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Text
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<a href="http://doi.org/10.1016/j.neulet.2013.11.051" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.neulet.2013.11.051</a>
Pages
152–157
Volume
559
Dublin Core
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Title
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Postnatal developmental changes in the medial nucleus of the trapezoid body in a mouse model of auditory pathology.
Publisher
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Neuroscience letters
Date
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2014
2014-01
Subject
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*Disease Models; AHL; Animal; Animals; Auditory brainstem responses; Auditory Pathways/*growth & development/*pathology; Auditory system; DBA/2; Hearing Loss/*pathology; Inbred CBA; Inbred DBA; Mice; MNTB; Newborn; Olivary Nucleus/*growth & development/*pathology; Organ Culture Techniques
Creator
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Grimsley Calum A; Sivaramakrishnan Shobhana
Description
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Age-related hearing loss (AHL) is a multifactorial disorder characterized by a decline in peripheral and central auditory function. Here, we examined synaptic transmission in DBA/2 mice, which carry the AHL8 gene, at the identifiable glutamatergic synapse in the medial nucleus of the trapezoid body (MNTB), a nucleus in the superior olivary complex critical for acoustic timing. Mice exhibited raised auditory brainstem thresholds by P14, soon after hearing onset. Excitatory postsynaptic currents were prolonged; however, postsynaptic excitability was normal. By P18, high-frequency hearing loss was evident. Coincident with the onset of hearing loss, MNTB principal neurons displayed changes in intrinsic firing properties. These results suggest that changes in transmission in the superior olivary complex are associated with early onset hearing loss.
Identifier
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<a href="http://doi.org/10.1016/j.neulet.2013.11.051" target="_blank" rel="noreferrer noopener">10.1016/j.neulet.2013.11.051</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Disease Models
2014
AHL
Animal
Animals
Auditory brainstem responses
Auditory Pathways/*growth & development/*pathology
Auditory system
DBA/2
Grimsley Calum A
Hearing Loss/*pathology
Inbred CBA
Inbred DBA
Mice
MNTB
Neuroscience letters
Newborn
Olivary Nucleus/*growth & development/*pathology
Organ Culture Techniques
Sivaramakrishnan Shobhana