1
40
2
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1016/j.brainresbull.2009.06.015" target="_blank" rel="noreferrer noopener">http://doi.org/10.1016/j.brainresbull.2009.06.015</a>
Pages
163–170
Issue
3
Volume
80
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Projections from auditory cortex to cholinergic cells in the midbrain tegmentum of guinea pigs.
Publisher
An entity responsible for making the resource available
Brain research bulletin
Date
A point or period of time associated with an event in the lifecycle of the resource
2009
2009-09
Subject
The topic of the resource
Animals; Auditory Cortex/*metabolism; Auditory Pathways/metabolism; Axonal Transport; Axons/metabolism; Choline O-Acetyltransferase/*metabolism; Efferent Pathways/metabolism; Female; Fluorescent Antibody Technique; Guinea Pigs; Immunohistochemistry; Male; Neurons/*metabolism; Tegmentum Mesencephali/*metabolism
Creator
An entity primarily responsible for making the resource
Schofield Brett R; Motts Susan D
Description
An account of the resource
Anterograde and retrograde tracing techniques were used to characterize projections from the auditory cortex to the pedunculopontine and laterodorsal tegmental nuclei (PPT and LDT, respectively) in the midbrain tegmentum in guinea pigs. For anterograde tracing, tetramethylrhodamine dextran (FluoroRuby) was injected at several sites within auditory cortex. After sufficient time for transport, the brain was processed for immunohistochemistry with anti-choline acetyltransferase to reveal presumptive cholinergic cells. Anterogradely labeled axons were observed ipsilaterally and, in smaller numbers, contralaterally, in both the pedunculopontine and laterodorsal tegmental nuclei. In all four nuclei, tracer-labeled boutons appeared to contact immunolabeled (i.e., cholinergic) cells. The contacts occurred on cell bodies and dendrites. The results were similar following injections that spread across multiple auditory cortical areas or injections that were within primary auditory cortex. In order to confirm the anterograde results, in a second series of experiments, retrograde tracers were deposited in the pedunculopontine tegmental nucleus. These injections labeled layer V pyramidal cells in the auditory cortex. The results suggest an excitatory projection from primary auditory cortex bilaterally to cholinergic cells in the midbrain tegmentum. Such a pathway could allow auditory cortex to activate brainstem cholinergic circuits, possibly including the cholinergic pathways associated with arousal and gating of acoustic stimuli.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1016/j.brainresbull.2009.06.015" target="_blank" rel="noreferrer noopener">10.1016/j.brainresbull.2009.06.015</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
2009
Animals
Auditory Cortex/*metabolism
Auditory Pathways/metabolism
Axonal Transport
Axons/metabolism
Brain research bulletin
Choline O-Acetyltransferase/*metabolism
Department of Anatomy & Neurobiology
Efferent Pathways/metabolism
Female
Fluorescent Antibody Technique
Guinea Pigs
Immunohistochemistry
Male
Motts Susan D
NEOMED College of Medicine
Neurons/*metabolism
Schofield Brett R
Tegmentum Mesencephali/*metabolism
-
Text
A resource consisting primarily of words for reading. Examples include books, letters, dissertations, poems, newspapers, articles, archives of mailing lists. Note that facsimiles or images of texts are still of the genre Text.
URL Address
<a href="http://doi.org/10.1152/physiolgenomics.2000.2.3.129" target="_blank" rel="noreferrer noopener">http://doi.org/10.1152/physiolgenomics.2000.2.3.129</a>
Pages
129–136
Issue
3
Volume
2
Dublin Core
The Dublin Core metadata element set is common to all Omeka records, including items, files, and collections. For more information see, http://dublincore.org/documents/dces/.
Title
A name given to the resource
Inactivation of one copy of the mouse neurotrophin-3 gene induces cardiac sympathetic deficits.
Publisher
An entity responsible for making the resource available
Physiological genomics
Date
A point or period of time associated with an event in the lifecycle of the resource
2000
2000-04
Subject
The topic of the resource
*Gene Dosage; Aging/metabolism; Animals; Axons/metabolism; Body Weight/genetics; Cell Count; Coronary Vessels/innervation; Heart Rate/genetics; Heart/*innervation; Heterozygote; Homozygote; In Situ Nick-End Labeling; Knockout; Mice; Muscle Tonus/genetics; Mutant Strains; Myocardium/cytology/*metabolism; Neurotrophin 3/deficiency/*genetics; Norepinephrine/metabolism; Organ Size/genetics; Stellate Ganglion/cytology; Sympathetic Nervous System/cytology/*growth & development/metabolism; Tyrosine 3-Monooxygenase/metabolism
Creator
An entity primarily responsible for making the resource
Story G M; DiCarlo S E; Rodenbaugh D W; Dluzen D E; Kucera J; Maron M B; Walro J M
Description
An account of the resource
Whether two copies of the neurotrophin-3 (NT3) gene are necessary for proper development of cardiac sympathetic innervation was investigated in mice carrying a targeted inactivation of the NT3 gene. Heterozygous (+/-) and null (-/-) mutant mice had fewer stellate ganglion neurons than did wild-type (+/+) mice at postnatal day 0 (P0 or birth), and this deficit was maintained between adult (P60) +/- and +/+ mice. The sympathetic innervation of the heart matured postnatally in +/+ and +/- mice. Tyrosine hydroxylase (TH)-positive axons were restricted largely to the epicardium at P0, were concentrated around large blood vessels in the myocardium at P21, and were present among cardiac myocytes at P60. Cardiac norepinephrine (NE) concentrations paralleled the growth of the sympathetic axons into the heart. NE concentrations were equivalent among +/+, +/-, and -/- mice at birth, but differences between +/- and +/+ mice increased with age. Adult +/- mice also exhibited lower resting heart rates and sympathetic tonus than +/+ mice. Thus deletion of one copy of the NT3 gene translates into anatomical, biochemical, and functional deficits in cardiac sympathetic innervation of postnatal mice, thereby indicating a gene-dosage effect for the NT3 gene.
Identifier
An unambiguous reference to the resource within a given context
<a href="http://doi.org/10.1152/physiolgenomics.2000.2.3.129" target="_blank" rel="noreferrer noopener">10.1152/physiolgenomics.2000.2.3.129</a>
Rights
Information about rights held in and over the resource
Article information provided for research and reference use only. All rights are retained by the journal listed under publisher and/or the creator(s).
*Gene Dosage
2000
Aging/metabolism
Animals
Axons/metabolism
Body Weight/genetics
Cell Count
Coronary Vessels/innervation
DiCarlo S E
Dluzen D E
Heart Rate/genetics
Heart/*innervation
Heterozygote
Homozygote
In Situ Nick-End Labeling
Knockout
Kucera J
Maron M B
Mice
Muscle Tonus/genetics
Mutant Strains
Myocardium/cytology/*metabolism
Neurotrophin 3/deficiency/*genetics
Norepinephrine/metabolism
Organ Size/genetics
Physiological genomics
Rodenbaugh D W
Stellate Ganglion/cytology
Story G M
Sympathetic Nervous System/cytology/*growth & development/metabolism
Tyrosine 3-Monooxygenase/metabolism
Walro J M