-arginine methyl ester increased maximal response to phenylephrine by >50% in F and Tfm but had no effect in M. Maximal contractile response to 80 mM KCl did not differ among M, F, or Tfm. Thus androgens and normal vascular AR function are important in the greater NO-mediated attenuation of reactivity to VP in M than in F rat aorta, which may involve specific modulation of endothelial VP signal transduction pathways and NO release by androgens. These data also establish the importance of the Tfm rat as a model to study the effects of androgens on cardiovascular function.
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<a href="http://doi.org/10.1152/jappl.2001.91.6.2602" target="_blank" rel="noreferrer noopener">10.1152/jappl.2001.91.6.2602</a>
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Journal Article
2001
Aorta
Arginine vasopressin
Binding
Brain
dependent gender differences
dimorphism
Endothelium
endothelium-derived relaxing factor
estrogen
Fulton C T
gonadal steroid hormones
Hormones
Journal Article
Journal of Applied Physiology
l-arginine
Muscle
Physiology
Salisbury R L
Sport Sciences
Stallone J N
testicular feminized rat
Vasoconstriction
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1111/j.1600-079X.1992.tb00054.x" target="_blank" rel="noreferrer noopener">http://doi.org/10.1111/j.1600-079X.1992.tb00054.x</a>
Rights
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
Pages
49-59
Issue
2
Volume
13
Search for Full-text
Locate full-text within NEOMED Library's e-journal collections
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Title
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EFFECTS OF MELATONIN ON WATER METABOLISM AND RENAL-FUNCTION IN MALE SYRIAN-HAMSTERS (MESOCRICETUS-AURATUS)
Publisher
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Journal of Pineal Research
Date
A point or period of time associated with an event in the lifecycle of the resource
1992
1992-09
Subject
The topic of the resource
arginine vasopressin; calcium; drinking; Endocrinology & Metabolism; localization; melatonin; neurohypophysis; Neurosciences & Neurology; osmotic pressure; oxytocin; Physiology; pineal-gland; pinealectomized rats; plasma; potassium; radioimmunoassay; responsiveness; sodium; urine; water balance
Creator
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Richardson B A; Studier E H; Stallone J N; Kennedy C M
Description
An account of the resource
The pineal indoleamine, melatonin, has been shown to influence many physiological systems within the mammalian body. Few studies, however, have examined the influence of melatonin on renal function. This study investigated the effects of melatonin on water metabolism and renal function. Young adult male Syrian hamsters were maintained on a long photoperiod (LD 14:10) in metabolic cages. The animals received daily (1700) injections of either control vehicle or 25 mug of melatonin for 85 consecutive days. Melatonin administration resulted in significant increases in water consumption and urine production. Water budgets were also significantly influenced by melatonin, as were urinary osmolality, urinary sodium, and potassium concentrations, but urinary calcium concentrations were essentially unaltered. When excretion rates for sodium, potassium, and calcium were calculated, no differences were observed between the vehicle control and melatonin-treated groups. Injections of melatonin also significantly decreased plasma antidiuretic hormone (ADH). These results demonstrate that afternoon injections of melatonin can alter renal function, which may involve direct (i.e., on ADH secretion and/or thirst mechanisms) or indirect (i.e., behavioral) effects.
Identifier
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<a href="http://doi.org/10.1111/j.1600-079X.1992.tb00054.x" target="_blank" rel="noreferrer noopener">10.1111/j.1600-079X.1992.tb00054.x</a>
Format
The file format, physical medium, or dimensions of the resource
Journal Article
1992
Arginine vasopressin
calcium
drinking
Endocrinology & Metabolism
Journal Article
Journal of Pineal Research
Kennedy C M
localization
Melatonin
neurohypophysis
Neurosciences & Neurology
Osmotic Pressure
Oxytocin
Physiology
pineal-gland
pinealectomized rats
Plasma
Potassium
Radioimmunoassay
responsiveness
Richardson B A
Sodium
Stallone J N
Studier E H
Urine
water balance
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.14740/cr553w" target="_blank" rel="noreferrer noopener">http://doi.org/10.14740/cr553w</a>
Pages
87–95
Issue
3
Volume
8
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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Cardiorenal Syndrome: Role of Arginine Vasopressin and Vaptans in Heart Failure.
Publisher
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Cardiology research
Date
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2017
2017-06
Subject
The topic of the resource
Arginine vasopressin; Cardiorenal syndrome; Conivaptan; Heart failure; Tolvaptan; Vaptans; Vasopressin receptor antagonists
Creator
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Vinod Poornima; Krishnappa Vinod; Chauvin Abigail M; Khare Anshika; Raina Rupesh
Description
An account of the resource
Heart and kidney failure continued to be of increasing prevalence in today's society, and their comorbidity has synergistic effect on the morbidity and mortality of patients. Cardiorenal syndrome (CRS) is a complex disease with multifactorial pathophysiology. Better understanding of this pathophysiological network is crucial for the successful intervention to prevent advancement of the disease process. One of the major factors in this process is neurohormonal activation, predominantly involving renin-angiotensin-aldosterone system (RAAS) and arginine vasopressin (AVP). Heart failure causes reduced cardiac output/cardiac index (CO/CI) and fall in renal perfusion pressures resulting in activation of baroreceptors and RAAS, respectively. Activated baroreceptors and RAAS stimulate the release of AVP (non-osmotic pathway), which acts on V2 receptors located in the renal collecting ducts, causing fluid retention and deterioration of heart failure. Effective blockade of AVP action on V2 receptors has emerged as a potential treatment option in volume overload conditions especially in the setting of hyponatremia. Vasopressin receptor antagonists (VRAs), such as vaptans, are potent aquaretics causing electrolyte-free water diuresis without significant electrolyte abnormalities. Vaptans are useful in hypervolemic hyponatremic conditions like heart failure and liver cirrhosis, and euvolemic hyponatremic conditions like syndrome of inappropriate anti-diuretic hormone secretion. Tolvaptan and conivaptan are pharmaceutical agents that are available for the treatment of these conditions.
Identifier
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<a href="http://doi.org/10.14740/cr553w" target="_blank" rel="noreferrer noopener">10.14740/cr553w</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2017
Arginine vasopressin
Cardiology research
Cardiorenal syndrome
Chauvin Abigail M
Conivaptan
Department of Internal Medicine
Heart failure
Khare Anshika
Krishnappa Vinod
NEOMED College of Graduate Studies Student
NEOMED College of Medicine
Raina Rupesh
Tolvaptan
Vaptans
Vasopressin receptor antagonists
Vinod Poornima