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Text
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URL Address
<a href="http://doi.org/10.1016/j.cyto.2014.11.026" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.cyto.2014.11.026</a>
Pages
319–325
Issue
2
Volume
73
Dublin Core
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Title
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The role of type I interferons and other cytokines in dermatomyositis.
Publisher
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Cytokine
Date
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2015
2015-06
Subject
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Autoantibodies/immunology; Biological; Cytokines; Dermatomyositis; Dermatomyositis/*immunology/physiopathology/therapy; Humans; Inflammatory myopathy; Interferon Type I/*metabolism; Models; Pathogenesis; Signal Transduction; Type I interferons
Creator
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Arshanapalli Ashish; Shah Mihir; Veerula Vindhya; Somani Ally-Khan
Description
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Much work has been done to unveil the mechanisms behind the pathogenesis of dermatomyositis (DM) - mainly those involving certain pathogenic cytokines, termed "pathokines" as the principal cytokines involved. Recently, it has become clear that a group of cytokines known as type I interferons (IFN-Is) play a significant role in the development of DM. We review the literature published between 1946 and 2014 using an Ovid Medline database search to provide an update on the role of IFN-Is and other cytokines in the pathogenesis of DM. We provide information about the genes and proteins induced by IFN-Is and potential mechanisms by which these downstream products relate to clinical disease activity. We also explore findings of other autoimmune phenomena that may contribute to disease onset and activity including T-helper 17 (Th17) cells and associated interleukins, as well as autoantibodies. Finally, we provide a brief update on current treatment options for DM as well as some new immunomodulatory treatment modalities in development.
Identifier
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<a href="http://doi.org/10.1016/j.cyto.2014.11.026" target="_blank" rel="noreferrer noopener">10.1016/j.cyto.2014.11.026</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2015
Arshanapalli Ashish
Autoantibodies/immunology
Biological
Cytokine
Cytokines
Dermatomyositis
Dermatomyositis/*immunology/physiopathology/therapy
Humans
Inflammatory myopathy
Interferon Type I/*metabolism
Models
Pathogenesis
Shah Mihir
Signal Transduction
Somani Ally-Khan
Type I interferons
Veerula Vindhya