Pseudogout following intraarticular injection of sodium hyaluronate.
Chondrocalcinosis/*chemically induced; Contraindications; Humans; Hyaluronic Acid/*adverse effects; Injections; Intra-Articular; Knee Joint/drug effects/physiopathology; Male; Middle Aged; Osteoarthritis/*drug therapy; Pain/drug therapy
Luzar M J; Altawil B
Arthritis and rheumatism
1998
1998-05
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
<a href="http://doi.org/10.1002/1529-0131(199805)41:5%3C939::AID-ART24%3E3.0.CO;2-D" target="_blank" rel="noreferrer noopener">10.1002/1529-0131(199805)41:5%3C939::AID-ART24%3E3.0.CO;2-D</a>
Hydroxychloroquine concentration-response relationships in patients with rheumatoid arthritis
drugs; efficacy; gold; low-dose methotrexate; ocular safety; pharmacokinetics; placebo; plasma; Rheumatology; serum concentrations; trial
Objective. A dose-response relationship for hydroxychloroquine (HCQ), in terms of the proportion of patients achieving the Paulus 20% criteria for improvement, had previously been observed in patients with rheumatoid arthritis (RA) receiving a 6-week loading regimen of 400, 800, or 1,200 mg HCQ daily. This present retrospective analysis was performed to investigate possible relationships between the blood HCQ and HCQ-metabolite concentrations and measures of efficacy and toxicity. In addition, we sought to ascertain whether further investigation of HCQ/HCQ-metabolite levels might lead to testing of one of these substances as a new antirheumatic drug. Methods. Patients with active RA (n = 212) began a 6-week, double-blind trial comparing 3 different doses of HCQ at 400, 800, or 1,200 mg/day, followed by 18 weeks of open-label HCQ treatment at 400 mg/day. Patients were repeatedly evaluated for treatment efficacy and toxicity. Blood samples were available from 123 patients for analysis of HCQ, desethylhydroxychloroquine (DHCQ), desethylchloroquine (DCQ), and bisdesethylchloroquine (BDCQ) levels using high-performance liquid chromatography. Achievement of the modified Paulus 20% improvement criteria for response in RA was used as the primary efficacy parameter. Spontaneously reported adverse events were categorized and analyzed as toxicity outcome variables. The relationship between response (efficacy and toxicity) and drug levels was evaluated using logistic regression analysis. Results. The subset of patients with blood concentration data was equivalent to the larger study population in all demographic and outcome characteristics. The mean HCQ, DHCQ, and DCQ elimination half-lives were 123, 161, and 180 hours, respectively. There was a positive correlation between the Paulus 20% improvement criteria response and blood DHCQ concentrations during weeks 1-6 (P < 0.001). A potential relationship between ocular adverse events and BDCQ levels was found (P = 0.036). Logistic regression analysis of adverse events data showed that adverse gastrointestinal events were associated with higher HCQ levels (P = 0.001-0.021) during weeks 1, 2, and 3. Conclusion. There is a weak, but predictable, relationship between blood DHCQ concentrations and efficacy of treatment with HCQ. In addition, there is an association between gastrointestinal adverse events and elevated blood HCQ concentrations. Further investigation of these relationships is warranted to see if DHCQ may be introduced as a new antirheumatic drug.
Munster T; Gibbs J P; Shen D; Baethge B A; Botstein G R; Caldwell J; Dietz F; Ettlinger R; Golden H E; Lindsley H; McLaughlin G E; Moreland L W; Roberts W N; Rooney T W; Rothschild B; Sack M; Sebba A I; Weisman M; Welch K E; Yocum D; Furst D E
Arthritis and Rheumatism
2002
2002-06
Journal Article
<a href="http://doi.org/10.1002/art.10307" target="_blank" rel="noreferrer noopener">10.1002/art.10307</a>
Response of engineered cartilage tissue to biochemical agents as studied by proton magnetic resonance microscopy
acid; anterior cruciate ligament; canine articular-cartilage; chondrocytes; interleukin-1; matrix; nmr; osteoarthritis; Rheumatology; self-diffusion; water
Objective, To test the hypothesis that magnetic resonance imaging (MRI) results correlate with the biochemical composition of cartilage matrix and can therefore be used to evaluate natural tissue development and the effects of biologic interventions. Methods. Chondrocytes harvested from day-16 chick embryo sterna were inoculated into an MRI-compatible hollow-fiber bioreactor, The tissue that formed over a period of 2-4 weeks was studied biochemically, histologically, and with MRI. Besides natural development, the response of the tissue to administration of retinoic acid, interleukin-1 beta (IL-1 beta), and daily dosing with ascorbic acid was studied. Results. Tissue wet and dry weight, glycosaminoglycan (GAG) content, and collagen content all increased with development time, while tissue hydration decreased. The administration of retinoic acid resulted in a significant reduction in tissue wet weight, proteoglycan content, and cell number and an increase in hydration as compared with controls. Daily dosing with ascorbic acid increased tissue collagen content significantly compared with controls, while the administration of IL-1 beta resulted in increased proteoglycan content. The water proton longitudinal and transverse relaxation rates correlated well with GAG and collagen concentrations of the matrix as well as with tissue hydration. In contrast, the magnetization transfer value for the tissue correlated only with total collagen, Finally, the self-coefficient of water correlated with tissue diffusion hydration. Conclusion. Parameters derived from MR images obtained noninvasively can be used to quantitatively assess the composition of cartilage tissue generated in a bioreactor. We conclude that MRI is a promising modality for the assessment of certain biochemical properties of cartilage in a wide variety of settings.
Potter K; Butler J J; Horton W E; Spencer R G S
Arthritis and Rheumatism
2000
2000-07
Journal Article
<a href="http://doi.org/10.1002/1529-0131(200007)43:7%3C1580::aid-anr23%3E3.3.co;2-7" target="_blank" rel="noreferrer noopener">10.1002/1529-0131(200007)43:7%3C1580::aid-anr23%3E3.3.co;2-7</a>
Benefit or risk of aspirin treatment of giant cell arteritis: comment on the article by Weyand et al
Rheumatology
Rothschild B M
Arthritis and Rheumatism
2002
2002-11
Journal Article
<a href="http://doi.org/10.1002/art.10528" target="_blank" rel="noreferrer noopener">10.1002/art.10528</a>
OLD-WORLD SPONDYLARTHROPATHY - THE GORILLA CONNECTION
Rheumatology
Rothschild B M; Woods R
Arthritis and Rheumatism
1988
1988-07
Journal Article
<a href="http://doi.org/10.1002/art.1780310722" target="_blank" rel="noreferrer noopener">10.1002/art.1780310722</a>
Suppressive treatment of calcium pyrophosphate deposition disease
arthropathy; Rheumatology
Rothschild B
Arthritis and Rheumatism
2007
2007-09
Journal Article
<a href="http://doi.org/10.1002/art.22945" target="_blank" rel="noreferrer noopener">10.1002/art.22945</a>
Horse and rhinoceros evolutionary evidence for protective effect of spondyloarthropathy?
Rheumatology
Rothschild B; Rothschild C
Arthritis and Rheumatism
1998
1998-09
Journal Article
n/a
MUSCULOSKELETAL MANIFESTATIONS OF SYPHILIS
Rheumatology
Rothschild B M; Rothschild C
Arthritis and Rheumatism
1995
1995-09
Journal Article
n/a
PARADOX OF EROSIVE ARTHRITIS IN NEW-WORLD MONKEYS - COLLAGEN-INDUCED VERSUS NATURALLY-OCCURRING SPONDYLOARTHROPATHY
Rheumatology
Rothschild B M; Woods R J; Rothschild C
Arthritis and Rheumatism
1993
1993-05
Journal Article
n/a
Primary care rheumatology rotation: Management skills versus actual time served
Rheumatology
Rothschild B M
Arthritis and Rheumatism
2002
2002-09
Journal Article
n/a
SACROILIAC ARTHROSCOPY - A NEW VALIDATION APPROACH TO THE DIAGNOSIS OF SPONDYLOARTHROPATHY
Rheumatology
Rothschild B M; Poteat B; Williams E; Woods R J; Pascale P J
Arthritis and Rheumatism
1993
1993-05
Journal Article
n/a
Does Treatment of Asymptomatic Hyperuricemia Improve Cardio and Neurovascular Outcomes? A Decision-Analytic Evaluation
Rheumatology
Akkineni R; Lee A; Miller K L; Tosteson A N A; Choi H K; Zhu Y Y; Albert D A
Arthritis and Rheumatism
2011
2011-10
Journal Article or Conference Abstract Publication
n/a
Matrix fixed-charge density as determined by magnetic resonance microscopy of bioreactor-derived hyaline cartilage correlates with biochemical and biomechanical properties
chondrocytes; Rheumatology; tissue; articular-cartilage; spectroscopy; mri; fluid-flow; hollow-fiber bioreactor
Objective. To use noninvasive magnetic resonance imaging (MRI), biochemical analyses, and mechanical testing of engineered neocartilage grown in a hollow-fiber bioreactor (HFBR) to establish tissue properties, and to test the hypothesis that MRI can be used to monitor biochemical and biomechanical properties of neocartilage. Methods. Chondrocytes from. day 16 embryonic chick sterna were inoculated into an HFBR and maintained for up to 4 weeks with and without exposure to chondroitinase ABC. The fixed-charge density (FCD) of the cartilage was determined using the MRI gadolinium exclusion method. The sulfated glycosaminoglycan (S-GAG), hydroxyproline, and DNA contents were determined using biochemical procedures, while dynamic and equilibrium moduli were determined from mechanical indentation tests. Results. S-GAG content, tissue cross-sectional area, and equilibrium modulus of the neocartilage increased with development time. There was a gradient of S-GAG content across the length of control neocartilage at the 4-week time point, with higher values being found toward the inflow region. Exposure to chondroitinase ABC resulted in a decrease in tissue area, negative FCD, proteoglycan content, and equilibrium and dynamic moduli. The treated bioreactors displayed a length wise variation in S-GAG content, with higher values toward the outflow end. Linear correlations were established among FCD, proteoglycan content, and biomechanical properties. Conclusion. HFBR-derived neocartilage showed regional variation in S-GAG content under control conditions, and in the decrease of S-GAG in response to enzyme treatment. In addition, the results support the hypothesis that tissue parameters derived from MRI can be used to noninvasively monitor focal neocartilage formation and biochemical and biomechanical properties.
Chen C T; Fishbein K W; Torzilli P A; Hilger A; Spencer R G S; Horton W E
Arthritis and Rheumatism
2003
2003-04
Journal Article or Conference Abstract Publication
<a href="http://doi.org/10.1002/art.10991" target="_blank" rel="noreferrer noopener">10.1002/art.10991</a>
Association Between Treatment With Central Nervous System Stimulants And Raynaud's Syndrome In Children
attention-deficit/hyperactivity disorder; disease; Rheumatology
Goldman W; Seltzer R; Reuman P
Arthritis and Rheumatism
2008
2008-02
Journal Article or Conference Abstract Publication
<a href="http://doi.org/10.1002/art.23301" target="_blank" rel="noreferrer noopener">10.1002/art.23301</a>
Terminal Uridyltransferase Enzyme Zcchc11 Regulates Interleukin-6 Expression In Primary Human Osteoarthritis Chondrocytes
Rheumatology
Haseeb A; Makki M S; Arida A; Haqqi T M
Arthritis and Rheumatism
2013
2013-10
Journal Article or Conference Abstract Publication
n/a