1
40
11
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.3389/fncir.2014.00051" target="_blank" rel="noreferrer noopener">http://doi.org/10.3389/fncir.2014.00051</a>
Pages
51–51
Volume
8
Dublin Core
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Title
A name given to the resource
Interplay between low threshold voltage-gated K(+) channels and synaptic inhibition in neurons of the chicken nucleus laminaris along its frequency axis.
Publisher
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Frontiers in neural circuits
Date
A point or period of time associated with an event in the lifecycle of the resource
2014
1905-07
Subject
The topic of the resource
Animals; IPSC; Chick Embryo; Patch-Clamp Techniques; Neurons/*physiology; Auditory Pathways/*physiology; GABAergic inhibition; Inhibitory Postsynaptic Potentials/*physiology; interaural time difference; IPSP; Sound Localization/physiology; Synaptic Transmission/*physiology; tonotopy; voltage-gated low-threshold potassium current; whole-cell patch; Potassium Channels; Voltage-Gated/*physiology
Creator
An entity primarily responsible for making the resource
Hamlet William R; Liu Yu-Wei; Tang Zheng-Quan; Lu Yong
Description
An account of the resource
Central auditory neurons that localize sound in horizontal space have specialized intrinsic and synaptic cellular mechanisms to tightly control the threshold and timing for action potential generation. However, the critical interplay between intrinsic voltage-gated conductances and extrinsic synaptic conductances in determining neuronal output are not well understood. In chicken, neurons in the nucleus laminaris (NL) encode sound location using interaural time difference (ITD) as a cue. Along the tonotopic axis of NL, there exist robust differences among low, middle, and high frequency (LF, MF, and HF, respectively) neurons in a variety of neuronal properties such as low threshold voltage-gated K(+) (LTK) channels and depolarizing inhibition. This establishes NL as an ideal model to examine the interactions between LTK currents and synaptic inhibition across the tonotopic axis. Using whole-cell patch clamp recordings prepared from chicken embryos (E17-E18), we found that LTK currents were larger in MF and HF neurons than in LF neurons. Kinetic analysis revealed that LTK currents in MF neurons activated at lower voltages than in LF and HF neurons, whereas the inactivation of the currents was similar across the tonotopic axis. Surprisingly, blockade of LTK currents using dendrotoxin-I (DTX) tended to broaden the duration and increase the amplitude of the depolarizing inhibitory postsynaptic potentials (IPSPs) in NL neurons without dependence on coding frequency regions. Analyses of the effects of DTX on inhibitory postsynaptic currents led us to interpret this unexpected observation as a result of primarily postsynaptic effects of LTK currents on MF and HF neurons, and combined presynaptic and postsynaptic effects in LF neurons. Furthermore, DTX transferred subthreshold IPSPs to spikes. Taken together, the results suggest a critical role for LTK currents in regulating inhibitory synaptic strength in ITD-coding neurons at various frequencies.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.3389/fncir.2014.00051" target="_blank" rel="noreferrer noopener">10.3389/fncir.2014.00051</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2014
Animals
Auditory Pathways/*physiology
Chick Embryo
Department of Anatomy & Neurobiology
Frontiers in neural circuits
GABAergic inhibition
Hamlet William R
Inhibitory Postsynaptic Potentials/*physiology
interaural time difference
IPSC
IPSP
Liu Yu-Wei
Lu Yong
NEOMED College of Medicine
Neurons/*physiology
Patch-Clamp Techniques
Potassium Channels
Sound Localization/physiology
Synaptic Transmission/*physiology
Tang Zheng-Quan
tonotopy
voltage-gated low-threshold potassium current
Voltage-Gated/*physiology
whole-cell patch
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.3389/fncir.2013.00174" target="_blank" rel="noreferrer noopener">http://doi.org/10.3389/fncir.2013.00174</a>
Pages
174–174
Volume
7
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Midbrain local circuits shape sound intensity codes.
Publisher
An entity responsible for making the resource available
Frontiers in neural circuits
Date
A point or period of time associated with an event in the lifecycle of the resource
2013
1905-7
Subject
The topic of the resource
inferior colliculus; Animals; Mice; Neurons/physiology; Acoustic Stimulation; Auditory Perception/*physiology; Inferior Colliculi/*physiology; Auditory Pathways/*physiology; Auditory Threshold/physiology; high divalents; local circuits; monosynaptic; Neural Inhibition/*physiology; sound intensity
Creator
An entity primarily responsible for making the resource
Grimsley Calum Alex; Sanchez Jason Tait; Sivaramakrishnan Shobhana
Description
An account of the resource
Hierarchical processing of sensory information requires interaction at multiple levels along the peripheral to central pathway. Recent evidence suggests that interaction between driving and modulating components can shape both top down and bottom up processing of sensory information. Here we show that a component inherited from extrinsic sources combines with local components to code sound intensity. By applying high concentrations of divalent cations to neurons in the nucleus of the inferior colliculus in the auditory midbrain, we show that as sound intensity increases, the source of synaptic efficacy changes from inherited inputs to local circuits. In neurons with a wide dynamic range response to intensity, inherited inputs increase firing rates at low sound intensities but saturate at mid-to-high intensities. Local circuits activate at high sound intensities and widen dynamic range by continuously increasing their output gain with intensity. Inherited inputs are necessary and sufficient to evoke tuned responses, however local circuits change peak output. Push-pull driving inhibition and excitation create net excitatory drive to intensity-variant neurons and tune neurons to intensity. Our results reveal that dynamic range and tuning re-emerge in the auditory midbrain through local circuits that are themselves variable or tuned.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.3389/fncir.2013.00174" target="_blank" rel="noreferrer noopener">10.3389/fncir.2013.00174</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2013
Acoustic Stimulation
Animals
Auditory Pathways/*physiology
Auditory Perception/*physiology
Auditory Threshold/physiology
Frontiers in neural circuits
Grimsley Calum Alex
high divalents
Inferior Colliculi/*physiology
inferior colliculus
local circuits
Mice
monosynaptic
Neural Inhibition/*physiology
Neurons/physiology
Sanchez Jason Tait
Sivaramakrishnan Shobhana
sound intensity
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1523/JNEUROSCI.4733-10.2011" target="_blank" rel="noreferrer noopener">http://doi.org/10.1523/JNEUROSCI.4733-10.2011</a>
Pages
6121–6131
Issue
16
Volume
31
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Ambient GABA-activated tonic inhibition sharpens auditory coincidence detection via a depolarizing shunting mechanism.
Publisher
An entity responsible for making the resource available
The Journal of neuroscience : the official journal of the Society for Neuroscience
Date
A point or period of time associated with an event in the lifecycle of the resource
2011
2011-04
Subject
The topic of the resource
Animals; Chick Embryo; Patch-Clamp Techniques; Electric Stimulation; Neurons/*physiology; gamma-Aminobutyric Acid/*physiology; Membrane Potentials/physiology; Auditory Pathways/*physiology; Neural Inhibition/*physiology; Inhibitory Postsynaptic Potentials; Receptors; Blotting; Western; GABA-A/*physiology
Creator
An entity primarily responsible for making the resource
Tang Zheng-Quan; Dinh Emilie Hoang; Shi Wei; Lu Yong
Description
An account of the resource
Tonic inhibition mediated by extrasynaptic GABA(A) receptors (GABA(A)Rs) has emerged as a novel form of neural inhibition in the CNS. However, little is known about its presence and function in the auditory system. Using whole-cell recordings in brain slices, we identified a tonic current mediated by GABA(A)Rs containing the delta subunit in middle/high-characteristic-frequency neurons of the chicken nucleus laminaris, the first interaural time difference encoder that computes information for sound localization. This tonic conductance was activated by ambient concentrations of GABA released from synaptic vesicles. Furthermore, pharmacological manipulations of the conductance demonstrated its essential role in coincidence detection. Remarkably, this depolarizing tonic conductance was strongly inhibitory primarily because of its shunting effect. These results demonstrate a novel role for tonic inhibition in central auditory information processing.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1523/JNEUROSCI.4733-10.2011" target="_blank" rel="noreferrer noopener">10.1523/JNEUROSCI.4733-10.2011</a>
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Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2011
Animals
Auditory Pathways/*physiology
Blotting
Chick Embryo
Department of Anatomy & Neurobiology
Dinh Emilie Hoang
Electric Stimulation
GABA-A/*physiology
gamma-Aminobutyric Acid/*physiology
Inhibitory Postsynaptic Potentials
Lu Yong
Membrane Potentials/physiology
NEOMED College of Medicine
Neural Inhibition/*physiology
Neurons/*physiology
Patch-Clamp Techniques
Receptors
Shi Wei
Tang Zheng-Quan
The Journal of neuroscience : the official journal of the Society for Neuroscience
Western
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1523/JNEUROSCI.3572-07.2008" target="_blank" rel="noreferrer noopener">http://doi.org/10.1523/JNEUROSCI.3572-07.2008</a>
Pages
80–90
Issue
1
Volume
28
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Glycinergic "inhibition" mediates selective excitatory responses to combinations of sounds.
Publisher
An entity responsible for making the resource available
The Journal of neuroscience : the official journal of the Society for Neuroscience
Date
A point or period of time associated with an event in the lifecycle of the resource
2008
2008-01
Subject
The topic of the resource
Animals; Acoustic Stimulation/methods; Neural Inhibition/drug effects/*physiology; *Sound; Excitatory Amino Acid Antagonists/pharmacology; Action Potentials/drug effects/physiology; Auditory Pathways/*physiology; Glycine Agents/pharmacology; Glycine/*physiology; Chiroptera/physiology; Drug Interactions; GABA Agents/pharmacology; Inferior Colliculi/cytology/drug effects/*physiology; Iontophoresis/methods; Neurons/drug effects/physiology/radiation effects; Piperazines/pharmacology; Dose-Response Relationship; Receptors; Radiation; GABA/physiology; N-Methyl-D-Aspartate/antagonists & inhibitors/physiology
Creator
An entity primarily responsible for making the resource
Sanchez Jason Tait; Gans Donald; Wenstrup Jeffrey J
Description
An account of the resource
In the mustached bat's inferior colliculus (IC), combination-sensitive neurons display time-sensitive facilitatory interactions between inputs tuned to distinct spectral elements in sonar or social vocalizations. Here we compare roles of ionotropic receptors to glutamate (iGluRs), glycine (GlyRs), and GABA (GABA(A)Rs) in facilitatory combination-sensitive interactions. Facilitatory responses to 36 single IC neurons were recorded before, during, and after local application of antagonists to these receptors. The NMDA receptor antagonist CPP [(+/-)-3-(2-carboxypiperazin-4-yl)-propyl-1-phosphonic acid], alone (n = 14) or combined with AMPA receptor antagonist NBQX (n = 22), significantly reduced or eliminated responses to best frequency (BF) sounds across a broad range of sound levels, but did not eliminate combination-sensitive facilitation. In a subset of neurons, GABA(A)R blockers bicuculline or gabazine were applied in addition to iGluR blockers. GABA(A)R blockers did not "uncover" residual iGluR-mediated excitation, and only rarely eliminated facilitation. In nearly all neurons for which the GlyR antagonist strychnine was applied in addition to iGluR blockade (22 of 23 neurons, with or without GABA(A)R blockade), facilitatory interactions were eliminated. Thus, neither glutamate nor GABA neurotransmission are required for facilitatory combination-sensitive interactions in IC. Instead, facilitation may depend entirely on glycinergic inputs that are presumed to be inhibitory. We propose that glycinergic inputs tuned to two distinct spectral elements in vocal signals each activate postinhibitory rebound excitation. When rebound excitations from two spectral elements coincide, the neuron discharges. Excitation from glutamatergic inputs, tuned to the BF of the neuron, is superimposed onto this facilitatory interaction, presumably mediating responses to a broader range of acoustic signals.
Identifier
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<a href="http://doi.org/10.1523/JNEUROSCI.3572-07.2008" target="_blank" rel="noreferrer noopener">10.1523/JNEUROSCI.3572-07.2008</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Sound
2008
Acoustic Stimulation/methods
Action Potentials/drug effects/physiology
Animals
Auditory Pathways/*physiology
Chiroptera/physiology
College of Anatomy & Neurobiology
Department of Anatomy & Neurobiology
Dose-Response Relationship
Drug Interactions
Excitatory Amino Acid Antagonists/pharmacology
GABA Agents/pharmacology
GABA/physiology
Gans Donald
Glycine Agents/pharmacology
Glycine/*physiology
Inferior Colliculi/cytology/drug effects/*physiology
Iontophoresis/methods
N-Methyl-D-Aspartate/antagonists & inhibitors/physiology
NEOMED College of Medicine
Neural Inhibition/drug effects/*physiology
Neurons/drug effects/physiology/radiation effects
Piperazines/pharmacology
Radiation
Receptors
Sanchez Jason Tait
The Journal of neuroscience : the official journal of the Society for Neuroscience
Wenstrup Jeffrey J
-
Text
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URL Address
<a href="http://doi.org/10.1523/JNEUROSCI.3529-11.2011" target="_blank" rel="noreferrer noopener">http://doi.org/10.1523/JNEUROSCI.3529-11.2011</a>
Pages
14424–14435
Issue
40
Volume
31
Dublin Core
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Title
A name given to the resource
Circuitry underlying spectrotemporal integration in the auditory midbrain.
Publisher
An entity responsible for making the resource available
The Journal of neuroscience : the official journal of the Society for Neuroscience
Date
A point or period of time associated with an event in the lifecycle of the resource
2011
2011-10
Subject
The topic of the resource
Female; Male; Time Factors; Animals; Acoustic Stimulation/*methods; Chiroptera; Auditory Pathways/*physiology; Mesencephalon/*physiology; Nerve Net/*physiology
Creator
An entity primarily responsible for making the resource
Yavuzoglu Asuman; Schofield Brett R; Wenstrup Jeffrey J
Description
An account of the resource
Combination sensitivity in central auditory neurons is a form of spectrotemporal integration in which excitatory responses to sounds at one frequency are facilitated by sounds within a distinctly different frequency band. Combination-sensitive neurons respond selectively to acoustic elements of sonar echoes or social vocalizations. In mustached bats, this response property originates in high-frequency representations of the inferior colliculus (IC) and depends on low and high frequency-tuned glycinergic inputs. To identify the source of these inputs, we combined glycine immunohistochemistry with retrograde tract tracing. Tracers were deposited at high-frequency (\textgreater56 kHz), combination-sensitive recording sites in IC. Most glycine-immunopositive, retrogradely labeled cells were in ipsilateral ventral and intermediate nuclei of the lateral lemniscus (VNLL and INLL), with some double labeling in ipsilateral lateral and medial superior olivary nuclei (LSO and MSO). Generally, double-labeled cells were in expected high-frequency tonotopic areas, but some VNLL and INLL labeling appeared to be in low-frequency representations. To test whether these nuclei provide low frequency-tuned input to the high-frequency IC, we combined retrograde tracing from IC combination-sensitive sites with anterograde tracing from low frequency-tuned sites in the anteroventral cochlear nucleus (AVCN). Only VNLL and INLL contained retrogradely labeled cells near (
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1523/JNEUROSCI.3529-11.2011" target="_blank" rel="noreferrer noopener">10.1523/JNEUROSCI.3529-11.2011</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2011
Acoustic Stimulation/*methods
Animals
Auditory Pathways/*physiology
Chiroptera
College of Anatomy & Neurobiology
Department of Anatomy & Neurobiology
Female
Male
Mesencephalon/*physiology
NEOMED College of Medicine
Nerve Net/*physiology
Schofield Brett R
The Journal of neuroscience : the official journal of the Society for Neuroscience
Time Factors
Wenstrup Jeffrey J
Yavuzoglu Asuman
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1152/jn.00451.2009" target="_blank" rel="noreferrer noopener">http://doi.org/10.1152/jn.00451.2009</a>
Pages
2050–2061
Issue
4
Volume
103
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Responses in the inferior colliculus of the guinea pig to concurrent harmonic series and the effect of inactivation of descending controls.
Publisher
An entity responsible for making the resource available
Journal of neurophysiology
Date
A point or period of time associated with an event in the lifecycle of the resource
2010
2010-04
Subject
The topic of the resource
*Acoustic Stimulation; Action Potentials/physiology; Animal; Animals; Auditory Cortex/*physiology; Auditory Pathways/*physiology; Female; Guinea Pigs; Inferior Colliculi/*physiology; Male; Models; Pitch Perception/physiology
Creator
An entity primarily responsible for making the resource
Nakamoto Kyle T; Shackleton Trevor M; Palmer Alan R
Description
An account of the resource
One of the fundamental questions of auditory research is how sounds are segregated because, in natural environments, multiple sounds tend to occur at the same time. Concurrent sounds, such as two talkers, physically add together and arrive at the ear as a single input sound wave. The auditory system easily segregates this input into a coherent perception of each of the multiple sources. A common feature of speech and communication calls is their harmonic structure and in this report we used two harmonic complexes to study the role of the corticofugal pathway in the processing of concurrent sounds. We demonstrate that, in the inferior colliculus (IC) of the anesthetized guinea pig, deactivation of the auditory cortex altered the temporal and/or the spike response to the concurrent, monaural harmonic complexes. More specifically, deactivating the auditory cortex altered the representation of the relative level of the complexes. This suggests that the auditory cortex modulates the representation of the level of two harmonic complexes in the IC. Since sound level is a cue used in the segregation of auditory input, the corticofugal pathway may play a role in this segregation.
Identifier
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<a href="http://doi.org/10.1152/jn.00451.2009" target="_blank" rel="noreferrer noopener">10.1152/jn.00451.2009</a>
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Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Acoustic Stimulation
2010
Action Potentials/physiology
Animal
Animals
Auditory Cortex/*physiology
Auditory Pathways/*physiology
Female
Guinea Pigs
Inferior Colliculi/*physiology
Journal of neurophysiology
Male
Models
Nakamoto Kyle T
Palmer Alan R
Pitch Perception/physiology
Shackleton Trevor M
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1152/jn.00422.2011" target="_blank" rel="noreferrer noopener">http://doi.org/10.1152/jn.00422.2011</a>
Pages
1047–1057
Issue
4
Volume
107
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
A novel coding mechanism for social vocalizations in the lateral amygdala.
Publisher
An entity responsible for making the resource available
Journal of neurophysiology
Date
A point or period of time associated with an event in the lifecycle of the resource
2012
2012-02
Subject
The topic of the resource
*Social Behavior; Acoustic Stimulation; Action Potentials/*physiology; Amygdala/*cytology/physiology; Animal/*physiology; Animals; Auditory Pathways/*physiology; Chiroptera; Dextrans/metabolism; Echolocation/physiology; Female; Male; Neurons/*physiology; Reaction Time/physiology; Rhodamines/metabolism; Time Factors; Vocalization
Creator
An entity primarily responsible for making the resource
Gadziola Marie A; Grimsley Jasmine M S; Shanbhag Sharad J; Wenstrup Jeffrey J
Description
An account of the resource
The amygdala plays a central role in evaluating the significance of acoustic signals and coordinating the appropriate behavioral responses. To understand how amygdalar responses modulate auditory processing and drive emotional expression, we assessed how neurons respond to and encode information that is carried within complex acoustic stimuli. We characterized responses of single neurons in the lateral nucleus of the amygdala to social vocalizations and synthetic acoustic stimuli in awake big brown bats. Neurons typically responded to most of the social vocalizations presented (mean = nine of 11 vocalizations) but differentially modulated both firing rate and response duration. Surprisingly, response duration provided substantially more information about vocalizations than did spike rate. In most neurons, variation in response duration depended, in part, on persistent excitatory discharge that extended beyond stimulus duration. Information in persistent firing duration was significantly greater than in spike rate, and the majority of neurons displayed more information in persistent firing, which was more likely to be observed in response to aggressive vocalizations (64%) than appeasement vocalizations (25%), suggesting that persistent firing may relate to the behavioral context of vocalizations. These findings suggest that the amygdala uses a novel coding strategy for discriminating among vocalizations and underscore the importance of persistent firing in the general functioning of the amygdala.
Identifier
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<a href="http://doi.org/10.1152/jn.00422.2011" target="_blank" rel="noreferrer noopener">10.1152/jn.00422.2011</a>
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Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Social Behavior
2012
Acoustic Stimulation
Action Potentials/*physiology
Amygdala/*cytology/physiology
Animal/*physiology
Animals
Auditory Pathways/*physiology
Chiroptera
College of Anatomy & Neurobiology
Department of Anatomy & Neurobiology
Dextrans/metabolism
Echolocation/physiology
Female
Gadziola Marie A
Grimsley Jasmine M S
Journal of neurophysiology
Male
NEOMED College of Medicine
Neurons/*physiology
Reaction Time/physiology
Rhodamines/metabolism
Shanbhag Sharad J
Time Factors
Vocalization
Wenstrup Jeffrey J
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.neuroscience.2010.04.073" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.neuroscience.2010.04.073</a>
Pages
906–919
Issue
2
Volume
169
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Substrates of auditory frequency integration in a nucleus of the lateral lemniscus.
Publisher
An entity responsible for making the resource available
Neuroscience
Date
A point or period of time associated with an event in the lifecycle of the resource
2010
2010-08
Subject
The topic of the resource
Acoustic Stimulation; Action Potentials; Animals; Auditory Pathways/*physiology; Brain Stem/anatomy & histology/*physiology; Chiroptera/*physiology; Glycine/physiology
Creator
An entity primarily responsible for making the resource
Yavuzoglu A; Schofield B R; Wenstrup J J
Description
An account of the resource
In the intermediate nucleus of the lateral lemniscus (INLL), some neurons display a form of spectral integration in which excitatory responses to sounds at their best frequency are inhibited by sounds within a frequency band at least one octave lower. Previous work showed that this response property depends on low-frequency-tuned glycinergic input. To identify all sources of inputs to these INLL neurons, and in particular the low-frequency glycinergic input, we combined retrograde tracing with immunohistochemistry for the neurotransmitter glycine. We deposited a retrograde tracer at recording sites displaying either high best frequencies (\textgreater75 kHz) in conjunction with combination-sensitive inhibition, or at sites displaying low best frequencies (23-30 kHz). Most retrogradely labeled cells were located in the ipsilateral medial nucleus of the trapezoid body (MNTB) and contralateral anteroventral cochlear nucleus. Consistent labeling, but in fewer numbers, was observed in the ipsilateral lateral nucleus of the trapezoid body (LNTB), contralateral posteroventral cochlear nucleus, and a few other brainstem nuclei. When tracer deposits were combined with glycine immunohistochemistry, most double-labeled cells were observed in the ipsilateral MNTB (84%), with fewer in LNTB (13%). After tracer deposits at combination-sensitive recording sites, a striking result was that MNTB labeling occurred in both medial and lateral regions. This labeling appeared to overlap the MNTB labeling that resulted from tracer deposits in low-frequency recording sites of INLL. These findings suggest that MNTB is the most likely source of low-frequency glycinergic input to INLL neurons with high best frequencies and combination-sensitive inhibition. This work establishes an anatomical basis for frequency integration in the auditory brainstem.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/j.neuroscience.2010.04.073" target="_blank" rel="noreferrer noopener">10.1016/j.neuroscience.2010.04.073</a>
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Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2010
Acoustic Stimulation
Action Potentials
Animals
Auditory Pathways/*physiology
Brain Stem/anatomy & histology/*physiology
Chiroptera/*physiology
College of Anatomy & Neurobiology
Department of Anatomy & Neurobiology
Glycine/physiology
NEOMED College of Medicine
Neuroscience
Schofield B R
Wenstrup J J
Yavuzoglu A
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.neubiorev.2010.12.015" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.neubiorev.2010.12.015</a>
Pages
2073–2083
Issue
10
Volume
35
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Neural processing of target distance by echolocating bats: functional roles of the auditory midbrain.
Publisher
An entity responsible for making the resource available
Neuroscience and biobehavioral reviews
Date
A point or period of time associated with an event in the lifecycle of the resource
2011
2011-11
Subject
The topic of the resource
Animals; Auditory Cortex/physiology; Auditory Pathways/*physiology; Auditory Perception/*physiology; Brain Mapping/psychology; Chiroptera/*physiology; Echolocation/*physiology; Inferior Colliculi/*physiology; Models; Neurological; Neurons/physiology
Creator
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Wenstrup Jeffrey J; Portfors Christine V
Description
An account of the resource
Using their biological sonar, bats estimate distance to avoid obstacles and capture moving prey. The primary distance cue is the delay between the bat's emitted echolocation pulse and the return of an echo. The mustached bat's auditory midbrain (inferior colliculus, IC) is crucial to the analysis of pulse-echo delay. IC neurons are selective for certain delays between frequency modulated (FM) elements of the pulse and echo. One role of the IC is to create these "delay-tuned", "FM-FM" response properties through a series of spectro-temporal integrative interactions. A second major role of the midbrain is to project target distance information to many parts of the brain. Pathways through auditory thalamus undergo radical reorganization to create highly ordered maps of pulse-echo delay in auditory cortex, likely contributing to perceptual features of target distance analysis. FM-FM neurons in IC also project strongly to pre-motor centers including the pretectum and the pontine nuclei. These pathways may contribute to rapid adjustments in flight, body position, and sonar vocalizations that occur as a bat closes in on a target.
Identifier
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<a href="http://doi.org/10.1016/j.neubiorev.2010.12.015" target="_blank" rel="noreferrer noopener">10.1016/j.neubiorev.2010.12.015</a>
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Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2011
Animals
Auditory Cortex/physiology
Auditory Pathways/*physiology
Auditory Perception/*physiology
Brain Mapping/psychology
Chiroptera/*physiology
College of Anatomy & Neurobiology
Department of Anatomy & Neurobiology
Echolocation/*physiology
Inferior Colliculi/*physiology
Models
NEOMED College of Medicine
Neurological
Neurons/physiology
Neuroscience and biobehavioral reviews
Portfors Christine V
Wenstrup Jeffrey J
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1007/s101620010057" target="_blank" rel="noreferrer noopener">http://doi.org/10.1007/s101620010057</a>
Pages
104–117
Issue
2
Volume
2
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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Responses to combinations of tones in the nuclei of the lateral lemniscus.
Publisher
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Journal of the Association for Research in Otolaryngology : JARO
Date
A point or period of time associated with an event in the lifecycle of the resource
2001
2001-06
Subject
The topic of the resource
Acoustic Stimulation/methods; Animals; Auditory Pathways/*physiology; Brain Stem/*physiology; Chiroptera; Electrophysiology; Neurons/physiology; Reaction Time/physiology
Creator
An entity primarily responsible for making the resource
Portfors C V; Wenstrup J J
Description
An account of the resource
Combination-sensitive neurons integrate specific spectral and temporal elements in biologically important sounds, and they may underlie the analysis of biosonar and social vocalizations. Combination-sensitive neurons are found in the forebrain of a variety of vertebrates. In the mustached bat, they also occur in the central nucleus of the inferior colliculus (ICC). However, it is not known where combination-sensitive response properties emerge. To address this question, we used a two-tone paradigm to examine responses of single units to combination stimuli in a brainstem structure, the nuclei of the lateral lemniscus (NLL). We recorded and histologically localized 101 single units in the NLL. The majority (82%) of units had a single excitatory frequency tuning curve. Seven units had two separate excitatory frequency tuning curves but displayed no combinatorial interaction. Twelve units were combination-sensitive. Of these, three units were facilitated by the combination of two separate frequency bands and nine units were inhibited by combinatorial stimuli. The three facilitatory neurons had excitatory responses tuned to the second harmonic constant frequency (CF2, 57-60 kHz) component of the biosonar signal and were facilitated by a second signal within the first harmonic (Hl, 24-30 kHz) of the biosonar call. Most of the inhibitory interactions occurred between signals in the frequency bands associated with the frequency-modulated (FM) components of the biosonar call. The strongest combinatorial effects (facilitatory and inhibitory) were elicited by simultaneous onset of the two signals (i.e., 0 ms delay). All combination-sensitive units were in the intermediate nucleus of the NLL (INLL), which in bats is a hypertrophied structure that projects strongly to combination-sensitive neurons in the ICC. Thus, the combination-sensitive neurons in the INLL may impart their response properties onto ICC neurons. However, the small number of facilitatory combination-sensitive neurons in the NLL suggests that the majority of these combinatorial responses originate in the ICC.
Identifier
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<a href="http://doi.org/10.1007/s101620010057" target="_blank" rel="noreferrer noopener">10.1007/s101620010057</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2001
Acoustic Stimulation/methods
Animals
Auditory Pathways/*physiology
Brain Stem/*physiology
Chiroptera
College of Anatomy & Neurobiology
Department of Anatomy & Neurobiology
Electrophysiology
Journal of the Association for Research in Otolaryngology : JARO
NEOMED College of Medicine
Neurons/physiology
Portfors C V
Reaction Time/physiology
Wenstrup J J
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1007/s00429-017-1599-4" target="_blank" rel="noreferrer noopener">http://doi.org/10.1007/s00429-017-1599-4</a>
Pages
1923–1936
Issue
4
Volume
223
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
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GABAergic and non-GABAergic projections to the superior colliculus from the auditory brainstem.
Publisher
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Brain structure & function
Date
A point or period of time associated with an event in the lifecycle of the resource
2018
2018-05
Subject
The topic of the resource
Animals; Attention; Auditory Pathways/*physiology; Avoidance behavior; Brain Mapping; Escape; Female; Fluorescent Dyes/metabolism; Functional Laterality; GABAergic Neurons/*physiology; Glutamate Decarboxylase/*metabolism; Guinea Pigs; Inferior colliculus; Inhibition; Male; Nitric Oxide Synthase/metabolism; Nucleus of the brachium of the inferior colliculus; Orienting; Superior Colliculi/*cytology
Creator
An entity primarily responsible for making the resource
Mellott Jeffrey G; Beebe Nichole L; Schofield Brett R
Description
An account of the resource
The superior colliculus (SC) contains an auditory space map that is shaped by projections from several subcortical auditory nuclei. Both GABAergic (inhibitory) and excitatory cells contribute to these inputs, but there are contradictory reports regarding the sources of these inputs. We used retrograde tracing techniques in guinea pigs to identify cells in the auditory brainstem that project to the SC. We combined retrograde tracing with immunohistochemistry for glutamic acid decarboxylase (GAD) to identify putative GABAergic cells that participate in this pathway. Following a tracer injection in the SC, the nucleus of the brachium of the inferior colliculus (NBIC) contained the most labeled cells, followed by the inferior colliculus (IC). Smaller populations were observed in the sagulum, paralemniscal area, periolivary nuclei and ventrolateral tegmental nucleus. Overall, only 10% of the retrogradely labeled cells were GAD immunopositive. The presumptive inhibitory cells were observed in the NBIC, IC, superior paraolivary nucleus, sagulum and paralemniscal area. We conclude that the guinea pig SC receives input from a diverse set of auditory brainstem nuclei, some of which provide GABAergic input. These diverse origins of input to the SC likely represent a variety of functions. Inputs from the NBIC and IC likely provide spatial information for guiding orienting behaviors. Inputs from subcollicular nuclei are less likely to provide spatial information; rather, they may provide a shorter route for auditory information to reach the SC, and could generate avoidance or escape responses to an external threat.
Identifier
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<a href="http://doi.org/10.1007/s00429-017-1599-4" target="_blank" rel="noreferrer noopener">10.1007/s00429-017-1599-4</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2018
Animals
Attention
Auditory Pathways/*physiology
Avoidance behavior
Beebe Nichole L
Brain Mapping
Brain structure & function
Department of Anatomy & Neurobiology
Escape
Female
Fluorescent Dyes/metabolism
Functional Laterality
GABAergic Neurons/*physiology
Glutamate Decarboxylase/*metabolism
Guinea Pigs
inferior colliculus
inhibition
Male
Mellott Jeffrey G
NEOMED College of Medicine
Nitric Oxide Synthase/metabolism
Nucleus of the brachium of the inferior colliculus
Orienting
Schofield Brett R
Superior Colliculi/*cytology